IMP

Process View

Homo sapiens

29 genes annotated in human

spindle assembly

The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "spindle assembly"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "spindle assembly" (in gray)

Name	Description	Probability	Func Analog Organism
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.997
AURKB	aurora kinase B	0.992
CCNB1	cyclin B1	0.989	Yeast
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.986	Fly
RACGAP1	Rac GTPase activating protein 1	0.982
PLK1	polo-like kinase 1	0.967	Yeast Fly
CCT2	chaperonin containing TCP1, subunit 2 (beta)	0.952	Fly
AURKA	aurora kinase A	0.909	Yeast Mouse Worm
CCNB2	cyclin B2	0.903	Yeast
HAUS6	HAUS augmin-like complex, subunit 6	0.901
CDK1	cyclin-dependent kinase 1	0.888
VIPAR	VPS33B interacting protein, apical-basolateral polarity regulator	0.842
BIRC5	baculoviral IAP repeat containing 5	0.801
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.775	Fly
CCT5	chaperonin containing TCP1, subunit 5 (epsilon)	0.759	Fly
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.730
CDKN3	cyclin-dependent kinase inhibitor 3	0.724
KIF20A	kinesin family member 20A	0.720	Human Worm
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.714
TUBB	tubulin, beta	0.714	Mouse
ARHGAP1	Rho GTPase activating protein 1	0.713
CDCA8	cell division cycle associated 8	0.703	Fly
KIF23	kinesin family member 23	0.669
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.668
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.662
CCNA2	cyclin A2	0.634
PRC1	protein regulator of cytokinesis 1	0.613
HAUS1	HAUS augmin-like complex, subunit 1	0.569
TCP1	t-complex 1	0.555	Fly
TTK	TTK protein kinase	0.532	Yeast
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.528	Mouse
CCT3	chaperonin containing TCP1, subunit 3 (gamma)	0.470	Fly
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.455
C13orf34	chromosome 13 open reading frame 34	0.446
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.427
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.404
CEP55	centrosomal protein 55kDa	0.400
CCT7	chaperonin containing TCP1, subunit 7 (eta)	0.394	Fly
ESPL1	extra spindle pole bodies homolog 1 (S. cerevisiae)	0.393
PSRC1	proline/serine-rich coiled-coil 1	0.366
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.347	Fly
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.325
HAUS2	HAUS augmin-like complex, subunit 2	0.321
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.289
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.287
FLNA	filamin A, alpha	0.286
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.283	Fly
SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	0.255
PTTG1	pituitary tumor-transforming 1	0.252
LIN9	lin-9 homolog (C. elegans)	0.246	Fly
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.241	Fly
INCENP	inner centromere protein antigens 135/155kDa	0.213
TACC3	transforming, acidic coiled-coil containing protein 3	0.212
CKS2	CDC28 protein kinase regulatory subunit 2	0.210	Fly
CKAP5	cytoskeleton associated protein 5	0.203
KIF15	kinesin family member 15	0.201
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.199
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.197
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.196
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.189
UBE2C	ubiquitin-conjugating enzyme E2C	0.170
PSMC6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.167
ECT2	epithelial cell transforming sequence 2 oncogene	0.162	Fly
PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3	0.161
IER3	immediate early response 3	0.160
GAS2L3	growth arrest-specific 2 like 3	0.149
SGOL2	shugoshin-like 2 (S. pombe)	0.149
HJURP	Holliday junction recognition protein	0.147
KIF4A	kinesin family member 4A	0.146	Fly
FOXM1	forkhead box M1	0.144
NCOR1	nuclear receptor corepressor 1	0.141
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.138
PRNP	prion protein	0.136
TUBB2C	tubulin, beta 2C	0.135
