IMP

Process View

Danio rerio

0 genes annotated in zebrafish

neurodegenerative disease

DOID:1289

A central nervous system disease that results in the progressive deterioration of function or structure of neurons.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in zebrafish Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "neurodegenerative disease" (in gray)

Name	Description	Probability	Func Analog Organism
safb	scaffold attachment factor B	0.555
hnrnph1l	heterogeneous nuclear ribonucleoprotein H1, like	0.431
snrnp70	small nuclear ribonucleoprotein 70 (U1)	0.264
ilf3b	interleukin enhancer binding factor 3b	0.170
htr1aa	5-hydroxytryptamine (serotonin) receptor 1A a	0.148
hnrnpa0	heterogeneous nuclear ribonucleoprotein A0	0.142
rbm17	RNA binding motif protein 17	0.139
ilf3a	interleukin enhancer binding factor 3a	0.137
sod2	superoxide dismutase 2, mitochondrial	0.117
hnrnpm	heterogeneous nuclear ribonucleoprotein M	0.112
aplp2	amyloid beta (A4) precursor-like protein 2	0.098
hint2	histidine triad nucleotide binding protein 2	0.094
srsf2	serine/arginine-rich splicing factor 2	0.089
ewsr1a	Ewing sarcoma breakpoint region 1a	0.086
sfrs3b	splicing factor, arginine/serine-rich 3b	0.084
hmga1a	high mobility group AT-hook 1a	0.083
dag1	dystroglycan 1	0.081
pafah1b1a	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a	0.077
hnrnpab	heterogeneous nuclear ribonucleoprotein A/B	0.076
eomesa	eomesodermin homolog a	0.075
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.073
hif1ab	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b	0.072
crh	corticotropin releasing hormone	0.071
arf1	ADP-ribosylation factor 1	0.071
acadm	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain	0.070
ef1a	elongation factor 1-alpha	0.064
aldh7a1	aldehyde dehydrogenase 7 family, member A1	0.063
acadl	acyl-Coenzyme A dehydrogenase, long chain	0.059
srsf11	serine/arginine-rich splicing factor 11	0.058
tardbp	TAR DNA binding protein	0.054	Human
foxj1b	forkhead box J1b	0.054
zgc:64133	zgc:64133	0.051
zgc:92139	zgc:92139	0.050
cd63	Cd63 antigen	0.050
hspa4b	heat shock protein 4b	0.049
si:ch211-59d15.5	si:ch211-59d15.5	0.048
ppp2cb	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	0.047
slc25a25a	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a	0.046
lepr	leptin receptor	0.046
tardbpl	TAR DNA binding protein, like	0.045	Human
prnprs3	prion protein, related sequence 3	0.044
api5	apoptosis inhibitor 5	0.043
hsd17b12b	hydroxysteroid (17-beta) dehydrogenase 12b	0.043
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.041
usp7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.041
spna2	spectrin alpha 2	0.041
rbm8a	RNA binding motif protein 8A	0.039
psmd1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.037
sart1	squamous cell carcinoma antigen recognised by T cells	0.037
vcp	valosin containing protein	0.036	Human
prpf40a	PRP40 pre-mRNA processing factor 40 homolog A (yeast)	0.036
zgc:77052	zgc:77052	0.035
atrx	alpha thalassemia/mental retardation syndrome X-linked homolog (human)	0.034
u2af2b	U2 small nuclear RNA auxiliary factor 2b	0.033
kdm5c	lysine (K)-specific demethylase 5C	0.033
smarce1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.033
cd2bp2	CD2 antigen (cytoplasmic tail) binding protein 2	0.033
slc7a6os	solute carrier family 7, member 6 opposite strand	0.032
psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.032
zgc:158363	zgc:158363	0.032
LOC100535549	cytoplasmic polyadenylation element-binding protein 4-like	0.032
snai1a	snail homolog 1a (Drosophila)	0.031
