IMP
Process View
The network for 'regulation of release of cytochrome c from mitochondria' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
regulation of release of cytochrome c from mitochondria
Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.998 | |
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.973 | |
| Bax | BCL2-associated X protein | 0.690 | |
| Vhl | von Hippel-Lindau tumor suppressor | 0.541 | |
| Ikzf1 | IKAROS family zinc finger 1 | 0.487 | |
| Bak1 | BCL2-antagonist/killer 1 | 0.375 | |
| Pten | phosphatase and tensin homolog | 0.374 | |
| Mcl1 | myeloid cell leukemia sequence 1 | 0.300 | |
| Lepr | leptin receptor | 0.288 | |
| Igf1r | insulin-like growth factor I receptor | 0.279 | |
| Gbp5 | guanylate binding protein 5 | 0.245 | |
| Grb10 | growth factor receptor bound protein 10 | 0.244 | |
| Aim2 | absent in melanoma 2 | 0.235 | |
| Ldb3 | LIM domain binding 3 | 0.211 | |
| Casp1 | caspase 1 | 0.186 | |
| Insr | insulin receptor | 0.184 | |
| Ptpn22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.183 | |
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.120 | |
| Igh | immunoglobulin heavy chain complex | 0.104 | |
| Lrrk2 | leucine-rich repeat kinase 2 | 0.103 | |
| Smn1 | survival motor neuron 1 | 0.098 | |
| Cd79a | CD79A antigen (immunoglobulin-associated alpha) | 0.098 | |
| Rxra | retinoid X receptor alpha | 0.083 | |
| Stim2 | stromal interaction molecule 2 | 0.072 | |
| Esr1 | estrogen receptor 1 (alpha) | 0.069 | |
| Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.069 | |
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.068 | |
| Becn1 | beclin 1, autophagy related | 0.067 | |
| Cd28 | CD28 antigen | 0.067 | |
| Gnas | GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus | 0.065 | |
| Traf3ip2 | TRAF3 interacting protein 2 | 0.063 | |
| Kit | kit oncogene | 0.061 | |
| Tnfrsf13b | tumor necrosis factor receptor superfamily, member 13b | 0.058 | |
| Ghr | growth hormone receptor | 0.056 | |
| Opa1 | optic atrophy 1 homolog (human) | 0.056 | |
| Pparg | peroxisome proliferator activated receptor gamma | 0.054 | |
| Egfr | epidermal growth factor receptor | 0.053 | |
| Casp3 | caspase 3 | 0.051 | |
| Mfn2 | mitofusin 2 | 0.048 | |
| Igf2r | insulin-like growth factor 2 receptor | 0.048 | |
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.047 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.047 | |
| Lyst | lysosomal trafficking regulator | 0.046 | |
| Cdkn1c | cyclin-dependent kinase inhibitor 1C (P57) | 0.045 | |
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.044 | |
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.042 | |
| Bcl2l1 | BCL2-like 1 | 0.039 | |
| Bbc3 | BCL2 binding component 3 | 0.038 | |
| Mtor | mechanistic target of rapamycin (serine/threonine kinase) | 0.038 | |
| Nphs2 | nephrosis 2 homolog, podocin (human) | 0.037 | |
| Cd151 | CD151 antigen | 0.035 | |
| Commd6 | COMM domain containing 6 | 0.034 | |
| Ncoa3 | nuclear receptor coactivator 3 | 0.032 | |
| Ccdc58 | coiled-coil domain containing 58 | 0.032 | |
| Trp53 | transformation related protein 53 | 0.031 | |
| Col4a3 | collagen, type IV, alpha 3 | 0.031 | |
| Triap1 | TP53 regulated inhibitor of apoptosis 1 | 0.030 | |
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.030 | |
| Tmem223 | transmembrane protein 223 | 0.029 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.029 | |
| Pard3 | par-3 (partitioning defective 3) homolog (C. elegans) | 0.028 | |
| Mmp2 | matrix metallopeptidase 2 | 0.027 | |
| Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.027 | |
| Mapkap1 | mitogen-activated protein kinase associated protein 1 | 0.027 | |
| Psma4 | proteasome (prosome, macropain) subunit, alpha type 4 | 0.025 | |
