The network for 'regulation of i kappab kinase nf kappab signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of i kappab kinase nf kappab signaling

Any process that modulates I-kappaB kinase/NF-kappaB signaling.

Homo sapiens
Name Description Probability Func Analog Organism
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 1.000
TRAF6 TNF receptor-associated factor 6 1.000
BIRC3 baculoviral IAP repeat containing 3 1.000
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 1.000
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 1.000
RIPK2 receptor-interacting serine-threonine kinase 2 1.000
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.000
XIAP X-linked inhibitor of apoptosis 1.000
SQSTM1 sequestosome 1 1.000
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.000
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.000
TRAF1 TNF receptor-associated factor 1 1.000
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 1.000
MAP3K7 mitogen-activated protein kinase kinase kinase 7 1.000
UBC ubiquitin C 1.000
MYD88 myeloid differentiation primary response gene (88) 1.000
TRAF2 TNF receptor-associated factor 2 1.000
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.999
BIRC2 baculoviral IAP repeat containing 2 0.999
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.998
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.997
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.997
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.997
TRAF3 TNF receptor-associated factor 3 0.996
CFLAR CASP8 and FADD-like apoptosis regulator 0.991
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.988
FAS Fas (TNF receptor superfamily, member 6) 0.988
CHUK conserved helix-loop-helix ubiquitous kinase 0.987
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.984
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.982
TRIM63 tripartite motif containing 63 0.980
IRAK1 interleukin-1 receptor-associated kinase 1 0.973
TNIP2 TNFAIP3 interacting protein 2 0.969
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.967
SMAD3 SMAD family member 3 0.965
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.964
TRADD TNFRSF1A-associated via death domain 0.959
ESR1 estrogen receptor 1 0.958
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.953
FADD Fas (TNFRSF6)-associated via death domain 0.945
C1QA complement component 1, q subcomponent, A chain 0.945
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.938
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.936
CD40 CD40 molecule, TNF receptor superfamily member 5 0.935
TNF tumor necrosis factor 0.921
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.903
CARD11 caspase recruitment domain family, member 11 0.902
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.893
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.888
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.887
S100A6 S100 calcium binding protein A6 0.874
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.868
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.868
BCL10 B-cell CLL/lymphoma 10 0.866
PML promyelocytic leukemia 0.864
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.862
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.852
ICAM1 intercellular adhesion molecule 1 0.825
IRAK2 interleukin-1 receptor-associated kinase 2 0.817
S100A9 S100 calcium binding protein A9 0.803
TANK TRAF family member-associated NFKB activator 0.798
TLR4 toll-like receptor 4 0.797
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.796
TRAF5 TNF receptor-associated factor 5 0.760
CAV1 caveolin 1, caveolae protein, 22kDa 0.757
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.749
ANXA2 annexin A2 0.729
CCL4 chemokine (C-C motif) ligand 4 0.695
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.694
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.680
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.673
IL1R1 interleukin 1 receptor, type I 0.665
