IMP

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Homo sapiens

50 genes annotated in human

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viral genome replication

GO:0019079

Any process involved directly in viral genome replication, including viral nucleotide metabolism.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "viral genome replication"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "viral genome replication" (in gray)

Name	Description	Probability	Func Analog Organism
IFIT3	interferon-induced protein with tetratricopeptide repeats 3	0.994	Human
OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa	0.978
IFIT1	interferon-induced protein with tetratricopeptide repeats 1	0.974
IFI44	interferon-induced protein 44	0.957
IFITM1	interferon induced transmembrane protein 1 (9-27)	0.953
MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	0.945
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.935
SP110	SP110 nuclear body protein	0.912
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.910	Human
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.909
IFI44L	interferon-induced protein 44-like	0.881
IFIH1	interferon induced with helicase C domain 1	0.846
STAT1	signal transducer and activator of transcription 1, 91kDa	0.818
IRF9	interferon regulatory factor 9	0.817
PLSCR1	phospholipid scramblase 1	0.807
IFI6	interferon, alpha-inducible protein 6	0.758
CXCL10	chemokine (C-X-C motif) ligand 10	0.747	Human
OASL	2'-5'-oligoadenylate synthetase-like	0.746
IFITM3	interferon induced transmembrane protein 3 (1-8U)	0.724
CXCL3	chemokine (C-X-C motif) ligand 3	0.717	Human
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.695	Human
IL8	interleukin 8	0.694
IFIT2	interferon-induced protein with tetratricopeptide repeats 2	0.674	Human
SP100	SP100 nuclear antigen	0.620
DICER1	dicer 1, ribonuclease type III	0.592	Mouse
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.576
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.556
ISG15	ISG15 ubiquitin-like modifier	0.555
CCR5	chemokine (C-C motif) receptor 5	0.517
DTX3L	deltex 3-like (Drosophila)	0.514
CXCL2	chemokine (C-X-C motif) ligand 2	0.503	Human
XAF1	XIAP associated factor 1	0.496
CCL8	chemokine (C-C motif) ligand 8	0.452	Human
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.449	Human
HERC5	hect domain and RLD 5	0.418
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.401	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.311	Human
CMPK2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.302
CCL2	chemokine (C-C motif) ligand 2	0.294	Human
IL6	interleukin 6 (interferon, beta 2)	0.290
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.259
IFIT5	interferon-induced protein with tetratricopeptide repeats 5	0.256	Human
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.251
OAS3	2'-5'-oligoadenylate synthetase 3, 100kDa	0.247
UBE2L6	ubiquitin-conjugating enzyme E2L 6	0.246
SAMD9	sterile alpha motif domain containing 9	0.241
CCL4	chemokine (C-C motif) ligand 4	0.234	Human
PARP9	poly (ADP-ribose) polymerase family, member 9	0.231	Human
IFI35	interferon-induced protein 35	0.229
IFI27	interferon, alpha-inducible protein 27	0.219
CXCL5	chemokine (C-X-C motif) ligand 5	0.216	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.207	Human
SAMD9L	sterile alpha motif domain containing 9-like	0.202
IDE	insulin-degrading enzyme	0.182
IL1B	interleukin 1, beta	0.179
BST2	bone marrow stromal cell antigen 2	0.176
CCL20	chemokine (C-C motif) ligand 20	0.167	Human
HNF4A	hepatocyte nuclear factor 4, alpha	0.154
DPP4	dipeptidyl-peptidase 4	0.142
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.138
IRF7	interferon regulatory factor 7	0.137
BCL2L1	BCL2-like 1	0.134
PRPF4	PRP4 pre-mRNA processing factor 4 homolog (yeast)	0.130
PARP14	poly (ADP-ribose) polymerase family, member 14	0.130	Human
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.129	Human
CARM1	coactivator-associated arginine methyltransferase 1	0.121
CHERP	calcium homeostasis endoplasmic reticulum protein	0.118
AXL	AXL receptor tyrosine kinase	0.114
RSAD2	radical S-adenosyl methionine domain containing 2	0.108