| Smad3 | MAD homolog 3 (Drosophila) | 0.025 | |
| Sncaip | synuclein, alpha interacting protein (synphilin) | 0.024 | |
| Tpi1 | triosephosphate isomerase 1 | 0.023 | |
| Apoe | apolipoprotein E | 0.023 | |
| Pomp | proteasome maturation protein | 0.022 | |
| Ins2 | insulin II | 0.020 | |
| Ifrd2 | interferon-related developmental regulator 2 | 0.020 | |
| Plcb1 | phospholipase C, beta 1 | 0.020 | |
| Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | 0.019 | |
| Tyro3 | TYRO3 protein tyrosine kinase 3 | 0.018 | |
| Gnaq | guanine nucleotide binding protein, alpha q polypeptide | 0.018 | |
| Wrn | Werner syndrome homolog (human) | 0.018 | |
| Blnk | B-cell linker | 0.018 | |
| Axl | AXL receptor tyrosine kinase | 0.018 | |
| Prkce | protein kinase C, epsilon | 0.017 | |
| Nubp1 | nucleotide binding protein 1 | 0.016 | |
| Gphn | gephyrin | 0.016 | |
| Mapk8 | mitogen-activated protein kinase 8 | 0.016 | |
| Pxn | paxillin | 0.016 | |
| Nlrp3 | NLR family, pyrin domain containing 3 | 0.015 | |
| E2f1 | E2F transcription factor 1 | 0.015 | |
| Egln1 | EGL nine homolog 1 (C. elegans) | 0.015 | |
| Actn2 | actinin alpha 2 | 0.015 | |
| Crim1 | cysteine rich transmembrane BMP regulator 1 (chordin like) | 0.015 | |
| Thrb | thyroid hormone receptor beta | 0.014 | |
| Ptk2 | PTK2 protein tyrosine kinase 2 | 0.014 | |
| Nampt | nicotinamide phosphoribosyltransferase | 0.014 | |
| Slc30a9 | solute carrier family 30 (zinc transporter), member 9 | 0.014 | |
| Marveld2 | MARVEL (membrane-associating) domain containing 2 | 0.014 | |
| Foxo1 | forkhead box O1 | 0.014 | |
| Btk | Bruton agammaglobulinemia tyrosine kinase | 0.014 | |
| Arpc4 | actin related protein 2/3 complex, subunit 4 | 0.014 | |
| Emg1 | EMG1 nucleolar protein homolog (S. cerevisiae) | 0.014 | |
| Atp6v1f | ATPase, H+ transporting, lysosomal V1 subunit F | 0.014 | |
| Col1a1 | collagen, type I, alpha 1 | 0.013 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| BCL2 | B-cell CLL/lymphoma 2 | 1.000 | |
| BCL2L1 | BCL2-like 1 | 1.000 | |
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 1.000 | |
| BAD | BCL2-associated agonist of cell death | 1.000 | |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.999 | |
| BAX | BCL2-associated X protein | 0.996 | |
| BID | BH3 interacting domain death agonist | 0.977 | |
| BAK1 | BCL2-antagonist/killer 1 | 0.933 | |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.919 | |
| TP53BP2 | tumor protein p53 binding protein, 2 | 0.879 | |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.872 | |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.785 | |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.773 | |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.770 | |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.758 | |
| FAS | Fas (TNF receptor superfamily, member 6) | 0.754 | |
| FADD | Fas (TNFRSF6)-associated via death domain | 0.726 | |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.631 | |
| BBC3 | BCL2 binding component 3 | 0.369 | |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.352 | |
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.341 | |
| BECN1 | beclin 1, autophagy related | 0.321 | |
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | 0.305 | |
| FKBP8 | FK506 binding protein 8, 38kDa | 0.294 | |
| VDAC2 | voltage-dependent anion channel 2 | 0.288 | |
| MCL1 | myeloid cell leukemia sequence 1 (BCL2-related) | 0.246 | |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | 0.237 | |
| MET | met proto-oncogene (hepatocyte growth factor receptor) | 0.229 | |
| NLRC4 | NLR family, CARD domain containing 4 | 0.159 | |
| ZNF746 | zinc finger protein 746 | 0.157 | |
| ARRB1 | arrestin, beta 1 | 0.142 | |
| PSMD6 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 0.140 | |