S100A8 S100 calcium binding protein A8 0.662
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.654
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.645
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.626
CXCL9 chemokine (C-X-C motif) ligand 9 0.624
IL8 interleukin 8 0.610
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.608
S100A16 S100 calcium binding protein A16 0.599
S100A11 S100 calcium binding protein A11 0.568
ANXA1 annexin A1 0.559
BCL3 B-cell CLL/lymphoma 3 0.549
SMAD7 SMAD family member 7 0.544
CXCL10 chemokine (C-X-C motif) ligand 10 0.535
S100A14 S100 calcium binding protein A14 0.533
MYH9 myosin, heavy chain 9, non-muscle 0.531
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.518
IL2RB interleukin 2 receptor, beta 0.514
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.506
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.490
TBK1 TANK-binding kinase 1 0.488
INSR insulin receptor 0.486
CCR5 chemokine (C-C motif) receptor 5 0.485
CCL2 chemokine (C-C motif) ligand 2 0.479
UBQLN1 ubiquilin 1 0.479
EEF1G eukaryotic translation elongation factor 1 gamma 0.474
TLR2 toll-like receptor 2 0.466
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.461
IRF1 interferon regulatory factor 1 0.460
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.749
cav1 caveolin 1 0.442
itm2bb integral membrane protein 2Bb 0.434
adipor2 adiponectin receptor 2 0.404
nod1 nucleotide-binding oligomerization domain containing 1 0.378
grifin galectin related inter-fiber protein 0.317
cd63 Cd63 antigen 0.281
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.262
caspa caspase a 0.261
tlr3 toll-like receptor 3 0.248
pycard PYD and CARD domain containing 0.242
lats1 LATS, large tumor suppressor, homolog 1 (Drosophila) 0.227
rel v-rel reticuloendotheliosis viral oncogene homolog 0.227
card9 caspase recruitment domain family, member 9 0.219
cbr1l carbonyl reductase 1-like 0.208
tlr9 toll-like receptor 9 0.192
serpinb1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.177
tgm2b transglutaminase 2b 0.172
slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 0.161
LOC557072 caspase recruitment domain-containing protein 11-like 0.157
hcrt hypocretin (orexin) neuropeptide precursor 0.149
LOC100003514 protein kinase C alpha type-like 0.142
ip6k2 inositol hexaphosphate kinase 2 0.141
mmp15b matrix metallopeptidase 15b 0.135
s100v2 S100 calcium binding protein V2 0.132
brd2b bromodomain containing 2b 0.131
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.130
unc5c unc-5 homolog C (C. elegans) 0.129
lgals3l lectin, galactoside-binding, soluble, 3 (galectin 3)-like 0.127
stat1a signal transduction and activation of transcription 1a 0.122
nt5c2l1 5'-nucleotidase, cytosolic II, like 1 0.117
comta catechol-O-methyltransferase a 0.116
per2 period homolog 2 (Drosophila) 0.116
il8 interleukin 8 0.113
nccrp1 nonspecific cytotoxic cell receptor protein 1 0.111
s100a10b S100 calcium binding protein A10b 0.108
bhlhe40 basic helix-loop-helix family, member e40 0.108
card14 caspase recruitment domain family, member 14 0.107
ube2nb ubiquitin-conjugating enzyme E2Nb 0.106
klfd Kruppel-like factor d 0.106
bhlhe41 basic helix-loop-helix family, member e41 0.105
sema3fb semaphorin 3fb 0.104
foxo3b forkhead box O3b 0.104
acp5b acid phosphatase 5b, tartrate resistant 0.102
th2 tyrosine hydroxylase 2 0.100
elovl4a elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4a 0.099
zgc:110340 zgc:110340 0.098
f2rl1.2 coagulation factor II (thrombin) receptor-like 1.2 0.098
adipor1b adiponectin receptor 1b 0.097
anxa5b annexin A5b 0.097
tsen54 tRNA splicing endonuclease 54 homolog (S. cerevisiae) 0.096
vcanb versican b 0.095
si:ch211-9d9.3 si:ch211-9d9.3 0.093
ighz immunoglobulin heavy constant zeta 0.093
LOC100004946 transient receptor potential cation channel subfamily M member 4-like 0.089
slc39a1 solute carrier family 39 (zinc transporter), member 1 0.087
zfand5a zinc finger, AN1-type domain 5a 0.087
rad21 RAD21 homolog (S. pombe) 0.086
blvrb biliverdin reductase B (flavin reductase (NADPH)) 0.085
adrb2a adrenergic receptor, beta 2a 0.085
angptl1 angiopoietin-like 1 0.084
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.083
stxbp2 syntaxin binding protein 2 0.083
slc7a6 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 0.082
sirt1 sirtuin (silent mating type information regulation 2 homolog) 1 0.080
LOC100000934 hypothetical protein LOC100000934 0.080
tlr18 toll-like receptor 18 0.079
arhgdig Rho GDP dissociation inhibitor (GDI) gamma 0.079
epb41 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) 0.077
icn ictacalcin 0.074
litaf lipopolysaccharide-induced TNF factor 0.073
rnf180 ring finger protein 180 0.073
ela2l elastase 2 like 0.073
tnfb tumor necrosis factor b (TNF superfamily, member 2) 0.073
tlr2 toll-like receptor 2 0.072
timm17a translocase of inner mitochondrial membrane 17 homolog A (yeast) 0.069
sdcbp syndecan binding protein (syntenin) 0.069
hoxa13a homeo box A13a 0.069
mcl1b myeloid cell leukemia sequence 1b 0.069
ecscr endothelial cell-specific chemotaxis regulator 0.068
zgc:92027 zgc:92027 0.068
mobkl3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 0.067
crygm2d1 crystallin, gamma M2d1 0.067
keap1a kelch-like ECH-associated protein 1a 0.066
pdcd6 programmed cell death 6 0.066
hbaa1 hemoglobin alpha adult-1 0.066
stc1l stanniocalcin 1, like 0.065
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.065
prkcz protein kinase C, zeta 0.065
tph2 tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) 0.065
chuk conserved helix-loop-helix ubiquitous kinase 0.064
pdgfaa platelet-derived growth factor alpha a 0.064
ctsba cathepsin B, a 0.064
carm1 coactivator-associated arginine methyltransferase 1 0.063
ptger4b prostaglandin E receptor 4 (subtype EP4) b 0.063
atf3 activating transcription factor 3 0.062
cldni claudin i 0.062
msi1 musashi homolog 1 (Drosophila) 0.062
cotl1 coactosin-like 1 (Dictyostelium) 0.062
mipa major intrinsic protein of lens fiber a 0.062
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Tl Toll 0.399
bai baiser 0.390
Toll-6 CG7250 gene product from transcript CG7250-RA 0.281
ird5 immune response deficient 5 0.266
Myd88 CG2078 gene product from transcript CG2078-RA 0.265
BG4 CG12297 gene product from transcript CG12297-RA 0.250
Toll-7 CG8595 gene product from transcript CG8595-RA 0.248
imd immune deficiency 0.219
Hsp27 Heat shock protein 27 0.181
Tak1 TGF-beta activated kinase 1 0.171
18w 18 wheeler 0.169
Cam Calmodulin 0.154
spz spatzle 0.126
Pli Pellino 0.125
Rel Relish 0.114
pan pangolin 0.109
p24-1 p24-related-1 0.106
Df31 Decondensation factor 31 0.096
pum pumilio 0.094
Akt1 CG4006 gene product from transcript CG4006-RA 0.084
Dcr-2 Dicer-2 0.082
Cf2 Chorion factor 2 0.082
CG10650 CG10650 gene product from transcript CG10650-RA 0.077
qkr58E-3 quaking related 58E-3 0.076
key kenny 0.074
Duox Dual oxidase 0.071
Nrx-IV Neurexin IV 0.069
Hsp23 Heat shock protein 23 0.069
CTCF CG8591 gene product from transcript CG8591-RA 0.068
Hcf Host cell factor 0.066
Hsp68 Heat shock protein 68 0.065
egr eiger 0.065
aPKC atypical protein kinase C 0.065
lat latheo 0.064
grn grain 0.063
CG16718 CG16718 gene product from transcript CG16718-RA 0.061
hth homothorax 0.060
e(y)3 enhancer of yellow 3 0.060
unc-13 CG2999 gene product from transcript CG2999-RA 0.059
jar jaguar 0.058
Dredd Death related ced-3/Nedd2-like protein 0.058
Atf-2 Activating transcription factor-2 0.057
TER94 CG2331 gene product from transcript CG2331-RA 0.057
Spn27A Serpin 27A 0.056
pr-set7 CG3307 gene product from transcript CG3307-RC 0.056
Cyt-c-d Cytochrome c distal 0.056
Dlc90F Dynein light chain 90F 0.056
Sdc Syndecan 0.055
mus309 mutagen-sensitive 309 0.055
nec necrotic 0.055
PRL-1 CG4993 gene product from transcript CG4993-RB 0.055
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.054
ari-2 ariadne 2 0.051
rok Rho-kinase 0.051
CG5384 CG5384 gene product from transcript CG5384-RA 0.051
SuUR Suppressor of Under-Replication 0.051
Mpk2 CG5475 gene product from transcript CG5475-RB 0.051
wee CG4488 gene product from transcript CG4488-RA 0.050
mnb minibrain 0.049
nopo no poles 0.049
lig lingerer 0.049
CG12918 CG12918 gene product from transcript CG12918-RA 0.049
ash1 absent, small, or homeotic discs 1 0.048
SoxN SoxNeuro 0.046
AGO2 Argonaute 2 0.046
Adar Adenosine deaminase acting on RNA 0.046
TBPH CG10327 gene product from transcript CG10327-RC 0.046
MED31 Mediator complex subunit 31 0.046
Cat Catalase 0.045
Rac2 CG8556 gene product from transcript CG8556-RA 0.044
magu CG2264 gene product from transcript CG2264-RD 0.044
ec echinus 0.043
hep hemipterous 0.042
trp transient receptor potential 0.042
Pi3K68D Phosphotidylinositol 3 kinase 68D 0.042
Med Medea 0.041
t tan 0.041
Gycalpha99B Guanylyl cyclase alpha-subunit at 99B 0.041
CG32711 CG32711 gene product from transcript CG32711-RA 0.041
slow slowdown 0.040
Akap200 A kinase anchor protein 200 0.040
Hsp26 Heat shock protein 26 0.039
cact cactus 0.039
cln3 CG5582 gene product from transcript CG5582-RA 0.038
Cdk5alpha Cdk5 activator-like protein 0.038
Thor CG8846 gene product from transcript CG8846-RA 0.038
TM9SF4 CG7364 gene product from transcript CG7364-RA 0.037
sinu sinuous 0.037
CG5741 CG5741 gene product from transcript CG5741-RC 0.036
Paip2 polyA-binding protein interacting protein 2 0.036
inaD inactivation no afterpotential D 0.036
PGRP-LE Peptidoglycan recognition protein LE 0.036
CG11299 CG11299 gene product from transcript CG11299-RA 0.036
Smg5 CG8954 gene product from transcript CG8954-RA 0.036
janA janus A 0.035
l(2)k16918 lethal (2) k16918 0.035
RASSF8 CG5053 gene product from transcript CG5053-RA 0.035
rt rotated abdomen 0.035
Nhe3 Na[+]/H[+] hydrogen exchanger 3 0.035
CG17107 CG17107 gene product from transcript CG17107-RA 0.035
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Vdac1 voltage-dependent anion channel 1 0.061
Il1a interleukin 1 alpha 0.044
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.031
Myd88 myeloid differentiation primary response gene 88 0.030
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.029
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.029
Il6 interleukin 6 0.029
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.028
Ccl2 chemokine (C-C motif) ligand 2 0.026
Cdk4 cyclin-dependent kinase 4 0.026
Stat3 signal transducer and activator of transcription 3 0.025
Cxcl10 chemokine (C-X-C motif) ligand 10 0.025
Eif4h eukaryotic translation initiation factor 4H 0.024
Rab7a RAB7A, member RAS oncogene family 0.023
Lgals5 lectin, galactose binding, soluble 5 0.020
Dtx3l deltex 3-like (Drosophila) 0.019
Cxcl2 chemokine (C-X-C motif) ligand 2 0.018
Syngr2 synaptogyrin 2 0.018
Vcam1 vascular cell adhesion molecule 1 0.017
Tpm3 tropomyosin 3, gamma 0.017
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.017
Zfp36 zinc finger protein 36 0.017
Pfn1 profilin 1 0.015
Selp selectin P 0.015
Adrb2 adrenergic, beta-2-, receptor, surface 0.014
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.014
Ednrb endothelin receptor type B 0.014
Mca32 mast cell antigen 32 0.014
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.014
Ube2e3 ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog (yeast) 0.013
Apol3 apolipoprotein L, 3 0.013
Casp1 caspase 1 0.013
Ccl4 chemokine (C-C motif) ligand 4 0.013
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.012
Marcks myristoylated alanine rich protein kinase C substrate 0.012
Hn1 hematological and neurological expressed 1 0.012
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.011
Prkar1a protein kinase, cAMP-dependent, regulatory, type I, alpha 0.011
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.011
Socs3 suppressor of cytokine signaling 3 0.011
Fgfr1 Fibroblast growth factor receptor 1 0.011
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.010
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.010
Nrg2 neuregulin 2 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism