IMP
Process View
The network for 'regulation of leukocyte activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
regulation of leukocyte activation
Any process that modulates the frequency, rate, or extent of leukocyte activation.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 1.000 | |
| LCK | lymphocyte-specific protein tyrosine kinase | 1.000 | |
| SYK | spleen tyrosine kinase | 0.998 | |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.996 | |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.992 | |
| GRB2 | growth factor receptor-bound protein 2 | 0.992 | |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 0.987 | |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.986 | |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.982 | |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.977 | |
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.967 | |
| IL4R | interleukin 4 receptor | 0.963 | |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.943 | |
| FYN | FYN oncogene related to SRC, FGR, YES | 0.916 | |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.888 | |
| ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.883 | |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 0.880 | |
| ICAM1 | intercellular adhesion molecule 1 | 0.861 | |
| MLLT4 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 0.847 | |
| TRAF1 | TNF receptor-associated factor 1 | 0.821 | |
| HLA-B | major histocompatibility complex, class I, B | 0.797 | |
| LILRB1 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | 0.793 | |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 0.782 | |
| BTN3A1 | butyrophilin, subfamily 3, member A1 | 0.746 | |
| BCL2 | B-cell CLL/lymphoma 2 | 0.731 | |
| AXL | AXL receptor tyrosine kinase | 0.731 | |
| TGIF1 | TGFB-induced factor homeobox 1 | 0.730 | |
| HLA-F | major histocompatibility complex, class I, F | 0.730 | |
| B2M | beta-2-microglobulin | 0.728 | |
| LTA | lymphotoxin alpha (TNF superfamily, member 1) | 0.716 | |
| PSTPIP1 | proline-serine-threonine phosphatase interacting protein 1 | 0.716 | |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.715 | |
| LILRB2 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 | 0.712 | |
| LILRA6 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 | 0.711 | |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 0.710 | |
| FGFR2 | fibroblast growth factor receptor 2 | 0.703 | |
| CTLA4 | cytotoxic T-lymphocyte-associated protein 4 | 0.695 | |
| CD80 | CD80 molecule | 0.693 | |
| LYN | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.681 | |
| HLA-DMB | major histocompatibility complex, class II, DM beta | 0.678 | |
| EGFR | epidermal growth factor receptor | 0.659 | |
| CCR7 | chemokine (C-C motif) receptor 7 | 0.653 | |
| IRF4 | interferon regulatory factor 4 | 0.646 | |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 0.643 | |
| CD2 | CD2 molecule | 0.632 | |
| HLA-E | major histocompatibility complex, class I, E | 0.627 | |
| BID | BH3 interacting domain death agonist | 0.623 | |
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | 0.614 | |
| PLCG1 | phospholipase C, gamma 1 | 0.583 | |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 | 0.581 | |
| SH2D1A | SH2 domain containing 1A | 0.574 | |
| TNFRSF9 | tumor necrosis factor receptor superfamily, member 9 | 0.570 | |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.544 | |
| HLA-C | major histocompatibility complex, class I, C | 0.543 | |
| MYD88 | myeloid differentiation primary response gene (88) | 0.542 | |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 0.540 | |
| CD28 | CD28 molecule | 0.534 | |
| CCL22 | chemokine (C-C motif) ligand 22 | 0.531 | |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.531 | |
| SIGLEC7 | sialic acid binding Ig-like lectin 7 | 0.527 | |
| PML | promyelocytic leukemia | 0.520 | |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.520 | |
| WAS | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 0.519 | |
| CD86 | CD86 molecule | 0.517 | |
| PAX3 | paired box 3 | 0.510 | |
| LILRA1 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 | 0.509 | |
| BCL2L1 | BCL2-like 1 | 0.509 | |
| CD6 | CD6 molecule | 0.505 | |
| ZAP70 | zeta-chain (TCR) associated protein kinase 70kDa | 0.505 | |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | 0.497 | |
| BTN3A3 | butyrophilin, subfamily 3, member A3 | 0.484 | |
| HLA-A | major histocompatibility complex, class I, A | 0.484 | |
| IL1R1 | interleukin 1 receptor, type I | 0.482 | |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 0.481 | |
| BLNK | B-cell linker | 0.474 | |
| SOCS3 | suppressor of cytokine signaling 3 | 0.471 | |
| NCK1 | NCK adaptor protein 1 | 0.459 | |
| PTPRC | protein tyrosine phosphatase, receptor type, C | 0.451 | |
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.450 | |
| TFF1 | trefoil factor 1 | 0.424 | |
| SMAD7 | SMAD family member 7 | 0.423 | |
| IL12B | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 0.420 | |
| CCL4 | chemokine (C-C motif) ligand 4 | 0.411 | |
| ABI1 | abl-interactor 1 | 0.410 | |
| CCR5 | chemokine (C-C motif) receptor 5 | 0.407 | |
| HLA-G | major histocompatibility complex, class I, G | 0.404 | |
| FGR | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 0.396 | |
| IL16 | interleukin 16 (lymphocyte chemoattractant factor) | 0.392 | |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.379 | |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | 0.378 | |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.368 | |
| FYB | FYN binding protein | 0.366 | |
| SLC9A3R1 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | 0.364 | |
| TCF3 | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) | 0.359 | |
| TNF | tumor necrosis factor | 0.349 | |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.343 | |
| CD247 | CD247 molecule | 0.343 | |
| IL4 | interleukin 4 | 0.342 | |
| BTN3A2 | butyrophilin, subfamily 3, member A2 | 0.341 | |
| CCL13 | chemokine (C-C motif) ligand 13 | 0.341 |
Loading network...
Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| RT1-Ba | RT1 class II, locus Ba | 0.778 | |
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.632 | |
| Cd5 | Cd5 molecule | 0.522 | |
| RT1-Bb | RT1 class II, locus Bb | 0.367 | |
| St8sia4 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | 0.307 | |
| Reg3b | regenerating islet-derived 3 beta | 0.304 | |
| RT1-Da | RT1 class II, locus Da | 0.301 | |
| Cd2 | Cd2 molecule | 0.298 | |
| Csf1 | colony stimulating factor 1 (macrophage) | 0.233 | |
| Ptafr | platelet-activating factor receptor | 0.189 | |
| Calcrl | calcitonin receptor-like | 0.174 | |
| Cd247 | Cd247 molecule | 0.172 | |
| Cd4 | Cd4 molecule | 0.165 | |
| Spn | sialophorin | 0.164 | |
| LOC100361571 | keratin associated protein 1-3-like | 0.161 | |
| Flt1 | FMS-related tyrosine kinase 1 | 0.154 | |
| Hdac7 | histone deacetylase 7 | 0.152 | |
| Il17ra | interleukin 17 receptor A | 0.142 | |
| Anxa2 | annexin A2 | 0.141 | |
| Sdc3 | syndecan 3 | 0.139 | |
| Slc6a3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 0.138 | |
| RT1-Db1 | RT1 class II, locus Db1 | 0.135 | |
| Gzmk | granzyme K | 0.131 | |
| Nr5a2 | nuclear receptor subfamily 5, group A, member 2 | 0.126 | |
| Ptger4 | prostaglandin E receptor 4 (subtype EP4) | 0.126 | |
| RT1-DMb | RT1 class II, locus DMb | 0.118 | |
| Cfp | complement factor properdin | 0.115 | |
| Cd44 | Cd44 molecule | 0.115 | |
| Lyz2 | lysozyme 2 | 0.113 | |
| Ciita | class II, major histocompatibility complex, transactivator | 0.112 | |
| Lef1 | lymphoid enhancer binding factor 1 | 0.112 | |
| Wipf1 | WAS/WASL interacting protein family, member 1 | 0.111 | |
| Arhgap4 | Rho GTPase activating protein 4 | 0.110 | |
| Il6 | interleukin 6 | 0.109 | |
| Dnase1l3 | deoxyribonuclease 1-like 3 | 0.109 | |
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.108 | |
| Tp53 | tumor protein p53 | 0.106 | |
| Slc18a2 | solute carrier family 18 (vesicular monoamine), member 2 | 0.105 | |
| Il1r1 | interleukin 1 receptor, type I | 0.104 | |
| Vip | vasoactive intestinal peptide | 0.099 | |
| RGD1304644 | similar to RIKEN cDNA 2310046K01 | 0.099 | |
| Cd3g | CD3 molecule, gamma | 0.099 | |
| Pla2g10 | phospholipase A2, group X | 0.098 | |
| Syt8 | synaptotagmin VIII | 0.098 | |
| Socs3 | suppressor of cytokine signaling 3 | 0.096 | |
| Apbb1ip | amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein | 0.095 | |
| Clec4a1 | C-type lectin domain family 4, member a1 | 0.093 | |
| Lta | lymphotoxin alpha (TNF superfamily, member 1) | 0.092 | |
| Gfra2 | GDNF family receptor alpha 2 | 0.092 | |
| Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | 0.089 | |
| Hck | hemopoietic cell kinase | 0.088 | |
| Slc12a1 | solute carrier family 12 (sodium/potassium/chloride transporters), member 1 | 0.088 | |
| Slc8a3 | solute carrier family 8 (sodium/calcium exchanger), member 3 | 0.088 | |
| Cybb | cytochrome b-245, beta polypeptide | 0.084 | |
| Il9r | interleukin 9 receptor | 0.084 | |
| Faslg | Fas ligand (TNF superfamily, member 6) | 0.084 | |
| Grin2a | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.083 | |
| Ptger2 | prostaglandin E receptor 2 (subtype EP2) | 0.079 | |
| Ppyr1 | pancreatic polypeptide receptor 1 | 0.076 | |
| Lrg1 | leucine-rich alpha-2-glycoprotein 1 | 0.076 | |
| Alox5 | arachidonate 5-lipoxygenase | 0.075 | |
| Itgb7 | integrin, beta 7 | 0.074 | |
| Cd53 | Cd53 molecule | 0.071 | |
| Aspg | asparaginase homolog (S. cerevisiae) | 0.071 | |
| Reg1a | regenerating islet-derived 1 alpha | 0.069 | |
| Csn1s1 | casein alpha s1 | 0.069 | |
| Il2rg | interleukin 2 receptor, gamma | 0.069 | |
| Itgad | integrin, alpha D | 0.068 | |
| Cxcr5 | chemokine (C-X-C motif) receptor 5 | 0.068 | |
| Psd4 | pleckstrin and Sec7 domain containing 4 | 0.067 | |
| Tshb | thyroid stimulating hormone, beta | 0.066 | |
| Slfn2 | schlafen 2 | 0.066 | |
| Tbxas1 | thromboxane A synthase 1, platelet | 0.065 | |
| Entpd1 | ectonucleoside triphosphate diphosphohydrolase 1 | 0.065 | |
| Ripk1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.065 | |
| Arhgap25 | Rho GTPase activating protein 25 | 0.065 | |
| Nrarp | Notch-regulated ankyrin repeat protein | 0.065 | |
| Olr1078 | olfactory receptor 1078 | 0.064 | |
| Scn11a | sodium channel, voltage-gated, type XI, alpha | 0.063 | |
| Rassf5 | Ras association (RalGDS/AF-6) domain family member 5 | 0.063 | |
| Reg3g | regenerating islet-derived 3 gamma | 0.063 | |
| Casp1 | caspase 1 | 0.063 | |
| Notch3 | Notch homolog 3 (Drosophila) | 0.063 | |
| Cd37 | CD37 molecule | 0.062 | |
| Tgfbr2 | transforming growth factor, beta receptor II | 0.062 | |
| Mmp10 | matrix metallopeptidase 10 | 0.062 | |
| Atp2b4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.061 | |
| Bcan | brevican | 0.059 | |
| Map4k1 | mitogen activated protein kinase kinase kinase kinase 1 | 0.059 | |
| Slc8a2 | solute carrier family 8 (sodium/calcium exchanger), member 2 | 0.058 | |
| Cd38 | CD38 molecule | 0.058 | |
| Sema3a | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.057 | |
| Lepr | leptin receptor | 0.057 | |
| Tgfbr3 | transforming growth factor, beta receptor III | 0.056 | |
| Tnfrsf8 | tumor necrosis factor receptor superfamily, member 8 | 0.055 | |
| Ncr1 | natural cytotoxicity triggering receptor 1 | 0.055 | |
| Bin2 | bridging integrator 2 | 0.055 | |
| Ndst1 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 | 0.054 | |
| Pecam1 | platelet/endothelial cell adhesion molecule 1 | 0.054 | |
| Cd40lg | CD40 ligand | 0.053 |