THOC4	THO complex 4	0.106
TARBP2	TAR (HIV-1) RNA binding protein 2	0.101
BAG2	BCL2-associated athanogene 2	0.098
NAMPT	nicotinamide phosphoribosyltransferase	0.085
CCL5	chemokine (C-C motif) ligand 5	0.083
SRPK1	SRSF protein kinase 1	0.082
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.081	Human
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.081
USP18	ubiquitin specific peptidase 18	0.080
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.077
CCL7	chemokine (C-C motif) ligand 7	0.070	Human
IFI16	interferon, gamma-inducible protein 16	0.066
APOL1	apolipoprotein L, 1	0.065
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.064
CXCL13	chemokine (C-X-C motif) ligand 13	0.061
TRIM14	tripartite motif containing 14	0.060
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.057
BCL2A1	BCL2-related protein A1	0.055
CCR1	chemokine (C-C motif) receptor 1	0.055
PDPK1	3-phosphoinositide dependent protein kinase-1	0.054
PI3	peptidase inhibitor 3, skin-derived	0.050
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.050
CCL13	chemokine (C-C motif) ligand 13	0.049	Human
OSBPL9	oxysterol binding protein-like 9	0.048
EPSTI1	epithelial stromal interaction 1 (breast)	0.047
GBP1	guanylate binding protein 1, interferon-inducible	0.046
IL10	interleukin 10	0.046
TP53	tumor protein p53	0.045
LAP3	leucine aminopeptidase 3	0.044
NMI	N-myc (and STAT) interactor	0.043
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.042
RAD23B	RAD23 homolog B (S. cerevisiae)	0.042	Human
IFNG	interferon, gamma	0.041
TMEM173	transmembrane protein 173	0.041
TRIM22	tripartite motif containing 22	0.041
IDO1	indoleamine 2,3-dioxygenase 1	0.041
LY6E	lymphocyte antigen 6 complex, locus E	0.040
DHX58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.039
SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	0.038
XAB2	XPA binding protein 2	0.037
RAB6A	RAB6A, member RAS oncogene family	0.037
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.036
MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)	0.036
ICAM1	intercellular adhesion molecule 1	0.036
LAMP3	lysosomal-associated membrane protein 3	0.033
ADAMDEC1	ADAM-like, decysin 1	0.033
CCL3	chemokine (C-C motif) ligand 3	0.032	Human
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.032
C17orf85	chromosome 17 open reading frame 85	0.031
WDFY3	WD repeat and FYVE domain containing 3	0.031
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.030
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.030
CCR7	chemokine (C-C motif) receptor 7	0.029
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.028
ZNFX1	zinc finger, NFX1-type containing 1	0.028
PTMA	prothymosin, alpha	0.027
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.027
IL7R	interleukin 7 receptor	0.027
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.027
SELE	selectin E	0.027
PRMT6	protein arginine methyltransferase 6	0.027
PF4	platelet factor 4	0.026
VCAM1	vascular cell adhesion molecule 1	0.026
UBD	ubiquitin D	0.026
RAB14	RAB14, member RAS oncogene family	0.026
CCL19	chemokine (C-C motif) ligand 19	0.025	Human
TUBA1B	tubulin, alpha 1b	0.025
AGL	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	0.025
DDX46	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	0.025
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.025
ZFP28	zinc finger protein 28 homolog (mouse)	0.024
TRIM25	tripartite motif containing 25	0.024
RGS1	regulator of G-protein signaling 1	0.024
ACTG1	actin, gamma 1	0.024
SOD2	superoxide dismutase 2, mitochondrial	0.024
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.023
CCR4	chemokine (C-C motif) receptor 4	0.023
PROX1	prospero homeobox 1	0.023
SLAMF8	SLAM family member 8	0.023
FPR3	formyl peptide receptor 3	0.022
PARP12	poly (ADP-ribose) polymerase family, member 12	0.022	Human
ULK1	unc-51-like kinase 1 (C. elegans)	0.022
PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.022
UBL7	ubiquitin-like 7 (bone marrow stromal cell-derived)	0.022
TRIM21	tripartite motif containing 21	0.021
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.021
LGALS9	lectin, galactoside-binding, soluble, 9	0.021
ATG3	ATG3 autophagy related 3 homolog (S. cerevisiae)	0.021
PTN	pleiotrophin	0.020
TMEM140	transmembrane protein 140	0.020
C2	complement component 2	0.020
GOLGA1	golgin A1	0.020
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.020
TDRD7	tudor domain containing 7	0.019
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.019
RBM14	RNA binding motif protein 14	0.019
NR5A2	nuclear receptor subfamily 5, group A, member 2	0.019
APOL6	apolipoprotein L, 6	0.018
UPF3B	UPF3 regulator of nonsense transcripts homolog B (yeast)	0.018
TOP1	topoisomerase (DNA) I	0.018
FTSJD2	FtsJ methyltransferase domain containing 2	0.018
ATXN3	ataxin 3	0.018
TFG	TRK-fused gene	0.018
CD163	CD163 molecule	0.018
CH25H	cholesterol 25-hydroxylase	0.018
IFNA10	interferon, alpha 10	0.018	Human
IER3	immediate early response 3	0.018
RPA1	replication protein A1, 70kDa	0.017
IFNA4	interferon, alpha 4	0.017
SLAMF7	SLAM family member 7	0.017
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.017
CCR3	chemokine (C-C motif) receptor 3	0.017
RTP4	receptor (chemosensory) transporter protein 4	0.017
PTTG1	pituitary tumor-transforming 1	0.017
PARN	poly(A)-specific ribonuclease (deadenylation nuclease)	0.017
UBE4A	ubiquitination factor E4A (UFD2 homolog, yeast)	0.017
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.017
RARRES1	retinoic acid receptor responder (tazarotene induced) 1	0.017
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.016
ARID1A	AT rich interactive domain 1A (SWI-like)	0.016
C1QB	complement component 1, q subcomponent, B chain	0.016
SRPK2	SRSF protein kinase 2	0.016
TRADD	TNFRSF1A-associated via death domain	0.016
RGL1	ral guanine nucleotide dissociation stimulator-like 1	0.016
HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B	0.016
TYMP	thymidine phosphorylase	0.016
PTGES3	prostaglandin E synthase 3 (cytosolic)	0.016
AMBRA1	autophagy/beclin-1 regulator 1	0.016
C3AR1	complement component 3a receptor 1	0.015
NECAP2	NECAP endocytosis associated 2	0.015
GLTPD1	glycolipid transfer protein domain containing 1	0.015
PSMD10	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	0.015
SS18	synovial sarcoma translocation, chromosome 18	0.015
CALR	calreticulin	0.015
CD80	CD80 molecule	0.014
VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	0.014
OSMR	oncostatin M receptor	0.014
PML	promyelocytic leukemia	0.014
QRSL1	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1	0.014
HMOX2	heme oxygenase (decycling) 2	0.014
C16orf70	chromosome 16 open reading frame 70	0.014
AQP1	aquaporin 1 (Colton blood group)	0.014
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.014
GBP2	guanylate binding protein 2, interferon-inducible	0.014
HDGF	hepatoma-derived growth factor	0.014
MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	0.014
TNF	tumor necrosis factor	0.014
ADAR	adenosine deaminase, RNA-specific	0.014
IL15RA	interleukin 15 receptor, alpha	0.014
MFN1	mitofusin 1	0.014
PRDX1	peroxiredoxin 1	0.013
MSH6	mutS homolog 6 (E. coli)	0.013
ARRB1	arrestin, beta 1	0.013
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.013
PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.013
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.013
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.013
CXCR3	chemokine (C-X-C motif) receptor 3	0.013
C1QA	complement component 1, q subcomponent, A chain	0.013
PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)	0.013
STAT4	signal transducer and activator of transcription 4	0.013
EFNA1	ephrin-A1	0.013
CCL11	chemokine (C-C motif) ligand 11	0.013	Human
CMKLR1	chemokine-like receptor 1	0.013
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.013
INHBA	inhibin, beta A	0.012
CCL23	chemokine (C-C motif) ligand 23	0.012	Human
AIM2	absent in melanoma 2	0.012	Human
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.012
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.012
TRANK1	tetratricopeptide repeat and ankyrin repeat containing 1	0.012
MOBKL2B	MOB1, Mps One Binder kinase activator-like 2B (yeast)	0.012
NUDT1	nudix (nucleoside diphosphate linked moiety X)-type motif 1	0.012
HBB	hemoglobin, beta	0.012
