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Homo sapiens

21 genes annotated in human

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negative regulation of neuron differentiation

GO:0045665

Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of neuron differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of neuron differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
NOTCH1	notch 1	0.790	Mouse Rat Fly
LRP1	low density lipoprotein receptor-related protein 1	0.702
FGF1	fibroblast growth factor 1 (acidic)	0.664
JAG1	jagged 1	0.661	Mouse
NOTCH3	notch 3	0.609	Mouse Fly
RXRA	retinoid X receptor, alpha	0.529
PBX1	pre-B-cell leukemia homeobox 1	0.524	Mouse
FYN	FYN oncogene related to SRC, FGR, YES	0.518
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.393
PSEN2	presenilin 2 (Alzheimer disease 4)	0.316
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.307
MEIS1	Meis homeobox 1	0.280	Mouse
BCAR1	breast cancer anti-estrogen resistance 1	0.252
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.206
RNF11	ring finger protein 11	0.163
CPE	carboxypeptidase E	0.149
FLNB	filamin B, beta	0.142
MEIS2	Meis homeobox 2	0.139
JAG2	jagged 2	0.120
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.118
TCF4	transcription factor 4	0.111
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.106
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.106	Mouse
TTR	transthyretin	0.102
ATG13	ATG13 autophagy related 13 homolog (S. cerevisiae)	0.093
RB1CC1	RB1-inducible coiled-coil 1	0.089
ATXN1	ataxin 1	0.087
PARP14	poly (ADP-ribose) polymerase family, member 14	0.084
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.083
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.080
FZD1	frizzled homolog 1 (Drosophila)	0.077
FBLN1	fibulin 1	0.077
MAPT	microtubule-associated protein tau	0.076
CDK5	cyclin-dependent kinase 5	0.073	Mouse
MAPK1	mitogen-activated protein kinase 1	0.072
DCC	deleted in colorectal carcinoma	0.071
FGFR1	fibroblast growth factor receptor 1	0.070	Fly
BMPR1B	bone morphogenetic protein receptor, type IB	0.067
SALL2	sal-like 2 (Drosophila)	0.066
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.066
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.066
A2M	alpha-2-macroglobulin	0.065
LUC7L2	LUC7-like 2 (S. cerevisiae)	0.063
HP	haptoglobin	0.061
VEGFA	vascular endothelial growth factor A	0.060
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.060
STMN2	stathmin-like 2	0.056
GSK3B	glycogen synthase kinase 3 beta	0.056	Mouse Rat
NCOA1	nuclear receptor coactivator 1	0.055
PRKD2	protein kinase D2	0.051
UBE3A	ubiquitin protein ligase E3A	0.049
ALK	anaplastic lymphoma receptor tyrosine kinase	0.048
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.048
MAP2K1	mitogen-activated protein kinase kinase 1	0.047
SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	0.046
NGFR	nerve growth factor receptor	0.046	Rat
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.046
LRP6	low density lipoprotein receptor-related protein 6	0.045
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.045
VSNL1	visinin-like 1	0.043
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.042
SETDB1	SET domain, bifurcated 1	0.042
SESN2	sestrin 2	0.041
CLIP1	CAP-GLY domain containing linker protein 1	0.041
APP	amyloid beta (A4) precursor protein	0.040	Mouse
RAB2A	RAB2A, member RAS oncogene family	0.039
TP73	tumor protein p73	0.038	Rat
TESC	tescalcin	0.036
CDK6	cyclin-dependent kinase 6	0.036
CTGF	connective tissue growth factor	0.036
BBS10	Bardet-Biedl syndrome 10	0.036
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.035
FGFR2	fibroblast growth factor receptor 2	0.035	Fly
MIB1	mindbomb homolog 1 (Drosophila)	0.035	Mouse
DDAH2	dimethylarginine dimethylaminohydrolase 2	0.035
OLIG2	oligodendrocyte lineage transcription factor 2	0.034	Mouse
EPOR	erythropoietin receptor	0.034
SLIT2	slit homolog 2 (Drosophila)	0.033
SOX2	SRY (sex determining region Y)-box 2	0.033	Mouse
FOXD3	forkhead box D3	0.033
STARD9	StAR-related lipid transfer (START) domain containing 9	0.033
CCDC85A	coiled-coil domain containing 85A	0.032
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.032
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.032
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.031
IL1R1	interleukin 1 receptor, type I	0.031
STAU1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.031
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.031
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.031
GABARAP	GABA(A) receptor-associated protein	0.030
PTN	pleiotrophin	0.030
GOLGA2	golgin A2	0.029
GANAB	glucosidase, alpha; neutral AB	0.028
HOXB1	homeobox B1	0.027
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.027
NCAN	neurocan	0.027
ATG9A	ATG9 autophagy related 9 homolog A (S. cerevisiae)	0.027
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.027
QKI	quaking homolog, KH domain RNA binding (mouse)	0.027
COL4A3BP	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein	0.027
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.027
CXCR4	chemokine (C-X-C motif) receptor 4	0.026
TEX11	testis expressed 11	0.026
SOX11	SRY (sex determining region Y)-box 11	0.026
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.026
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.026
TGFB2	transforming growth factor, beta 2	0.026
DLL1	delta-like 1 (Drosophila)	0.025	Mouse
RAX	retina and anterior neural fold homeobox	0.025
NOTCH2	notch 2	0.025	Fly
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.025
FN1	fibronectin 1	0.025
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.024
SIX3	SIX homeobox 3	0.024
FAM160A2	family with sequence similarity 160, member A2	0.024
XIAP	X-linked inhibitor of apoptosis	0.024
P4HB	prolyl 4-hydroxylase, beta polypeptide	0.024
POU3F2	POU class 3 homeobox 2	0.024
SOX10	SRY (sex determining region Y)-box 10	0.024
SNX9	sorting nexin 9	0.024
SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	0.024
EFNB2	ephrin-B2	0.023
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.023
LCAT	lecithin-cholesterol acyltransferase	0.023
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.023
STK36	serine/threonine kinase 36	0.023
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.022
SOX1	SRY (sex determining region Y)-box 1	0.022
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.022
APOC3	apolipoprotein C-III	0.022
MYH10	myosin, heavy chain 10, non-muscle	0.022
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.021	Rat
TAF1D	TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa	0.021
RTN4	reticulon 4	0.021
JAK3	Janus kinase 3	0.021
EFNB3	ephrin-B3	0.021
LRP2	low density lipoprotein receptor-related protein 2	0.021
AR	androgen receptor	0.021
PPP1R8	protein phosphatase 1, regulatory (inhibitor) subunit 8	0.021
PDIA3	protein disulfide isomerase family A, member 3	0.020
APLP1	amyloid beta (A4) precursor-like protein 1	0.020
CREB1	cAMP responsive element binding protein 1	0.020
HPCAL4	hippocalcin like 4	0.020
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.020
AATK	apoptosis-associated tyrosine kinase	0.020	Mouse
NOG	noggin	0.020
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.020
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.020
DCTN1	dynactin 1	0.020
FGF8	fibroblast growth factor 8 (androgen-induced)	0.019
TSC22D4	TSC22 domain family, member 4	0.019
MAP1S	microtubule-associated protein 1S	0.019
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.019	Human
TMED3	transmembrane emp24 protein transport domain containing 3	0.019
LCMT1	leucine carboxyl methyltransferase 1	0.019
LHX3	LIM homeobox 3	0.019
NR2F1	nuclear receptor subfamily 2, group F, member 1	0.019	Rat
SMAD1	SMAD family member 1	0.019
HYOU1	hypoxia up-regulated 1	0.018
WASL	Wiskott-Aldrich syndrome-like	0.018
TGFB1	transforming growth factor, beta 1	0.018
APLP2	amyloid beta (A4) precursor-like protein 2	0.018
EEF2K	eukaryotic elongation factor-2 kinase	0.018
COL2A1	collagen, type II, alpha 1	0.018
BMP7	bone morphogenetic protein 7	0.018
PDX1	pancreatic and duodenal homeobox 1	0.018
FGF10	fibroblast growth factor 10	0.017
FZD8	frizzled homolog 8 (Drosophila)	0.017
JAK2	Janus kinase 2	0.017
ZMYM2	zinc finger, MYM-type 2	0.017
RCOR1	REST corepressor 1	0.017
HOXA9	homeobox A9	0.017
RUNDC3A	RUN domain containing 3A	0.017
FGFR3	fibroblast growth factor receptor 3	0.017	Fly
HMG20B	high mobility group 20B	0.017
RAP1A	RAP1A, member of RAS oncogene family	0.017
DUSP1	dual specificity phosphatase 1	0.017
ATN1	atrophin 1	0.017
SEPT4	septin 4	0.017
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.017
FXR1	fragile X mental retardation, autosomal homolog 1	0.017	Fly
BMP4	bone morphogenetic protein 4	0.017
BACE1	beta-site APP-cleaving enzyme 1	0.017
WBP2	WW domain binding protein 2	0.017
COL5A1	collagen, type V, alpha 1	0.016
WWOX	WW domain containing oxidoreductase	0.016
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.016
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.016
RTN3	reticulon 3	0.016	Human
TBC1D14	TBC1 domain family, member 14	0.016
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.016
PDGFC	platelet derived growth factor C	0.016
CEBPZ	CCAAT/enhancer binding protein (C/EBP), zeta	0.016
CNTN1	contactin 1	0.016	Human
MBP	myelin basic protein	0.016
NKX2-2	NK2 homeobox 2	0.016	Mouse
CALR	calreticulin	0.015
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.015
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.015	Mouse
ZNF746	zinc finger protein 746	0.015
PKP4	plakophilin 4	0.015
PEA15	phosphoprotein enriched in astrocytes 15	0.015
PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	0.015
CXCL14	chemokine (C-X-C motif) ligand 14	0.015
HTRA1	HtrA serine peptidase 1	0.015
PAX6	paired box 6	0.015	Mouse
AP1M1	adaptor-related protein complex 1, mu 1 subunit	0.015
MAP2K4	mitogen-activated protein kinase kinase 4	0.015
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.015
PKN2	protein kinase N2	0.015
DUSP3	dual specificity phosphatase 3	0.015
FGF2	fibroblast growth factor 2 (basic)	0.015
PCDH17	protocadherin 17	0.015
CCNK	cyclin K	0.015
COL11A1	collagen, type XI, alpha 1	0.015
CDYL	chromodomain protein, Y-like	0.014
NGF	nerve growth factor (beta polypeptide)	0.014
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.014
LAPTM4A	lysosomal protein transmembrane 4 alpha	0.014
MCAM	melanoma cell adhesion molecule	0.014
EED	embryonic ectoderm development	0.014
ZNF331	zinc finger protein 331	0.014
EPRS	glutamyl-prolyl-tRNA synthetase	0.014
SFRP1	secreted frizzled-related protein 1	0.014
PTPRR	protein tyrosine phosphatase, receptor type, R	0.014
FZD7	frizzled homolog 7 (Drosophila)	0.014
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.014
EDNRA	endothelin receptor type A	0.014
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.014
KCNRG	potassium channel regulator	0.014
ALB	albumin	0.014
BCAN	brevican	0.014
MED13	mediator complex subunit 13	0.014
CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.013
SLC9A3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.013
IL12RB2	interleukin 12 receptor, beta 2	0.013
GJA1	gap junction protein, alpha 1, 43kDa	0.013
PTPN5	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	0.013
MBD2	methyl-CpG binding domain protein 2	0.013
EPHB3	EPH receptor B3	0.013
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.013
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.013
ATG4B	ATG4 autophagy related 4 homolog B (S. cerevisiae)	0.013
MAPK3	mitogen-activated protein kinase 3	0.013
CFL1	cofilin 1 (non-muscle)	0.013
EGFL7	EGF-like-domain, multiple 7	0.013
MYO6	myosin VI	0.013
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.013
SOX4	SRY (sex determining region Y)-box 4	0.013
SLC6A1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	0.013
LHX2	LIM homeobox 2	0.013
THRA	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	0.012
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.012
DAXX	death-domain associated protein	0.012
BCAS2	breast carcinoma amplified sequence 2	0.012
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.012
PRKCG	protein kinase C, gamma	0.012
MYT1	myelin transcription factor 1	0.012
CRMP1	collapsin response mediator protein 1	0.012
SNX5	sorting nexin 5	0.012
C10orf116	chromosome 10 open reading frame 116	0.012
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.012
SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.012	Rat
GPRASP2	G protein-coupled receptor associated sorting protein 2	0.012
LMO4	LIM domain only 4	0.012
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.012
DUSP6	dual specificity phosphatase 6	0.012
NELL2	NEL-like 2 (chicken)	0.012
FOXC1	forkhead box C1	0.012
MPP1	membrane protein, palmitoylated 1, 55kDa	0.012
OTX2	orthodenticle homeobox 2	0.012
ELAVL3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.012
LAMB1	laminin, beta 1	0.012
FZD5	frizzled homolog 5 (Drosophila)	0.012
SOX9	SRY (sex determining region Y)-box 9	0.012	Mouse
ASCL1	achaete-scute complex homolog 1 (Drosophila)	0.012
SAP30	Sin3A-associated protein, 30kDa	0.012
SENP2	SUMO1/sentrin/SMT3 specific peptidase 2	0.012
SF3A1	splicing factor 3a, subunit 1, 120kDa	0.011
VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)	0.011
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.011
ACAN	aggrecan	0.011
RAB33A	RAB33A, member RAS oncogene family	0.011
FOXF2	forkhead box F2	0.011
PAX3	paired box 3	0.011
CDC40	cell division cycle 40 homolog (S. cerevisiae)	0.011
GAP43	growth associated protein 43	0.011
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.011
NR2E1	nuclear receptor subfamily 2, group E, member 1	0.011	Mouse
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.011
DDR1	discoidin domain receptor tyrosine kinase 1	0.011
ARL4D	ADP-ribosylation factor-like 4D	0.011
HSF2	heat shock transcription factor 2	0.011
SPTBN4	spectrin, beta, non-erythrocytic 4	0.011
SMAD9	SMAD family member 9	0.011
BCL2	B-cell CLL/lymphoma 2	0.011
ADD3	adducin 3 (gamma)	0.011
LDLR	low density lipoprotein receptor	0.011
POLR2G	polymerase (RNA) II (DNA directed) polypeptide G	0.011
NOS3	nitric oxide synthase 3 (endothelial cell)	0.011
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.011
APOE	apolipoprotein E	0.011
SNCAIP	synuclein, alpha interacting protein	0.011
TSC2	tuberous sclerosis 2	0.011
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.011
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.011
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.011
SOX21	SRY (sex determining region Y)-box 21	0.011
MYOD1	myogenic differentiation 1	0.011
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.011
POU5F1	POU class 5 homeobox 1	0.011
MED12	mediator complex subunit 12	0.011
RBM7	RNA binding motif protein 7	0.011
PHF17	PHD finger protein 17	0.011
CSNK2A2	casein kinase 2, alpha prime polypeptide	0.011
ONECUT1	one cut homeobox 1	0.011
LHX1	LIM homeobox 1	0.010
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.010
PRR13	proline rich 13	0.010
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.010
KCTD4	potassium channel tetramerisation domain containing 4	0.010
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.010
CABLES1	Cdk5 and Abl enzyme substrate 1	0.010
ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2	0.010
CSNK1E	casein kinase 1, epsilon	0.010
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.010
APOA2	apolipoprotein A-II	0.010
SORBS1	sorbin and SH3 domain containing 1	0.010
DCX	doublecortin	0.010
PARP9	poly (ADP-ribose) polymerase family, member 9	0.010
FEZF2	FEZ family zinc finger 2	0.010
IGF1R	insulin-like growth factor 1 receptor	0.010
PAX7	paired box 7	0.010
TMEM214	transmembrane protein 214	0.010
SLC17A7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	0.010
DLL3	delta-like 3 (Drosophila)	0.010