IMP

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Mus musculus

23 genes annotated in mouse

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains" (in gray)

Name	Description	Probability	Func Analog Organism
Fas	Fas (TNF receptor superfamily member 6)	0.975
Ikzf1	IKAROS family zinc finger 1	0.948
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.886
Ptprc	protein tyrosine phosphatase, receptor type, C	0.854
Stat3	signal transducer and activator of transcription 3	0.852
Tnf	tumor necrosis factor	0.832
Tcra	T-cell receptor alpha chain	0.783
Fyn	Fyn proto-oncogene	0.754
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.719
Ifng	interferon gamma	0.710
Il2rg	interleukin 2 receptor, gamma chain	0.703
Lyz2	lysozyme 2	0.522
Lat	linker for activation of T cells	0.409
Cd247	CD247 antigen	0.391
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.387
Stat6	signal transducer and activator of transcription 6	0.351
Inpp5d	inositol polyphosphate-5-phosphatase D	0.333
Rag1	recombination activating gene 1	0.328
Clec4d	C-type lectin domain family 4, member d	0.305	Mouse
Foxn1	forkhead box N1	0.295
Igh	immunoglobulin heavy chain complex	0.289
Cd40	CD40 antigen	0.249
Foxp3	forkhead box P3	0.244
Il1b	interleukin 1 beta	0.230
Cd19	CD19 antigen	0.208
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.199
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.194
Il10	interleukin 10	0.186
Il6	interleukin 6	0.183
Ccr1	chemokine (C-C motif) receptor 1	0.183
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.169
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.168
Cd44	CD44 antigen	0.167
Ccr7	chemokine (C-C motif) receptor 7	0.164
Prf1	perforin 1 (pore forming protein)	0.153
Itgb2	integrin beta 2	0.145
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.145
Tnip1	TNFAIP3 interacting protein 1	0.140
Il4	interleukin 4	0.137
Il2	interleukin 2	0.126
Mefv	Mediterranean fever	0.124
Clec4e	C-type lectin domain family 4, member e	0.107	Mouse
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.102
Btk	Bruton agammaglobulinemia tyrosine kinase	0.097
Rag2	recombination activating gene 2	0.092
Rc3h1	RING CCCH (C3H) domains 1	0.086
Ccr6	chemokine (C-C motif) receptor 6	0.084
Il27ra	interleukin 27 receptor, alpha	0.084
Cxcr2	chemokine (C-X-C motif) receptor 2	0.081
Pten	phosphatase and tensin homolog	0.079
Selp	selectin, platelet	0.076
Sfpi1	SFFV proviral integration 1	0.076
Jak2	Janus kinase 2	0.075	Mouse
Msr1	macrophage scavenger receptor 1	0.068
Lck	lymphocyte protein tyrosine kinase	0.066
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.066
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.065
Tcrd	T-cell receptor delta chain	0.063
Cd22	CD22 antigen	0.060
Cd209a	CD209a antigen	0.060	Mouse
Runx1	runt related transcription factor 1	0.059
Jak1	Janus kinase 1	0.050	Mouse
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.049	Mouse
Vav1	vav 1 oncogene	0.049
Card11	caspase recruitment domain family, member 11	0.047
Plcg2	phospholipase C, gamma 2	0.046
Ccl24	chemokine (C-C motif) ligand 24	0.043
Ifngr1	interferon gamma receptor 1	0.043
Cd40lg	CD40 ligand	0.042
Gp1ba	glycoprotein 1b, alpha polypeptide	0.042
Grb2	growth factor receptor bound protein 2	0.041
Gli2	GLI-Kruppel family member GLI2	0.039
Prdm1	PR domain containing 1, with ZNF domain	0.037
Cr2	complement receptor 2	0.037
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.037
Cd86	CD86 antigen	0.036
Cd209d	CD209d antigen	0.036	Mouse
S1pr4	sphingosine-1-phosphate receptor 4	0.036
Ncr1	natural cytotoxicity triggering receptor 1	0.035
Ccl22	chemokine (C-C motif) ligand 22	0.035
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.034
Il18rap	interleukin 18 receptor accessory protein	0.033	Mouse
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.033
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)	0.032
Cd209g	CD209g antigen	0.031
Cd209b	CD209b antigen	0.031	Mouse
Fcrla	Fc receptor-like A	0.031	Mouse
Clec4n	C-type lectin domain family 4, member n	0.030	Mouse
Lta	lymphotoxin A	0.029
Il1r2	interleukin 1 receptor, type II	0.029	Mouse
Clec4b1	C-type lectin domain family 4, member b1	0.028	Mouse
Cd28	CD28 antigen	0.028
Il10ra	interleukin 10 receptor, alpha	0.028
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.028
Cd47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	0.028
Trp53	transformation related protein 53	0.028
Il1r1	interleukin 1 receptor, type I	0.028	Mouse
Mmp8	matrix metallopeptidase 8	0.028
S100a8	S100 calcium binding protein A8 (calgranulin A)	0.028
Fpr1	formyl peptide receptor 1	0.027
Socs1	suppressor of cytokine signaling 1	0.026
Il15	interleukin 15	0.026
Ttc7	tetratricopeptide repeat domain 7	0.026
Nodal	nodal	0.025
Mpl	myeloproliferative leukemia virus oncogene	0.025	Mouse
Pax5	paired box gene 5	0.025
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.025
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.025
Flt3	FMS-like tyrosine kinase 3	0.025
Myd88	myeloid differentiation primary response gene 88	0.025
Tlr8	toll-like receptor 8	0.024
Vpreb3	pre-B lymphocyte gene 3	0.024
Ccr3	chemokine (C-C motif) receptor 3	0.024
Fasl	Fas ligand (TNF superfamily, member 6)	0.024
Nlrp3	NLR family, pyrin domain containing 3	0.024	Mouse
Cd4	CD4 antigen	0.023
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.023
Mgl2	macrophage galactose N-acetyl-galactosamine specific lectin 2	0.023
Fpr2	formyl peptide receptor 2	0.023
Cd80	CD80 antigen	0.023
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.023
Cd300ld	CD300 molecule-like family member d	0.022
Niacr1	niacin receptor 1	0.022
Tlr6	toll-like receptor 6	0.022
Has1	hyaluronan synthase1	0.021
Siglece	sialic acid binding Ig-like lectin E	0.021
Ccr5	chemokine (C-C motif) receptor 5	0.021
Bcl3	B-cell leukemia/lymphoma 3	0.021
Klra2	killer cell lectin-like receptor, subfamily A, member 2	0.021
Noto	notochord homolog (Xenopus laevis)	0.021
Lair1	leukocyte-associated Ig-like receptor 1	0.021
Klra17	killer cell lectin-like receptor, subfamily A, member 17	0.021
Marco	macrophage receptor with collagenous structure	0.021
Ifna12	interferon alpha 12	0.020	Human
Il7	interleukin 7	0.020
Ear11	eosinophil-associated, ribonuclease A family, member 11	0.020
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.020
Pou2af1	POU domain, class 2, associating factor 1	0.020
Prkcd	protein kinase C, delta	0.020
Slpi	secretory leukocyte peptidase inhibitor	0.020
Icos	inducible T-cell co-stimulator	0.020
Ceacam9	carcinoembryonic antigen-related cell adhesion molecule 9	0.019
Wipf1	WAS/WASL interacting protein family, member 1	0.019
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.019	Mouse
Itk	IL2-inducible T-cell kinase	0.019
Ptk2	PTK2 protein tyrosine kinase 2	0.018
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.018
Dnahc11	dynein, axonemal, heavy chain 11	0.018
Kif19a	kinesin family member 19A	0.018
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.018
Ifnab	interferon alpha B	0.018	Human
Tspo2	translocator protein 2	0.018
Ccl8	chemokine (C-C motif) ligand 8	0.018
Hbb-b1	hemoglobin, beta adult major chain	0.018
Saa4	serum amyloid A 4	0.018
Ccbp2	chemokine binding protein 2	0.018
Blk	B lymphoid kinase	0.018
Il13ra2	interleukin 13 receptor, alpha 2	0.018
Ggt5	gamma-glutamyltransferase 5	0.018
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.018
Il22	interleukin 22	0.018
H2-DMb2	histocompatibility 2, class II, locus Mb2	0.018
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.017
Hivep2	human immunodeficiency virus type I enhancer binding protein 2	0.017
Il1rl1	interleukin 1 receptor-like 1	0.017
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.017
Cd209c	CD209c antigen	0.017	Mouse
Mpo	myeloperoxidase	0.017
Ear2	eosinophil-associated, ribonuclease A family, member 2	0.016
Ubl3	ubiquitin-like 3	0.016
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.016
Gdf3	growth differentiation factor 3	0.016
Xcl1	chemokine (C motif) ligand 1	0.016
Socs3	suppressor of cytokine signaling 3	0.016
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.016
Egfr	epidermal growth factor receptor	0.016
Hhex	hematopoietically expressed homeobox	0.016
Tlr4	toll-like receptor 4	0.016
Pigr	polymeric immunoglobulin receptor	0.016
Mmp12	matrix metallopeptidase 12	0.016
Itgal	integrin alpha L	0.015
Tbx21	T-box 21	0.015
Il1rn	interleukin 1 receptor antagonist	0.015
Ptgir	prostaglandin I receptor (IP)	0.015
Ascl3	achaete-scute complex homolog 3 (Drosophila)	0.015
Tlr7	toll-like receptor 7	0.015
Aoah	acyloxyacyl hydrolase	0.015
Tshb	thyroid stimulating hormone, beta subunit	0.015
Il17a	interleukin 17A	0.015
Gpr143	G protein-coupled receptor 143	0.015
Sell	selectin, lymphocyte	0.015
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.015
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.015
Ros1	Ros1 proto-oncogene	0.014
Folr2	folate receptor 2 (fetal)	0.014
C3ar1	complement component 3a receptor 1	0.014
Pilrb1	paired immunoglobin-like type 2 receptor beta 1	0.014
Ms4a6d	membrane-spanning 4-domains, subfamily A, member 6D	0.014
Ooep	oocyte expressed protein homolog (dog)	0.014
Mll5	myeloid/lymphoid or mixed-lineage leukemia 5	0.014
C78444	expressed sequence C78444	0.014
Irf1	interferon regulatory factor 1	0.014
Ebi3	Epstein-Barr virus induced gene 3	0.014
Gpr132	G protein-coupled receptor 132	0.014
Cnga1	cyclic nucleotide gated channel alpha 1	0.014
St6galnac1	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	0.014
Il18r1	interleukin 18 receptor 1	0.014	Mouse
Tmem30a	transmembrane protein 30A	0.014
Cd180	CD180 antigen	0.014
Cbl	Casitas B-lineage lymphoma	0.014
Bach2	BTB and CNC homology 2	0.014
Birc3	baculoviral IAP repeat-containing 3	0.013
Zp2	zona pellucida glycoprotein 2	0.013
Inhba	inhibin beta-A	0.013
Tnfaip8l2	tumor necrosis factor, alpha-induced protein 8-like 2	0.013
Cd7	CD7 antigen	0.013
Msh5	mutS homolog 5 (E. coli)	0.013
Slc10a6	solute carrier family 10 (sodium/bile acid cotransporter family), member 6	0.013
Lipc	lipase, hepatic	0.013
Trem1	triggering receptor expressed on myeloid cells 1	0.013
Ear5	eosinophil-associated, ribonuclease A family, member 5	0.013
Elane	elastase, neutrophil expressed	0.013
Arrb2	arrestin, beta 2	0.013
Il2rb	interleukin 2 receptor, beta chain	0.013
Trem3	triggering receptor expressed on myeloid cells 3	0.013
Sykb	spleen tyrosine kinase	0.013
Cd72	CD72 antigen	0.013
Bst1	bone marrow stromal cell antigen 1	0.013
Pabpc2	poly(A) binding protein, cytoplasmic 2	0.013
Sprr2k	small proline-rich protein 2K	0.013
Gata4	GATA binding protein 4	0.013
Lcp1	lymphocyte cytosolic protein 1	0.013
Dsg4	desmoglein 4	0.012
Cd209f	CD209f antigen	0.012	Mouse
Mbl1	mannose-binding lectin (protein A) 1	0.012
Siglecg	sialic acid binding Ig-like lectin G	0.012
Klk1b1	kallikrein 1-related peptidase b1	0.012
Dclre1c	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)	0.012
Fcna	ficolin A	0.012
Tnfrsf17	tumor necrosis factor receptor superfamily, member 17	0.012
Il12rb2	interleukin 12 receptor, beta 2	0.012
Ccl7	chemokine (C-C motif) ligand 7	0.012
Muc13	mucin 13, epithelial transmembrane	0.012
Fyb	FYN binding protein	0.012
Ifna9	interferon alpha 9	0.012	Human
Nfam1	Nfat activating molecule with ITAM motif 1	0.012
Clec4g	C-type lectin domain family 4, member g	0.012
Laptm5	lysosomal-associated protein transmembrane 5	0.012
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.012
Cxcr5	chemokine (C-X-C motif) receptor 5	0.012
Myo1f	myosin IF	0.012
Gp9	glycoprotein 9 (platelet)	0.012
Ccr2	chemokine (C-C motif) receptor 2	0.011
Mcpt8	mast cell protease 8	0.011
Cd33	CD33 antigen	0.011
Batf	basic leucine zipper transcription factor, ATF-like	0.011
Vsig4	V-set and immunoglobulin domain containing 4	0.011
Mef2a	myocyte enhancer factor 2A	0.011
Expi	extracellular proteinase inhibitor	0.011
Rptn	repetin	0.011
Sele	selectin, endothelial cell	0.011
Ubxn11	UBX domain protein 11	0.011
Itgb2l	integrin beta 2-like	0.011
Chl1	cell adhesion molecule with homology to L1CAM	0.011
Clec4a2	C-type lectin domain family 4, member a2	0.011	Mouse
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.011
Epor	erythropoietin receptor	0.011	Mouse
Igll1	immunoglobulin lambda-like polypeptide 1	0.011
Pstpip2	proline-serine-threonine phosphatase-interacting protein 2	0.011
Pag1	phosphoprotein associated with glycosphingolipid microdomains 1	0.011
Tyrobp	TYRO protein tyrosine kinase binding protein	0.011
Mmp9	matrix metallopeptidase 9	0.011
Cd300a	CD300A antigen	0.011
Ctsg	cathepsin G	0.011
Plek	pleckstrin	0.011
Clec10a	C-type lectin domain family 10, member A	0.011
Nckap1l	NCK associated protein 1 like	0.011
Mesp2	mesoderm posterior 2	0.011
Il12b	interleukin 12b	0.011
Ifnar2	interferon (alpha and beta) receptor 2	0.011
Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	0.011	Mouse
Pla2g2d	phospholipase A2, group IID	0.010
Pramel7	preferentially expressed antigen in melanoma like 7	0.010
Dok1	docking protein 1	0.010
Rc3h2	ring finger and CCCH-type zinc finger domains 2	0.010	Mouse
Scgb1a1	secretoglobin, family 1A, member 1 (uteroglobin)	0.010
Cybb	cytochrome b-245, beta polypeptide	0.010
Smr3a	submaxillary gland androgen regulated protein 3A	0.010
Adam4	a disintegrin and metallopeptidase domain 4	0.010
Nfil3	nuclear factor, interleukin 3, regulated	0.010
Car1	carbonic anhydrase 1	0.010
Il6st	interleukin 6 signal transducer	0.010
Irf4	interferon regulatory factor 4	0.010
Akap5	A kinase (PRKA) anchor protein 5	0.010
Gab2	growth factor receptor bound protein 2-associated protein 2	0.010
Inhbe	inhibin beta E	0.010
Aqp9	aquaporin 9	0.010
Epb4.2	erythrocyte protein band 4.2	0.010
Gzma	granzyme A	0.010
Il4ra	interleukin 4 receptor, alpha	0.010
2810449G22Rik	RIKEN cDNA 2810449G22 gene	0.010
Cd200r1	CD200 receptor 1	0.010
Mmp3	matrix metallopeptidase 3	0.010
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.010
Spna1	spectrin alpha 1	0.010