PSMA6	proteasome (prosome, macropain) subunit, alpha type, 6	0.128
KIF18A	kinesin family member 18A	0.128	Fly
CENPA	centromere protein A	0.128
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.119
TP53	tumor protein p53	0.112
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.111	Fly
PPP4C	protein phosphatase 4, catalytic subunit	0.109
APC	adenomatous polyposis coli	0.106
CENPF	centromere protein F, 350/400kDa (mitosin)	0.105
CDK5RAP2	CDK5 regulatory subunit associated protein 2	0.104
DEPDC1	DEP domain containing 1	0.104
KIF2C	kinesin family member 2C	0.103	Fly
LIN54	lin-54 homolog (C. elegans)	0.097
HAUS3	HAUS augmin-like complex, subunit 3	0.097
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.095	Fly
TUBA1B	tubulin, alpha 1b	0.095
KIF1B	kinesin family member 1B	0.088
PSMA4	proteasome (prosome, macropain) subunit, alpha type, 4	0.087
LMO2	LIM domain only 2 (rhombotin-like 1)	0.086
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.082	Mouse
RB1	retinoblastoma 1	0.079
NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	0.077
TUBA1C	tubulin, alpha 1c	0.076
CENPE	centromere protein E, 312kDa	0.076
TNFAIP1	tumor necrosis factor, alpha-induced protein 1 (endothelial)	0.071
RAD51AP1	RAD51 associated protein 1	0.071
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.070
SPAG5	sperm associated antigen 5	0.068
ACTR5	ARP5 actin-related protein 5 homolog (yeast)	0.068
PSMC2	proteasome (prosome, macropain) 26S subunit, ATPase, 2	0.067
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.067
GTSE1	G-2 and S-phase expressed 1	0.066
CCNF	cyclin F	0.062
TUBGCP3	tubulin, gamma complex associated protein 3	0.062
UBE2S	ubiquitin-conjugating enzyme E2S	0.062
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.062	Fly
FBXW11	F-box and WD repeat domain containing 11	0.062
BTRC	beta-transducin repeat containing	0.060
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.058
WEE1	WEE1 homolog (S. pombe)	0.058	Fly
YY1	YY1 transcription factor	0.058
RBL1	retinoblastoma-like 1 (p107)	0.057
SDSL	serine dehydratase-like	0.057
CDK2	cyclin-dependent kinase 2	0.056
STMN1	stathmin 1	0.056
CCT6A	chaperonin containing TCP1, subunit 6A (zeta 1)	0.056
CDCA3	cell division cycle associated 3	0.056
PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5	0.054
FASLG	Fas ligand (TNF superfamily, member 6)	0.054
PSMD14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.052
MZT2B	mitotic spindle organizing protein 2B	0.052
RAN	RAN, member RAS oncogene family	0.052
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.052
KIFAP3	kinesin-associated protein 3	0.051
FAM64A	family with sequence similarity 64, member A	0.051
PPP2R5E	protein phosphatase 2, regulatory subunit B', epsilon isoform	0.051	Fly
NEDD1	neural precursor cell expressed, developmentally down-regulated 1	0.050	Fly
FBF1	Fas (TNFRSF6) binding factor 1	0.050
MAPRE2	microtubule-associated protein, RP/EB family, member 2	0.048	Fly
CDCA2	cell division cycle associated 2	0.048
GPSM2	G-protein signaling modulator 2	0.046
CHMP4B	chromatin modifying protein 4B	0.046
MAGEA2	melanoma antigen family A, 2	0.044
HDAC3	histone deacetylase 3	0.044
CLIP1	CAP-GLY domain containing linker protein 1	0.044
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.043
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.041
PLK4	polo-like kinase 4	0.040
EZR	ezrin	0.040
KIFC1	kinesin family member C1	0.040
CEBPE	CCAAT/enhancer binding protein (C/EBP), epsilon	0.039
NUSAP1	nucleolar and spindle associated protein 1	0.039
TROAP	trophinin associated protein (tastin)	0.037
ETF1	eukaryotic translation termination factor 1	0.037
DNM1	dynamin 1	0.036
MELK	maternal embryonic leucine zipper kinase	0.036
G2E3	G2/M-phase specific E3 ubiquitin protein ligase	0.036
SASS6	spindle assembly 6 homolog (C. elegans)	0.035
CDK7	cyclin-dependent kinase 7	0.035
NCAPG	non-SMC condensin I complex, subunit G	0.035
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.034	Fly
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.034
FBXO5	F-box protein 5	0.034	Mouse
MAPK9	mitogen-activated protein kinase 9	0.033
MAPRE3	microtubule-associated protein, RP/EB family, member 3	0.033	Fly
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.032
FAM83D	family with sequence similarity 83, member D	0.032
KIF14	kinesin family member 14	0.031
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.031
HIPK2	homeodomain interacting protein kinase 2	0.031
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.029
BRCA1	breast cancer 1, early onset	0.029
CLTC	clathrin, heavy chain (Hc)	0.029
L3MBTL2	l(3)mbt-like 2 (Drosophila)	0.029
TUBG1	tubulin, gamma 1	0.028	Fly
PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.028
TRPS1	trichorhinophalangeal syndrome I	0.028
SGCG	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	0.028
PCM1	pericentriolar material 1	0.027
PSEN2	presenilin 2 (Alzheimer disease 4)	0.027
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.027
SLBP	stem-loop binding protein	0.027
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.027
HMGB2	high mobility group box 2	0.027
ZNF148	zinc finger protein 148	0.026
ARHGAP11A	Rho GTPase activating protein 11A	0.026
XPO1	exportin 1 (CRM1 homolog, yeast)	0.026
TARBP2	TAR (HIV-1) RNA binding protein 2	0.026
PPP2R2D	protein phosphatase 2, regulatory subunit B, delta	0.026
KIF20B	kinesin family member 20B	0.025	Human Worm
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.025
CUL1	cullin 1	0.025
GAS7	growth arrest-specific 7	0.025
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.024
PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	0.024
PFDN2	prefoldin subunit 2	0.024
NUDT1	nudix (nucleoside diphosphate linked moiety X)-type motif 1	0.024
TUBB3	tubulin, beta 3	0.024
MAPK1	mitogen-activated protein kinase 1	0.024
PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1	0.023
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.023
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.023	Mouse Fly
RFWD2	ring finger and WD repeat domain 2	0.023
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.022
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.022
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.022
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.022
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.022	Fly
PRMT5	protein arginine methyltransferase 5	0.021
FLNB	filamin B, beta	0.021	Human
DDX47	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	0.021
KIF22	kinesin family member 22	0.021
HSPA4	heat shock 70kDa protein 4	0.020
PSMB7	proteasome (prosome, macropain) subunit, beta type, 7	0.020
MED21	mediator complex subunit 21	0.020
MARK2	MAP/microtubule affinity-regulating kinase 2	0.020
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.020
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.020
KIF18B	kinesin family member 18B	0.019	Yeast Fly
KIF5B	kinesin family member 5B	0.019
PIAS4	protein inhibitor of activated STAT, 4	0.019
ATP8	ATP synthase F0 subunit 8	0.019
PGR	progesterone receptor	0.018
MYOZ1	myozenin 1	0.018
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.018	Fly
MKI67	antigen identified by monoclonal antibody Ki-67	0.018
BPTF	bromodomain PHD finger transcription factor	0.018
PKP4	plakophilin 4	0.018
CEBPZ	CCAAT/enhancer binding protein (C/EBP), zeta	0.017
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.017
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.017	Fly
CEP350	centrosomal protein 350kDa	0.017
HAUS8	HAUS augmin-like complex, subunit 8	0.017
NLK	nemo-like kinase	0.017
MYH9	myosin, heavy chain 9, non-muscle	0.017
SNW1	SNW domain containing 1	0.016
KDM1A	lysine (K)-specific demethylase 1A	0.016
CCNE1	cyclin E1	0.016
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.016
AXIN1	axin 1	0.016
MAP3K4	mitogen-activated protein kinase kinase kinase 4	0.016
SPTBN1	spectrin, beta, non-erythrocytic 1	0.016
APOBEC3B	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	0.016
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.015
YTHDC2	YTH domain containing 2	0.015
ANAPC4	anaphase promoting complex subunit 4	0.015
KLC1	kinesin light chain 1	0.015
TNRC6A	trinucleotide repeat containing 6A	0.015
CHD1	chromodomain helicase DNA binding protein 1	0.015
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.015
ACTR8	ARP8 actin-related protein 8 homolog (yeast)	0.015
SETD2	SET domain containing 2	0.015
LMNA	lamin A/C	0.015
SLMAP	sarcolemma associated protein	0.015
XIRP1	xin actin-binding repeat containing 1	0.014
BCCIP	BRCA2 and CDKN1A interacting protein	0.014
E2F4	E2F transcription factor 4, p107/p130-binding	0.014
MZT1	mitotic spindle organizing protein 1	0.014
KIAA0528	KIAA0528	0.014
CKAP2	cytoskeleton associated protein 2	0.014
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	0.014	Fly
MTUS2	microtubule associated tumor suppressor candidate 2	0.014
KIF11	kinesin family member 11	0.014
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.013
ACTN4	actinin, alpha 4	0.013
HAUS5	HAUS augmin-like complex, subunit 5	0.013
DBN1	drebrin 1	0.013
HDGF	hepatoma-derived growth factor	0.013
UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.013
FBLIM1	filamin binding LIM protein 1	0.013
NUP50	nucleoporin 50kDa	0.013
GSK3B	glycogen synthase kinase 3 beta	0.013
MIS18BP1	MIS18 binding protein 1	0.013
TRIP13	thyroid hormone receptor interactor 13	0.013
FRYL	FRY-like	0.013
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.013
OIP5	Opa interacting protein 5	0.012
PSMC5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.012
VCP	valosin containing protein	0.012
HDAC7	histone deacetylase 7	0.012
CENPI	centromere protein I	0.012
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.012
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.012
ATXN1L	ataxin 1-like	0.012
EIF4E	eukaryotic translation initiation factor 4E	0.012
MCC	mutated in colorectal cancers	0.012
PSMB2	proteasome (prosome, macropain) subunit, beta type, 2	0.012
RANBP2	RAN binding protein 2	0.012
PHLDB2	pleckstrin homology-like domain, family B, member 2	0.012
JUND	jun D proto-oncogene	0.012
NHP2L1	NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)	0.012
HDAC10	histone deacetylase 10	0.011
ARHGAP19	Rho GTPase activating protein 19	0.011
RANBP3	RAN binding protein 3	0.011
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.011
JUN	jun proto-oncogene	0.011
ZFP28	zinc finger protein 28 homolog (mouse)	0.011
MAPK1IP1L	mitogen-activated protein kinase 1 interacting protein 1-like	0.011
ITGB3BP	integrin beta 3 binding protein (beta3-endonexin)	0.011
PML	promyelocytic leukemia	0.011
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.011
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.011
ANKRD17	ankyrin repeat domain 17	0.011
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.011
ANKRD24	ankyrin repeat domain 24	0.011
HSF2	heat shock transcription factor 2	0.011
DZIP1	DAZ interacting protein 1	0.011
DRG1	developmentally regulated GTP binding protein 1	0.011
C12orf11	chromosome 12 open reading frame 11	0.011
RAB28	RAB28, member RAS oncogene family	0.011
EPRS	glutamyl-prolyl-tRNA synthetase	0.011
PSMB5	proteasome (prosome, macropain) subunit, beta type, 5	0.011
C12orf48	chromosome 12 open reading frame 48	0.011
PLEC	plectin	0.011
PPP2R5B	protein phosphatase 2, regulatory subunit B', beta	0.010	Fly
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.010
RFC1	replication factor C (activator 1) 1, 145kDa	0.010
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.010
LIG1	ligase I, DNA, ATP-dependent	0.010
WDR67	WD repeat domain 67	0.010
INO80D	INO80 complex subunit D	0.010
AXIN2	axin 2	0.010
PSEN1	presenilin 1	0.010
HN1	hematological and neurological expressed 1	0.010
STK24	serine/threonine kinase 24	0.010
DDX21	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	0.010
EFHC2	EF-hand domain (C-terminal) containing 2	0.010
MIS18A	MIS18 kinetochore protein homolog A (S. pombe)	0.010