IMP

Process View

Mus musculus

6 genes annotated in mouse

heart field specification

The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "heart field specification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "heart field specification" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	1.000
Foxc1	forkhead box C1	1.000
Ctnnb1	catenin (cadherin associated protein), beta 1	1.000
Fgfr2	fibroblast growth factor receptor 2	1.000
Pitx2	paired-like homeodomain transcription factor 2	1.000
Vangl2	vang-like 2 (van gogh, Drosophila)	1.000
Fgf8	fibroblast growth factor 8	0.999
Hand2	heart and neural crest derivatives expressed transcript 2	0.999
Tbx1	T-box 1	0.999
Pax3	paired box gene 3	0.999
Tgfb2	transforming growth factor, beta 2	0.998
Sox9	SRY-box containing gene 9	0.998
Bmp4	bone morphogenetic protein 4	0.997	Human
Fgfr1	fibroblast growth factor receptor 1	0.997
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.996
Foxc2	forkhead box C2	0.995
Msx1	homeobox, msh-like 1	0.995
Chrd	chordin	0.992
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.992
Otx2	orthodenticle homolog 2 (Drosophila)	0.992
Smo	smoothened homolog (Drosophila)	0.988
Hand1	heart and neural crest derivatives expressed transcript 1	0.985
Gata4	GATA binding protein 4	0.983
Rarg	retinoic acid receptor, gamma	0.983
Gli3	GLI-Kruppel family member GLI3	0.982
Acvr1	activin A receptor, type 1	0.978
Nodal	nodal	0.977
Prrx1	paired related homeobox 1	0.977
Bmp7	bone morphogenetic protein 7	0.971
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.959
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.955
Tcfap2a	transcription factor AP-2, alpha	0.950
Wnt3a	wingless-related MMTV integration site 3A	0.942
Apc	adenomatosis polyposis coli	0.920
Gsc	goosecoid homeobox	0.910
Ednra	endothelin receptor type A	0.910
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.905
Psen1	presenilin 1	0.902
Vangl1	vang-like 1 (van gogh, Drosophila)	0.895
Dlx5	distal-less homeobox 5	0.844
Eya1	eyes absent 1 homolog (Drosophila)	0.839
Rxra	retinoid X receptor alpha	0.768
Notch1	Notch gene homolog 1 (Drosophila)	0.760
Lrp6	low density lipoprotein receptor-related protein 6	0.753
Vegfa	vascular endothelial growth factor A	0.729
Tgfbr2	transforming growth factor, beta receptor II	0.714
Rarb	retinoic acid receptor, beta	0.707
Sall4	sal-like 4 (Drosophila)	0.704
Runx2	runt related transcription factor 2	0.680
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.644
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.635
Rara	retinoic acid receptor, alpha	0.599
Prrx2	paired related homeobox 2	0.584
Smad4	MAD homolog 4 (Drosophila)	0.583
Gsk3b	glycogen synthase kinase 3 beta	0.575
Hoxa3	homeobox A3	0.567
Gli2	GLI-Kruppel family member GLI2	0.565
Hoxa2	homeobox A2	0.531
Pten	phosphatase and tensin homolog	0.507
Cfc1	cripto, FRL-1, cryptic family 1	0.480
Meox2	mesenchyme homeobox 2	0.476
Msx2	homeobox, msh-like 2	0.464
Hdac5	histone deacetylase 5	0.463
Smad3	MAD homolog 3 (Drosophila)	0.449
Lef1	lymphoid enhancer binding factor 1	0.447
Lmx1b	LIM homeobox transcription factor 1 beta	0.445
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.427
Jag1	jagged 1	0.391
Alx4	aristaless-like homeobox 4	0.386
Mesp1	mesoderm posterior 1	0.385
Notch2	Notch gene homolog 2 (Drosophila)	0.381
Isl1	ISL1 transcription factor, LIM/homeodomain	0.364	Human
Ece1	endothelin converting enzyme 1	0.343
Hdac4	histone deacetylase 4	0.315
Arid1a	AT rich interactive domain 1A (SWI-like)	0.294
Smad7	MAD homolog 7 (Drosophila)	0.291
Ptch1	patched homolog 1	0.274
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.264
Bmp2	bone morphogenetic protein 2	0.263
Pax9	paired box gene 9	0.257
Pitx1	paired-like homeodomain transcription factor 1	0.251
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.246
Sox4	SRY-box containing gene 4	0.242
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.236
Gata6	GATA binding protein 6	0.232
Pbx1	pre B-cell leukemia transcription factor 1	0.219
Hoxa1	homeobox A1	0.216
Dlx6	distal-less homeobox 6	0.212
Fgfr3	fibroblast growth factor receptor 3	0.209
Smad2	MAD homolog 2 (Drosophila)	0.204
Trp53	transformation related protein 53	0.174
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.174
Pax6	paired box gene 6	0.173
Esrrb	estrogen related receptor, beta	0.172
Tcfcp2l1	transcription factor CP2-like 1	0.167
Gbx2	gastrulation brain homeobox 2	0.167
Axin1	axin 1	0.163	Mouse
Smad6	MAD homolog 6 (Drosophila)	0.157
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.151
Lrp5	low density lipoprotein receptor-related protein 5	0.142
Dnahc5	dynein, axonemal, heavy chain 5	0.139
Rnf111	ring finger 111	0.138
Tbx3	T-box 3	0.135
Ntf3	neurotrophin 3	0.134
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.131
Gja1	gap junction protein, alpha 1	0.129
Zeb1	zinc finger E-box binding homeobox 1	0.125
Alx3	aristaless-like homeobox 3	0.125
Foxg1	forkhead box G1	0.123
Zic3	zinc finger protein of the cerebellum 3	0.118
Foxa2	forkhead box A2	0.108
Hes1	hairy and enhancer of split 1 (Drosophila)	0.107
Chd7	chromodomain helicase DNA binding protein 7	0.097
Dll1	delta-like 1 (Drosophila)	0.095
Pou5f1	POU domain, class 5, transcription factor 1	0.093
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.088
Pkd1	polycystic kidney disease 1 homolog	0.088
Serinc1	serine incorporator 1	0.086
Hdac7	histone deacetylase 7	0.084
Lhx1	LIM homeobox protein 1	0.081
Pax1	paired box gene 1	0.080
Efnb2	ephrin B2	0.078
Mn1	meningioma 1	0.072
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.071
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.068
Smad1	MAD homolog 1 (Drosophila)	0.068
Hoxb3	homeobox B3	0.066
Fgf15	fibroblast growth factor 15	0.060
Nog	noggin	0.060
Alx1	ALX homeobox 1	0.058
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.057
T	brachyury	0.056
Gata5	GATA binding protein 5	0.055
Htt	huntingtin	0.054
Zfpm2	zinc finger protein, multitype 2	0.054
Pax8	paired box gene 8	0.054
Myod1	myogenic differentiation 1	0.052
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.051
Wnt1	wingless-related MMTV integration site 1	0.047
Nf1	neurofibromatosis 1	0.046
Rb1	retinoblastoma 1	0.045
Pax2	paired box gene 2	0.045
Fgf10	fibroblast growth factor 10	0.045
Wnt6	wingless-related MMTV integration site 6	0.044
Csnk1e	casein kinase 1, epsilon	0.042
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.042
Dlx2	distal-less homeobox 2	0.040
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.040
Kif3a	kinesin family member 3A	0.039
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.039
En1	engrailed 1	0.039
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.037
Wnt4	wingless-related MMTV integration site 4	0.036
Efna4	ephrin A4	0.035
Utf1	undifferentiated embryonic cell transcription factor 1	0.035
Sall3	sal-like 3 (Drosophila)	0.035
Emid2	EMI domain containing 2	0.034
Sox13	SRY-box containing gene 13	0.034
Emx1	empty spiracles homolog 1 (Drosophila)	0.034
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.034
Klhl24	kelch-like 24 (Drosophila)	0.033
Fuz	fuzzy homolog (Drosophila)	0.033
Hrc	histidine rich calcium binding protein	0.032
Rdh10	retinol dehydrogenase 10 (all-trans)	0.032
Foxi3	forkhead box I3	0.031
Adam17	a disintegrin and metallopeptidase domain 17	0.031
Hes2	hairy and enhancer of split 2 (Drosophila)	0.031
Sox2	SRY-box containing gene 2	0.031
Dmpk	dystrophia myotonica-protein kinase	0.030
Dnahc11	dynein, axonemal, heavy chain 11	0.030
Ptk7	PTK7 protein tyrosine kinase 7	0.030
Tbx15	T-box 15	0.030
Lhx3	LIM homeobox protein 3	0.029
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.029
Cdx2	caudal type homeobox 2	0.029
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.028
Tcfap2c	transcription factor AP-2, gamma	0.028
Pla2g10	phospholipase A2, group X	0.028
Sox11	SRY-box containing gene 11	0.028
Ptf1a	pancreas specific transcription factor, 1a	0.028
Thra	thyroid hormone receptor alpha	0.028
Llgl2	lethal giant larvae homolog 2 (Drosophila)	0.027
Hes3	hairy and enhancer of split 3 (Drosophila)	0.027
Krt14	keratin 14	0.027
Pitx3	paired-like homeodomain transcription factor 3	0.027
Krt13	keratin 13	0.026
Fgf4	fibroblast growth factor 4	0.026
Trp73	transformation related protein 73	0.026
Ubl3	ubiquitin-like 3	0.025
Slmap	sarcolemma associated protein	0.025
Bmp5	bone morphogenetic protein 5	0.025
Efnb1	ephrin B1	0.025
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.024
Nfic	nuclear factor I/C	0.024
Hoxd3	homeobox D3	0.024
Ptk2	PTK2 protein tyrosine kinase 2	0.024
Dmrtb1	DMRT-like family B with proline-rich C-terminal, 1	0.023
Egfr	epidermal growth factor receptor	0.023
Otx1	orthodenticle homolog 1 (Drosophila)	0.023
Foxf1a	forkhead box F1a	0.023
Smarcc2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.023
Mecom	MDS1 and EVI1 complex locus	0.022
Tbx5	T-box 5	0.022
Bmper	BMP-binding endothelial regulator	0.022
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.022
Foxe3	forkhead box E3	0.022
Tlx2	T-cell leukemia, homeobox 2	0.022
Tcf15	transcription factor 15	0.022
Sorbs3	sorbin and SH3 domain containing 3	0.022
Zfp358	zinc finger protein 358	0.021
Wls	wntless homolog (Drosophila)	0.021
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.021
Zmynd11	zinc finger, MYND domain containing 11	0.021
Hoxa4	homeobox A4	0.021
Kif1b	kinesin family member 1B	0.021
Qk	quaking	0.021
Sox3	SRY-box containing gene 3	0.020
Gli1	GLI-Kruppel family member GLI1	0.020
Tead3	TEA domain family member 3	0.020
Etv2	ets variant gene 2	0.020
Hist1h1t	histone cluster 1, H1t	0.020
Zeb2	zinc finger E-box binding homeobox 2	0.020
Prkaca	protein kinase, cAMP dependent, catalytic, alpha	0.020
Rfx2	regulatory factor X, 2 (influences HLA class II expression)	0.020
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.020
Tcf4	transcription factor 4	0.020
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.020
Wnt11	wingless-related MMTV integration site 11	0.020
Fgfrl1	fibroblast growth factor receptor-like 1	0.020
Padi3	peptidyl arginine deiminase, type III	0.020
Zbtb20	zinc finger and BTB domain containing 20	0.020
Axin2	axin2	0.019
Cldn6	claudin 6	0.019
Wnt3	wingless-related MMTV integration site 3	0.019
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.019
Acvr2b	activin receptor IIB	0.019
Tnnt3	troponin T3, skeletal, fast	0.019
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.019
Slc34a2	solute carrier family 34 (sodium phosphate), member 2	0.019
Phox2a	paired-like homeobox 2a	0.019
Gata3	GATA binding protein 3	0.019
Nf2	neurofibromatosis 2	0.019
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.019
Cxadr	coxsackie virus and adenovirus receptor	0.019
Fzd8	frizzled homolog 8 (Drosophila)	0.018
Jag2	jagged 2	0.018
Mark4	MAP/microtubule affinity-regulating kinase 4	0.018
Fgf3	fibroblast growth factor 3	0.018
Adra2b	adrenergic receptor, alpha 2b	0.018
Hoxa13	homeobox A13	0.018
Fgf17	fibroblast growth factor 17	0.018
Hbb-bh1	hemoglobin Z, beta-like embryonic chain	0.017
Myf5	myogenic factor 5	0.017
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.017
Nkx3-2	NK3 homeobox 2	0.017
Il6st	interleukin 6 signal transducer	0.017
Mitf	microphthalmia-associated transcription factor	0.017
Fgfr4	fibroblast growth factor receptor 4	0.017
Ret	ret proto-oncogene	0.016
Lrp2	low density lipoprotein receptor-related protein 2	0.016
Ulk1	Unc-51 like kinase 1 (C. elegans)	0.016
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.016
Hoxb1	homeobox B1	0.016
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.016
Fzd7	frizzled homolog 7 (Drosophila)	0.016
Phox2b	paired-like homeobox 2b	0.016
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.016
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.016
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.016
Srms	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	0.016
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.016
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.016
Ppp3ca	protein phosphatase 3, catalytic subunit, alpha isoform	0.015
Neurog3	neurogenin 3	0.015
Mfi2	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	0.015
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.015
Gja5	gap junction protein, alpha 5	0.015
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.015
Twist2	twist homolog 2 (Drosophila)	0.015
Efna2	ephrin A2	0.015
Sall1	sal-like 1 (Drosophila)	0.015
Acr	acrosin prepropeptide	0.015
Hoxb4	homeobox B4	0.015
Bmp10	bone morphogenetic protein 10	0.015
Nrtn	neurturin	0.014
Tgfbr1	transforming growth factor, beta receptor I	0.014
Cdx1	caudal type homeobox 1	0.014
Myog	myogenin	0.014
Wiz	widely-interspaced zinc finger motifs	0.014
Rxrb	retinoid X receptor beta	0.014
Dag1	dystroglycan 1	0.014
Rab12	RAB12, member RAS oncogene family	0.014
Pcgf2	polycomb group ring finger 2	0.014
Hoxc9	homeobox C9	0.014
Pla2g2a	phospholipase A2, group IIA (platelets, synovial fluid)	0.014
Usp9x	ubiquitin specific peptidase 9, X chromosome	0.014
Mmp15	matrix metallopeptidase 15	0.014
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.014
Tcf21	transcription factor 21	0.014
Dll4	delta-like 4 (Drosophila)	0.014
Tcf7	transcription factor 7, T-cell specific	0.014
Art5	ADP-ribosyltransferase 5	0.014
Podxl	podocalyxin-like	0.013
Rmnd5a	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	0.013
Zfp42	zinc finger protein 42	0.013
Sycn	syncollin	0.013
Ctnna1	catenin (cadherin associated protein), alpha 1	0.013
Ncor2	nuclear receptor co-repressor 2	0.013
Chrne	cholinergic receptor, nicotinic, epsilon polypeptide	0.013
Hoxd9	homeobox D9	0.013
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.013
Gdf1	growth differentiation factor 1	0.013
Tead2	TEA domain family member 2	0.013
Numb	numb gene homolog (Drosophila)	0.013
Tssk1	testis-specific serine kinase 1	0.013
Phf1	PHD finger protein 1	0.012
Myl7	myosin, light polypeptide 7, regulatory	0.012
Nrg1	neuregulin 1	0.012
Nanog	Nanog homeobox	0.012
Mdm2	transformed mouse 3T3 cell double minute 2	0.012
Hsf4	heat shock transcription factor 4	0.012
Wnt10b	wingless related MMTV integration site 10b	0.012
Nfix	nuclear factor I/X	0.012
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.012
Hoxd13	homeobox D13	0.012
Tert	telomerase reverse transcriptase	0.012
Hoxb13	homeobox B13	0.012
Eomes	eomesodermin homolog (Xenopus laevis)	0.012
Fgf6	fibroblast growth factor 6	0.012
Lemd2	LEM domain containing 2	0.012
Arid1b	AT rich interactive domain 1B (SWI-like)	0.012
Fbln1	fibulin 1	0.012
Klc2	kinesin light chain 2	0.011
Zscan2	zinc finger and SCAN domain containing 2	0.011
Gpc3	glypican 3	0.011
Smurf1	SMAD specific E3 ubiquitin protein ligase 1	0.011
Evx1	even skipped homeotic gene 1 homolog	0.011
Hoxa7	homeobox A7	0.011
Wdr26	WD repeat domain 26	0.011
Otp	orthopedia homolog (Drosophila)	0.011
Bmp8b	bone morphogenetic protein 8b	0.011
Ctnnd1	catenin (cadherin associated protein), delta 1	0.011
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.011
Vcl	vinculin	0.011
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.011
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.011
Clic3	chloride intracellular channel 3	0.011
Tbx2	T-box 2	0.011
Gucy1b3	guanylate cyclase 1, soluble, beta 3	0.011
Ctf1	cardiotrophin 1	0.011
Prop1	paired like homeodomain factor 1	0.011
Mta1	metastasis associated 1	0.011
Otog	otogelin	0.011
Rax	retina and anterior neural fold homeobox	0.011
Ptch2	patched homolog 2	0.011
Emp2	epithelial membrane protein 2	0.011
Hoxb6	homeobox B6	0.011
Tigd5	tigger transposable element derived 5	0.011
Mdfi	MyoD family inhibitor	0.011
Trp63	transformation related protein 63	0.011
Notch3	Notch gene homolog 3 (Drosophila)	0.011
Esx1	extraembryonic, spermatogenesis, homeobox 1	0.011
Plxnd1	plexin D1	0.011
Mks1	Meckel syndrome, type 1	0.011
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.011
Zfp185	zinc finger protein 185	0.011
Zfp703	zinc finger protein 703	0.011
Dyrk1b	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b	0.011
Edn3	endothelin 3	0.011
Celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.011
Col2a1	collagen, type II, alpha 1	0.011
Nynrin	NYN domain and retroviral integrase containing	0.010
Hoxb7	homeobox B7	0.010
Cmtm8	CKLF-like MARVEL transmembrane domain containing 8	0.010
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.010
Smad5	MAD homolog 5 (Drosophila)	0.010
Agrn	agrin	0.010
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.010
Phlda2	pleckstrin homology-like domain, family A, member 2	0.010
Dlg1	discs, large homolog 1 (Drosophila)	0.010
Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.010
Itga8	integrin alpha 8	0.010
Tbx18	T-box18	0.010
Ccnd1	cyclin D1	0.010