The network for 'interleukin 12 production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

interleukin 12 production

The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 1.000
Cd40 CD40 antigen 0.961
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.917
Traf6 TNF receptor-associated factor 6 0.913
Cd44 CD44 antigen 0.898
Lta lymphotoxin A 0.895
Socs1 suppressor of cytokine signaling 1 0.865
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.844
Ccr1 chemokine (C-C motif) receptor 1 0.730
Ikzf1 IKAROS family zinc finger 1 0.690
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.687
Ccl2 chemokine (C-C motif) ligand 2 0.634
Irf4 interferon regulatory factor 4 0.603
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.581
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.548
Ccl3 chemokine (C-C motif) ligand 3 0.503
Ccr2 chemokine (C-C motif) receptor 2 0.495
Ccl4 chemokine (C-C motif) ligand 4 0.414
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.407
Ifng interferon gamma 0.348
Il4 interleukin 4 0.317
Btk Bruton agammaglobulinemia tyrosine kinase 0.306
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.277
Arrb1 arrestin, beta 1 0.272
Prkcd protein kinase C, delta 0.271
Sfpi1 SFFV proviral integration 1 0.270
Bcl3 B-cell leukemia/lymphoma 3 0.265
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.242
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.228
Ccr5 chemokine (C-C motif) receptor 5 0.223
Myd88 myeloid differentiation primary response gene 88 0.216
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.215
Selp selectin, platelet 0.211
Cxcr5 chemokine (C-X-C motif) receptor 5 0.209
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.208
Arrb2 arrestin, beta 2 0.202
Cd7 CD7 antigen 0.199
Cxcl13 chemokine (C-X-C motif) ligand 13 0.193
Il2rb interleukin 2 receptor, beta chain 0.173
Icos inducible T-cell co-stimulator 0.172
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.169
Epor erythropoietin receptor 0.156
Vhl von Hippel-Lindau tumor suppressor 0.154
Ccr7 chemokine (C-C motif) receptor 7 0.151
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.146
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.146
Fcgr2b Fc receptor, IgG, low affinity IIb 0.140
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.137
Il10ra interleukin 10 receptor, alpha 0.137
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.134
Inpp5d inositol polyphosphate-5-phosphatase D 0.134
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.133
Ccr6 chemokine (C-C motif) receptor 6 0.117
Irf5 interferon regulatory factor 5 0.117
Il27ra interleukin 27 receptor, alpha 0.115
Ctsw cathepsin W 0.108
Birc3 baculoviral IAP repeat-containing 3 0.106
Il4ra interleukin 4 receptor, alpha 0.102
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.101
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.099
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.095
Xcr1 chemokine (C motif) receptor 1 0.095
Tlr5 toll-like receptor 5 0.093
Icam1 intercellular adhesion molecule 1 0.089
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.085
Gpr132 G protein-coupled receptor 132 0.085
S1pr2 sphingosine-1-phosphate receptor 2 0.083
Lag3 lymphocyte-activation gene 3 0.082
Fasl Fas ligand (TNF superfamily, member 6) 0.079
Itgax integrin alpha X 0.079
Fcgr1 Fc receptor, IgG, high affinity I 0.076
Gdf15 growth differentiation factor 15 0.076
Il1r1 interleukin 1 receptor, type I 0.076
Blnk B-cell linker 0.071
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.071
Ncr1 natural cytotoxicity triggering receptor 1 0.070
Il1rn interleukin 1 receptor antagonist 0.069
Il1b interleukin 1 beta 0.069
Ccl8 chemokine (C-C motif) ligand 8 0.068
Flt3 FMS-like tyrosine kinase 3 0.067
Cd96 CD96 antigen 0.067
Pou3f4 POU domain, class 3, transcription factor 4 0.067
Il12b interleukin 12b 0.066
Ltb lymphotoxin B 0.065
Ch25h cholesterol 25-hydroxylase 0.064
Irg1 immunoresponsive gene 1 0.061
Rhoh ras homolog gene family, member H 0.061
Irf7 interferon regulatory factor 7 0.060
Gbx2 gastrulation brain homeobox 2 0.059
Cd47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) 0.059
Gm12185 predicted gene 12185 0.058
Crb2 crumbs homolog 2 (Drosophila) 0.058
Card11 caspase recruitment domain family, member 11 0.057
Cd86 CD86 antigen 0.057
Sh2d2a SH2 domain protein 2A 0.057
Itgal integrin alpha L 0.057
Stat2 signal transducer and activator of transcription 2 0.055
Msr1 macrophage scavenger receptor 1 0.055
Plau plasminogen activator, urokinase 0.054
Il12rb2 interleukin 12 receptor, beta 2 0.054
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
B2M beta-2-microglobulin 0.932
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.931
MYD88 myeloid differentiation primary response gene (88) 0.926
HLA-B major histocompatibility complex, class I, B 0.872
HLA-G major histocompatibility complex, class I, G 0.861
HLA-C major histocompatibility complex, class I, C 0.854
HLA-A major histocompatibility complex, class I, A 0.780
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.777
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.567
HLA-F major histocompatibility complex, class I, F 0.506
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.486
IRAK1 interleukin-1 receptor-associated kinase 1 0.473
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.434
HLA-E major histocompatibility complex, class I, E 0.393
IRAK2 interleukin-1 receptor-associated kinase 2 0.385
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.373
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.245
BIRC3 baculoviral IAP repeat containing 3 0.244
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.219
TRAF1 TNF receptor-associated factor 1 0.104
CDHR2 cadherin-related family member 2 0.104
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.070
IRAK3 interleukin-1 receptor-associated kinase 3 0.069
PELI3 pellino homolog 3 (Drosophila) 0.068
PILRA paired immunoglobin-like type 2 receptor alpha 0.065
TAPBP TAP binding protein (tapasin) 0.059
TKT transketolase 0.058
STAT2 signal transducer and activator of transcription 2, 113kDa 0.050
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.046
SIGLEC7 sialic acid binding Ig-like lectin 7 0.042
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.041
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.039
IRAK4 interleukin-1 receptor-associated kinase 4 0.039
CD80 CD80 molecule 0.038
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.035
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.035
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.034
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.029
TRAF3 TNF receptor-associated factor 3 0.028
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.028
CXCL9 chemokine (C-X-C motif) ligand 9 0.026
RAB5C RAB5C, member RAS oncogene family 0.026
CD40 CD40 molecule, TNF receptor superfamily member 5 0.026
PYCARD PYD and CARD domain containing 0.026
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.026
RIPK2 receptor-interacting serine-threonine kinase 2 0.025
NCF2 neutrophil cytosolic factor 2 0.024
NLRP3 NLR family, pyrin domain containing 3 0.023
CD14 CD14 molecule 0.022
PTAFR platelet-activating factor receptor 0.022
TNIP2 TNFAIP3 interacting protein 2 0.022
TRAF6 TNF receptor-associated factor 6 0.021
IL10 interleukin 10 0.021
TLR4 toll-like receptor 4 0.019
TLR2 toll-like receptor 2 0.018
BTK Bruton agammaglobulinemia tyrosine kinase 0.018
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.017
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.017
SOCS3 suppressor of cytokine signaling 3 0.017
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.017
CD86 CD86 molecule 0.017
CTSS cathepsin S 0.016
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.015
TRAF5 TNF receptor-associated factor 5 0.014
NCL nucleolin 0.014
SLAMF7 SLAM family member 7 0.014
IRF4 interferon regulatory factor 4 0.014
CXCR3 chemokine (C-X-C motif) receptor 3 0.014
CCL22 chemokine (C-C motif) ligand 22 0.013
IRF7 interferon regulatory factor 7 0.013
CD300A CD300a molecule 0.013
IL1R1 interleukin 1 receptor, type I 0.013
CD28 CD28 molecule 0.012
PLEK pleckstrin 0.012
CST3 cystatin C 0.012
AIM2 absent in melanoma 2 0.012
HK3 hexokinase 3 (white cell) 0.012
TICAM2 toll-like receptor adaptor molecule 2 0.012
CSK c-src tyrosine kinase 0.012
IL2RB interleukin 2 receptor, beta 0.012
CDCP1 CUB domain containing protein 1 0.012
CCR1 chemokine (C-C motif) receptor 1 0.012
FPR3 formyl peptide receptor 3 0.012
CMKLR1 chemokine-like receptor 1 0.012
TLR6 toll-like receptor 6 0.011
ARRB1 arrestin, beta 1 0.011
IL18RAP interleukin 18 receptor accessory protein 0.011
NCF1 neutrophil cytosolic factor 1 0.011
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 0.011
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.011
CYTH4 cytohesin 4 0.011
IL2RA interleukin 2 receptor, alpha 0.011
VNN2 vanin 2 0.011
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.010
HCP5 HLA complex P5 0.010
IL21R interleukin 21 receptor 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
LOC100363783 rCG53773-like 0.079
Sell selectin L 0.063
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.057
