The network for 'regulation of erythrocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of erythrocyte differentiation

Any process that modulates the frequency, rate or extent of erythrocyte differentiation.

Mus musculus
Name Description Probability Func Analog Organism
Gata4 GATA binding protein 4 0.997
Ikzf1 IKAROS family zinc finger 1 0.995
Tal1 T-cell acute lymphocytic leukemia 1 0.994
Neurod1 neurogenic differentiation 1 0.978
Mapk14 mitogen-activated protein kinase 14 0.966
Gata1 GATA binding protein 1 0.955
Kit kit oncogene 0.929
Epor erythropoietin receptor 0.901
Pten phosphatase and tensin homolog 0.896
Trp53 transformation related protein 53 0.815
Stat5a signal transducer and activator of transcription 5A 0.779
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.736
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.696
Stat5b signal transducer and activator of transcription 5B 0.664
Foxp3 forkhead box P3 0.657
Slc4a1 solute carrier family 4 (anion exchanger), member 1 0.656
Mdm2 transformed mouse 3T3 cell double minute 2 0.646
Otx2 orthodenticle homolog 2 (Drosophila) 0.626
Isl1 ISL1 transcription factor, LIM/homeodomain 0.593
Pitx1 paired-like homeodomain transcription factor 1 0.588
Irf9 interferon regulatory factor 9 0.572
Spna1 spectrin alpha 1 0.522
Runx1 runt related transcription factor 1 0.501
Vhl von Hippel-Lindau tumor suppressor 0.491
Shh sonic hedgehog 0.466
Was Wiskott-Aldrich syndrome homolog (human) 0.462
Ank1 ankyrin 1, erythroid 0.452
Prlr prolactin receptor 0.441
Vegfa vascular endothelial growth factor A 0.435
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.423
Cd19 CD19 antigen 0.372
Epas1 endothelial PAS domain protein 1 0.357
Ssbp2 single-stranded DNA binding protein 2 0.352
Hoxa1 homeobox A1 0.350
Klf1 Kruppel-like factor 1 (erythroid) 0.349
Egln1 EGL nine homolog 1 (C. elegans) 0.348
Hhex hematopoietically expressed homeobox 0.320
Plcg2 phospholipase C, gamma 2 0.307
Prkce protein kinase C, epsilon 0.299
Gbx2 gastrulation brain homeobox 2 0.297
Hbb-b1 hemoglobin, beta adult major chain 0.286
Gata3 GATA binding protein 3 0.285
Hand2 heart and neural crest derivatives expressed transcript 2 0.279
Hes1 hairy and enhancer of split 1 (Drosophila) 0.277
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.269
Fst follistatin 0.264
En1 engrailed 1 0.246
Ghr growth hormone receptor 0.246
Tcf4 transcription factor 4 0.242
Smad3 MAD homolog 3 (Drosophila) 0.239
Pax3 paired box gene 3 0.237
Gpr50 G-protein-coupled receptor 50 0.233
Rxra retinoid X receptor alpha 0.231
Meox2 mesenchyme homeobox 2 0.229
Igh immunoglobulin heavy chain complex 0.227
Dok1 docking protein 1 0.227
Usp18 ubiquitin specific peptidase 18 0.226
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.225
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.222
Hoxb5 homeobox B5 0.219
Hand1 heart and neural crest derivatives expressed transcript 1 0.213
Tcfap2a transcription factor AP-2, alpha 0.205
Fgfr2 fibroblast growth factor receptor 2 0.197
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.197
Mecom MDS1 and EVI1 complex locus 0.194
Atf2 activating transcription factor 2 0.189
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.187
Hoxc5 homeobox C5 0.184
Ar androgen receptor 0.182
Hba-x hemoglobin X, alpha-like embryonic chain in Hba complex 0.181
Tal2 T-cell acute lymphocytic leukemia 2 0.180
Smad4 MAD homolog 4 (Drosophila) 0.179
Ahsp alpha hemoglobin stabilizing protein 0.178
Cbfa2t3 core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) 0.175
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.171
Nos3 nitric oxide synthase 3, endothelial cell 0.170
Sox2 SRY-box containing gene 2 0.164
Pax6 paired box gene 6 0.164
Smad6 MAD homolog 6 (Drosophila) 0.163
Ptf1a pancreas specific transcription factor, 1a 0.151
Fli1 Friend leukemia integration 1 0.150
Snai1 snail homolog 1 (Drosophila) 0.150
S1pr2 sphingosine-1-phosphate receptor 2 0.149
Fgf8 fibroblast growth factor 8 0.147
Tcf3 transcription factor 3 0.145
Bmp4 bone morphogenetic protein 4 0.144
Onecut1 one cut domain, family member 1 0.142
Apc adenomatosis polyposis coli 0.141
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.139
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.138
Ptprc protein tyrosine phosphatase, receptor type, C 0.137
Hoxc8 homeobox C8 0.137
Mapk8 mitogen-activated protein kinase 8 0.134
Prox1 prospero-related homeobox 1 0.127
Smad2 MAD homolog 2 (Drosophila) 0.125
Pitx2 paired-like homeodomain transcription factor 2 0.125
Lyl1 lymphoblastomic leukemia 1 0.125
Sox4 SRY-box containing gene 4 0.125
Gnrhr gonadotropin releasing hormone receptor 0.124
Kiss1 KiSS-1 metastasis-suppressor 0.122
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tal1 T-cell acute lymphocytic leukemia 1 0.991
gata1a GATA binding protein 1a 0.725
runx1 runt-related transcription factor 1 0.692
lmo2 LIM domain only 2 (rhombotin-like 1) 0.674
hbae1 hemoglobin alpha embryonic-1 0.667
mpx myeloid-specific peroxidase 0.464
hoxd4a homeo box D4a 0.341
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.302
plcg1 phospholipase C, gamma 1 0.297
pitx2 paired-like homeodomain transcription factor 2 0.289
cmyb transcription factor cmyb 0.252
drl draculin 0.219
lyz lysozyme 0.177
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.161
inha inhibin, alpha 0.143
hbbe1.1 hemoglobin beta embryonic-1.1 0.131
acvr2b activin receptor IIb 0.111
gata2a GATA-binding protein 2a 0.092
hmgb3a high-mobility group box 3a 0.081
hoxb4a homeo box B4a 0.081
irf8 interferon regulatory factor 8 0.073
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.071
LOC100151531 zinc finger protein Gfi-1b-like 0.069
epor erythropoietin receptor 0.066
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.065
cx43 connexin 43 0.064
alas2 aminolevulinate, delta-, synthetase 2 0.063
hoxa4a homeo box A4a 0.062
hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.062
h3f3a H3 histone, family 3A 0.061
fli1a friend leukemia integration 1a 0.059
hoxb5b homeo box B5b 0.059
hoxc5a homeo box C5a 0.058
tfr1a transferrin receptor 1a 0.055
akt2 v-akt murine thymoma viral oncogene homolog 2 0.053
hmgb1b high-mobility group box 1b 0.050
lhcgr luteinizing hormone/choriogonadotropin receptor 0.050
eif3hb eukaryotic translation initiation factor 3, subunit H, b 0.050
mmp9 matrix metalloproteinase 9 0.049
spns2 spinster homolog 2 (Drosophila) 0.049
hoxb3a homeo box B3a 0.048
zbtb4 zinc finger and BTB domain containing 4 0.047
LOC566708 FL cytokine receptor-like 0.046
cpox coproporphyrinogen oxidase 0.045
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.045
efnb2a ephrin B2a 0.045
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.045
myl7 myosin, light polypeptide 7, regulatory 0.044
dusp5 dual specificity phosphatase 5 0.044
f2r coagulation factor II (thrombin) receptor 0.043
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.042
gata3 GATA-binding protein 3 0.042
ptpra protein tyrosine phosphatase, receptor type, A 0.042
rarga retinoic acid receptor gamma a 0.042
sept9b septin 9b 0.041
egr2b early growth response 2b 0.041
pcdh8 protocadherin 8 0.041
mmp13a matrix metalloproteinase 13a 0.041
znf148 zinc finger protein 148 0.040
gpc4 glypican 4 0.039
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.038
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.037
si:dkey-12o15.1 si:dkey-12o15.1 0.037
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.037
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.037
inhbaa inhibin, beta Aa 0.036
flt4 fms-related tyrosine kinase 4 0.036
zeb2a zinc finger E-box binding homeobox 2a 0.035
nfe2 nuclear factor, erythroid-derived 2 0.035
myca myelocytomatosis oncogene a 0.035
notch3 notch homolog 3 0.035
mef2a myocyte enhancer factor 2a 0.034
urod uroporphyrinogen decarboxylase 0.033
cry2a cryptochrome 2a 0.033
tie2 endothelium-specific receptor tyrosine kinase 2 0.033
aplp2 amyloid beta (A4) precursor-like protein 2 0.033
fli1b friend leukemia integration 1b 0.032
zgc:112425 zgc:112425 0.032
smc3 structural maintenance of chromosomes 3 0.031
cry1a cryptochrome 1a 0.031
hoxd3a homeo box D3a 0.031
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.031
cbfb core-binding factor, beta subunit 0.031
frmd6 FERM domain containing 6 0.031
stab2 stabilin 2 0.031
ptrfb polymerase I and transcript release factor b 0.030
hhex hematopoietically expressed homeobox 0.029
lcp1 lymphocyte cytosolic plastin 1 0.029
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.029
fes feline sarcoma oncogene 0.029
mpll myeloproliferative leukemia virus oncogene, like 0.029
cpla2 cytosolic phospholipase a2 0.028
ednra endothelin receptor type A 0.028
ptprc protein tyrosine phosphatase, receptor type, C 0.028
fb06f03 high-mobility group nucleosome binding domain 1-like 0.028
epb41 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) 0.027
crip2 cysteine-rich protein 2 0.027
pdcd2 programmed cell death 2 0.027
LOC560602 novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6) 0.027
cdc42 cell division cycle 42 0.027
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CREBBP CREB binding protein 0.998
TAL1 T-cell acute lymphocytic leukemia 1 0.997
HSPA1B heat shock 70kDa protein 1B 0.978
RUNX1 runt-related transcription factor 1 0.937
KAT2B K(lysine) acetyltransferase 2B 0.916
SMAD7 SMAD family member 7 0.853
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.829
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 0.799
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.797
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.795
HSPA1A heat shock 70kDa protein 1A 0.790
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.780
CCND1 cyclin D1 0.745
GATA2 GATA binding protein 2 0.734
HOXA10 homeobox A10 0.697
HOXB5 homeobox B5 0.670
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.636
FKBP1A FK506 binding protein 1A, 12kDa 0.586
BMP2 bone morphogenetic protein 2 0.568
AR androgen receptor 0.528
NCOA1 nuclear receptor coactivator 1 0.478
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.439
JUN jun proto-oncogene 0.429
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.429
PPP5C protein phosphatase 5, catalytic subunit 0.428
TP53 tumor protein p53 0.427
TGFB1 transforming growth factor, beta 1 0.423
CDK2 cyclin-dependent kinase 2 0.362
HSPH1 heat shock 105kDa/110kDa protein 1 0.266
NCOA6 nuclear receptor coactivator 6 0.259
NCOA2 nuclear receptor coactivator 2 0.253
HOXA5 homeobox A5 0.244
CDK6 cyclin-dependent kinase 6 0.224
CCND3 cyclin D3 0.220
KLF13 Kruppel-like factor 13 0.190
EP300 E1A binding protein p300 0.187
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.176
HOXB6 homeobox B6 0.168
DAXX death-domain associated protein 0.160
ENG endoglin 0.151
SETD8 SET domain containing (lysine methyltransferase) 8 0.150
BAG3 BCL2-associated athanogene 3 0.149
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.149
RBBP4 retinoblastoma binding protein 4 0.144
SUMO3 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) 0.143
MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) 0.139
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.128
RB1 retinoblastoma 1 0.119
HOXB3 homeobox B3 0.114
RXRA retinoid X receptor, alpha 0.108
PRMT6 protein arginine methyltransferase 6 0.108
HOXB7 homeobox B7 0.102
ESR1 estrogen receptor 1 0.100
SMAD2 SMAD family member 2 0.097
LMO4 LIM domain only 4 0.094
HOXA7 homeobox A7 0.093
ACVR1 activin A receptor, type I 0.091
GATA4 GATA binding protein 4 0.088
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.088
BMPR1A bone morphogenetic protein receptor, type IA 0.081
MAFB v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) 0.075
HDAC2 histone deacetylase 2 0.070
HOXB9 homeobox B9 0.064
GDF5 growth differentiation factor 5 0.062
INSR insulin receptor 0.060
HOXA4 homeobox A4 0.057
SP1 Sp1 transcription factor 0.057
TCF12 transcription factor 12 0.056
EPOR erythropoietin receptor 0.054
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.051
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.051
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.050
AHR aryl hydrocarbon receptor 0.043
HDAC1 histone deacetylase 1 0.043
RFWD2 ring finger and WD repeat domain 2 0.043
PRKG1 protein kinase, cGMP-dependent, type I 0.042
HOXC6 homeobox C6 0.041
PTMA prothymosin, alpha 0.040
HMGA1 high mobility group AT-hook 1 0.040
SP100 SP100 nuclear antigen 0.039
PDX1 pancreatic and duodenal homeobox 1 0.039
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.038
TBX5 T-box 5 0.038
NFIL3 nuclear factor, interleukin 3 regulated 0.037
LMO2 LIM domain only 2 (rhombotin-like 1) 0.035
HOXA2 homeobox A2 0.035
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.035
BAG1 BCL2-associated athanogene 0.034
MTA3 metastasis associated 1 family, member 3 0.034
HOXA6 homeobox A6 0.034
DDIT3 DNA-damage-inducible transcript 3 0.034
CCND2 cyclin D2 0.034
IRS2 insulin receptor substrate 2 0.033
FSTL1 follistatin-like 1 0.033
TWIST2 twist homolog 2 (Drosophila) 0.032
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.032
HOXC10 homeobox C10 0.032
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.032
HIPK2 homeodomain interacting protein kinase 2 0.031
HTT huntingtin 0.031
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism