IMP

Process View

Mus musculus

13 genes annotated in mouse

t helper 1 cell differentiation

The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "t helper 1 cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "t helper 1 cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Tnf	tumor necrosis factor	0.967
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.960	Mouse
Socs1	suppressor of cytokine signaling 1	0.938	Mouse
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.857
Il6st	interleukin 6 signal transducer	0.853
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.839	Mouse
Jak2	Janus kinase 2	0.814	Mouse
Stat5b	signal transducer and activator of transcription 5B	0.766	Mouse
Ccr1	chemokine (C-C motif) receptor 1	0.704
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.700
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.656	Mouse
Stat3	signal transducer and activator of transcription 3	0.629	Mouse
Stat5a	signal transducer and activator of transcription 5A	0.625	Mouse
Il1b	interleukin 1 beta	0.602
Fas	Fas (TNF receptor superfamily member 6)	0.597
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.572	Mouse
Lepr	leptin receptor	0.535
Bcl3	B-cell leukemia/lymphoma 3	0.495
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.461
Ccl2	chemokine (C-C motif) ligand 2	0.459
Lef1	lymphoid enhancer binding factor 1	0.406
Ccl7	chemokine (C-C motif) ligand 7	0.369	Mouse
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.348
Il6	interleukin 6	0.344
Il1r1	interleukin 1 receptor, type I	0.342	Mouse
Ccl12	chemokine (C-C motif) ligand 12	0.339	Mouse
Foxp3	forkhead box P3	0.326
Cxcl2	chemokine (C-X-C motif) ligand 2	0.287
Batf	basic leucine zipper transcription factor, ATF-like	0.258
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.250
Ccl4	chemokine (C-C motif) ligand 4	0.249	Mouse
Msr1	macrophage scavenger receptor 1	0.248
Irf9	interferon regulatory factor 9	0.209
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.203	Mouse
Cd86	CD86 antigen	0.186
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.171
Ccl3	chemokine (C-C motif) ligand 3	0.164	Mouse
Mmp12	matrix metallopeptidase 12	0.163
Tcf7	transcription factor 7, T-cell specific	0.161	Mouse
Clec4d	C-type lectin domain family 4, member d	0.160
Selp	selectin, platelet	0.146
Ifng	interferon gamma	0.141
Nckap1l	NCK associated protein 1 like	0.128
Il2rb	interleukin 2 receptor, beta chain	0.125
Ccr5	chemokine (C-C motif) receptor 5	0.124
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.114
Saa3	serum amyloid A 3	0.107
Il1rn	interleukin 1 receptor antagonist	0.103
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.096
Ccl8	chemokine (C-C motif) ligand 8	0.092
Traf1	TNF receptor-associated factor 1	0.091
Cxcl13	chemokine (C-X-C motif) ligand 13	0.085
Cxcl1	chemokine (C-X-C motif) ligand 1	0.083
Ccr7	chemokine (C-C motif) receptor 7	0.080
Rel	reticuloendotheliosis oncogene	0.080	Mouse
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.080
Il1r2	interleukin 1 receptor, type II	0.078	Mouse
Egfr	epidermal growth factor receptor	0.078
Ikzf1	IKAROS family zinc finger 1	0.076
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.073
Runx1	runt related transcription factor 1	0.071
Xcl1	chemokine (C motif) ligand 1	0.065	Mouse
Il4ra	interleukin 4 receptor, alpha	0.063
Pim1	proviral integration site 1	0.063
Ccr2	chemokine (C-C motif) receptor 2	0.061
Ch25h	cholesterol 25-hydroxylase	0.060
Ccl6	chemokine (C-C motif) ligand 6	0.058	Mouse
Irg1	immunoresponsive gene 1	0.056
Socs3	suppressor of cytokine signaling 3	0.054	Mouse
Lta	lymphotoxin A	0.053
Ccl22	chemokine (C-C motif) ligand 22	0.052
Il1rap	interleukin 1 receptor accessory protein	0.052	Mouse
Il10ra	interleukin 10 receptor, alpha	0.052
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.051
Il10	interleukin 10	0.051
Cxcl9	chemokine (C-X-C motif) ligand 9	0.050
Mmp3	matrix metallopeptidase 3	0.050
Cd40	CD40 antigen	0.050
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.050
Foxn1	forkhead box N1	0.050
Plxna4	plexin A4	0.049
C78513	EST C78513	0.047
Mmp8	matrix metallopeptidase 8	0.044
S1pr3	sphingosine-1-phosphate receptor 3	0.043
Slpi	secretory leukocyte peptidase inhibitor	0.042
Csf1	colony stimulating factor 1 (macrophage)	0.040
Il7	interleukin 7	0.040
Clec4e	C-type lectin domain family 4, member e	0.040
Il1rl1	interleukin 1 receptor-like 1	0.040	Mouse
C5ar1	complement component 5a receptor 1	0.038
Cxcr5	chemokine (C-X-C motif) receptor 5	0.038
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.037
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.037
Chi3l3	chitinase 3-like 3	0.037
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.036
Cd80	CD80 antigen	0.036
Sfn	stratifin	0.034
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.033
Ccl17	chemokine (C-C motif) ligand 17	0.032	Mouse
Has1	hyaluronan synthase1	0.032
Ptprc	protein tyrosine phosphatase, receptor type, C	0.031
Cxcl10	chemokine (C-X-C motif) ligand 10	0.030
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.030
Irf1	interferon regulatory factor 1	0.030
Il2	interleukin 2	0.030
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.029
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.029
Il18rap	interleukin 18 receptor accessory protein	0.029	Mouse
Lag3	lymphocyte-activation gene 3	0.029
St3gal1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	0.029
Adam8	a disintegrin and metallopeptidase domain 8	0.028
Ms4a6c	membrane-spanning 4-domains, subfamily A, member 6C	0.028
Ptgir	prostaglandin I receptor (IP)	0.028
Il2rg	interleukin 2 receptor, gamma chain	0.027
Fcgr1	Fc receptor, IgG, high affinity I	0.027
Jak3	Janus kinase 3	0.024
Il17ra	interleukin 17 receptor A	0.024
Il33	interleukin 33	0.024
Serpina3g	serine (or cysteine) peptidase inhibitor, clade A, member 3G	0.024
Sfpi1	SFFV proviral integration 1	0.023
Tnfrsf18	tumor necrosis factor receptor superfamily, member 18	0.023
Gzmc	granzyme C	0.023
Rgs16	regulator of G-protein signaling 16	0.022
Tgfb1	transforming growth factor, beta 1	0.022
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.022
Il7r	interleukin 7 receptor	0.022
Ctsw	cathepsin W	0.022
Nfkbie	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.022
Icam1	intercellular adhesion molecule 1	0.021
Pdcd1	programmed cell death 1	0.021
Hic1	hypermethylated in cancer 1	0.020
Lcp2	lymphocyte cytosolic protein 2	0.020
Mx2	myxovirus (influenza virus) resistance 2	0.020
Gab2	growth factor receptor bound protein 2-associated protein 2	0.020
Ccl1	chemokine (C-C motif) ligand 1	0.020	Mouse
Cish	cytokine inducible SH2-containing protein	0.019	Mouse
Bdkrb1	bradykinin receptor, beta 1	0.019
Slfn4	schlafen 4	0.019
Il4	interleukin 4	0.019
Birc3	baculoviral IAP repeat-containing 3	0.019
Adar	adenosine deaminase, RNA-specific	0.019
Il1a	interleukin 1 alpha	0.019
Il18r1	interleukin 18 receptor 1	0.018
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.018
Agap2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.018
Fpr2	formyl peptide receptor 2	0.018
Elk4	ELK4, member of ETS oncogene family	0.018
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.017
Rasal3	RAS protein activator like 3	0.017
Ltb	lymphotoxin B	0.017
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.017
S100a9	S100 calcium binding protein A9 (calgranulin B)	0.017
Slfn1	schlafen 1	0.017
Ccrl2	chemokine (C-C motif) receptor-like 2	0.016
Myd88	myeloid differentiation primary response gene 88	0.016
Esr2	estrogen receptor 2 (beta)	0.016
Ptpn2	protein tyrosine phosphatase, non-receptor type 2	0.016
H2-Aa	histocompatibility 2, class II antigen A, alpha	0.016
Ccl9	chemokine (C-C motif) ligand 9	0.016	Mouse
Ppard	peroxisome proliferator activator receptor delta	0.016
Traf6	TNF receptor-associated factor 6	0.016
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.016
Ddr2	discoidin domain receptor family, member 2	0.016
Klra2	killer cell lectin-like receptor, subfamily A, member 2	0.016
Irf4	interferon regulatory factor 4	0.015
Cul5	cullin 5	0.015
Dlg4	discs, large homolog 4 (Drosophila)	0.015
Gzma	granzyme A	0.015
C3ar1	complement component 3a receptor 1	0.015
Folr2	folate receptor 2 (fetal)	0.015
Msx2	homeobox, msh-like 2	0.015
Cd14	CD14 antigen	0.015
Ubd	ubiquitin D	0.015
Sh2d2a	SH2 domain protein 2A	0.015
Gp49a	glycoprotein 49 A	0.015
Cpa3	carboxypeptidase A3, mast cell	0.015
S100a8	S100 calcium binding protein A8 (calgranulin A)	0.015
Cxcl5	chemokine (C-X-C motif) ligand 5	0.014
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.014
Gdf15	growth differentiation factor 15	0.014
Tmem173	transmembrane protein 173	0.014
Icos	inducible T-cell co-stimulator	0.014
Casp8	caspase 8	0.014
Inpp5d	inositol polyphosphate-5-phosphatase D	0.013
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.013
Slc10a6	solute carrier family 10 (sodium/bile acid cotransporter family), member 6	0.013
Slfn2	schlafen 2	0.013
Mxd1	MAX dimerization protein 1	0.013
Axin2	axin2	0.013
Lgals7	lectin, galactose binding, soluble 7	0.013
Irf5	interferon regulatory factor 5	0.013
Has2	hyaluronan synthase 2	0.013
Gbp1	guanylate binding protein 1	0.012
F10	coagulation factor X	0.012
Plek	pleckstrin	0.012
Retnla	resistin like alpha	0.012
Wnt11	wingless-related MMTV integration site 11	0.012
Ear11	eosinophil-associated, ribonuclease A family, member 11	0.012
Fpr1	formyl peptide receptor 1	0.012
Niacr1	niacin receptor 1	0.012
Fzd7	frizzled homolog 7 (Drosophila)	0.012
Mefv	Mediterranean fever	0.012
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.012
Ptpn1	protein tyrosine phosphatase, non-receptor type 1	0.012
Rgs1	regulator of G-protein signaling 1	0.012
Gzmb	granzyme B	0.012
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.012
Clec4a2	C-type lectin domain family 4, member a2	0.011
Tlr7	toll-like receptor 7	0.011
Tgfbr3	transforming growth factor, beta receptor III	0.011
Osmr	oncostatin M receptor	0.011
AI607873	expressed sequence AI607873	0.011
Vav1	vav 1 oncogene	0.011
Tnfaip6	tumor necrosis factor alpha induced protein 6	0.011
Il13ra2	interleukin 13 receptor, alpha 2	0.011
Robo3	roundabout homolog 3 (Drosophila)	0.011
Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.011
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.011
Numb	numb gene homolog (Drosophila)	0.011
Fgf7	fibroblast growth factor 7	0.011
Ugcg	UDP-glucose ceramide glucosyltransferase	0.011
Sykb	spleen tyrosine kinase	0.011
Cma1	chymase 1, mast cell	0.011
Stat6	signal transducer and activator of transcription 6	0.011
Ifnar1	interferon (alpha and beta) receptor 1	0.011
Nfil3	nuclear factor, interleukin 3, regulated	0.011
Lrg1	leucine-rich alpha-2-glycoprotein 1	0.011
Arid5a	AT rich interactive domain 5A (MRF1-like)	0.011
Alox15	arachidonate 15-lipoxygenase	0.011
Hgf	hepatocyte growth factor	0.011
Gm11428	predicted gene 11428	0.010
Ifnar2	interferon (alpha and beta) receptor 2	0.010
Cd44	CD44 antigen	0.010
Clec4n	C-type lectin domain family 4, member n	0.010