IMP
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regulation of natural killer cell mediated cytotoxicity
Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.
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Click on a gene's description to view its network relationships with genes known to be involved in "regulation of natural killer cell mediated cytotoxicity"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| H2-K1 | histocompatibility 2, K1, K region | 0.986 | Mouse Rat | |
| Tapbp | TAP binding protein | 0.981 | ||
| H2-D1 | histocompatibility 2, D region locus 1 | 0.965 | Mouse | |
| Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.937 | ||
| Slamf1 | signaling lymphocytic activation molecule family member 1 | 0.907 | ||
| Tap2 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | 0.855 | Rat | |
| Klra9 | killer cell lectin-like receptor subfamily A, member 9 | 0.844 | ||
| Psmb9 | proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) | 0.827 | ||
| Psmb8 | proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) | 0.745 | ||
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.644 | Mouse | |
| Irf9 | interferon regulatory factor 9 | 0.602 | ||
| Klrc1 | killer cell lectin-like receptor subfamily C, member 1 | 0.589 | Mouse | |
| H2-Q7 | histocompatibility 2, Q region locus 7 | 0.585 | ||
| B2m | beta-2 microglobulin | 0.556 | ||
| Gzma | granzyme A | 0.485 | ||
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.424 | ||
| Stat1 | signal transducer and activator of transcription 1 | 0.357 | Mouse | |
| Trim21 | tripartite motif-containing 21 | 0.352 | ||
| Tap1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 0.316 | Rat | |
| Gzmk | granzyme K | 0.288 | ||
| Il6 | interleukin 6 | 0.288 | ||
| H2-Q6 | histocompatibility 2, Q region locus 6 | 0.258 | Rat | |
| Gbp2 | guanylate binding protein 2 | 0.248 | ||
| Irgm2 | immunity-related GTPase family M member 2 | 0.247 | ||
| Itk | IL2-inducible T-cell kinase | 0.217 | ||
| Xcl1 | chemokine (C motif) ligand 1 | 0.201 | ||
| Klra7 | killer cell lectin-like receptor, subfamily A, member 7 | 0.197 | Mouse | |
| Igtp | interferon gamma induced GTPase | 0.192 | ||
| Gzmb | granzyme B | 0.181 | ||
| H2-Q8 | histocompatibility 2, Q region locus 8 | 0.181 | ||
| Gbp7 | guanylate binding protein 7 | 0.156 | ||
| Irf1 | interferon regulatory factor 1 | 0.153 | ||
| Psmb10 | proteasome (prosome, macropain) subunit, beta type 10 | 0.148 | ||
| Ncr1 | natural cytotoxicity triggering receptor 1 | 0.136 | ||
| Pyhin1 | pyrin and HIN domain family, member 1 | 0.135 | ||
| Parp14 | poly (ADP-ribose) polymerase family, member 14 | 0.127 | ||
| Klra3 | killer cell lectin-like receptor, subfamily A, member 3 | 0.115 | Mouse | |
| Il18rap | interleukin 18 receptor accessory protein | 0.086 | ||
| Irgm1 | immunity-related GTPase family M member 1 | 0.085 | ||
| Stat2 | signal transducer and activator of transcription 2 | 0.084 | Mouse | |
| Arrb1 | arrestin, beta 1 | 0.084 | ||
| Klrb1b | killer cell lectin-like receptor subfamily B member 1B | 0.082 | ||
| Cd7 | CD7 antigen | 0.081 | ||
| AW112010 | expressed sequence AW112010 | 0.078 | ||
| Slamf7 | SLAM family member 7 | 0.069 | ||
| BC147527 | cDNA sequence BC147527 | 0.067 | ||
