IMP

Process View

Mus musculus

18 genes annotated in mouse

lymph node development

The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lymph node development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "lymph node development" (in gray)

Name	Description	Probability	Func Analog Organism
Map3k14	mitogen-activated protein kinase kinase kinase 14	1.000
Tnf	tumor necrosis factor	0.999	Mouse
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.998
Lta	lymphotoxin A	0.998
Ifng	interferon gamma	0.972
Igh	immunoglobulin heavy chain complex	0.958
Cd19	CD19 antigen	0.946
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.935	Mouse
Il2rg	interleukin 2 receptor, gamma chain	0.924
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.914
Ikzf1	IKAROS family zinc finger 1	0.888
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.846
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.844	Mouse
Ltb	lymphotoxin B	0.790
Cxcr5	chemokine (C-X-C motif) receptor 5	0.726
Cd40	CD40 antigen	0.705	Mouse
Il4	interleukin 4	0.700
Il7	interleukin 7	0.595
Cd247	CD247 antigen	0.592
Cxcl13	chemokine (C-X-C motif) ligand 13	0.585
Btk	Bruton agammaglobulinemia tyrosine kinase	0.577
Casp8	caspase 8	0.470
Fas	Fas (TNF receptor superfamily member 6)	0.411
Foxp3	forkhead box P3	0.400
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.365
Ccr6	chemokine (C-C motif) receptor 6	0.350	Mouse
Il15ra	interleukin 15 receptor, alpha chain	0.298
Icos	inducible T-cell co-stimulator	0.270
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.269
Rc3h1	RING CCCH (C3H) domains 1	0.228
Pou2af1	POU domain, class 2, associating factor 1	0.220
Ptf1a	pancreas specific transcription factor, 1a	0.207
Ccr7	chemokine (C-C motif) receptor 7	0.177	Mouse
Sfpi1	SFFV proviral integration 1	0.162
Zeb1	zinc finger E-box binding homeobox 1	0.153
Prdm1	PR domain containing 1, with ZNF domain	0.149
Ikbkg	inhibitor of kappaB kinase gamma	0.149
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.149	Mouse
Il2	interleukin 2	0.131
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.125	Mouse
Inpp5d	inositol polyphosphate-5-phosphatase D	0.114
Id2	inhibitor of DNA binding 2	0.113
Ccr2	chemokine (C-C motif) receptor 2	0.113	Mouse
Ccl2	chemokine (C-C motif) ligand 2	0.106
Il1r1	interleukin 1 receptor, type I	0.103
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.097
Mmp9	matrix metallopeptidase 9	0.095
Atxn1	ataxin 1	0.093
Traf2	TNF receptor-associated factor 2	0.091
Cd44	CD44 antigen	0.087
Foxe1	forkhead box E1	0.085
Prf1	perforin 1 (pore forming protein)	0.080
Bcl3	B-cell leukemia/lymphoma 3	0.080
Selp	selectin, platelet	0.078
Wfikkn2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.076
Il27ra	interleukin 27 receptor, alpha	0.066
Traf6	TNF receptor-associated factor 6	0.065
Socs1	suppressor of cytokine signaling 1	0.065
Ccl4	chemokine (C-C motif) ligand 4	0.062
Fadd	Fas (TNFRSF6)-associated via death domain	0.061
Ltbr	lymphotoxin B receptor	0.061	Mouse
Il17a	interleukin 17A	0.059
Rxra	retinoid X receptor alpha	0.059
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.057
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.055
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.055
Fasl	Fas ligand (TNF superfamily, member 6)	0.054	Mouse
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.052
Jak3	Janus kinase 3	0.052
Rgs9	regulator of G-protein signaling 9	0.047
Ccl3	chemokine (C-C motif) ligand 3	0.046
Gzmb	granzyme B	0.045
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.042
Ptprc	protein tyrosine phosphatase, receptor type, C	0.041
Tox	thymocyte selection-associated high mobility group box	0.038
Tgfbr2	transforming growth factor, beta receptor II	0.038
Cd22	CD22 antigen	0.037
Omp	olfactory marker protein	0.037
Gzmk	granzyme K	0.036
Card11	caspase recruitment domain family, member 11	0.034
Fgf10	fibroblast growth factor 10	0.033
Ncr1	natural cytotoxicity triggering receptor 1	0.033
Itga4	integrin alpha 4	0.033
Xcr1	chemokine (C motif) receptor 1	0.032	Mouse
Chst3	carbohydrate (chondroitin 6/keratan) sulfotransferase 3	0.031
Gpr132	G protein-coupled receptor 132	0.030
Bcl6	B-cell leukemia/lymphoma 6	0.030
Efna1	ephrin A1	0.030
Inhba	inhibin beta-A	0.030
Myct1	myc target 1	0.030
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.030
Elf4	E74-like factor 4 (ets domain transcription factor)	0.030
Rc3h2	ring finger and CCCH-type zinc finger domains 2	0.029
Sh2d2a	SH2 domain protein 2A	0.029
Cd86	CD86 antigen	0.029
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.028
Gimap4	GTPase, IMAP family member 4	0.027
Fcrla	Fc receptor-like A	0.026
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.025
Prkcd	protein kinase C, delta	0.025
Tspo2	translocator protein 2	0.025
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.025
Itch	itchy, E3 ubiquitin protein ligase	0.025
Slurp1	secreted Ly6/Plaur domain containing 1	0.024
Il2rb	interleukin 2 receptor, beta chain	0.024
Cd180	CD180 antigen	0.024
Cd4	CD4 antigen	0.024
S1pr2	sphingosine-1-phosphate receptor 2	0.022
Ciita	class II transactivator	0.022
Itgal	integrin alpha L	0.021
Olfr71	olfactory receptor 71	0.021
Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	0.021
Gp9	glycoprotein 9 (platelet)	0.021
Fut7	fucosyltransferase 7	0.021
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.021
Ccr10	chemokine (C-C motif) receptor 10	0.021	Mouse
Itk	IL2-inducible T-cell kinase	0.021
Tlr2	toll-like receptor 2	0.020
Cxcl12	chemokine (C-X-C motif) ligand 12	0.020
Lat	linker for activation of T cells	0.020
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.020
Bgn	biglycan	0.019
Lox	lysyl oxidase	0.019
Gimap1	GTPase, IMAP family member 1	0.018
Il18rap	interleukin 18 receptor accessory protein	0.018
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.018
Lalba	lactalbumin, alpha	0.017
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.017
Klf1	Kruppel-like factor 1 (erythroid)	0.017
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.017
Foxn1	forkhead box N1	0.017
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.017	Mouse
Oxt	oxytocin	0.017
Nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.016
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.016
Csf1	colony stimulating factor 1 (macrophage)	0.016
5730559C18Rik	RIKEN cDNA 5730559C18 gene	0.016
Cx3cr1	chemokine (C-X3-C) receptor 1	0.016	Mouse
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.016
Lepr	leptin receptor	0.016
Nos2	nitric oxide synthase 2, inducible	0.016
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.016
Cd96	CD96 antigen	0.016
Cd28	CD28 antigen	0.016
Sell	selectin, lymphocyte	0.016
Rel	reticuloendotheliosis oncogene	0.015
Pdcd1	programmed cell death 1	0.015
Il18r1	interleukin 18 receptor 1	0.015
Pdx1	pancreatic and duodenal homeobox 1	0.015
Il1b	interleukin 1 beta	0.015
Cxcr2	chemokine (C-X-C motif) receptor 2	0.015	Mouse
Cdh5	cadherin 5	0.014
Flt3	FMS-like tyrosine kinase 3	0.014
Il12rb2	interleukin 12 receptor, beta 2	0.014
Tek	endothelial-specific receptor tyrosine kinase	0.014
Il2ra	interleukin 2 receptor, alpha chain	0.014
Irf4	interferon regulatory factor 4	0.014
Bmp8b	bone morphogenetic protein 8b	0.014
Mcl1	myeloid cell leukemia sequence 1	0.014
Pou2f2	POU domain, class 2, transcription factor 2	0.014
Ifngr1	interferon gamma receptor 1	0.014
Efnb2	ephrin B2	0.013
Gbp1	guanylate binding protein 1	0.013
Hr	hairless	0.013
Icam1	intercellular adhesion molecule 1	0.013
Cd8a	CD8 antigen, alpha chain	0.013
St6galnac1	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	0.013
Cort	cortistatin	0.013
Rarb	retinoic acid receptor, beta	0.013
Cyld	cylindromatosis (turban tumor syndrome)	0.013
Pklr	pyruvate kinase liver and red blood cell	0.013
Lhx4	LIM homeobox protein 4	0.013
Bmp10	bone morphogenetic protein 10	0.012
Atoh7	atonal homolog 7 (Drosophila)	0.012
Gpr97	G protein-coupled receptor 97	0.012
Mcpt8	mast cell protease 8	0.012
Runx1	runt related transcription factor 1	0.012
Ccr9	chemokine (C-C motif) receptor 9	0.012	Mouse
Ucn	urocortin	0.012
Lat2	linker for activation of T cells family, member 2	0.012
Krt84	keratin 84	0.012
Il22	interleukin 22	0.012
Dock1	dedicator of cytokinesis 1	0.012
Blk	B lymphoid kinase	0.012
Krtap3-1	keratin associated protein 3-1	0.012
Apoe	apolipoprotein E	0.012
Zan	zonadhesin	0.012
Nkx3-2	NK3 homeobox 2	0.012	Mouse
Il10	interleukin 10	0.012
Wisp2	WNT1 inducible signaling pathway protein 2	0.012
Bdkrb2	bradykinin receptor, beta 2	0.012
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.012
Olfr70	olfactory receptor 70	0.012
Art2a-ps	ADP-ribosyltransferase 2a, pseudogene	0.011
Rara	retinoic acid receptor, alpha	0.011
Rarg	retinoic acid receptor, gamma	0.011
Zic4	zinc finger protein of the cerebellum 4	0.011
Pax6	paired box gene 6	0.011
Gypa	glycophorin A	0.011
Il10ra	interleukin 10 receptor, alpha	0.011
Elk4	ELK4, member of ETS oncogene family	0.011
Col4a1	collagen, type IV, alpha 1	0.011
Hrh1	histamine receptor H1	0.011
Cd7	CD7 antigen	0.011
Avp	arginine vasopressin	0.010
Tm4sf1	transmembrane 4 superfamily member 1	0.010
Ntf3	neurotrophin 3	0.010
Asb16	ankyrin repeat and SOCS box-containing 16	0.010
Myadm	myeloid-associated differentiation marker	0.010
Ptgs2	prostaglandin-endoperoxide synthase 2	0.010
St6galnac3	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	0.010
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.010