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Mus musculus

15 genes annotated in mouse

chromatin silencing

Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "chromatin silencing"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "chromatin silencing" (in gray)

Name	Description	Probability	Func Analog Organism
Rnf2	ring finger protein 2	0.999	Fly
Smarcc1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.992
Hdac1	histone deacetylase 1	0.983	Fly
Ezh2	enhancer of zeste homolog 2 (Drosophila)	0.979
Pou5f1	POU domain, class 5, transcription factor 1	0.961	Human
Nanog	Nanog homeobox	0.941
Mcm3	minichromosome maintenance deficient 3 (S. cerevisiae)	0.924	Yeast
Arid1b	AT rich interactive domain 1B (SWI-like)	0.903	Mouse
Rybp	RING1 and YY1 binding protein	0.896
Ctcf	CCCTC-binding factor	0.852
Hdac2	histone deacetylase 2	0.791	Human Fly
Dnmt3a	DNA methyltransferase 3A	0.764
Wdr5	WD repeat domain 5	0.747
Suz12	suppressor of zeste 12 homolog (Drosophila)	0.701
Mcm5	minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)	0.681	Yeast
Dnmt3b	DNA methyltransferase 3B	0.632
Pcgf2	polycomb group ring finger 2	0.629	Fly
Trp53	transformation related protein 53	0.613
H3f3a	H3 histone, family 3A	0.553
Mcm2	minichromosome maintenance deficient 2 mitotin (S. cerevisiae)	0.547
Rbbp4	retinoblastoma binding protein 4	0.478	Yeast Fly
Bmi1	Bmi1 polycomb ring finger oncogene	0.462	Fly
Dnmt1	DNA methyltransferase (cytosine-5) 1	0.443
Mta2	metastasis-associated gene family, member 2	0.400
Pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.380
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.349
Mll3	myeloid/lymphoid or mixed-lineage leukemia 3	0.336
Kdm2b	lysine (K)-specific demethylase 2B	0.330
Nipbl	Nipped-B homolog (Drosophila)	0.322
Trim28	tripartite motif-containing 28	0.322
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.320
Chd4	chromodomain helicase DNA binding protein 4	0.318
Ep400	E1A binding protein p400	0.312
Ash2l	ash2 (absent, small, or homeotic)-like (Drosophila)	0.297
Smc1a	structural maintenance of chromosomes 1A	0.275
Crebbp	CREB binding protein	0.266
Mta1	metastasis associated 1	0.258
Mcm7	minichromosome maintenance deficient 7 (S. cerevisiae)	0.252	Yeast
Ep300	E1A binding protein p300	0.238
Phc2	polyhomeotic-like 2 (Drosophila)	0.231
Brca1	breast cancer 1	0.227
Mecp2	methyl CpG binding protein 2	0.219
Rb1	retinoblastoma 1	0.216
Brca2	breast cancer 2	0.210
Smc3	structural maintenace of chromosomes 3	0.209
Sin3a	transcriptional regulator, SIN3A (yeast)	0.202	Human Yeast
Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	0.200
E2f1	E2F transcription factor 1	0.198
Sall4	sal-like 4 (Drosophila)	0.198
Bptf	bromodomain PHD finger transcription factor	0.195
Matr3	matrin 3	0.188
Hist1h3g	histone cluster 1, H3g	0.176
Arid1a	AT rich interactive domain 1A (SWI-like)	0.171
Ddx6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	0.162
Atrx	alpha thalassemia/mental retardation syndrome X-linked homolog (human)	0.158	Fly
Mcm4	minichromosome maintenance deficient 4 homolog (S. cerevisiae)	0.154
Lmnb1	lamin B1	0.144	Fly
Rbbp7	retinoblastoma binding protein 7	0.133	Yeast Fly
Hmgb1	high mobility group box 1	0.129
Mcm6	minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)	0.127
Sp1	trans-acting transcription factor 1	0.125
Stag1	stromal antigen 1	0.122
Sp4	trans-acting transcription factor 4	0.122
Trim24	tripartite motif-containing 24	0.106
Rbl2	retinoblastoma-like 2	0.105
Mll5	myeloid/lymphoid or mixed-lineage leukemia 5	0.105
Tcfcp2l1	transcription factor CP2-like 1	0.100
Parp1	poly (ADP-ribose) polymerase family, member 1	0.099
Dnmt3l	DNA (cytosine-5-)-methyltransferase 3-like	0.095	Mouse
Mga	MAX gene associated	0.094
Cdk4	cyclin-dependent kinase 4	0.091
L3mbtl2	l(3)mbt-like 2 (Drosophila)	0.090	Fly
Brd4	bromodomain containing 4	0.088
Nacc1	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	0.084
Men1	multiple endocrine neoplasia 1	0.081
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.079	Human Fly
Scaf11	SR-related CTD-associated factor 11	0.076
Nup85	nucleoporin 85	0.073
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.070
Mbtd1	mbt domain containing 1	0.069	Fly
Nucks1	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.067
Usp9x	ubiquitin specific peptidase 9, X chromosome	0.065
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.064
Rfc5	replication factor C (activator 1) 5	0.063
Erbb2ip	Erbb2 interacting protein	0.062
Csnk1a1	casein kinase 1, alpha 1	0.061
Mdm4	transformed mouse 3T3 cell double minute 4	0.061
Msh2	mutS homolog 2 (E. coli)	0.060	Yeast
Tcf3	transcription factor 3	0.059
Ran	RAN, member RAS oncogene family	0.058
Zmym5	zinc finger, MYM-type 5	0.058
Rpa2	replication protein A2	0.057
Ccna2	cyclin A2	0.057
Zfp292	zinc finger protein 292	0.056
Eed	embryonic ectoderm development	0.056	Fly
Jarid2	jumonji, AT rich interactive domain 2	0.052
Hells	helicase, lymphoid specific	0.051
Rcc2	regulator of chromosome condensation 2	0.050
Cdk2	cyclin-dependent kinase 2	0.049
Rrm1	ribonucleotide reductase M1	0.049
Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.047	Yeast Mouse
Cbx2	chromobox homolog 2 (Drosophila Pc class)	0.047
Creb1	cAMP responsive element binding protein 1	0.046
Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.046
Baz1b	bromodomain adjacent to zinc finger domain, 1B	0.045
Suds3	suppressor of defective silencing 3 homolog (S. cerevisiae)	0.045
Rest	RE1-silencing transcription factor	0.044
Rrm2	ribonucleotide reductase M2	0.043
Lmnb2	lamin B2	0.041	Fly
Zmym2	zinc finger, MYM-type 2	0.041
Cbx7	chromobox homolog 7	0.040
Esrrb	estrogen related receptor, beta	0.039
Cdk1	cyclin-dependent kinase 1	0.039
Morf4l1	mortality factor 4 like 1	0.039
Bod1l	biorientation of chromosomes in cell division 1-like	0.039
Mtf2	metal response element binding transcription factor 2	0.038
Ncor1	nuclear receptor co-repressor 1	0.038
Slbp	stem-loop binding protein	0.037
Cbx5	chromobox homolog 5 (Drosophila HP1a)	0.036	Fly
Cdt1	chromatin licensing and DNA replication factor 1	0.036
Bclaf1	BCL2-associated transcription factor 1	0.036
Sox2	SRY-box containing gene 2	0.035
Hnrnpr	heterogeneous nuclear ribonucleoprotein R	0.035
Pten	phosphatase and tensin homolog	0.035
Nono	non-POU-domain-containing, octamer binding protein	0.035
Pdpk1	3-phosphoinositide dependent protein kinase 1	0.035
Hnrnpk	heterogeneous nuclear ribonucleoprotein K	0.035
Akap9	A kinase (PRKA) anchor protein (yotiao) 9	0.034
Kdm5b	lysine (K)-specific demethylase 5B	0.033
Thoc2	THO complex 2	0.033
Klhl24	kelch-like 24 (Drosophila)	0.033
Kif22	kinesin family member 22	0.033
Krit1	KRIT1, ankyrin repeat containing	0.031
Lbr	lamin B receptor	0.031
March7	membrane-associated ring finger (C3HC4) 7	0.031
Hcfc1	host cell factor C1	0.030
Arid4b	AT rich interactive domain 4B (RBP1-like)	0.029
Eme1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.029
Ewsr1	Ewing sarcoma breakpoint region 1	0.029
Tcf12	transcription factor 12	0.029
Smarca5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.028
Mllt3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	0.028
Rsf1	remodeling and spacing factor 1	0.027
Sfpq	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.027
Arid2	AT rich interactive domain 2 (ARID, RFX-like)	0.027	Fly
Lig1	ligase I, DNA, ATP-dependent	0.027
Kdm6a	4lysine (K)-specific demethylase 6A	0.027	Mouse
Trip12	thyroid hormone receptor interactor 12	0.026
Ddx3y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked	0.026
Trrap	transformation/transcription domain-associated protein	0.025
Tfdp1	transcription factor Dp 1	0.025
Mybbp1a	MYB binding protein (P160) 1a	0.024
Orc1	origin recognition complex, subunit 1	0.024
Cbx8	chromobox homolog 8 (Drosophila Pc class)	0.023
Snrnp40	small nuclear ribonucleoprotein 40 (U5)	0.023
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.023
Capn7	calpain 7	0.023
Asf1a	ASF1 anti-silencing function 1 homolog A (S. cerevisiae)	0.023
Fen1	flap structure specific endonuclease 1	0.023
Max	Max protein	0.022
Supt16h	suppressor of Ty 16 homolog (S. cerevisiae)	0.022
Ehmt1	euchromatic histone methyltransferase 1	0.022
Sae1	SUMO1 activating enzyme subunit 1	0.022
Orc6	origin recognition complex, subunit 6	0.022
Ccne1	cyclin E1	0.022
Phc1	polyhomeotic-like 1 (Drosophila)	0.022
Smad4	MAD homolog 4 (Drosophila)	0.022
Dnajc9	DnaJ (Hsp40) homolog, subfamily C, member 9	0.021
Zfp148	zinc finger protein 148	0.021
Acin1	apoptotic chromatin condensation inducer 1	0.021
Cdca8	cell division cycle associated 8	0.021
Ncaph	non-SMC condensin I complex, subunit H	0.020
Ddx46	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	0.020
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.020
Chaf1a	chromatin assembly factor 1, subunit A (p150)	0.020
Cdca7	cell division cycle associated 7	0.020
Phc3	polyhomeotic-like 3 (Drosophila)	0.020
Eftud2	elongation factor Tu GTP binding domain containing 2	0.019
Pcgf6	polycomb group ring finger 6	0.019
Foxo3	forkhead box O3	0.019
Usp34	ubiquitin specific peptidase 34	0.019
Wnk1	WNK lysine deficient protein kinase 1	0.019
Hist2h4	histone cluster 2, H4	0.019
Cry1	cryptochrome 1 (photolyase-like)	0.018
Baz2a	bromodomain adjacent to zinc finger domain, 2A	0.018
Pms2	postmeiotic segregation increased 2 (S. cerevisiae)	0.018
Ulk2	Unc-51 like kinase 2 (C. elegans)	0.018
Xrn1	5'-3' exoribonuclease 1	0.018
Fyttd1	forty-two-three domain containing 1	0.018
Brd8	bromodomain containing 8	0.018
Cdc73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.017
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.017
Skp1a	S-phase kinase-associated protein 1A	0.017
Aurka	aurora kinase A	0.017
Stk11	serine/threonine kinase 11	0.017
H2afy	H2A histone family, member Y	0.017
Hira	histone cell cycle regulation defective homolog A (S. cerevisiae)	0.017
Ehmt2	euchromatic histone lysine N-methyltransferase 2	0.017
Yy1	YY1 transcription factor	0.017	Fly
Sesn1	sestrin 1	0.017
Ubtf	upstream binding transcription factor, RNA polymerase I	0.016
Rnf220	ring finger protein 220	0.016
Vezf1	vascular endothelial zinc finger 1	0.016
Pabpc1	poly(A) binding protein, cytoplasmic 1	0.016
Mll2	myeloid/lymphoid or mixed-lineage leukemia 2	0.016
Rbbp6	retinoblastoma binding protein 6	0.016
Ccnd1	cyclin D1	0.016
Hdac3	histone deacetylase 3	0.016
Chd7	chromodomain helicase DNA binding protein 7	0.016
Zfp260	zinc finger protein 260	0.016
Atf2	activating transcription factor 2	0.016
Cnot2	CCR4-NOT transcription complex, subunit 2	0.015
Tnrc6b	trinucleotide repeat containing 6b	0.015
Wac	WW domain containing adaptor with coiled-coil	0.015
Pum1	pumilio 1 (Drosophila)	0.015
Arid4a	AT rich interactive domain 4A (RBP1-like)	0.015
Trim32	tripartite motif-containing 32	0.015
Naa30	N(alpha)-acetyltransferase 30, NatC catalytic subunit	0.015
1110028C15Rik	RIKEN cDNA 1110028C15 gene	0.015
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.015
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.015
Pds5a	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	0.015
Dmap1	DNA methyltransferase 1-associated protein 1	0.015
Rev3l	REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae)	0.015
Fancd2	Fanconi anemia, complementation group D2	0.014
Zfp871	zinc finger protein 871	0.014
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.014
Ppp1cb	protein phosphatase 1, catalytic subunit, beta isoform	0.014
Brd1	bromodomain containing 1	0.014
Ring1	ring finger protein 1	0.014	Fly
Timeless	timeless homolog (Drosophila)	0.014
Rbl1	retinoblastoma-like 1 (p107)	0.014
Rcc1	regulator of chromosome condensation 1	0.014
Pbrm1	polybromo 1	0.014	Fly
Top2a	topoisomerase (DNA) II alpha	0.014
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.014
Spast	spastin	0.014
Txndc16	thioredoxin domain containing 16	0.013
Safb	scaffold attachment factor B	0.013
Mms22l	MMS22-like, DNA repair protein	0.013
Dcaf7	DDB1 and CUL4 associated factor 7	0.013
Tbl1xr1	transducin (beta)-like 1X-linked receptor 1	0.012
Ncapd2	non-SMC condensin I complex, subunit D2	0.012
Kat2a	K(lysine) acetyltransferase 2A	0.012
Rad51	RAD51 homolog (S. cerevisiae)	0.012
Pou2f1	POU domain, class 2, transcription factor 1	0.012
Ube2g1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)	0.012
Rmnd5a	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	0.012
Zfr	zinc finger RNA binding protein	0.012
Pcgf1	polycomb group ring finger 1	0.012
Rttn	rotatin	0.012
H2afz	H2A histone family, member Z	0.012	Yeast
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.012
Brd2	bromodomain containing 2	0.012
Mterfd1	MTERF domain containing 1	0.012
Zfml	zinc finger, matrin-like	0.011
Tpr	translocated promoter region	0.011
Espl1	extra spindle poles-like 1 (S. cerevisiae)	0.011
Cep350	centrosomal protein 350	0.011
Ggps1	geranylgeranyl diphosphate synthase 1	0.011
Qser1	glutamine and serine rich 1	0.011
Cdc6	cell division cycle 6 homolog (S. cerevisiae)	0.011
Ankhd1	ankyrin repeat and KH domain containing 1	0.011
Mdm2	transformed mouse 3T3 cell double minute 2	0.011
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.011
Rara	retinoic acid receptor, alpha	0.011
Plk1	polo-like kinase 1 (Drosophila)	0.011
Sf3b1	splicing factor 3b, subunit 1	0.011
Zfp42	zinc finger protein 42	0.011	Fly
BC005537	cDNA sequence BC005537	0.010
Mael	maelstrom homolog (Drosophila)	0.010
Racgap1	Rac GTPase-activating protein 1	0.010
Smc6	structural maintenance of chromosomes 6	0.010
Dek	DEK oncogene (DNA binding)	0.010
Nup93	nucleoporin 93	0.010
Piwil2	piwi-like homolog 2 (Drosophila)	0.010	Fly
Cstf2	cleavage stimulation factor, 3' pre-RNA subunit 2	0.010
Fbxw7	F-box and WD-40 domain protein 7	0.010
Zfp146	zinc finger protein 146	0.010
Nup188	nucleoporin 188	0.010
Apc	adenomatosis polyposis coli	0.010
Wdhd1	WD repeat and HMG-box DNA binding protein 1	0.010
Qk	quaking	0.010