| Il18r1 | interleukin 18 receptor 1 | 0.067 | ||
| Nkg7 | natural killer cell group 7 sequence | 0.066 | ||
| Ifi35 | interferon-induced protein 35 | 0.065 | ||
| Stat4 | signal transducer and activator of transcription 4 | 0.064 | Mouse | |
| Klrg1 | killer cell lectin-like receptor subfamily G, member 1 | 0.064 | Mouse | |
| Tgtp2 | T-cell specific GTPase 2 | 0.062 | ||
| Ccr9 | chemokine (C-C motif) receptor 9 | 0.059 | ||
| Gbp3 | guanylate binding protein 3 | 0.057 | ||
| Klrb1c | killer cell lectin-like receptor subfamily B member 1C | 0.056 | ||
| Cd84 | CD84 antigen | 0.055 | ||
| Klrb1f | killer cell lectin-like receptor subfamily B member 1F | 0.055 | Mouse | |
| H2-Q5 | histocompatibility 2, Q region locus 5 | 0.054 | ||
| Il2ra | interleukin 2 receptor, alpha chain | 0.053 | ||
| Tnfsf10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.053 | ||
| Cxcl9 | chemokine (C-X-C motif) ligand 9 | 0.050 | ||
| Iigp1 | interferon inducible GTPase 1 | 0.048 | ||
| Emr4 | EGF-like module containing, mucin-like, hormone receptor-like sequence 4 | 0.047 | ||
| Ccr3 | chemokine (C-C motif) receptor 3 | 0.047 | ||
| Ctsw | cathepsin W | 0.046 | ||
| Cd160 | CD160 antigen | 0.045 | ||
| Pilrb1 | paired immunoglobin-like type 2 receptor beta 1 | 0.045 | ||
| Cd180 | CD180 antigen | 0.044 | ||
| Nmi | N-myc (and STAT) interactor | 0.044 | ||
| Lgals3bp | lectin, galactoside-binding, soluble, 3 binding protein | 0.044 | ||
| Il4ra | interleukin 4 receptor, alpha | 0.044 | ||
| Ccl5 | chemokine (C-C motif) ligand 5 | 0.043 | ||
| Prf1 | perforin 1 (pore forming protein) | 0.042 | ||
| Aoah | acyloxyacyl hydrolase | 0.042 | ||
| Cd244 | CD244 natural killer cell receptor 2B4 | 0.042 | ||
| Parp10 | poly (ADP-ribose) polymerase family, member 10 | 0.041 | ||
| Icos | inducible T-cell co-stimulator | 0.039 | ||
| H2-Eb1 | histocompatibility 2, class II antigen E beta | 0.039 | ||
| Klra8 | killer cell lectin-like receptor, subfamily A, member 8 | 0.039 | ||
| Parp9 | poly (ADP-ribose) polymerase family, member 9 | 0.038 | ||
| Ifi47 | interferon gamma inducible protein 47 | 0.037 | ||
| Kmo | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | 0.036 | ||
| Zfp36 | zinc finger protein 36 | 0.036 | ||
| Cxcr6 | chemokine (C-X-C motif) receptor 6 | 0.036 | ||
| Gbp1 | guanylate binding protein 1 | 0.035 | ||
| Uba7 | ubiquitin-like modifier activating enzyme 7 | 0.035 | ||
| Cd3g | CD3 antigen, gamma polypeptide | 0.035 | ||
| Klrb1a | killer cell lectin-like receptor subfamily B member 1A | 0.033 | Mouse | |
| Fcrla | Fc receptor-like A | 0.033 | ||
| Slfn1 | schlafen 1 | 0.032 | ||
| Itgax | integrin alpha X | 0.031 | ||
| Cd2 | CD2 antigen | 0.030 | ||
| Il10 | interleukin 10 | 0.030 | ||
| C920025E04Rik | RIKEN cDNA C920025E04 gene | 0.030 | ||
| Bex6 | brain expressed gene 6 | 0.030 | ||
| Sh2d2a | SH2 domain protein 2A | 0.029 | ||
| Klra5 | killer cell lectin-like receptor, subfamily A, member 5 | 0.029 | Mouse | |
| Slamf6 | SLAM family member 6 | 0.029 | ||
| Klra17 | killer cell lectin-like receptor, subfamily A, member 17 | 0.029 | Mouse | |
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.028 | ||
| Tapbpl | TAP binding protein-like | 0.027 | ||
| Ms4a1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.027 | ||
| Slc40a1 | solute carrier family 40 (iron-regulated transporter), member 1 | 0.027 | ||
| Psme1 | proteasome (prosome, macropain) 28 subunit, alpha | 0.027 | ||
| Gimap7 | GTPase, IMAP family member 7 | 0.026 | ||
| Txk | TXK tyrosine kinase | 0.026 | ||
| Sp100 | nuclear antigen Sp100 | 0.026 | ||
| Stap1 | signal transducing adaptor family member 1 | 0.026 | ||
| Ctla4 | cytotoxic T-lymphocyte-associated protein 4 | 0.025 | ||
| Ms4a4b | membrane-spanning 4-domains, subfamily A, member 4B | 0.025 | ||
| Clec2i | C-type lectin domain family 2, member i | 0.025 | Mouse | |
| Lair1 | leukocyte-associated Ig-like receptor 1 | 0.024 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.024 | Mouse | |
| Gzmc | granzyme C | 0.024 | ||
| Itga4 | integrin alpha 4 | 0.024 | ||
| Ly6e | lymphocyte antigen 6 complex, locus E | 0.024 | ||
| Ifnar2 | interferon (alpha and beta) receptor 2 | 0.024 | ||
| Bst2 | bone marrow stromal cell antigen 2 | 0.023 | ||
| Stat6 | signal transducer and activator of transcription 6 | 0.023 | Mouse | |
| Cd96 | CD96 antigen | 0.023 | ||
| Cd3d | CD3 antigen, delta polypeptide | 0.022 | ||
| Gcet2 | germinal center expressed transcript 2 | 0.022 | ||
| Myd88 | myeloid differentiation primary response gene 88 | 0.022 | ||
| Klra2 | killer cell lectin-like receptor, subfamily A, member 2 | 0.022 | Mouse | |
| Herc6 | hect domain and RLD 6 | 0.022 | ||
| Il2rb | interleukin 2 receptor, beta chain | 0.021 | ||
| Ifi203 | interferon activated gene 203 | 0.021 | ||
| Cp | ceruloplasmin | 0.020 | ||
| Art2b | ADP-ribosyltransferase 2b | 0.020 | ||
| H2-Ob | histocompatibility 2, O region beta locus | 0.020 | ||
| Eomes | eomesodermin homolog (Xenopus laevis) | 0.019 | ||
| Lcn4 | lipocalin 4 | 0.019 | ||
| Kynu | kynureninase (L-kynurenine hydrolase) | 0.019 | ||
| Klre1 | killer cell lectin-like receptor family E member 1 | 0.018 | ||
| Klra6 | killer cell lectin-like receptor, subfamily A, member 6 | 0.018 | Mouse | |
| Casp12 | caspase 12 | 0.018 | ||
| Cxcl10 | chemokine (C-X-C motif) ligand 10 | 0.017 | ||
| Cd28 | CD28 antigen | 0.017 | ||
| H2-M3 | histocompatibility 2, M region locus 3 | 0.016 | ||
| Csprs | component of Sp100-rs | 0.016 | ||
| H2-M2 | histocompatibility 2, M region locus 2 | 0.016 | ||
| Spna1 | spectrin alpha 1 | 0.016 | ||
| Irf7 | interferon regulatory factor 7 | 0.016 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.016 | ||
| Cd74 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | 0.016 | ||
| Ly9 | lymphocyte antigen 9 | 0.016 | ||
| Junb | Jun-B oncogene | 0.016 | ||
| Tor3a | torsin family 3, member A | 0.015 | ||
| Parp12 | poly (ADP-ribose) polymerase family, member 12 | 0.015 | ||
| Nfil3 | nuclear factor, interleukin 3, regulated | 0.015 | ||
| Cd3e | CD3 antigen, epsilon polypeptide | 0.015 | ||
| Il15ra | interleukin 15 receptor, alpha chain | 0.015 | ||
| Trem3 | triggering receptor expressed on myeloid cells 3 | 0.015 | ||
| C2 | complement component 2 (within H-2S) | 0.014 | ||
| Psme2 | proteasome (prosome, macropain) 28 subunit, beta | 0.014 | ||
| Lgals9 | lectin, galactose binding, soluble 9 | 0.014 | ||
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.014 | ||
| Lgals8 | lectin, galactose binding, soluble 8 | 0.014 | ||
| Fpr2 | formyl peptide receptor 2 | 0.014 | ||
| Gfi1 | growth factor independent 1 | 0.014 | ||
| Ms4a4c | membrane-spanning 4-domains, subfamily A, member 4C | 0.014 | ||
| H2-DMb2 | histocompatibility 2, class II, locus Mb2 | 0.014 | ||
| Hexa | hexosaminidase A | 0.013 | ||
| H2-T10 | histocompatibility 2, T region locus 10 | 0.013 | ||
| Adar | adenosine deaminase, RNA-specific | 0.013 | ||
| Gbp6 | guanylate binding protein 6 | 0.013 | ||
| Ctsb | cathepsin B | 0.013 | ||
| Psap | prosaposin | 0.013 | ||
| LOC677008 | natural killer cell receptor 2B4-like | 0.013 | ||
| Il2 | interleukin 2 | 0.013 | ||
| Xcr1 | chemokine (C motif) receptor 1 | 0.013 | ||
| Serpinb9 | serine (or cysteine) peptidase inhibitor, clade B, member 9 | 0.013 | ||
| Tlr4 | toll-like receptor 4 | 0.013 | ||
| Cst7 | cystatin F (leukocystatin) | 0.013 | ||
| AA408251 | expressed sequence AA408251 | 0.013 | ||
| Pion | pigeon homolog (Drosophila) | 0.013 | ||
| H2-Aa | histocompatibility 2, class II antigen A, alpha | 0.013 | ||
| Nfkbie | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.013 | ||
| Stat5b | signal transducer and activator of transcription 5B | 0.012 | ||
| Art2a-ps | ADP-ribosyltransferase 2a, pseudogene | 0.012 | ||
| Tmbim6 | transmembrane BAX inhibitor motif containing 6 | 0.012 | ||
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.012 | ||
| Cyp4v3 | cytochrome P450, family 4, subfamily v, polypeptide 3 | 0.012 | ||
| Traf1 | TNF receptor-associated factor 1 | 0.012 | ||
| Ddx60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.012 | ||
| Klrc3 | killer cell lectin-like receptor subfamily C, member 3 | 0.012 | ||
| Mtap2 | microtubule-associated protein 2 | 0.012 | ||
| Mx1 | myxovirus (influenza virus) resistance 1 | 0.012 | ||
| Flt3 | FMS-like tyrosine kinase 3 | 0.012 | ||
| Gpr174 | G protein-coupled receptor 174 | 0.012 | ||
| Oxsm | 3-oxoacyl-ACP synthase, mitochondrial | 0.011 | ||
| Themis | thymocyte selection associated | 0.011 | ||
| Pbsn | probasin | 0.011 | ||
| Erap1 | endoplasmic reticulum aminopeptidase 1 | 0.011 | ||
| Abcg3 | ATP-binding cassette, sub-family G (WHITE), member 3 | 0.011 | ||
| P2ry10 | purinergic receptor P2Y, G-protein coupled 10 | 0.011 | ||
| Tnfsf8 | tumor necrosis factor (ligand) superfamily, member 8 | 0.011 | ||
| Cd274 | CD274 antigen | 0.011 | ||
| Ifit3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.011 | ||
| Shisa5 | shisa homolog 5 (Xenopus laevis) | 0.011 | ||
| Il1a | interleukin 1 alpha | 0.011 | ||
| Gpr33 | G protein-coupled receptor 33 | 0.011 | ||
| Tm4sf5 | transmembrane 4 superfamily member 5 | 0.011 | ||
| Cd27 | CD27 antigen | 0.011 | ||
| Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.011 | ||
| Camk4 | calcium/calmodulin-dependent protein kinase IV | 0.011 | ||
| Haao | 3-hydroxyanthranilate 3,4-dioxygenase | 0.010 | ||
| Ciita | class II transactivator | 0.010 | ||
| Gimap3 | GTPase, IMAP family member 3 | 0.010 | ||
| Emr1 | EGF-like module containing, mucin-like, hormone receptor-like sequence 1 | 0.010 | ||
| Cxcr3 | chemokine (C-X-C motif) receptor 3 | 0.010 | ||
| Klra1 | killer cell lectin-like receptor, subfamily A, member 1 | 0.010 | Mouse | |
| Casp7 | caspase 7 | 0.010 | ||
| Samhd1 | SAM domain and HD domain, 1 | 0.010 |