| FBXO7 | F-box protein 7 | 0.123 | |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.119 | |
| MAPK8 | mitogen-activated protein kinase 8 | 0.112 | |
| SMCR7 | Smith-Magenis syndrome chromosome region, candidate 7 | 0.112 | |
| ZFYVE1 | zinc finger, FYVE domain containing 1 | 0.111 | |
| WWOX | WW domain containing oxidoreductase | 0.108 | |
| KRT5 | keratin 5 | 0.101 | |
| GRPEL1 | GrpE-like 1, mitochondrial (E. coli) | 0.082 | |
| HUWE1 | HECT, UBA and WWE domain containing 1 | 0.076 | |
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 0.074 | |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.073 | |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.065 | |
| PSEN2 | presenilin 2 (Alzheimer disease 4) | 0.058 | |
| H2AFX | H2A histone family, member X | 0.058 | |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | 0.053 | |
| MDM4 | Mdm4 p53 binding protein homolog (mouse) | 0.051 | |
| PDPK1 | 3-phosphoinositide dependent protein kinase-1 | 0.051 | |
| PSMC2 | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | 0.049 | |
| MEFV | Mediterranean fever | 0.049 | |
| BCL2L2 | BCL2-like 2 | 0.048 | |
| VDAC1 | voltage-dependent anion channel 1 | 0.042 | |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 0.041 | |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.040 | |
| ACTB | actin, beta | 0.040 | |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.039 | |
| HRK | harakiri, BCL2 interacting protein (contains only BH3 domain) | 0.038 | |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.037 | |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.037 | |
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.035 | |
| MAPK1 | mitogen-activated protein kinase 1 | 0.034 | |
| AMBRA1 | autophagy/beclin-1 regulator 1 | 0.032 | |
| ZHX1 | zinc fingers and homeoboxes 1 | 0.032 | |
| TAGLN2 | transgelin 2 | 0.031 | |
| CLU | clusterin | 0.031 | |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 0.031 | |
| SMCR7L | Smith-Magenis syndrome chromosome region, candidate 7-like | 0.031 | |
| PSMC5 | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | 0.031 | |
| TSPO | translocator protein (18kDa) | 0.027 | |
| YPEL5 | yippee-like 5 (Drosophila) | 0.027 | |
| MAGEH1 | melanoma antigen family H, 1 | 0.027 | |
| AMT | aminomethyltransferase | 0.027 | |
| SPNS1 | spinster homolog 1 (Drosophila) | 0.027 | |
| ORM1 | orosomucoid 1 | 0.027 | |
| RNF144B | ring finger protein 144B | 0.027 | |
| C1orf93 | chromosome 1 open reading frame 93 | 0.026 | |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.023 | |
| SQSTM1 | sequestosome 1 | 0.022 | |
| YAP1 | Yes-associated protein 1 | 0.022 | |
| TMEM11 | transmembrane protein 11 | 0.021 | |
| PSEN1 | presenilin 1 | 0.021 | |
| CDKN2A | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 0.021 | |
| PPP1CA | protein phosphatase 1, catalytic subunit, alpha isozyme | 0.020 | |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.019 | |
| PPHLN1 | periphilin 1 | 0.018 | |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | 0.017 | |
| ARPC4 | actin related protein 2/3 complex, subunit 4, 20kDa | 0.017 | |
| C4orf14 | chromosome 4 open reading frame 14 | 0.017 | |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 0.017 | |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.016 | |
| KRT6C | keratin 6C | 0.016 | |
| MAP1LC3A | microtubule-associated protein 1 light chain 3 alpha | 0.016 | |
| FLNA | filamin A, alpha | 0.016 | |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.016 | |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.015 | |
| VTN | vitronectin | 0.015 | |
| LRRK2 | leucine-rich repeat kinase 2 | 0.015 | |
| FLNB | filamin B, beta | 0.015 | |
| BCAP31 | B-cell receptor-associated protein 31 | 0.015 |