IMP

Process View

Mus musculus

19 genes annotated in mouse

endoplasmic reticulum unfolded protein response

The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endoplasmic reticulum unfolded protein response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "endoplasmic reticulum unfolded protein response" (in gray)

Name	Description	Probability	Func Analog Organism
Hspa5	heat shock protein 5	0.999
Hsp90b1	heat shock protein 90, beta (Grp94), member 1	0.997
Dnajb11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.949
Dnajc3	DnaJ (Hsp40) homolog, subfamily C, member 3	0.882	Worm
Manf	mesencephalic astrocyte-derived neurotrophic factor	0.817
Creld2	cysteine-rich with EGF-like domains 2	0.717
Pdia3	protein disulfide isomerase associated 3	0.714
Uso1	USO1 homolog, vesicle docking protein (yeast)	0.705
Cdk4	cyclin-dependent kinase 4	0.634
Sdf2l1	stromal cell-derived factor 2-like 1	0.596
Vcp	valosin containing protein	0.532	Worm
Cdk6	cyclin-dependent kinase 6	0.389
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.365
Pdia6	protein disulfide isomerase associated 6	0.364
Dnajb9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.318
Xbp1	X-box binding protein 1	0.294
Sel1l	sel-1 suppressor of lin-12-like (C. elegans)	0.286
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.247
Pycard	PYD and CARD domain containing	0.239
Serp1	stress-associated endoplasmic reticulum protein 1	0.236
Hspa9	heat shock protein 9	0.230
Edem1	ER degradation enhancer, mannosidase alpha-like 1	0.223
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.201	Mouse
Surf4	surfeit gene 4	0.199
Tlr4	toll-like receptor 4	0.194
Sec61a1	Sec61 alpha 1 subunit (S. cerevisiae)	0.181
Ncstn	nicastrin	0.174
Spcs2	signal peptidase complex subunit 2 homolog (S. cerevisiae)	0.171
H47	histocompatibility 47	0.167
Mgat2	mannoside acetylglucosaminyltransferase 2	0.158
Slc39a7	solute carrier family 39 (zinc transporter), member 7	0.154
Ssr2	signal sequence receptor, beta	0.150
Rpn2	ribophorin II	0.144
Calr	calreticulin	0.144	Worm
Spcs3	signal peptidase complex subunit 3 homolog (S. cerevisiae)	0.139
Hif1a	hypoxia inducible factor 1, alpha subunit	0.137
Prkcsh	protein kinase C substrate 80K-H	0.126
Ngly1	N-glycanase 1	0.123
P4hb	prolyl 4-hydroxylase, beta polypeptide	0.111	Worm
Magt1	magnesium transporter 1	0.104
Fas	Fas (TNF receptor superfamily member 6)	0.101
Slc30a5	solute carrier family 30 (zinc transporter), member 5	0.099
Trp53	transformation related protein 53	0.087
Slc35b1	solute carrier family 35, member B1	0.086
Stat3	signal transducer and activator of transcription 3	0.083
Casp1	caspase 1	0.081	Mouse
Rpn1	ribophorin I	0.079
Uba5	ubiquitin-like modifier activating enzyme 5	0.076
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.075
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.073
Atf6	activating transcription factor 6	0.072
Bcl2	B-cell leukemia/lymphoma 2	0.071
Sec23b	SEC23B (S. cerevisiae)	0.069
Tm9sf3	transmembrane 9 superfamily member 3	0.069
Ssr1	signal sequence receptor, alpha	0.061
Gbp5	guanylate binding protein 5	0.060
Il18	interleukin 18	0.060
Erp44	endoplasmic reticulum protein 44	0.051
Tram1	translocating chain-associating membrane protein 1	0.050
Rrbp1	ribosome binding protein 1	0.050
Gmppb	GDP-mannose pyrophosphorylase B	0.048
Fndc3a	fibronectin type III domain containing 3A	0.046
Canx	calnexin	0.044	Worm
Ubxn1	UBX domain protein 1	0.044
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.043
Txndc5	thioredoxin domain containing 5	0.043
Myd88	myeloid differentiation primary response gene 88	0.043
Lman1	lectin, mannose-binding, 1	0.042
Nus1	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)	0.042
Tmed7	transmembrane emp24 protein transport domain containing 7	0.041
Stt3a	STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)	0.040
Lyz2	lysozyme 2	0.038
Hspa8	heat shock protein 8	0.037
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.035
Ccnd1	cyclin D1	0.034
Atf4	activating transcription factor 4	0.033
Bak1	BCL2-antagonist/killer 1	0.032
Copb2	coatomer protein complex, subunit beta 2 (beta prime)	0.032
Slc3a2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	0.032
Hsph1	heat shock 105kDa/110kDa protein 1	0.032
Rb1	retinoblastoma 1	0.031
Yars	tyrosyl-tRNA synthetase	0.030
Birc3	baculoviral IAP repeat-containing 3	0.030
Lrrc59	leucine rich repeat containing 59	0.030
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.030
Slc33a1	solute carrier family 33 (acetyl-CoA transporter), member 1	0.030
Ifngr1	interferon gamma receptor 1	0.030
Rag1	recombination activating gene 1	0.030
D4Wsu53e	DNA segment, Chr 4, Wayne State University 53, expressed	0.029
Dnm1	dynamin 1	0.029
Mafk	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	0.029
Psmd3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.028
Rnf103	ring finger protein 103	0.028
Arhgap31	Rho GTPase activating protein 31	0.028
Sars	seryl-aminoacyl-tRNA synthetase	0.027
Gars	glycyl-tRNA synthetase	0.027
Eif3b	eukaryotic translation initiation factor 3, subunit B	0.027
Mcfd2	multiple coagulation factor deficiency 2	0.027
Syvn1	synovial apoptosis inhibitor 1, synoviolin	0.025	Fly
Ssr3	signal sequence receptor, gamma	0.025
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.025
Adam9	a disintegrin and metallopeptidase domain 9 (meltrin gamma)	0.025
Copb1	coatomer protein complex, subunit beta 1	0.025
Nploc4	nuclear protein localization 4 homolog (S. cerevisiae)	0.024
Amfr	autocrine motility factor receptor	0.024	Human
Il1r1	interleukin 1 receptor, type I	0.024
Ccnd2	cyclin D2	0.023	Mouse
Hsp90aa1	heat shock protein 90, alpha (cytosolic), class A member 1	0.023
Aim2	absent in melanoma 2	0.022
Bhlha15	basic helix-loop-helix family, member a15	0.022
Gpr132	G protein-coupled receptor 132	0.022
1300001I01Rik	RIKEN cDNA 1300001I01 gene	0.022
Mrpl2	mitochondrial ribosomal protein L2	0.021
Adam17	a disintegrin and metallopeptidase domain 17	0.021
Dpagt1	dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)	0.021
Hspa13	heat shock protein 70 family, member 13	0.021
Sec63	SEC63-like (S. cerevisiae)	0.021	Zebrafish
Stat1	signal transducer and activator of transcription 1	0.021
Txndc11	thioredoxin domain containing 11	0.021
Herpud1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.021
Pdia4	protein disulfide isomerase associated 4	0.020	Worm
Kdelr2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	0.020
Map3k2	mitogen-activated protein kinase kinase kinase 2	0.020
C1qbp	complement component 1, q subcomponent binding protein	0.020
Derl1	Der1-like domain family, member 1	0.020
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.020
Dnajb2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.020
Lonp1	lon peptidase 1, mitochondrial	0.020
Acsl4	acyl-CoA synthetase long-chain family member 4	0.019
Hyou1	hypoxia up-regulated 1	0.019
Il1b	interleukin 1 beta	0.019
Lman2	lectin, mannose-binding 2	0.019
Yipf5	Yip1 domain family, member 5	0.019
Atp5b	ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit	0.019
Samm50	sorting and assembly machinery component 50 homolog (S. cerevisiae)	0.019
Ero1lb	ERO1-like beta (S. cerevisiae)	0.019	Mouse
Fadd	Fas (TNFRSF6)-associated via death domain	0.019
Lyst	lysosomal trafficking regulator	0.018
Cdk2	cyclin-dependent kinase 2	0.018
Cyld	cylindromatosis (turban tumor syndrome)	0.018
Vmp1	vacuole membrane protein 1	0.018
Edem3	ER degradation enhancer, mannosidase alpha-like 3	0.018	Fly
Tars	threonyl-tRNA synthetase	0.018
A630007B06Rik	RIKEN cDNA A630007B06 gene	0.017
Skil	SKI-like	0.017
Clptm1l	CLPTM1-like	0.017
Srsf9	serine/arginine-rich splicing factor 9	0.017
Gorasp2	golgi reassembly stacking protein 2	0.017
Mrpl12	mitochondrial ribosomal protein L12	0.017
Dusp1	dual specificity phosphatase 1	0.016
Foxp1	forkhead box P1	0.016
Tmed2	transmembrane emp24 domain trafficking protein 2	0.016
Elf4	E74-like factor 4 (ets domain transcription factor)	0.016
Tgfb1	transforming growth factor, beta 1	0.016
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.016
P4ha1	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide	0.016
Sec22b	SEC22 vesicle trafficking protein homolog B (S. cerevisiae)	0.016
Sec24d	Sec24 related gene family, member D (S. cerevisiae)	0.016
Hsd17b12	hydroxysteroid (17-beta) dehydrogenase 12	0.015
Nsfl1c	NSFL1 (p97) cofactor (p47)	0.015
Mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.015
Itch	itchy, E3 ubiquitin protein ligase	0.015
Arcn1	archain 1	0.015
Eif2ak3	eukaryotic translation initiation factor 2 alpha kinase 3	0.015
Prf1	perforin 1 (pore forming protein)	0.015
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.015
Tmed9	transmembrane emp24 protein transport domain containing 9	0.015
Wrn	Werner syndrome homolog (human)	0.015
Ikbkg	inhibitor of kappaB kinase gamma	0.015
Mmp9	matrix metallopeptidase 9	0.014
Ficd	FIC domain containing	0.014
Irgm1	immunity-related GTPase family M member 1	0.014
Lass2	LAG1 homolog, ceramide synthase 2	0.014
Ikbkb	inhibitor of kappaB kinase beta	0.014
Ostc	oligosaccharyltransferase complex subunit	0.014
Derl2	Der1-like domain family, member 2	0.014	Human
Psen1	presenilin 1	0.014
C78339	expressed sequence C78339	0.014
Casp7	caspase 7	0.014	Mouse
Cpeb2	cytoplasmic polyadenylation element binding protein 2	0.013
Lap3	leucine aminopeptidase 3	0.013
Ulk2	Unc-51 like kinase 2 (C. elegans)	0.013
Rbl2	retinoblastoma-like 2	0.013
Osbp	oxysterol binding protein	0.013
Brd2	bromodomain containing 2	0.013
Vhl	von Hippel-Lindau tumor suppressor	0.013
Dab1	disabled homolog 1 (Drosophila)	0.013
Stat2	signal transducer and activator of transcription 2	0.013
Srprb	signal recognition particle receptor, B subunit	0.013
Sqstm1	sequestosome 1	0.013
Mfn2	mitofusin 2	0.013
Afg3l1	AFG3(ATPase family gene 3)-like 1 (yeast)	0.013
Irf9	interferon regulatory factor 9	0.013
Trib3	tribbles homolog 3 (Drosophila)	0.013
App	amyloid beta (A4) precursor protein	0.012
Nars	asparaginyl-tRNA synthetase	0.012
Cflar	CASP8 and FADD-like apoptosis regulator	0.012
Mdm4	transformed mouse 3T3 cell double minute 4	0.012
2310036O22Rik	RIKEN cDNA 2310036O22 gene	0.012
Gbp7	guanylate binding protein 7	0.012
Hmox1	heme oxygenase (decycling) 1	0.012
Dhh	desert hedgehog	0.012
Mt1	metallothionein 1	0.012
Gbp3	guanylate binding protein 3	0.012
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.012
Bid	BH3 interacting domain death agonist	0.012
Ifnar1	interferon (alpha and beta) receptor 1	0.012
Dnajc1	DnaJ (Hsp40) homolog, subfamily C, member 1	0.012
Foxn1	forkhead box N1	0.012
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.011
St3gal4	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	0.011
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.011
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.011
Il10	interleukin 10	0.011
Nfya	nuclear transcription factor-Y alpha	0.011
Cd70	CD70 antigen	0.011
Atf5	activating transcription factor 5	0.011
Golga2	golgi autoantigen, golgin subfamily a, 2	0.011
Ccpg1	cell cycle progression 1	0.011
Ccdc47	coiled-coil domain containing 47	0.011
Pdx1	pancreatic and duodenal homeobox 1	0.011
Flcn	folliculin	0.011
Trim21	tripartite motif-containing 21	0.011
Mt2	metallothionein 2	0.011
Hoxb4	homeobox B4	0.011
Ccr1	chemokine (C-C motif) receptor 1	0.010
Vamp4	vesicle-associated membrane protein 4	0.010
Bsdc1	BSD domain containing 1	0.010
Tm9sf2	transmembrane 9 superfamily member 2	0.010
Timm13	translocase of inner mitochondrial membrane 13 homolog (yeast)	0.010
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.010
Pml	promyelocytic leukemia	0.010
Golph3	golgi phosphoprotein 3	0.010
Stt3b	STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)	0.010
Ppm1g	protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform	0.010
Oxt	oxytocin	0.010