myog	myogenin	0.031
sdha	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.030
dlx5a	distal-less homeobox gene 5a	0.030
slc39a7	solute carrier family 39 (zinc transporter), member 7	0.029
lcp1	lymphocyte cytosolic plastin 1	0.028
ndrg1	N-myc downstream regulated gene 1	0.027
zgc:73293	zgc:73293	0.027
tectb	tectorin beta	0.027
leo1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.027
sfpq	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.026
alcama	activated leukocyte cell adhesion molecule a	0.026
LOC100535373	hypothetical protein LOC100535373	0.026
col5a3b	collagen type V alpha-3b	0.026
nkd2	naked cuticle homolog 2 and naked 2a	0.026
hmgb3b	high-mobility group box 3b	0.026
cdc37	cell division cycle 37 homolog (S. cerevisiae)	0.025
hnrpdl	heterogeneous nuclear ribonucleoprotein D-like	0.025
pnn	pinin, desmosome associated protein	0.025
tcea1	transcription elongation factor A (SII), 1	0.025
rbp4	retinol binding protein 4, plasma	0.025
lgi1b	leucine-rich, glioma inactivated 1b	0.025
smu1	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	0.025
zgc:113210	zgc:113210	0.024
eprs	glutamyl-prolyl-tRNA synthetase	0.024
col1a1a	collagen, type I, alpha 1a	0.024
tfa	transferrin-a	0.024
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.023
lama2	laminin, alpha 2	0.023
dip2c	DIP2 disco-interacting protein 2 homolog C (Drosophila)	0.023
ddx6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	0.023
prom1a	prominin 1a	0.023
psmb5	proteasome (prosome, macropain) subunit, beta type, 5	0.022
LOC796298	isotocin receptor-like 1	0.022
sec24c	SEC24 family, member C (S. cerevisiae)	0.022
krt18	keratin 18	0.022
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.022
hif1al	hypoxia-inducible factor 1, alpha subunit, like	0.022
ilf2	interleukin enhancer binding factor 2	0.022
ryr1b	ryanodine receptor 1b (skeletal)	0.022
mstna	myostatin a	0.022
chat	choline acetyltransferase	0.022
appa	amyloid beta (A4) precursor protein a	0.021	Human
myod1	myogenic differentiation 1	0.021
si:dkey-181m9.9	si:dkey-181m9.9	0.021
ptgds	prostaglandin D2 synthase	0.021
cpt2	carnitine palmitoyltransferase II	0.020
LOC556124	hypothetical LOC556124	0.020
zgc:113143	zgc:113143	0.020
grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.020
ptpn11a	protein tyrosine phosphatase, non-receptor type 11, a	0.020
eaf2	ELL associated factor 2	0.020
nbl1	neuroblastoma, suppression of tumorigenicity 1	0.020
srrm2	serine/arginine repetitive matrix 2	0.020
zgc:77366	zgc:77366	0.020
galcb	galactosylceramidase b	0.020
abcf1	ATP-binding cassette, sub-family F (GCN20), member 1	0.020
got2a	glutamic-oxaloacetic transaminase 2a, mitochondrial (aspartate aminotransferase 2)	0.020
fxr1	fragile X mental retardation, autosomal homolog 1	0.020
stau1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.019
si:ch1073-351m12.1	si:ch1073-351m12.1	0.019
casrl	calcium-sensing receptor, like	0.019
smarca5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.019
zgc:112425	zgc:112425	0.019
gnb1a	guanine nucleotide binding protein (G protein), beta polypeptide 1a	0.019
zgc:111961	zgc:111961	0.019
cirbp	cold inducible RNA binding protein	0.019
os9	amplified in osteosarcoma	0.018
srsf6b	serine/arginine-rich splicing factor 6b	0.018
g3bp1	GTPase activating protein (SH3 domain) binding protein 1	0.018
acin1a	apoptotic chromatin condensation inducer 1a	0.018
sod1	superoxide dismutase 1, soluble	0.018	Human
prpf8	pre-mRNA processing factor 8	0.018
kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.018
polr2b	polymerase (RNA) II (DNA directed) polypeptide B	0.018
bactin1	bactin1	0.018
ddx19	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 homolog, yeast)	0.018
trpc1	transient receptor potential cation channel, subfamily C, member 1	0.018
krt8	keratin 8	0.018
pafah1b1b	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b	0.018
smyd1b	SET and MYND domain containing 1b	0.018
ppp2r5d	protein phosphatase 2, regulatory subunit B', delta	0.018
slc30a7	solute carrier family 30 (zinc transporter), member 7	0.018
gpia	glucose phosphate isomerase a	0.018
echs1	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial	0.018
rnd3a	Rho family GTPase 3a	0.017
ash1l	ash1 (absent, small, or homeotic)-like (Drosophila)	0.017
nr1h3	nuclear receptor subfamily 1, group H, member 3	0.017
mbnl2	muscleblind-like 2 (Drosophila)	0.017
psmc1b	proteasome (prosome, macropain) 26S subunit, ATPase, 1b	0.017
ppig	peptidyl-prolyl isomerase G (cyclophilin G)	0.017
axin1	axin 1	0.017
rtn4a	reticulon 4a	0.017
spry4	sprouty (Drosophila) homolog 4	0.016
si:ch211-254d18.3	si:ch211-254d18.3	0.016
keap1a	kelch-like ECH-associated protein 1a	0.016
notum3	notum 3	0.016
zgc:123194	zgc:123194	0.016
si:dkey-250d21.1	si:dkey-250d21.1	0.016
ck2b	casein kinase 2 beta	0.016
snap25a	synaptosome-associated protein 25a	0.016
si:ch211-51e12.7	si:ch211-51e12.7	0.016
fdx1	ferredoxin 1	0.016
aars	alanyl-tRNA synthetase	0.016
gpatch8	G patch domain containing 8	0.016
pi4kb	phosphatidylinositol 4-kinase, catalytic, beta	0.016
eef2b	eukaryotic translation elongation factor 2b	0.016
zgc:112056	zgc:112056	0.016
gapdhs	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	0.016
nlgn4b	neuroligin 4b	0.016
cfl2l	cofilin 2, like	0.016
lama5	laminin, alpha 5	0.016
anp32e	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	0.015
slc25a3b	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3b	0.015
mbp	myelin basic protein	0.015
mapk3	mitogen-activated protein kinase 3	0.015
sdcbp	syndecan binding protein (syntenin)	0.015
cat	catalase	0.015
hspa8	heat shock protein 8	0.015
cct8	chaperonin containing TCP1, subunit 8 (theta)	0.015
pgam1b	phosphoglycerate mutase 1b	0.015
arid4a	AT rich interactive domain 4A (RBP1-like)	0.015
socs1	suppressor of cytokine signaling 1	0.015
atp5a1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.015
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.015
hnrnpl2	heterogeneous nuclear ribonucleoprotein L2	0.015
mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.015
copeb	core promoter element binding protein	0.015
zgc:158327	zgc:158327	0.015
gcm2	glial cells missing homolog 2 (Drosophila)	0.015
srrt	serrate RNA effector molecule homolog (Arabidopsis)	0.014
crhbp	corticotropin releasing hormone binding protein	0.014
ap2a1	adaptor-related protein complex 2, alpha 1 subunit	0.014
pkm2a	pyruvate kinase, muscle, a	0.014
acvr2b	activin receptor IIb	0.014
anxa11a	annexin A11a	0.014
ctsc	cathepsin C	0.014
tnrc6b	trinucleotide repeat containing 6B	0.014
wnt9b	wingless-type MMTV integration site family, member 9B	0.014
rhoab	ras homolog gene family, member Ab	0.014
si:ch211-12e1.4	si:ch211-12e1.4	0.014
cyp1a	cytochrome P450, family 1, subfamily A	0.014
got2b	glutamic-oxaloacetic transaminase 2b, mitochondrial (aspartate aminotransferase 2)	0.014
kpna4	karyopherin alpha 4 (importin alpha 3)	0.014
yes1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.014
psmc2	proteasome (prosome, macropain) 26S subunit, ATPase 2	0.014
krt4	keratin 4	0.014
nsdhl	NAD(P) dependent steroid dehydrogenase-like	0.014
