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Process View

Homo sapiens

25 genes annotated in human

stem cell proliferation

GO:0072089

The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "stem cell proliferation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "stem cell proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.887	Mouse
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.723
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.488	Fly
FGFR2	fibroblast growth factor receptor 2	0.399	Mouse
FBXW11	F-box and WD repeat domain containing 11	0.398
EGFR	epidermal growth factor receptor	0.386
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.383
SMAD7	SMAD family member 7	0.377
PRKCZ	protein kinase C, zeta	0.372
YAP1	Yes-associated protein 1	0.211	Mouse Fly
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.201	Human
STK11	serine/threonine kinase 11	0.193	Worm Fly
GRB2	growth factor receptor-bound protein 2	0.192
FGFR1	fibroblast growth factor receptor 1	0.180	Mouse Rat
IGF1R	insulin-like growth factor 1 receptor	0.168
SMAD2	SMAD family member 2	0.161
PLCG1	phospholipase C, gamma 1	0.159
FGF1	fibroblast growth factor 1 (acidic)	0.159	Human
INSR	insulin receptor	0.148
JUP	junction plakoglobin	0.128
PAX3	paired box 3	0.117
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.115
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.112	Fly
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.108
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.101	Fly
SKP1	S-phase kinase-associated protein 1	0.099
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.096
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.094	Human
NRP1	neuropilin 1	0.085
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.084	Fly
ARHGAP1	Rho GTPase activating protein 1	0.075
SOS1	son of sevenless homolog 1 (Drosophila)	0.074
GSK3B	glycogen synthase kinase 3 beta	0.073
FKBP1A	FK506 binding protein 1A, 12kDa	0.070
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.067
EIF2C4	eukaryotic translation initiation factor 2C, 4	0.067	Human
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.066	Fly
POU3F2	POU class 3 homeobox 2	0.064
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.061
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.059
EIF2C3	eukaryotic translation initiation factor 2C, 3	0.059
TCF4	transcription factor 4	0.057
IRS1	insulin receptor substrate 1	0.057	Mouse
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.055	Fly
TNIP2	TNFAIP3 interacting protein 2	0.055
CDH5	cadherin 5, type 2 (vascular endothelium)	0.052
MAPT	microtubule-associated protein tau	0.051
BMPR1A	bone morphogenetic protein receptor, type IA	0.050	Mouse
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.050
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.050
ELN	elastin	0.048
PSEN1	presenilin 1	0.048
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.048	Zebrafish Fly
IL8	interleukin 8	0.047
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.046
HSPG2	heparan sulfate proteoglycan 2	0.045
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.045	Mouse
ATN1	atrophin 1	0.042
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.042
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.041
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.040	Fly
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.040
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.038	Mouse
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.038
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.038
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.037	Mouse
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.036	Mouse
CDK2	cyclin-dependent kinase 2	0.036
FSTL1	follistatin-like 1	0.035
APC	adenomatous polyposis coli	0.034	Fly
CTBP1	C-terminal binding protein 1	0.034
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.033	Fly
COX6C	cytochrome c oxidase subunit VIc	0.033
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.033
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.032
CXCL3	chemokine (C-X-C motif) ligand 3	0.032	Mouse
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.032
LTBP4	latent transforming growth factor beta binding protein 4	0.031	Human
CBX5	chromobox homolog 5	0.030
ZMYND11	zinc finger, MYND-type containing 11	0.030
SNW1	SNW domain containing 1	0.030
GRB10	growth factor receptor-bound protein 10	0.030
FBLN5	fibulin 5	0.030	Human
TBX2	T-box 2	0.030
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.030
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.030
JUB	jub, ajuba homolog (Xenopus laevis)	0.030
ZBED1	zinc finger, BED-type containing 1	0.030
DAXX	death-domain associated protein	0.029
SIRT1	sirtuin 1	0.029
SFRP1	secreted frizzled-related protein 1	0.029
TGFB1	transforming growth factor, beta 1	0.028	Rat
PKP2	plakophilin 2	0.028
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.028	Fly
FBLN1	fibulin 1	0.027	Human
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.027
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.027
NCOR1	nuclear receptor corepressor 1	0.026
ARID1A	AT rich interactive domain 1A (SWI-like)	0.026
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.025
FGF10	fibroblast growth factor 10	0.025	Human
NUMA1	nuclear mitotic apparatus protein 1	0.025
CSH2	chorionic somatomammotropin hormone 2	0.025	Rat
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.024	Fly
BMP2	bone morphogenetic protein 2	0.024	Human Mouse
PRKCI	protein kinase C, iota	0.024	Zebrafish
TNRC6A	trinucleotide repeat containing 6A	0.023
NOG	noggin	0.023
BMP4	bone morphogenetic protein 4	0.023
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.023
FZD1	frizzled homolog 1 (Drosophila)	0.022
JAG2	jagged 2	0.022
SMAD4	SMAD family member 4	0.022
GLIS2	GLIS family zinc finger 2	0.022
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.021
IQGAP1	IQ motif containing GTPase activating protein 1	0.021
TJP1	tight junction protein 1 (zona occludens 1)	0.021
CDK8	cyclin-dependent kinase 8	0.021
CDK1	cyclin-dependent kinase 1	0.021	Fly
SFN	stratifin	0.021
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.020
COL6A2	collagen, type VI, alpha 2	0.020
LOXL1	lysyl oxidase-like 1	0.020
PDGFC	platelet derived growth factor C	0.020
COL6A1	collagen, type VI, alpha 1	0.020
FGF2	fibroblast growth factor 2 (basic)	0.020	Human
BAIAP2	BAI1-associated protein 2	0.020
FGF18	fibroblast growth factor 18	0.020
ETFA	electron-transfer-flavoprotein, alpha polypeptide	0.020
GATAD2B	GATA zinc finger domain containing 2B	0.020
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.020
TP53	tumor protein p53	0.019	Mouse Fly
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.019	Fly
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.019
TNRC6C	trinucleotide repeat containing 6C	0.019
LTBP2	latent transforming growth factor beta binding protein 2	0.019	Human
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.019
STRADA	STE20-related kinase adaptor alpha	0.018	Worm
FYN	FYN oncogene related to SRC, FGR, YES	0.018
COL1A2	collagen, type I, alpha 2	0.018
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.018
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.018
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.018
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.018
GH2	growth hormone 2	0.018	Rat
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.018
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.018
ENG	endoglin	0.017
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.017
EGR1	early growth response 1	0.017
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.017
CTGF	connective tissue growth factor	0.017
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.017
CAV1	caveolin 1, caveolae protein, 22kDa	0.017
COX5B	cytochrome c oxidase subunit Vb	0.017
CAB39	calcium binding protein 39	0.017	Worm
CSH1	chorionic somatomammotropin hormone 1 (placental lactogen)	0.017	Rat
TGFB2	transforming growth factor, beta 2	0.017
CREBBP	CREB binding protein	0.017
FERMT2	fermitin family member 2	0.017
TNRC6B	trinucleotide repeat containing 6B	0.017
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.017	Mouse
HOXD9	homeobox D9	0.016
APP	amyloid beta (A4) precursor protein	0.016
BMP1	bone morphogenetic protein 1	0.016
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.016	Fly
ECT2	epithelial cell transforming sequence 2 oncogene	0.016
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.016
OXSR1	oxidative-stress responsive 1	0.016
SNAI1	snail homolog 1 (Drosophila)	0.016	Fly
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.016
SOX11	SRY (sex determining region Y)-box 11	0.016
ZBTB20	zinc finger and BTB domain containing 20	0.016
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.016
TOP1	topoisomerase (DNA) I	0.016
AMOTL1	angiomotin like 1	0.016
RHOXF2	Rhox homeobox family, member 2	0.015
TRAF5	TNF receptor-associated factor 5	0.015
SKA3	spindle and kinetochore associated complex subunit 3	0.015
IGFBP5	insulin-like growth factor binding protein 5	0.015
PPP2R5E	protein phosphatase 2, regulatory subunit B', epsilon isoform	0.015
RANBP9	RAN binding protein 9	0.015
FGF8	fibroblast growth factor 8 (androgen-induced)	0.015
NDUFS4	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	0.015
HTT	huntingtin	0.015
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.015
NFYB	nuclear transcription factor Y, beta	0.015
LGALS8	lectin, galactoside-binding, soluble, 8	0.014
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.014
HMGA1	high mobility group AT-hook 1	0.014	Human
HDAC4	histone deacetylase 4	0.014
GFI1B	growth factor independent 1B transcription repressor	0.014
RUNX1	runt-related transcription factor 1	0.014
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.014
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.014
HIPK2	homeodomain interacting protein kinase 2	0.014
EP300	E1A binding protein p300	0.014
ERBB2IP	erbb2 interacting protein	0.014
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.014
LIN28B	lin-28 homolog B (C. elegans)	0.014
MEOX2	mesenchyme homeobox 2	0.014
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.014
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.013
NCF2	neutrophil cytosolic factor 2	0.013
LRP6	low density lipoprotein receptor-related protein 6	0.013	Human Mouse
ERRFI1	ERBB receptor feedback inhibitor 1	0.013
AMOTL2	angiomotin like 2	0.013
FGF7	fibroblast growth factor 7	0.013
GH1	growth hormone 1	0.013	Rat
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.013	Fly
GAB1	GRB2-associated binding protein 1	0.013
SOX1	SRY (sex determining region Y)-box 1	0.013	Human
HIC1	hypermethylated in cancer 1	0.013
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.013
DICER1	dicer 1, ribonuclease type III	0.012
ITSN1	intersectin 1 (SH3 domain protein)	0.012	Fly
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.012
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.012
ADORA2A	adenosine A2a receptor	0.012
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.012
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.012
HIST1H3B	histone cluster 1, H3b	0.012
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.012	Mouse
WNT1	wingless-type MMTV integration site family, member 1	0.012	Human Mouse Fly
CXCL2	chemokine (C-X-C motif) ligand 2	0.012	Mouse
TGFBR1	transforming growth factor, beta receptor 1	0.012	Fly
AGFG1	ArfGAP with FG repeats 1	0.012
IPO8	importin 8	0.012
LHX2	LIM homeobox 2	0.012
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.012
TP53BP2	tumor protein p53 binding protein, 2	0.012
FOXD3	forkhead box D3	0.012
LDLR	low density lipoprotein receptor	0.011
ZFYVE9	zinc finger, FYVE domain containing 9	0.011
LCK	lymphocyte-specific protein tyrosine kinase	0.011
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.011
TJP2	tight junction protein 2 (zona occludens 2)	0.011
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.011
QKI	quaking homolog, KH domain RNA binding (mouse)	0.011
FGF4	fibroblast growth factor 4	0.011
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.011
BCL3	B-cell CLL/lymphoma 3	0.011
NFYC	nuclear transcription factor Y, gamma	0.011
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.011
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.011
GAS1	growth arrest-specific 1	0.011	Mouse
CCNB1	cyclin B1	0.011
SALL2	sal-like 2 (Drosophila)	0.011
PECAM1	platelet/endothelial cell adhesion molecule	0.011
HMOX2	heme oxygenase (decycling) 2	0.011
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.011
DAZAP2	DAZ associated protein 2	0.011
CAPNS1	calpain, small subunit 1	0.011
GABARAP	GABA(A) receptor-associated protein	0.011
PGF	placental growth factor	0.011
NCOR2	nuclear receptor corepressor 2	0.011
KRT5	keratin 5	0.011
MED28	mediator complex subunit 28	0.011
FOXF2	forkhead box F2	0.011
TP73	tumor protein p73	0.011
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.011
DDR2	discoidin domain receptor tyrosine kinase 2	0.011
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.011
KAT2B	K(lysine) acetyltransferase 2B	0.011
NFIA	nuclear factor I/A	0.010
MSX2	msh homeobox 2	0.010
FRS2	fibroblast growth factor receptor substrate 2	0.010	Mouse
AR	androgen receptor	0.010
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.010
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.010
MAP1A	microtubule-associated protein 1A	0.010
PRKCA	protein kinase C, alpha	0.010
COL2A1	collagen, type II, alpha 1	0.010
WDYHV1	WDYHV motif containing 1	0.010
CCND2	cyclin D2	0.010
COX7C	cytochrome c oxidase subunit VIIc	0.010
FZD7	frizzled homolog 7 (Drosophila)	0.010
JAG1	jagged 1	0.010
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.010	Fly
GNAI1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	0.010	Fly
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.010