IFNA16	interferon, alpha 16	0.012	Human
ISY1	ISY1 splicing factor homolog (S. cerevisiae)	0.012
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.012
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.012
IFNA17	interferon, alpha 17	0.012
RRAS	related RAS viral (r-ras) oncogene homolog	0.012
KYNU	kynureninase	0.012
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.012
IL1A	interleukin 1, alpha	0.012
RBM10	RNA binding motif protein 10	0.012
LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein	0.012
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.012
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.012
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	0.012
FANCA	Fanconi anemia, complementation group A	0.012
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.012
IL9	interleukin 9	0.012
TUBA1C	tubulin, alpha 1c	0.012
XCL2	chemokine (C motif) ligand 2	0.012
CCL1	chemokine (C-C motif) ligand 1	0.012
XPC	xeroderma pigmentosum, complementation group C	0.012
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.011
IFNA14	interferon, alpha 14	0.011
C1S	complement component 1, s subcomponent	0.011
IFIT1B	interferon-induced protein with tetratricopeptide repeats 1B	0.011
DEFB4A	defensin, beta 4A	0.011
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.011
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.011
MKI67	antigen identified by monoclonal antibody Ki-67	0.011
CCBP2	chemokine binding protein 2	0.011
CCL22	chemokine (C-C motif) ligand 22	0.011
C19orf43	chromosome 19 open reading frame 43	0.011
CXCR2	chemokine (C-X-C motif) receptor 2	0.011
SEPT7	septin 7	0.011
NCOR1	nuclear receptor corepressor 1	0.011
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.011
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.011
RAD23A	RAD23 homolog A (S. cerevisiae)	0.011
SNRPA	small nuclear ribonucleoprotein polypeptide A	0.011
CHD4	chromodomain helicase DNA binding protein 4	0.011
IMMT	inner membrane protein, mitochondrial	0.011
APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	0.011
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.011
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.011
S100A12	S100 calcium binding protein A12	0.011
SLFN5	schlafen family member 5	0.011
S100A8	S100 calcium binding protein A8	0.011
CLEC7A	C-type lectin domain family 7, member A	0.011
TLR3	toll-like receptor 3	0.011
SAMHD1	SAM domain and HD domain 1	0.011
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.011
EREG	epiregulin	0.011
MSR1	macrophage scavenger receptor 1	0.011
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.010
ERCC6	excision repair cross-complementing rodent repair deficiency, complementation group 6	0.010
C1QC	complement component 1, q subcomponent, C chain	0.010
CXCR6	chemokine (C-X-C motif) receptor 6	0.010
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.010
RHOXF2	Rhox homeobox family, member 2	0.010
HNRNPL	heterogeneous nuclear ribonucleoprotein L	0.010
DARC	Duffy blood group, chemokine receptor	0.010
SNRPE	small nuclear ribonucleoprotein polypeptide E	0.010
TMSB10	thymosin beta 10	0.010
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.010
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.010
ARGLU1	arginine and glutamate rich 1	0.010
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.010
RNPS1	RNA binding protein S1, serine-rich domain	0.010
CMTM6	CKLF-like MARVEL transmembrane domain containing 6	0.010
ADORA2A	adenosine A2a receptor	0.010
GUF1	GUF1 GTPase homolog (S. cerevisiae)	0.010
USP42	ubiquitin specific peptidase 42	0.010
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.010
IFNA21	interferon, alpha 21	0.010	Human
CSF1	colony stimulating factor 1 (macrophage)	0.010
DEFB1	defensin, beta 1	0.010
CARHSP1	calcium regulated heat stable protein 1, 24kDa	0.010
TAS2R16	taste receptor, type 2, member 16	0.010
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.010
SART3	squamous cell carcinoma antigen recognized by T cells 3	0.010
SP140L	SP140 nuclear body protein-like	0.010
FAM103A1	family with sequence similarity 103, member A1	0.010
PLA1A	phospholipase A1 member A	0.010