IMP

Process View

Homo sapiens

37 genes annotated in human

actin cytoskeleton reorganization

A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "actin cytoskeleton reorganization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "actin cytoskeleton reorganization" (in gray)

Name	Description	Probability	Func Analog Organism
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.972	Fly
GRB2	growth factor receptor-bound protein 2	0.884
FLNA	filamin A, alpha	0.690
EGFR	epidermal growth factor receptor	0.496
RHOA	ras homolog gene family, member A	0.492	Yeast Fly
FGFR2	fibroblast growth factor receptor 2	0.460
FYN	FYN oncogene related to SRC, FGR, YES	0.357	Human
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.257
ILK	integrin-linked kinase	0.246
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.223
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.205	Fly
NCK1	NCK adaptor protein 1	0.198
PTPRB	protein tyrosine phosphatase, receptor type, B	0.190
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.188
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.186
ACTN4	actinin, alpha 4	0.174	Fly
ARHGAP1	Rho GTPase activating protein 1	0.163
ABI1	abl-interactor 1	0.143
PLCG1	phospholipase C, gamma 1	0.136
GHR	growth hormone receptor	0.125
SPRR2A	small proline-rich protein 2A	0.092
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.084	Worm
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.078
ZNF746	zinc finger protein 746	0.076
TJP1	tight junction protein 1 (zona occludens 1)	0.076
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.076	Human
MYO9B	myosin IXB	0.073
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.073
BCAR1	breast cancer anti-estrogen resistance 1	0.071
IQGAP1	IQ motif containing GTPase activating protein 1	0.071
ANGPT2	angiopoietin 2	0.070
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.067
FGFR1	fibroblast growth factor receptor 1	0.064
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.061
NRP1	neuropilin 1	0.060
ROCK1	Rho-associated, coiled-coil containing protein kinase 1	0.060	Human Fly
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.058	Human
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.055	Mouse
ZYX	zyxin	0.055
NCF2	neutrophil cytosolic factor 2	0.052
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.051
SYK	spleen tyrosine kinase	0.051
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.050
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.049	Fly
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.048
SOS1	son of sevenless homolog 1 (Drosophila)	0.048
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.047
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.047	Rat
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.046	Human
IGF1R	insulin-like growth factor 1 receptor	0.045	Human
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.045
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.044
GAS7	growth arrest-specific 7	0.043
ARHGAP10	Rho GTPase activating protein 10	0.042
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.041
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.041
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.038
FYB	FYN binding protein	0.038
GRB7	growth factor receptor-bound protein 7	0.036
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.034
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	0.034	Human
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.033
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.033
HCK	hemopoietic cell kinase	0.033
GRB10	growth factor receptor-bound protein 10	0.033
ENG	endoglin	0.032
WIPF1	WAS/WASL interacting protein family, member 1	0.032
MSN	moesin	0.031
RAP1A	RAP1A, member of RAS oncogene family	0.031	Human
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.029
LAT	linker for activation of T cells	0.029
GBP3	guanylate binding protein 3	0.028
MYOZ1	myozenin 1	0.028
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.026
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.026
NGF	nerve growth factor (beta polypeptide)	0.025	Human
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.025
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.025
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.025
PLXNB1	plexin B1	0.024
RALGDS	ral guanine nucleotide dissociation stimulator	0.024
VAV1	vav 1 guanine nucleotide exchange factor	0.024	Fly
PECAM1	platelet/endothelial cell adhesion molecule	0.023
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.022	Human
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.022
ACTN1	actinin, alpha 1	0.022	Fly
KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.022
NCKIPSD	NCK interacting protein with SH3 domain	0.022
FKBP8	FK506 binding protein 8, 38kDa	0.022
EMP3	epithelial membrane protein 3	0.021
FN1	fibronectin 1	0.021
HSPG2	heparan sulfate proteoglycan 2	0.021
TNK2	tyrosine kinase, non-receptor, 2	0.021
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.021
SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	0.021
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.020
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.020
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.020
LCK	lymphocyte-specific protein tyrosine kinase	0.020	Human
SMAD2	SMAD family member 2	0.020
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.019	Human
ANGPT1	angiopoietin 1	0.019
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.019
TLN1	talin 1	0.019
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.019
EPS8	epidermal growth factor receptor pathway substrate 8	0.018	Mouse
PAWR	PRKC, apoptosis, WT1, regulator	0.018
IRS1	insulin receptor substrate 1	0.018
MYH9	myosin, heavy chain 9, non-muscle	0.018
DISC1	disrupted in schizophrenia 1	0.018
RALBP1	ralA binding protein 1	0.018
CD151	CD151 molecule (Raph blood group)	0.018
CSNK1E	casein kinase 1, epsilon	0.018
NCKAP1	NCK-associated protein 1	0.018
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.017	Human
NAV1	neuron navigator 1	0.017
SORBS2	sorbin and SH3 domain containing 2	0.016
EPOR	erythropoietin receptor	0.016
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.016
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.016
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.016
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.016	Human
PGF	placental growth factor	0.016
THBS1	thrombospondin 1	0.016
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.016
TMOD3	tropomodulin 3 (ubiquitous)	0.016
BAZ1A	bromodomain adjacent to zinc finger domain, 1A	0.016
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.015	Human
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.015
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	0.015	Fly
CD2AP	CD2-associated protein	0.015	Mouse
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.015
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.015
CAPZA1	capping protein (actin filament) muscle Z-line, alpha 1	0.015
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.015
IBTK	inhibitor of Bruton agammaglobulinemia tyrosine kinase	0.015
CEP55	centrosomal protein 55kDa	0.015
LIMS1	LIM and senescent cell antigen-like domains 1	0.015
RAP1B	RAP1B, member of RAS oncogene family	0.015	Human
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.015	Fly
SORBS3	sorbin and SH3 domain containing 3	0.014
PDCD6IP	programmed cell death 6 interacting protein	0.014
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.014
NTF4	neurotrophin 4	0.014	Human
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.014
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.014
CNKSR1	connector enhancer of kinase suppressor of Ras 1	0.014
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.014
BCR	breakpoint cluster region	0.014
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.014
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.014	Mouse
SPTBN1	spectrin, beta, non-erythrocytic 1	0.014
PTEN	phosphatase and tensin homolog	0.014
BDNF	brain-derived neurotrophic factor	0.014	Human
WASF2	WAS protein family, member 2	0.014
CNN2	calponin 2	0.014
STAT5A	signal transducer and activator of transcription 5A	0.014
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.014
TRIM63	tripartite motif containing 63	0.014
TPM4	tropomyosin 4	0.013
TSG101	tumor susceptibility gene 101	0.013
PDGFC	platelet derived growth factor C	0.013
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.013
ARHGAP26	Rho GTPase activating protein 26	0.013
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.013
LRRK2	leucine-rich repeat kinase 2	0.013
HGS	hepatocyte growth factor-regulated tyrosine kinase substrate	0.013
ERBB2IP	erbb2 interacting protein	0.013
RIN1	Ras and Rab interactor 1	0.013
TGFBR1	transforming growth factor, beta receptor 1	0.013
RAB11FIP1	RAB11 family interacting protein 1 (class I)	0.013
PILRA	paired immunoglobin-like type 2 receptor alpha	0.013
RUNDC3A	RUN domain containing 3A	0.013
PSEN2	presenilin 2 (Alzheimer disease 4)	0.013
PLEC	plectin	0.013
MYL9	myosin, light chain 9, regulatory	0.013
BTK	Bruton agammaglobulinemia tyrosine kinase	0.013	Human
KITLG	KIT ligand	0.013
CENPE	centromere protein E, 312kDa	0.013
ABI2	abl-interactor 2	0.013
JAG2	jagged 2	0.013
GMFB	glia maturation factor, beta	0.013
COTL1	coactosin-like 1 (Dictyostelium)	0.012
PBX1	pre-B-cell leukemia homeobox 1	0.012
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.012
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.012
GFI1B	growth factor independent 1B transcription repressor	0.012
PDCD10	programmed cell death 10	0.012
LMNA	lamin A/C	0.012
PAK3	p21 protein (Cdc42/Rac)-activated kinase 3	0.012	Human
MYL12B	myosin, light chain 12B, regulatory	0.012
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.012
SLA	Src-like-adaptor	0.012
PPP1R12A	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.012
MAPK8	mitogen-activated protein kinase 8	0.012
JUND	jun D proto-oncogene	0.012
CDC34	cell division cycle 34 homolog (S. cerevisiae)	0.012
JAK2	Janus kinase 2	0.012
FLNB	filamin B, beta	0.012	Human
RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	0.011	Human
PDGFA	platelet-derived growth factor alpha polypeptide	0.011
TNS4	tensin 4	0.011
PNPLA6	patatin-like phospholipase domain containing 6	0.011
MATK	megakaryocyte-associated tyrosine kinase	0.011
PDE4DIP	phosphodiesterase 4D interacting protein	0.011
ARRB2	arrestin, beta 2	0.011
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.011
CSRP1	cysteine and glycine-rich protein 1	0.011
SRI	sorcin	0.011
SH3KBP1	SH3-domain kinase binding protein 1	0.011
XIRP1	xin actin-binding repeat containing 1	0.011
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.011
SPRY4	sprouty homolog 4 (Drosophila)	0.011
SGCG	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	0.011
DST	dystonin	0.011
PDLIM7	PDZ and LIM domain 7 (enigma)	0.011
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.011
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.011
LGALS1	lectin, galactoside-binding, soluble, 1	0.011
VHL	von Hippel-Lindau tumor suppressor	0.011
PDLIM1	PDZ and LIM domain 1	0.011
WDR1	WD repeat domain 1	0.011
TTN	titin	0.011
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.011
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.011
BLNK	B-cell linker	0.011
CAV1	caveolin 1, caveolae protein, 22kDa	0.010
SH2B2	SH2B adaptor protein 2	0.010
INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	0.010
APC	adenomatous polyposis coli	0.010
SHB	Src homology 2 domain containing adaptor protein B	0.010
LTK	leukocyte receptor tyrosine kinase	0.010	Human
CDH5	cadherin 5, type 2 (vascular endothelium)	0.010
NTF3	neurotrophin 3	0.010
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.010
CORO1C	coronin, actin binding protein, 1C	0.010
BTRC	beta-transducin repeat containing	0.010
RHOG	ras homolog gene family, member G (rho G)	0.010
CD33	CD33 molecule	0.010
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.010
FGF8	fibroblast growth factor 8 (androgen-induced)	0.010
ZNRD1	zinc ribbon domain containing 1	0.010