setd8a	SET domain containing (lysine methyltransferase) 8a	0.014
arf2	ADP-ribosylation factor 2	0.013
sdf2	stromal cell-derived factor 2	0.013
rbmx	RNA binding motif protein, X-linked	0.013
cx43	connexin 43	0.013
zgc:65895	zgc:65895	0.013
hcrt	hypocretin (orexin) neuropeptide precursor	0.013
pola2	polymerase (DNA directed), alpha 2	0.013
usp5	ubiquitin specific protease 5	0.013
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.013
zgc:110256	zgc:110256	0.013
mmp9	matrix metalloproteinase 9	0.013
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.013
rplp0	ribosomal protein, large, P0	0.013
pdha1a	pyruvate dehydrogenase (lipoamide) alpha 1a	0.013
smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.013
bactin2	bactin2	0.013
zgc:171802	zgc:171802	0.013
zgc:64137	zgc:64137	0.013
hirip3	HIRA interacting protein 3	0.013
sc:d0319	sc:d0319	0.013
lnx2b	ligand of numb-protein X 2b	0.013
zgc:101761	zgc:101761	0.013
dusp6	dual specificity phosphatase 6	0.013
foxo3b	forkhead box O3b	0.013
tm9sf3	transmembrane 9 superfamily member 3	0.013
pth1a	parathyroid hormone 1a	0.013
cct6a	chaperonin containing TCP1, subunit 6A (zeta 1)	0.013
phf2	PHD finger protein 2	0.013
park7	parkinson disease (autosomal recessive, early onset) 7	0.013	Human
rnaseh1	ribonuclease H1	0.013
gna12	guanine nucleotide binding protein (G protein) alpha 12	0.013
pink1	PTEN induced putative kinase 1	0.013	Human
abca5	ATP-binding cassette, sub-family A (ABC1), member 5	0.012
zgc:77262	zgc:77262	0.012
fas	Fas (TNF receptor superfamily, member 6)	0.012
fam168a	family with sequence similarity 168, member A	0.012
eif3ha	eukaryotic translation initiation factor 3, subunit H, a	0.012
c1qc	complement component 1, q subcomponent, C chain	0.012
zgc:110775	zgc:110775	0.012
zgc:103549	zgc:103549	0.012
luc7l	LUC7-like (S. cerevisiae)	0.012
clstn1	calsyntenin 1	0.012
mmp17a	matrix metallopeptidase 17a	0.012
tspan3a	tetraspanin 3a	0.012
fzd7b	frizzled homolog 7b	0.012
nfe2l2	nuclear factor (erythroid-derived 2)-like 2	0.012
atl3	atlastin 3	0.012
npc1	Niemann-Pick disease, type C1	0.012
smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.012
ppp1r13b	protein phosphatase 1, regulatory (inhibitor) subunit 13B	0.012
thraa	thyroid hormone receptor alpha a	0.012
ndrg4	N-myc downstream regulated gene 4	0.012
pbrm1l	polybromo 1, like	0.012
celsr1a	cadherin EGF LAG seven-pass G-type receptor 1a	0.012
psma6a	proteasome (prosome, macropain) subunit, alpha type, 6a	0.012
wu:fi18a01	wu:fi18a01	0.012
ppp4cb	protein phosphatase 4 (formerly X), catalytic subunit b	0.012
hsd17b3	hydroxysteroid (17-beta) dehydrogenase 3	0.012
e4f1	E4F transcription factor 1	0.012
hnrnpk	heterogeneous nuclear ribonucleoprotein K	0.012
zgc:153148	zgc:153148	0.012
kars	lysyl-tRNA synthetase	0.012
ca15a	carbonic anhydrase XV a	0.012
ryk	receptor-like tyrosine kinase	0.012
qars	glutaminyl-tRNA synthetase	0.012
chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1	0.012
fn1b	fibronectin 1b	0.012
spsb1	splA/ryanodine receptor domain and SOCS box containing 1	0.012
myh10	myosin, heavy polypeptide 10, non-muscle and myosin, heavy chain 10, non-muscle	0.012
ftr82	finTRIM family, member 82	0.012
bhmt	betaine-homocysteine methyltransferase	0.011
morf4l1	mortality factor 4 like 1	0.011
cul1a	cullin 1a	0.011
ywhaqa	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a	0.011
copa	coatomer protein complex, subunit alpha	0.011
ctsd	cathepsin D	0.011
sfrp1b	secreted frizzled-related protein 1b	0.011
nup50	nucleoporin 50	0.011
si:ch211-148j1.1	si:ch211-148j1.1	0.011
eno2	enolase 2	0.011
grin1b	glutamate receptor, ionotropic, N-methyl D-aspartate 1b	0.011
ywhae1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	0.011
si:ch211-166a6.5	si:ch211-166a6.5	0.011
usp12a	ubiquitin specific peptidase 12a	0.011
tp53	tumor protein p53	0.011
mpz	myelin protein zero	0.011
prmt1	protein arginine methyltransferase 1	0.011
cltcb	clathrin, heavy polypeptide b (Hc)	0.011
uba1	ubiquitin-like modifier activating enzyme 1	0.011
cldnc	claudin c	0.011
atp2b4	ATPase, Ca++ transporting, plasma membrane 4	0.011
pdcd7	programmed cell death 7	0.011
mapkapk2a	mitogen-activated protein kinase-activated protein kinase 2a	0.011
ech1	enoyl CoA hydratase 1, peroxisomal	0.011
zgc:158852	zgc:158852	0.011
mpp1	membrane protein, palmitoylated 1	0.011
zgc:152997	zgc:152997	0.011
ywhaba	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a	0.011
pdzd11	PDZ domain containing 11	0.011
rab5b	RAB5B, member RAS oncogene family	0.011
adrm1b	adhesion regulating molecule 1b	0.011
nr4a2a	nuclear receptor subfamily 4, group A, member 2a	0.011
cep290	centrosomal protein 290	0.011
hmgb1b	high-mobility group box 1b	0.011
fkbp4	FK506 binding protein 4	0.011
c1ql4l	complement component 1, q subcomponent-like 4 like	0.011
inppl1a	inositol polyphosphate phosphatase-like 1a	0.011
decr1	2,4-dienoyl CoA reductase 1, mitochondrial	0.011
hmgb2a	high-mobility group box 2a	0.011
rhcgl1	Rhesus blood group, C glycoprotein, like 1	0.011
kidins220b	kinase D-interacting substrate of 220b	0.011
rpl4	ribosomal protein L4	0.011
ywhaqb	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b	0.011
ntrk3b	neurotrophic tyrosine kinase, receptor, type 3b	0.011
hnrnpa0l	heterogeneous nuclear ribonucleoprotein A0, like	0.011
psma2	proteasome (prosome, macropain) subunit, alpha type, 2	0.011
zgc:110116	zgc:110116	0.010
akap8l	A kinase (PRKA) anchor protein 8-like	0.010
prkar2aa	protein kinase, cAMP-dependent, regulatory, type II, alpha A	0.010
acox1	acyl-Coenzyme A oxidase 1, palmitoyl	0.010
lum	lumican	0.010
entpd4	ectonucleoside triphosphate diphosphohydrolase 4	0.010
snx27	sorting nexin family member 27	0.010
mgp	matrix Gla protein	0.010
zgc:56488	zgc:56488	0.010
cct5	chaperonin containing TCP1, subunit 5 (epsilon)	0.010
eif4h	eukaryotic translation initiation factor 4h	0.010
pdcd10a	programmed cell death 10a	0.010
aldoaa	aldolase a, fructose-bisphosphate, a	0.010
si:dkey-223d9.2	si:dkey-223d9.2	0.010
ogdh	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	0.010
tra2a	transformer-2 alpha	0.010
rnf40	ring finger protein 40	0.010
bmpr1ab	bone morphogenetic protein receptor, type 1ab	0.010
ppp1cab	protein phosphatase 1, catalytic subunit, alpha isoform b	0.010
oxsr1a	oxidative-stress responsive 1a	0.010
si:dkeyp-55c8.3	si:dkeyp-55c8.3	0.010
robo1	roundabout homolog 1	0.010
rhogc	ras homolog gene family, member Gc	0.010
pom121	POM121 membrane glycoprotein (rat)	0.010
keap1b	kelch-like ECH-associated protein 1b	0.010
chuk	conserved helix-loop-helix ubiquitous kinase	0.010
hnrnpd	heterogeneous nuclear ribonucleoprotein D	0.010
rpn1	ribophorin I	0.010
LOC569976	hypothetical protein LOC569976	0.010
ehhadh	enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase	0.010
ppp4ca	protein phosphatase 4 (formerly X), catalytic subunit a	0.010
kif5bb	kinesin family member 5B, b	0.010
zgc:101723	zgc:101723	0.010
sparc	secreted acidic cysteine rich glycoprotein	0.010
dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.010
ndel1a	nudE nuclear distribution gene E homolog like 1 (A. nidulans) A	0.010