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.051
Cd247 Cd247 molecule 0.051
Lpl lipoprotein lipase 0.042
Pgam1 phosphoglycerate mutase 1 (brain) 0.038
Litaf lipopolysaccharide-induced TNF factor 0.037
Slc25a5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.035
Syk spleen tyrosine kinase 0.034
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.033
Il6 interleukin 6 0.031
Casp12 caspase 12 0.030
Ripk3 receptor-interacting serine-threonine kinase 3 0.029
Sfrp4 secreted frizzled-related protein 4 0.028
Fcnb ficolin B 0.028
Prkcb protein kinase C, beta 0.028
Plau plasminogen activator, urokinase 0.028
Stat3 signal transducer and activator of transcription 3 0.028
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.026
Arhgap25 Rho GTPase activating protein 25 0.026
Ccr2 chemokine (C-C motif) receptor 2 0.026
Hsph1 heat shock 105/110 protein 1 0.026
RT1-A3 RT1 class I, locus A3 0.025
Cd86 CD86 molecule 0.024
Lat linker for activation of T cells 0.024
Nfkbie nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.024
Shc1 SHC (Src homology 2 domain containing) transforming protein 1 0.023
LOC681996 similar to AHA1, activator of heat shock 90kDa protein ATPase homolog 1 0.023
Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.023
P2ry2 purinergic receptor P2Y, G-protein coupled, 2 0.023
Arl5c ADP-ribosylation factor-like 5C 0.022
Acsl1 acyl-CoA synthetase long-chain family member 1 0.022
Cd38 CD38 molecule 0.022
Dlst dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.022
Cycs cytochrome c, somatic 0.022
Arhgap27 Rho GTPase activating protein 27 0.021
Ctse cathepsin E 0.021
Nos2 nitric oxide synthase 2, inducible 0.021
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.021
Map3k1 mitogen activated protein kinase kinase kinase 1 0.020
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.020
Hspa5 heat shock protein 5 0.020
Dram damage-regulated autophagy modulator 0.019
Mobkl2a MOB1, Mps One Binder kinase activator-like 2A (yeast) 0.019
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.019
Hspe1 heat shock protein 1 (chaperonin 10) 0.019
Rapgef2 Rap guanine nucleotide exchange factor (GEF) 2 0.019
Lst1 leukocyte specific transcript 1 0.019
Lgmn legumain 0.019
Nkg7 natural killer cell group 7 sequence 0.019
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.018
Il15 interleukin 15 0.018
C1qbp complement component 1, q subcomponent binding protein 0.018
Ccl3 chemokine (C-C motif) ligand 3 0.018
Ugt2b5 UDP glucuronosyltransferase 2 family, polypeptide B5 0.018
Rhog ras homolog gene family, member G (rho G) 0.018
Anxa2 annexin A2 0.018
Psd4 pleckstrin and Sec7 domain containing 4 0.017
Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.017
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.017
Sele selectin E 0.017
Slc20a1 solute carrier family 20 (phosphate transporter), member 1 0.017
Plcg2 phospholipase C, gamma 2 0.017
Birc3 baculoviral IAP repeat-containing 3 0.016
Ube2d4 ubiquitin-conjugating enzyme E2D 4 0.016
Arhgap4 Rho GTPase activating protein 4 0.016
Il2rg interleukin 2 receptor, gamma 0.016
Atp5f1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 0.016
Ciita class II, major histocompatibility complex, transactivator 0.016
Il1rl1 interleukin 1 receptor-like 1 0.016
Ecel1 endothelin converting enzyme-like 1 0.016
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.016
Slfn2 schlafen 2 0.016
Odc1 ornithine decarboxylase 1 0.016
Leng4 leukocyte receptor cluster (LRC) member 4 0.016
Ptpre protein tyrosine phosphatase, receptor type, E 0.015
Havcr1 hepatitis A virus cellular receptor 1 0.015
S100a8 S100 calcium binding protein A8 0.015
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.015
Fabp4 fatty acid binding protein 4, adipocyte 0.015
Il1b interleukin 1 beta 0.015
Cxcl10 chemokine (C-X-C motif) ligand 10 0.015
Il16 interleukin 16 0.015
Cd2 Cd2 molecule 0.015
Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 0.015
Casp1 caspase 1 0.015
Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.015
Crlf2 cytokine receptor-like factor 2 0.015
Il9r interleukin 9 receptor 0.015
Pld1 phospholipase D1 0.014
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.014
Cdh17 cadherin 17 0.014
Mpeg1 macrophage expressed 1 0.014
Lilrb3l leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like 0.014
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.014
Socs3 suppressor of cytokine signaling 3 0.014
Mmp12 matrix metallopeptidase 12 0.014
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.014
Irf1 interferon regulatory factor 1 0.014
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism