The network for 'cytokine production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cytokine production

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

Mus musculus
Name Description Probability Func Analog Organism
Stat3 signal transducer and activator of transcription 3 1.000
Tlr4 toll-like receptor 4 1.000
Tnf tumor necrosis factor 1.000
Myd88 myeloid differentiation primary response gene 88 0.999
Lyz2 lysozyme 2 0.999
Cd40 CD40 antigen 0.997
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.996
Il1r1 interleukin 1 receptor, type I 0.996
Casp1 caspase 1 0.994
Il2rg interleukin 2 receptor, gamma chain 0.992
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.986
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.984
Lepr leptin receptor 0.984
Fasl Fas ligand (TNF superfamily, member 6) 0.983
Il1rn interleukin 1 receptor antagonist 0.980
Il10ra interleukin 10 receptor, alpha 0.979
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.976
Il1b interleukin 1 beta 0.975
Il10 interleukin 10 0.975
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.972
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.972
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.970
Apoe apolipoprotein E 0.969
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.967
Cd28 CD28 antigen 0.967
Traf6 TNF receptor-associated factor 6 0.963
Socs1 suppressor of cytokine signaling 1 0.959
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.959
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.958
Il2rb interleukin 2 receptor, beta chain 0.955
Icos inducible T-cell co-stimulator 0.954
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.953
Nlrp3 NLR family, pyrin domain containing 3 0.948
Ccl2 chemokine (C-C motif) ligand 2 0.947
Thrb thyroid hormone receptor beta 0.947
Batf basic leucine zipper transcription factor, ATF-like 0.945
Tgfb1 transforming growth factor, beta 1 0.943
Ptgs2 prostaglandin-endoperoxide synthase 2 0.943
Nos2 nitric oxide synthase 2, inducible 0.941
Axl AXL receptor tyrosine kinase 0.939
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.921
Cybb cytochrome b-245, beta polypeptide 0.920
Il6 interleukin 6 0.918
Cd86 CD86 antigen 0.918
Slamf1 signaling lymphocytic activation molecule family member 1 0.916
Birc3 baculoviral IAP repeat-containing 3 0.912
Rxra retinoid X receptor alpha 0.912
Il12b interleukin 12b 0.905
Il7r interleukin 7 receptor 0.904
Ccl4 chemokine (C-C motif) ligand 4 0.902
Ncr1 natural cytotoxicity triggering receptor 1 0.898
Foxf1a forkhead box F1a 0.896
Osmr oncostatin M receptor 0.894
Unc93b1 unc-93 homolog B1 (C. elegans) 0.893
Clec4d C-type lectin domain family 4, member d 0.887
Irf9 interferon regulatory factor 9 0.887
Sh2d2a SH2 domain protein 2A 0.885
Blk B lymphoid kinase 0.885
Csf1 colony stimulating factor 1 (macrophage) 0.884
Stat1 signal transducer and activator of transcription 1 0.884
Inhba inhibin beta-A 0.883
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.871
Pitx1 paired-like homeodomain transcription factor 1 0.870
Snai1 snail homolog 1 (Drosophila) 0.865
Cd14 CD14 antigen 0.865
Pcdh12 protocadherin 12 0.860
Cd44 CD44 antigen 0.858
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.857
Klrb1c killer cell lectin-like receptor subfamily B member 1C 0.856
Ccr7 chemokine (C-C motif) receptor 7 0.854
Gzma granzyme A 0.851
Sfpi1 SFFV proviral integration 1 0.836
Acvrl1 activin A receptor, type II-like 1 0.836
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.834
Cd6 CD6 antigen 0.833
Lif leukemia inhibitory factor 0.832
Gbp7 guanylate binding protein 7 0.832
Pax8 paired box gene 8 0.831
Tlr2 toll-like receptor 2 0.829
Grap2 GRB2-related adaptor protein 2 0.824
Fas Fas (TNF receptor superfamily member 6) 0.823
Notch2 Notch gene homolog 2 (Drosophila) 0.822
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.817
Fpr3 formyl peptide receptor 3 0.816
Mefv Mediterranean fever 0.814
C3ar1 complement component 3a receptor 1 0.809
Traf1 TNF receptor-associated factor 1 0.809
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.808
Fpr2 formyl peptide receptor 2 0.807
Cd96 CD96 antigen 0.805
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.805
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.803
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.800
Il4ra interleukin 4 receptor, alpha 0.799
Cd7 CD7 antigen 0.797
Lta lymphotoxin A 0.797
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.795
Gata4 GATA binding protein 4 0.795
Gzmk granzyme K 0.793
Itgal integrin alpha L 0.792
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
mpx myeloid-specific peroxidase 0.135
bmp2b bone morphogenetic protein 2b 0.057
plcg1 phospholipase C, gamma 1 0.046
nod1 nucleotide-binding oligomerization domain containing 1 0.030
fzd7b frizzled homolog 7b 0.030
pcdh18b protocadherin 18b 0.028
anxa1b annexin A1b 0.027
pglyrp5 peptidoglycan recognition protein 5 0.025
sulf2l sulfatase 2, like 0.024
wasa Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a 0.023
col10a1 collagen, type X, alpha 1 0.021
igf1 insulin-like growth factor 1 0.021
epor erythropoietin receptor 0.020
il1b interleukin 1, beta and interleukin 1, beta 0.019
gpia glucose phosphate isomerase a 0.019
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.018
stat1b signal transducer and activator of transcription 1b 0.017
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.017
c3b complement component c3b 0.017
plagl2 pleiomorphic adenoma gene-like 2 0.016
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.016
lyz lysozyme 0.015
b2m beta-2-microglobulin 0.014
myf5 myogenic factor 5 0.013
cav1 caveolin 1 0.013
bmp4 bone morphogenetic protein 4 0.013
alcama activated leukocyte cell adhesion molecule a 0.013
irak4 interleukin-1 receptor-associated kinase 4 0.012
dlb deltaB 0.012
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.012
tal1 T-cell acute lymphocytic leukemia 1 0.012
LOC557072 caspase recruitment domain-containing protein 11-like 0.012
s100v2 S100 calcium binding protein V2 0.012
mpll myeloproliferative leukemia virus oncogene, like 0.011
ripk2 receptor-interacting serine-threonine kinase 2 0.011
pxn paxillin 0.010
notch1a notch homolog 1a 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
IRAK1 interleukin-1 receptor-associated kinase 1 1.000
IL1B interleukin 1, beta 0.999
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.998
TRAF6 TNF receptor-associated factor 6 0.998
SMAD3 SMAD family member 3 0.998
MYD88 myeloid differentiation primary response gene (88) 0.997
MAPK14 mitogen-activated protein kinase 14 0.997
BIRC3 baculoviral IAP repeat containing 3 0.996
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.995
IRAK2 interleukin-1 receptor-associated kinase 2 0.994
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.994
CREBBP CREB binding protein 0.993
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.992
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.990
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.979
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.979
SOCS3 suppressor of cytokine signaling 3 0.978
RIPK2 receptor-interacting serine-threonine kinase 2 0.977
CXCL10 chemokine (C-X-C motif) ligand 10 0.976
IL6 interleukin 6 (interferon, beta 2) 0.973
C1QA complement component 1, q subcomponent, A chain 0.972
IL1R1 interleukin 1 receptor, type I 0.972
CXCL9 chemokine (C-X-C motif) ligand 9 0.969
IL8 interleukin 8 0.968
TRIM22 tripartite motif containing 22 0.968
IL2RB interleukin 2 receptor, beta 0.967
HCK hemopoietic cell kinase 0.966
ICAM1 intercellular adhesion molecule 1 0.965
CCL4 chemokine (C-C motif) ligand 4 0.962
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.962
HLA-DRA major histocompatibility complex, class II, DR alpha 0.961
NOTCH1 notch 1 0.960
SMAD2 SMAD family member 2 0.960
ANXA1 annexin A1 0.958
CD80 CD80 molecule 0.957
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.954
SMAD4 SMAD family member 4 0.951
LCK lymphocyte-specific protein tyrosine kinase 0.949
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.948
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.948
EGFR epidermal growth factor receptor 0.946
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.944
CCL5 chemokine (C-C motif) ligand 5 0.941
CD86 CD86 molecule 0.940
CCR5 chemokine (C-C motif) receptor 5 0.940
IL10RA interleukin 10 receptor, alpha 0.940
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.934
SH2D1A SH2 domain containing 1A 0.934
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.932
HLA-B major histocompatibility complex, class I, B 0.929
HLA-DMA major histocompatibility complex, class II, DM alpha 0.926
SYK spleen tyrosine kinase 0.916
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.909
IL4R interleukin 4 receptor 0.909
PRKD2 protein kinase D2 0.900
TLR2 toll-like receptor 2 0.899
CCR1 chemokine (C-C motif) receptor 1 0.897
TRAF1 TNF receptor-associated factor 1 0.893
CCR7 chemokine (C-C motif) receptor 7 0.881
IRAK3 interleukin-1 receptor-associated kinase 3 0.870
SLAMF1 signaling lymphocytic activation molecule family member 1 0.868
S100A6 S100 calcium binding protein A6 0.868
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.868
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.866
IL1RN interleukin 1 receptor antagonist 0.865
PML promyelocytic leukemia 0.864
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.864
TNF tumor necrosis factor 0.863
IL10 interleukin 10 0.856
BTN3A3 butyrophilin, subfamily 3, member A3 0.850
B2M beta-2-microglobulin 0.847
STAT1 signal transducer and activator of transcription 1, 91kDa 0.847
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.847
ARRB1 arrestin, beta 1 0.845
CCL2 chemokine (C-C motif) ligand 2 0.844
PLAUR plasminogen activator, urokinase receptor 0.843
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.843
HLA-C major histocompatibility complex, class I, C 0.842
HLA-DMB major histocompatibility complex, class II, DM beta 0.838
TRAF5 TNF receptor-associated factor 5 0.837
PYCARD PYD and CARD domain containing 0.836
TLR4 toll-like receptor 4 0.833
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.826
IRF1 interferon regulatory factor 1 0.824
IFNG interferon, gamma 0.819
SLA Src-like-adaptor 0.818
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.818
CXCL2 chemokine (C-X-C motif) ligand 2 0.806
BCL3 B-cell CLL/lymphoma 3 0.801
PLEK pleckstrin 0.799
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.798
RUNX1 runt-related transcription factor 1 0.796
DUSP1 dual specificity phosphatase 1 0.796
HP haptoglobin 0.788
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.785
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.785
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.784
JAG1 jagged 1 0.777
CCL22 chemokine (C-C motif) ligand 22 0.773
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.770
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Rattus norvegicus
Name Description Probability Func Analog Organism
Il2rb interleukin 2 receptor, beta 0.761
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.690
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.685
Cxcl10 chemokine (C-X-C motif) ligand 10 0.671
Il2rg interleukin 2 receptor, gamma 0.642
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.638
Ccr2 chemokine (C-C motif) receptor 2 0.627
Cd14 CD14 molecule 0.587
Csf1 colony stimulating factor 1 (macrophage) 0.564
Ccr5 chemokine (C-C motif) receptor 5 0.515
Il6 interleukin 6 0.512
Arl11 ADP-ribosylation factor-like 11 0.490
Ccl2 chemokine (C-C motif) ligand 2 0.460
Ccl3 chemokine (C-C motif) ligand 3 0.429
Cd80 Cd80 molecule 0.409
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.390
Tlr4 toll-like receptor 4 0.321
Cdh6 cadherin 6 0.288
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.282
Mca32 mast cell antigen 32 0.281
Igsf6 immunoglobulin superfamily, member 6 0.258
Jak1 Janus kinase 1 0.258
Casp1 caspase 1 0.246
Il1b interleukin 1 beta 0.228
Fgfr2 fibroblast growth factor receptor 2 0.227
Cxcl2 chemokine (C-X-C motif) ligand 2 0.226
Casp3 caspase 3 0.224
Mmp3 matrix metallopeptidase 3 0.218
Ncr1 natural cytotoxicity triggering receptor 1 0.218
Gzmk granzyme K 0.215
Sell selectin L 0.205
Oprk1 opioid receptor, kappa 1 0.204
S1pr2 sphingosine-1-phosphate receptor 2 0.204
Il1rl1 interleukin 1 receptor-like 1 0.198
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.197
Plau plasminogen activator, urokinase 0.197
Socs3 suppressor of cytokine signaling 3 0.195
Cd44 Cd44 molecule 0.191
Fosl1 fos-like antigen 1 0.184
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.176
Stat3 signal transducer and activator of transcription 3 0.175
Ccl4 chemokine (C-C motif) ligand 4 0.174
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.174
Hck hemopoietic cell kinase 0.150
Ccl5 chemokine (C-C motif) ligand 5 0.149
Nras neuroblastoma ras oncogene 0.149
Jun Jun oncogene 0.148
Mmp12 matrix metallopeptidase 12 0.144
Cd4 Cd4 molecule 0.138
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.137
Sox17 SRY (sex determining region Y)-box 17 0.135
RatNP-3b defensin RatNP-3 precursor 0.134
Trim47 tripartite motif-containing 47 0.134
Selp selectin P 0.131
Casp12 caspase 12 0.130
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.129
Il1r2 interleukin 1 receptor, type II 0.128
Gimap4 GTPase, IMAP family member 4 0.127
Nkg7 natural killer cell group 7 sequence 0.122
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.121
Ccl7 chemokine (C-C motif) ligand 7 0.121
Cd200r1 CD200 receptor 1 0.117
Icam1 intercellular adhesion molecule 1 0.115
Plaur plasminogen activator, urokinase receptor 0.114
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.113
RGD1559748 similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein) 0.111
Ciita class II, major histocompatibility complex, transactivator 0.109
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 0.108
Inpp5d inositol polyphosphate-5-phosphatase D 0.107
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.106
Slc15a3 solute carrier family 15, member 3 0.101
Sirpa signal-regulatory protein alpha 0.101
Lepr leptin receptor 0.098
Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 0.096
Cd2 Cd2 molecule 0.095
Abi3 ABI family, member 3 0.095
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.095
Ctse cathepsin E 0.092
Il1a interleukin 1 alpha 0.092
Apol3 apolipoprotein L, 3 0.091
Adora2a adenosine A2a receptor 0.090
Rgs1 regulator of G-protein signaling 1 0.090
Ins1 insulin 1 0.089
Acrv1 acrosomal vesicle protein 1 0.089
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.089
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.088
Phkg1 phosphorylase kinase, gamma 1 0.087
Ripk3 receptor-interacting serine-threonine kinase 3 0.085
Iapp islet amyloid polypeptide 0.083
Calcrl calcitonin receptor-like 0.083
Cd38 CD38 molecule 0.082
Cybb cytochrome b-245, beta polypeptide 0.081
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.081
RGD1559588 similar to cell surface receptor FDFACT 0.080
Neurog3 neurogenin 3 0.080
Litaf lipopolysaccharide-induced TNF factor 0.079
Folr2 folate receptor 2 (fetal) 0.078
Cd3g CD3 molecule, gamma 0.078
Parm1 prostate androgen-regulated mucin-like protein 1 0.078
Cd36 CD36 molecule (thrombospondin receptor) 0.078
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism