IMP

Process View

Drosophila melanogaster

22 genes annotated in fly

response to toxic substance

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.

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Known genes in the process in fly Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to toxic substance"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to toxic substance" (in gray)

Name	Description	Probability	Func Analog Organism
Cyp12a4	CG6042 gene product from transcript CG6042-RA	0.974
Ugt35a	UDP-glycosyltransferase 35a	0.936
para	paralytic	0.759
Cyp12d1-p	CG30489 gene product from transcript CG30489-RA	0.552
tipE	temperature-induced paralytic E	0.545
NPFR1	neuropeptide F receptor	0.488
Cyp12d1-d	CG33503 gene product from transcript CG33503-RA	0.408
Tre	Trehalose-sensitivity	0.358
BG4	CG12297 gene product from transcript CG12297-RA	0.342
Rac1	CG2248 gene product from transcript CG2248-RA	0.313
Cyp9f2	CG11466 gene product from transcript CG11466-RB	0.309	Fly
eff	effete	0.305
ort	ora transientless	0.275
Crz	Corazonin	0.272
Cyp6g2	CG8859 gene product from transcript CG8859-RA	0.267
ush	u-shaped	0.258
Met	Methoprene-tolerant	0.235
nAcRbeta-96A	nicotinic Acetylcholine Receptor beta 96A	0.232
CG12171	CG12171 gene product from transcript CG12171-RA	0.213
CG6834	CG6834 gene product from transcript CG6834-RA	0.213
CG12672	CG12672 gene product from transcript CG12672-RA	0.195
Cyp4ac1	CG14032 gene product from transcript CG14032-RA	0.194
CycA	Cyclin A	0.193
Cyp6d5	CG3050 gene product from transcript CG3050-RA	0.185
alpha-Est7	alpha-Esterase-7	0.168
Cyp6a21	CG10247 gene product from transcript CG10247-RA	0.156	Fly
Cyp4e2	Cytochrome P450-4e2	0.154
Pka-R1	cAMP-dependent protein kinase R1	0.154
Cyp9b2	Cytochrome P450-9b2	0.148	Fly
ap	apterous	0.135
Dll	Distal-less	0.134
Poxn	Pox neuro	0.132
ple	pale	0.131
Cyp12a5	CG11821 gene product from transcript CG11821-RA	0.122	Fly
Cyp6a2	Cytochrome P450-6a2	0.113
sev	sevenless	0.110
Rya-r44F	Ryanodine receptor 44F	0.107
slo	slowpoke	0.103
ST6Gal	Sialyltransferase	0.099
Egfr	Epidermal growth factor receptor	0.098
stmA	stambha A	0.097
CG10550	CG10550 gene product from transcript CG10550-RB	0.094
CG34139	CG34139 gene product from transcript CG34139-RD	0.090
Smg1	CG32743 gene product from transcript CG32743-RA	0.090
nAcRalpha-30D	nicotinic Acetylcholine Receptor alpha 30D	0.083
Ilp5	Insulin-like peptide 5	0.079
HisCl1	Histamine-gated chloride channel subunit 1	0.077	Fly
y	yellow	0.075
mys	myospheroid	0.075
inaC	inactivation no afterpotential C	0.073
Cat	Catalase	0.071
Cyp6a23	CG10242 gene product from transcript CG10242-RA	0.067	Fly
Itp-r83A	Inositol 1,4,5,-tris-phosphate receptor	0.066
Ilp2	Insulin-like peptide 2	0.066
Cyp4p1	Cytochrome P450-4p1	0.066
JhI-26	Juvenile hormone-inducible protein 26	0.066
LamC	Lamin C	0.065
na	narrow abdomen	0.065
Rdl	Resistant to dieldrin	0.065	Fly
Osi6	Osiris 6	0.064
Cyp6a9	Cytochrome P450-6a9	0.063	Fly
loco	locomotion defects	0.062
DJ-1alpha	CG6646 gene product from transcript CG6646-RA	0.061
CG10562	CG10562 gene product from transcript CG10562-RA	0.061
if	inflated	0.057
sad	shadow	0.056
Cyp6g1	CG8453 gene product from transcript CG8453-RA	0.054
Gr28b	Gustatory receptor 28b	0.054	Fly
CG3835	CG3835 gene product from transcript CG3835-RB	0.051
AGO2	Argonaute 2	0.050
TotA	Turandot A	0.048
imd	immune deficiency	0.047
Cyp28a5	CG8864 gene product from transcript CG8864-RA	0.045	Fly
Est-Q	Esterase Q	0.045
LvpD	Larval visceral protein D	0.045
CG2789	CG2789 gene product from transcript CG2789-RA	0.043
nAcRalpha-96Aa	nicotinic Acetylcholine Receptor alpha 96Aa	0.043
Tsp29Fb	Tetraspanin 29Fb	0.042
Gr43a	Gustatory receptor 43a	0.041
CG14815	CG14815 gene product from transcript CG14815-RA	0.040
Ast	Allatostatin	0.039
Oamb	Octopamine receptor in mushroom bodies	0.037
CG33120	CG33120 gene product from transcript CG33120-RA	0.037
Akt1	CG4006 gene product from transcript CG4006-RA	0.036
Shab	Shaker cognate b	0.036
CG6830	CG6830 gene product from transcript CG6830-RA	0.036
mi	minus	0.036
bnl	branchless	0.035
Rab27	CG14791 gene product from transcript CG14791-RB	0.035
CG31549	CG31549 gene product from transcript CG31549-RA	0.034
CG10560	CG10560 gene product from transcript CG10560-RA	0.034
CG16799	CG16799 gene product from transcript CG16799-RA	0.033
Ppat-Dpck	Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase	0.033
Ctr1A	Copper transporter 1A	0.032
Tbh	Tyramine beta hydroxylase	0.031
kcc	kazachoc	0.031
ttk	tramtrack	0.031
CG15784	CG15784 gene product from transcript CG15784-RA	0.030
Cyp12e1	CG14680 gene product from transcript CG14680-RC	0.030	Fly
Spn28D	Serpin 28D	0.030
sro	shroud	0.030
Doc3	Dorsocross3	0.029
ine	inebriated	0.029
CG13568	CG13568 gene product from transcript CG13568-RG	0.029
Tab2	TAK1-associated binding protein 2	0.029
Antp	Antennapedia	0.029
scb	scab	0.028
dsx	doublesex	0.028
CG12020	CG12020 gene product from transcript CG12020-RA	0.028
puc	puckered	0.027
CG3759	CG3759 gene product from transcript CG3759-RB	0.026
Ace	Acetylcholine esterase	0.025
Ilp4	Insulin-like peptide 4	0.025
CG10553	CG10553 gene product from transcript CG10553-RA	0.025
Megalin	CG42611 gene product from transcript CG42611-RA	0.025
CG4365	CG4365 gene product from transcript CG4365-RB	0.025
to	takeout	0.025
Gr93a	Gustatory receptor 93a	0.024
Cyp6a13	CG2397 gene product from transcript CG2397-RA	0.024	Fly
NAAT1	Nutrient Amino Acid Transporter 1	0.024
Sh	Shaker	0.024
Cyp9b1	Cytochrome P450-9b1	0.024	Fly
CG12512	CG12512 gene product from transcript CG12512-RA	0.024
CG1315	CG1315 gene product from transcript CG1315-RA	0.023
Cyp4d2	Cytochrome P450-4d2	0.023
Epac	CG34392 gene product from transcript CG34392-RC	0.022
ERR	estrogen-related receptor	0.022
fusl	fuseless	0.022
Ugt86Dd	CG6633 gene product from transcript CG6633-RB	0.022
MTF-1	Metal response element-binding Transcription Factor-1	0.022
alpha-Est8	alpha-Esterase-8	0.022
Eip93F	CG18389 gene product from transcript CG18389-RB	0.021
nAcRbeta-64B	nicotinic Acetylcholine Receptor beta 64B	0.021	Fly
CG13458	CG13458 gene product from transcript CG13458-RA	0.021
foxo	forkhead box, sub-group O	0.021
sNPF-R	short neuropeptide F receptor	0.021
CG4302	CG4302 gene product from transcript CG4302-RA	0.021
wts	warts	0.021
CG5819	CG5819 gene product from transcript CG5819-RA	0.020
eg	eagle	0.020
CG31140	CG31140 gene product from transcript CG31140-RF	0.020
CG12338	CG12338 gene product from transcript CG12338-RA	0.020
axo	axotactin	0.020
ninaB	neither inactivation nor afterpotential B	0.020
CG1702	CG1702 gene product from transcript CG1702-RB	0.020
lkb1	CG9374 gene product from transcript CG9374-RJ	0.020
CG4893	CG4893 gene product from transcript CG4893-RA	0.020
CG10483	CG10483 gene product from transcript CG10483-RA	0.019
CG2604	CG2604 gene product from transcript CG2604-RA	0.019
Cyp6a22	CG10240 gene product from transcript CG10240-RA	0.019	Fly
Adgf-D	Adenosine deaminase-related growth factor D	0.019
kst	karst	0.019
CG3967	CG3967 gene product from transcript CG3967-RC	0.019
pog	poor gastrulation	0.019
Jhe	Juvenile hormone esterase	0.019
CG15267	CG15267 gene product from transcript CG15267-RA	0.019
D2R	Dopamine 2-like receptor	0.019	Rat
egr	eiger	0.018
lab	labial	0.018
Qm	CG17521 gene product from transcript CG17521-RC	0.018
Ork1	Open rectifier K[+] channel 1	0.018
CG6028	CG6028 gene product from transcript CG6028-RA	0.018
Dredd	Death related ced-3/Nedd2-like protein	0.018	Rat
Jra	Jun-related antigen	0.018
Syx5	Syntaxin 5	0.018
CG3415	CG3415 gene product from transcript CG3415-RA	0.018
CG7470	CG7470 gene product from transcript CG7470-RA	0.018
dpr5	CG5308 gene product from transcript CG5308-RA	0.018
CG3348	CG3348 gene product from transcript CG3348-RA	0.018
Cyp6d4	CG12800 gene product from transcript CG12800-RA	0.017
CG5577	CG5577 gene product from transcript CG5577-RA	0.017
CG9436	CG9436 gene product from transcript CG9436-RA	0.017
CG12746	CG12746 gene product from transcript CG12746-RD	0.017
CG13650	CG13650 gene product from transcript CG13650-RB	0.017
CG18135	CG18135 gene product from transcript CG18135-RC	0.017
CG4630	CG4630 gene product from transcript CG4630-RA	0.017
CG42813	CG42813 gene product from transcript CG42813-RA	0.016
CG31937	CG31937 gene product from transcript CG31937-RA	0.016
Src42A	Src oncogene at 42A	0.016
VAChT	CG32848 gene product from transcript CG32848-RA	0.016
Cyp28d1	CG10833 gene product from transcript CG10833-RA	0.016	Fly
Cyp18a1	Cytochrome P450-18a1	0.016
CG9498	CG9498 gene product from transcript CG9498-RA	0.016
wal	walrus	0.016
Shaw	Shaker cognate w	0.016
tbce	tubulin-specific chaperone E	0.016
ppk25	pickpocket 25	0.016
Hnf4	Hepatocyte nuclear factor 4	0.016
CG6283	CG6283 gene product from transcript CG6283-RA	0.016
Cyp9h1	CG17577 gene product from transcript CG17577-RA	0.016	Fly
CG33307	CG33307 gene product from transcript CG33307-RA	0.015
Z600	CG17962 gene product from transcript CG17962-RA	0.015
Arf51F	ADP ribosylation factor 51F	0.015
Gr64e	Gustatory receptor 64e	0.015
GlcT-1	CG6437 gene product from transcript CG6437-RA	0.015
CG32687	CG32687 gene product from transcript CG32687-RA	0.015
CG10804	CG10804 gene product from transcript CG10804-RB	0.015
Acox57D-p	acyl-Coenzyme A oxidase at 57D proximal	0.015
mus205	mutagen-sensitive 205	0.015
CG8311	CG8311 gene product from transcript CG8311-RA	0.015
NLaz	Neural Lazarillo	0.015
CG9360	CG9360 gene product from transcript CG9360-RA	0.015
pan	pangolin	0.015
CG1927	CG1927 gene product from transcript CG1927-RA	0.014
CG9394	CG9394 gene product from transcript CG9394-RA	0.014
CG4328	CG4328 gene product from transcript CG4328-RB	0.014
Krn	Keren	0.014
CG5999	CG5999 gene product from transcript CG5999-RB	0.014
CG31005	CG31005 gene product from transcript CG31005-RA	0.014
CG5910	CG5910 gene product from transcript CG5910-RA	0.014
wrapper	CG10382 gene product from transcript CG10382-RA	0.014
mGluRA	metabotropic glutamate receptor	0.014
CG14853	CG14853 gene product from transcript CG14853-RB	0.014
CG8910	CG8910 gene product from transcript CG8910-RA	0.014
nonA	no on or off transient A	0.014
CG13912	CG13912 gene product from transcript CG13912-RA	0.014
alpha-Est1	alpha-Esterase-1	0.014
Ac78C	Adenylyl cyclase 78C	0.013
CG8768	CG8768 gene product from transcript CG8768-RA	0.013
beat-Ia	beaten path Ia	0.013
CG15408	CG15408 gene product from transcript CG15408-RA	0.013
crl	courtless	0.013
ref(2)P	refractory to sigma P	0.013
Fmo-1	Flavin-containing monooxygenase 1	0.013
spo	spook	0.013
CG11426	CG11426 gene product from transcript CG11426-RA	0.013
CG6045	CG6045 gene product from transcript CG6045-RA	0.013
CG14369	CG14369 gene product from transcript CG14369-RA	0.013
Cyp6a20	CG10245 gene product from transcript CG10245-RB	0.013	Fly
burs	bursicon	0.013
jar	jaguar	0.013
CG31974	CG31974 gene product from transcript CG31974-RB	0.013
sra	sarah	0.013
Cyp4ac3	CG14031 gene product from transcript CG14031-RA	0.013
CG12140	CG12140 gene product from transcript CG12140-RA	0.013
mtt	mangetout	0.013
spz6	spatzle 6	0.013
Smr	Smrter	0.013
CG12026	CG12026 gene product from transcript CG12026-RB	0.013
Mlp84B	Muscle LIM protein at 84B	0.013
CG2254	CG2254 gene product from transcript CG2254-RA	0.012
Trf2	TATA box binding protein-related factor 2	0.012
fas	faint sausage	0.012
CG3081	CG3081 gene product from transcript CG3081-RA	0.012
Mtl	Mig-2-like	0.012
slbo	slow border cells	0.012
CG5335	CG5335 gene product from transcript CG5335-RA	0.012
Ugt35b	UDP-glycosyltransferase 35b	0.012
dve	defective proventriculus	0.012
unc-13	CG2999 gene product from transcript CG2999-RA	0.012
Frq1	Frequenin 1	0.012
CG6579	CG6579 gene product from transcript CG6579-RB	0.012
vib	vibrator	0.012
CG12075	CG12075 gene product from transcript CG12075-RB	0.012
CG17181	CG17181 gene product from transcript CG17181-RA	0.012
Hrs	Hepatocyte growth factor regulated tyrosine kinase substrate	0.012
IP3K1	Inositol 1,4,5-triphosphate kinase 1	0.012
homer	CG11324 gene product from transcript CG11324-RC	0.012
Ast-C	Allatostatin C	0.012
cdc2c	CG10498 gene product from transcript CG10498-RC	0.012	Rat
nAcRalpha-7E	nicotinic Acetylcholine Receptor alpha 7E	0.012	Fly
Gip	GIP-like	0.012
CG9512	CG9512 gene product from transcript CG9512-RA	0.011
Rel	Relish	0.011
ATP7	CG1886 gene product from transcript CG1886-RB	0.011	Mouse
CG13565	CG13565 gene product from transcript CG13565-RA	0.011
nvd	neverland	0.011
CG8051	CG8051 gene product from transcript CG8051-RA	0.011
CG14655	CG14655 gene product from transcript CG14655-RA	0.011
CG1208	CG1208 gene product from transcript CG1208-RB	0.011
NaCP60E	Na channel protein 60E	0.011
CG4678	CG4678 gene product from transcript CG4678-RE	0.011
Rh50	CG7499 gene product from transcript CG7499-RA	0.011
CG9134	CG9134 gene product from transcript CG9134-RB	0.011
CG7589	CG7589 gene product from transcript CG7589-RA	0.011
fru	fruitless	0.011
CG16965	CG16965 gene product from transcript CG16965-RB	0.011
sni	sniffer	0.011
CG15739	CG15739 gene product from transcript CG15739-RA	0.011
CG11309	CG11309 gene product from transcript CG11309-RA	0.011	Fly
Cyp309a1	CG9964 gene product from transcript CG9964-RA	0.011
Tpi	Triose phosphate isomerase	0.011
CG10251	CG10251 gene product from transcript CG10251-RB	0.011
CG2678	CG2678 gene product from transcript CG2678-RA	0.011
CG13875	CG13875 gene product from transcript CG13875-RA	0.011
nos	nanos	0.011
CG1827	CG1827 gene product from transcript CG1827-RC	0.011
ewg	erect wing	0.010
CkIIalpha-i1	CKII-alpha subunit interactor-1	0.010
Cyp6t1	CG1644 gene product from transcript CG1644-RA	0.010	Fly
Cyp4d8	Cytochrome P450-4d8	0.010
Gclc	Glutamate-cysteine ligase catalytic subunit	0.010
CadN	Cadherin-N	0.010
alpha-Spec	alpha Spectrin	0.010
csw	corkscrew	0.010
ImpL2	Ecdysone-inducible gene L2	0.010
CG13631	CG13631 gene product from transcript CG13631-RA	0.010
CG8550	CG8550 gene product from transcript CG8550-RA	0.010
CG18249	CG18249 gene product from transcript CG18249-RB	0.010
CG17086	CG17086 gene product from transcript CG17086-RA	0.010
CG16898	CG16898 gene product from transcript CG16898-RA	0.010