IMP

Process View

Homo sapiens

32 genes annotated in human

execution phase of apoptosis

A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "execution phase of apoptosis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "execution phase of apoptosis" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2	B-cell CLL/lymphoma 2	1.000	Human
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.976
BCL2L1	BCL2-like 1	0.963
XIAP	X-linked inhibitor of apoptosis	0.916
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.891
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.888
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.828	Human
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.819	Human
FASLG	Fas ligand (TNF superfamily, member 6)	0.628
CFLAR	CASP8 and FADD-like apoptosis regulator	0.598
BID	BH3 interacting domain death agonist	0.580
SNX6	sorting nexin 6	0.522
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.499	Human
FAS	Fas (TNF receptor superfamily, member 6)	0.493
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.451
SOCS3	suppressor of cytokine signaling 3	0.375
FKBP1A	FK506 binding protein 1A, 12kDa	0.356
APAF1	apoptotic peptidase activating factor 1	0.327	Mouse
BAX	BCL2-associated X protein	0.312
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.302	Human
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.263	Human
FADD	Fas (TNFRSF6)-associated via death domain	0.234
DFFA	DNA fragmentation factor, 45kDa, alpha polypeptide	0.230
TGFB1	transforming growth factor, beta 1	0.224
BAD	BCL2-associated agonist of cell death	0.222
BAK1	BCL2-antagonist/killer 1	0.218	Human
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.200
CCL5	chemokine (C-C motif) ligand 5	0.194
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.183
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.177
BMP2	bone morphogenetic protein 2	0.170
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.166
TRAF1	TNF receptor-associated factor 1	0.150
POU5F1	POU class 5 homeobox 1	0.147
STRN4	striatin, calmodulin binding protein 4	0.146
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.141
DFFB	DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)	0.137
EXOSC3	exosome component 3	0.124
CCR2	chemokine (C-C motif) receptor 2	0.122	Human
TP53	tumor protein p53	0.119
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.115	Human
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.093	Human
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.092
IL2RB	interleukin 2 receptor, beta	0.083
BIRC2	baculoviral IAP repeat containing 2	0.081
FNBP1	formin binding protein 1	0.081
ENG	endoglin	0.077
CCR5	chemokine (C-C motif) receptor 5	0.075	Human
LRRK2	leucine-rich repeat kinase 2	0.074
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.071
IFNG	interferon, gamma	0.070
PRKG1	protein kinase, cGMP-dependent, type I	0.065
STK4	serine/threonine kinase 4	0.065
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.065
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.064
CXCR6	chemokine (C-X-C motif) receptor 6	0.058	Human
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.055
GDF5	growth differentiation factor 5	0.053
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.052
CCL22	chemokine (C-C motif) ligand 22	0.047
EXOSC2	exosome component 2	0.045
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.043
TGFBR1	transforming growth factor, beta receptor 1	0.042	Human
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.042
BIK	BCL2-interacting killer (apoptosis-inducing)	0.041
GATA4	GATA binding protein 4	0.041
DIS3	DIS3 mitotic control homolog (S. cerevisiae)	0.040
FAM40B	family with sequence similarity 40, member B	0.039
EXOSC10	exosome component 10	0.038	Worm
ACVR1	activin A receptor, type I	0.037	Human
BBC3	BCL2 binding component 3	0.037
CXCR3	chemokine (C-X-C motif) receptor 3	0.036
STRN3	striatin, calmodulin binding protein 3	0.036
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.034
C4orf14	chromosome 4 open reading frame 14	0.034
CXCL9	chemokine (C-X-C motif) ligand 9	0.033
MAPK8	mitogen-activated protein kinase 8	0.032
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.032
EXOSC4	exosome component 4	0.031
FSTL1	follistatin-like 1	0.030
STRN	striatin, calmodulin binding protein	0.030
IRF4	interferon regulatory factor 4	0.030
TGFB3	transforming growth factor, beta 3	0.029
CD40LG	CD40 ligand	0.029
RANBP3	RAN binding protein 3	0.026
CCR7	chemokine (C-C motif) receptor 7	0.026	Human
BECN1	beclin 1, autophagy related	0.026
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.026
NLRC4	NLR family, CARD domain containing 4	0.025
XAB2	XPA binding protein 2	0.025
NMI	N-myc (and STAT) interactor	0.024
ABCF3	ATP-binding cassette, sub-family F (GCN20), member 3	0.024
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.024
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.024
CXCR4	chemokine (C-X-C motif) receptor 4	0.024	Human
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.023
SLAMF7	SLAM family member 7	0.023
SLMAP	sarcolemma associated protein	0.022
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.022
CCR4	chemokine (C-C motif) receptor 4	0.022	Human
MDH2	malate dehydrogenase 2, NAD (mitochondrial)	0.022
BMPR1A	bone morphogenetic protein receptor, type IA	0.021	Human
DIS3L	DIS3 mitotic control homolog (S. cerevisiae)-like	0.021
TP53BP2	tumor protein p53 binding protein, 2	0.021
IQGAP1	IQ motif containing GTPase activating protein 1	0.021
CASP8AP2	caspase 8 associated protein 2	0.020
AMBRA1	autophagy/beclin-1 regulator 1	0.020
PDPK1	3-phosphoinositide dependent protein kinase-1	0.020
RNR2	l-rRNA	0.020
NDUFS1	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	0.019
CPSF1	cleavage and polyadenylation specific factor 1, 160kDa	0.019
NRP1	neuropilin 1	0.018
CXCR5	chemokine (C-X-C motif) receptor 5	0.018	Human
SNX1	sorting nexin 1	0.018	Worm
SMAD7	SMAD family member 7	0.018
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.018
EXOSC7	exosome component 7	0.018
TFG	TRK-fused gene	0.017
WT1	Wilms tumor 1	0.017
VDAC1	voltage-dependent anion channel 1	0.017
DCTN1	dynactin 1	0.017
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.017
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.017
EXOSC1	exosome component 1	0.016
SOX2	SRY (sex determining region Y)-box 2	0.016
STK3	serine/threonine kinase 3	0.015
PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	0.015
NAF1	nuclear assembly factor 1 homolog (S. cerevisiae)	0.015
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.015
FKBP8	FK506 binding protein 8, 38kDa	0.015
CARD16	caspase recruitment domain family, member 16	0.015
ZMYND11	zinc finger, MYND-type containing 11	0.015
CCL3	chemokine (C-C motif) ligand 3	0.015
CCL11	chemokine (C-C motif) ligand 11	0.015
UBA2	ubiquitin-like modifier activating enzyme 2	0.015
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.015
IL10	interleukin 10	0.015
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.015
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.015
ELF4	E74-like factor 4 (ets domain transcription factor)	0.015
CCR9	chemokine (C-C motif) receptor 9	0.014	Human
CSNK1E	casein kinase 1, epsilon	0.014
NUCB2	nucleobindin 2	0.014
BIRC3	baculoviral IAP repeat containing 3	0.014
ZFYVE1	zinc finger, FYVE domain containing 1	0.014
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.014
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.014
CDK11B	cyclin-dependent kinase 11B	0.014
CTSS	cathepsin S	0.014
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.014
SMAD1	SMAD family member 1	0.014
RIPK2	receptor-interacting serine-threonine kinase 2	0.014
FGL2	fibrinogen-like 2	0.014
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.014
VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)	0.014
CXCL13	chemokine (C-X-C motif) ligand 13	0.014
EXOSC8	exosome component 8	0.014
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.013	Mouse
MUS81	MUS81 endonuclease homolog (S. cerevisiae)	0.013
PDCD10	programmed cell death 10	0.013
BAG1	BCL2-associated athanogene	0.013
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.013	Human Mouse
BMP4	bone morphogenetic protein 4	0.013
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.013
CDK6	cyclin-dependent kinase 6	0.013
IL10RA	interleukin 10 receptor, alpha	0.013
NOD2	nucleotide-binding oligomerization domain containing 2	0.013
IL21R	interleukin 21 receptor	0.013
INHBB	inhibin, beta B	0.013
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.013
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.013	Human
BCL2A1	BCL2-related protein A1	0.012	Human
TBX21	T-box 21	0.012	Human
SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	0.012
HUWE1	HECT, UBA and WWE domain containing 1	0.012
CLEC7A	C-type lectin domain family 7, member A	0.012
FOXRED1	FAD-dependent oxidoreductase domain containing 1	0.012
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.012
TNF	tumor necrosis factor	0.012
ITK	IL2-inducible T-cell kinase	0.012
GBP2	guanylate binding protein 2, interferon-inducible	0.012
CCL19	chemokine (C-C motif) ligand 19	0.012
PARP1	poly (ADP-ribose) polymerase 1	0.012
CCR6	chemokine (C-C motif) receptor 6	0.012	Human
MED25	mediator complex subunit 25	0.012
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.012
RASSF3	Ras association (RalGDS/AF-6) domain family member 3	0.012
SELL	selectin L	0.012
NCL	nucleolin	0.012
EVI2B	ecotropic viral integration site 2B	0.012
ARFGAP2	ADP-ribosylation factor GTPase activating protein 2	0.012
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.011
MTHFD1L	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	0.011
SUB1	SUB1 homolog (S. cerevisiae)	0.011
SH3RF3	SH3 domain containing ring finger 3	0.011
CCL4	chemokine (C-C motif) ligand 4	0.011
PIWIL1	piwi-like 1 (Drosophila)	0.011
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.011
CD80	CD80 molecule	0.011
GPR18	G protein-coupled receptor 18	0.011
NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive	0.011
CD86	CD86 molecule	0.011
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.011
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.011
FGFR1OP2	FGFR1 oncogene partner 2	0.011
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.011
RBPMS	RNA binding protein with multiple splicing	0.011
FGF8	fibroblast growth factor 8 (androgen-induced)	0.011
IL13	interleukin 13	0.011
CD84	CD84 molecule	0.011
CCR8	chemokine (C-C motif) receptor 8	0.011	Human
TXN2	thioredoxin 2	0.011
CD2	CD2 molecule	0.011
IL2RG	interleukin 2 receptor, gamma	0.011
EME1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.011
EIF3F	eukaryotic translation initiation factor 3, subunit F	0.010
FKBP3	FK506 binding protein 3, 25kDa	0.010
LAG3	lymphocyte-activation gene 3	0.010
CXCL11	chemokine (C-X-C motif) ligand 11	0.010
SNX2	sorting nexin 2	0.010	Worm
CXCR2	chemokine (C-X-C motif) receptor 2	0.010	Human
FOXF2	forkhead box F2	0.010