The network for 'positive regulation of nf kappab transcription factor activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of nf kappab transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.

Homo sapiens
Name Description Probability Func Analog Organism
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 1.000
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 1.000
BIRC3 baculoviral IAP repeat containing 3 0.998
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.996
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.996
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.992
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.991
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.991
NCF1 neutrophil cytosolic factor 1 0.991
RIPK2 receptor-interacting serine-threonine kinase 2 0.983
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.980
SQSTM1 sequestosome 1 0.977
TRAF2 TNF receptor-associated factor 2 0.972
BIRC2 baculoviral IAP repeat containing 2 0.968
TRAF1 TNF receptor-associated factor 1 0.967
MYD88 myeloid differentiation primary response gene (88) 0.951
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.914
TRAF3 TNF receptor-associated factor 3 0.907
PRKCA protein kinase C, alpha 0.903
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.889
PML promyelocytic leukemia 0.887
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.881
IRAK2 interleukin-1 receptor-associated kinase 2 0.873
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.852
SMAD3 SMAD family member 3 0.844
TRAF6 TNF receptor-associated factor 6 0.842
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.840
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.792
NLRC4 NLR family, CARD domain containing 4 0.789
IRAK1 interleukin-1 receptor-associated kinase 1 0.782
TRIM21 tripartite motif containing 21 0.663
IL1R1 interleukin 1 receptor, type I 0.653
PYCARD PYD and CARD domain containing 0.641
TICAM2 toll-like receptor adaptor molecule 2 0.630
BCL3 B-cell CLL/lymphoma 3 0.606
CREBBP CREB binding protein 0.588
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.545
BCL10 B-cell CLL/lymphoma 10 0.516
TXN thioredoxin 0.498
PRKCZ protein kinase C, zeta 0.498
TTN titin 0.496
CARD11 caspase recruitment domain family, member 11 0.482
RNF31 ring finger protein 31 0.444
TNIP2 TNFAIP3 interacting protein 2 0.442
TNF tumor necrosis factor 0.422
TRIM63 tripartite motif containing 63 0.413
INADL InaD-like (Drosophila) 0.409
UBE2U ubiquitin-conjugating enzyme E2U (putative) 0.405
ESR1 estrogen receptor 1 0.392
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.389
TRIM41 tripartite motif containing 41 0.362
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.361
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.352
PSEN2 presenilin 2 (Alzheimer disease 4) 0.350
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.347
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.338
IRAK3 interleukin-1 receptor-associated kinase 3 0.319
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.287
ZMYND11 zinc finger, MYND-type containing 11 0.286
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.281
SPRR2A small proline-rich protein 2A 0.276
TRIM5 tripartite motif containing 5 0.270
GSK3B glycogen synthase kinase 3 beta 0.265
NCF4 neutrophil cytosolic factor 4, 40kDa 0.251
NMI N-myc (and STAT) interactor 0.246
PRKCB protein kinase C, beta 0.244
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.244
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.239
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.230
TRAF5 TNF receptor-associated factor 5 0.230
SP110 SP110 nuclear body protein 0.211
IRF7 interferon regulatory factor 7 0.206
TNIP1 TNFAIP3 interacting protein 1 0.198
NOXA1 NADPH oxidase activator 1 0.198
NCOA1 nuclear receptor coactivator 1 0.192
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.188
ZC3H12A zinc finger CCCH-type containing 12A 0.188
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.187
NCOA3 nuclear receptor coactivator 3 0.186
ZNRF1 zinc and ring finger 1 0.186
TRIM22 tripartite motif containing 22 0.185
TSC22D1 TSC22 domain family, member 1 0.185
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.183
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.177
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.175
NCL nucleolin 0.168
PRDX4 peroxiredoxin 4 0.164
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.160
EFCAB4B EF-hand calcium binding domain 4B 0.156
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.156
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.153
MAP2K1 mitogen-activated protein kinase kinase 1 0.151
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 0.146
ARIH2 ariadne homolog 2 (Drosophila) 0.146
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.145
PDPK1 3-phosphoinositide dependent protein kinase-1 0.144
ZNF746 zinc finger protein 746 0.143
MED15 mediator complex subunit 15 0.143
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.142
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.139
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Myd88 myeloid differentiation primary response gene 88 0.997
Traf6 TNF receptor-associated factor 6 0.997
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.977
Tnf tumor necrosis factor 0.953
Tlr4 toll-like receptor 4 0.948
Cd44 CD44 antigen 0.926
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.885
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.852
Ldb3 LIM domain binding 3 0.766
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.761
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.735
Il10 interleukin 10 0.718
Cd40 CD40 antigen 0.638
Ikbkg inhibitor of kappaB kinase gamma 0.501
Acvrl1 activin A receptor, type II-like 1 0.466
Casp1 caspase 1 0.463
Adam12 a disintegrin and metallopeptidase domain 12 (meltrin alpha) 0.433
Prkcc protein kinase C, gamma 0.377
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.351
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.265
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.265
Tlr2 toll-like receptor 2 0.255
Il1r1 interleukin 1 receptor, type I 0.252
Actn2 actinin alpha 2 0.252
Rarg retinoic acid receptor, gamma 0.249
Mmp9 matrix metallopeptidase 9 0.248
Nos2 nitric oxide synthase 2, inducible 0.235
Csf1 colony stimulating factor 1 (macrophage) 0.234
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.222
Fas Fas (TNF receptor superfamily member 6) 0.222
Mavs mitochondrial antiviral signaling protein 0.206
Irak4 interleukin-1 receptor-associated kinase 4 0.203
Ikbkb inhibitor of kappaB kinase beta 0.191
Vdr vitamin D receptor 0.180
Igh immunoglobulin heavy chain complex 0.178
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.177
Birc3 baculoviral IAP repeat-containing 3 0.162
Lepr leptin receptor 0.162
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.149
Trp53 transformation related protein 53 0.149
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.141
Pycard PYD and CARD domain containing 0.137
Smad3 MAD homolog 3 (Drosophila) 0.132
Adam17 a disintegrin and metallopeptidase domain 17 0.127
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.125
Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.122
Bcl3 B-cell leukemia/lymphoma 3 0.122
Adam15 a disintegrin and metallopeptidase domain 15 (metargidin) 0.119
Itch itchy, E3 ubiquitin protein ligase 0.116
Clock circadian locomotor output cycles kaput 0.115
Il6st interleukin 6 signal transducer 0.115
Casp8 caspase 8 0.115
Btk Bruton agammaglobulinemia tyrosine kinase 0.107
Plxna1 plexin A1 0.100
Ccl2 chemokine (C-C motif) ligand 2 0.097
Pten phosphatase and tensin homolog 0.097
Stat3 signal transducer and activator of transcription 3 0.093
Ptgs2 prostaglandin-endoperoxide synthase 2 0.093
Akt1 thymoma viral proto-oncogene 1 0.091
Irak3 interleukin-1 receptor-associated kinase 3 0.082
Pparg peroxisome proliferator activated receptor gamma 0.082
Prkcd protein kinase C, delta 0.078
Ccr2 chemokine (C-C motif) receptor 2 0.077
Cyld cylindromatosis (turban tumor syndrome) 0.075
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.073
Ltbr lymphotoxin B receptor 0.071
Hif1a hypoxia inducible factor 1, alpha subunit 0.069
Prkce protein kinase C, epsilon 0.068
Il4 interleukin 4 0.068
Il4ra interleukin 4 receptor, alpha 0.063
Hdac7 histone deacetylase 7 0.056
Nlrp3 NLR family, pyrin domain containing 3 0.055
Fzd1 frizzled homolog 1 (Drosophila) 0.053
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.049
Myo1c myosin IC 0.049
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.047
Ksr1 kinase suppressor of ras 1 0.047
Lta lymphotoxin A 0.046
Il6 interleukin 6 0.045
Vhl von Hippel-Lindau tumor suppressor 0.045
2010106G01Rik RIKEN cDNA 2010106G01 gene 0.045
Arhgef1 Rho guanine nucleotide exchange factor (GEF) 1 0.044
Sfn stratifin 0.044
Inha inhibin alpha 0.044
Dlg4 discs, large homolog 4 (Drosophila) 0.044
Ifi44 interferon-induced protein 44 0.043
Lyz2 lysozyme 2 0.042
Eif2c1 eukaryotic translation initiation factor 2C, 1 0.042
Foxf1a forkhead box F1a 0.041
Traf3ip2 TRAF3 interacting protein 2 0.041
Irf9 interferon regulatory factor 9 0.041
Prnp prion protein 0.040
Runx1 runt related transcription factor 1 0.040
Klf3 Kruppel-like factor 3 (basic) 0.040
Ticam1 toll-like receptor adaptor molecule 1 0.040
Rnf31 ring finger protein 31 0.039
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.039
Epb4.1l2 erythrocyte protein band 4.1-like 2 0.035
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.034
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.034
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Rattus norvegicus
Name Description Probability Func Analog Organism
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.046
Zyx zyxin 0.020
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.012
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.011
Stat3 signal transducer and activator of transcription 3 0.011
Ltbr lymphotoxin beta receptor (TNFR superfamily, member 3) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism