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Process View

Danio rerio

13 genes annotated in zebrafish

heart formation

The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "heart formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "heart formation" (in gray)

Name	Description	Probability	Func Analog Organism
tbx1	T-box 1	0.999
tbx5a	T-box 5a	0.945	Zebrafish Mouse
chd	chordin	0.935
gata6	GATA-binding protein 6	0.847
ndr2	nodal-related 2	0.766
robo3	roundabout homolog 3	0.747	Zebrafish
shha	sonic hedgehog a	0.746	Fly
gata5	GATA-binding protein 5	0.722
runx1	runt-related transcription factor 1	0.673
lft1	lefty1	0.665	Zebrafish
pax2a	paired box gene 2a	0.644
eya1	eyes absent homolog 1	0.629	Mouse
bmp4	bone morphogenetic protein 4	0.603	Human
cdh2	cadherin 2, neuronal	0.574
bmp2b	bone morphogenetic protein 2b	0.574
tbx20	T-box 20	0.554	Zebrafish
flh	floating head	0.511
spaw	southpaw	0.441
lft2	lefty2	0.372
pitx2	paired-like homeodomain transcription factor 2	0.325
has2	hyaluronan synthase 2	0.300
fn1	fibronectin 1	0.293
mef2cb	myocyte enhancer factor 2cb	0.282
dlx5a	distal-less homeobox gene 5a	0.281
pcdh8	protocadherin 8	0.274
tal1	T-cell acute lymphocytic leukemia 1	0.272
mib	mind bomb	0.262
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.262
sox4b	SRY-box containing gene 4b	0.259
vent	ventral expressed homeobox	0.252
spry4	sprouty (Drosophila) homolog 4	0.238
pkd2	polycystic kidney disease 2	0.231
cdx4	caudal type homeo box transcription factor 4	0.225
wnt5b	wingless-type MMTV integration site family, member 5b	0.214
sox3	SRY-box containing gene 3	0.208	Zebrafish
sulf1	sulfatase 1	0.199
fgf10a	fibroblast growth factor 10a	0.196
oep	one-eyed pinhead	0.191
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.185
hnf1ba	HNF1 homeobox Ba	0.184
gata2a	GATA-binding protein 2a	0.180	Zebrafish
mmp2	matrix metalloproteinase 2	0.178
dld	deltaD	0.169
igf1rb	insulin-like growth factor 1b receptor	0.168
nkx2.5	NK2 transcription factor related 5	0.159
evx1	even-skipped homeobox 1	0.156
tfap2a	transcription factor AP-2 alpha	0.152
ndr1	nodal-related 1	0.149
axin1	axin 1	0.147
etv2	ets variant gene 2	0.137
notch3	notch homolog 3	0.137
tbx2a	T-box gene 2a	0.134	Zebrafish
myod1	myogenic differentiation 1	0.132
runx2b	runt-related transcription factor 2b	0.132
her7	hairy and enhancer of split related-7	0.128
jag2	jagged 2	0.125
eomesa	eomesodermin homolog a	0.125	Zebrafish
kdrl	kinase insert domain receptor like	0.124
six4b	sine oculis homeobox homolog 4b	0.122
tbx16	T-box gene 16	0.117	Zebrafish
gsc	goosecoid	0.115
zic2a	zic family member 2 (odd-paired homolog, Drosophila), a	0.111
sox17	SRY-box containing gene 17	0.107	Zebrafish
ttna	titin a	0.107
fgf8a	fibroblast growth factor 8 a	0.105
dlx3b	distal-less homeobox gene 3b	0.105
foxg1a	forkhead box G1a	0.100
osr1	odd-skipped related 1 (Drosophila)	0.100
foxa3	forkhead box A3	0.100
fzd10	frizzled homolog 10	0.099
dzip1	DAZ interacting protein 1	0.099
wnt3	wingless-type MMTV integration site family, member 3	0.095
wnt11	wingless-type MMTV integration site family, member 11	0.095
wls	wntless homolog (Drosophila)	0.094
hoxa11a	homeo box A11a	0.091
ntla	no tail a	0.090	Zebrafish
foxa1	forkhead box A1	0.089
klf4	Kruppel-like factor 4	0.088
wnt11r	wingless-type MMTV integration site family, member 11, related	0.087
lfng	lunatic fringe homolog	0.084
znf503	zinc finger protein 503	0.084
otx2	orthodenticle homolog 2	0.082
cdh1	cadherin 1, epithelial	0.080
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.079
gata4	GATA-binding protein 4	0.077
si:ch211-235f6.2	si:ch211-235f6.2	0.076
wnt4a	wingless-type MMTV integration site family, member 4a	0.070
her1	hairy-related 1	0.068
snai1b	snail homolog 1b (Drosophila)	0.068
foxi1	forkhead box I1	0.068
foxn4	forkhead box N4	0.067
dlx2a	distal-less homeobox gene 2a	0.066
emx1	empty spiracles homeobox 1	0.066
neo1	neogenin 1	0.066
hmx3	homeo box (H6 family) 3	0.064
sox1a	SRY-box containing gene 1a	0.062	Zebrafish
rarga	retinoic acid receptor gamma a	0.062
irx5a	iroquois homeobox protein 5a	0.062
wnt9a	wingless-type MMTV integration site family, member 9A	0.059
fgf3	fibroblast growth factor 3	0.057
fzd7a	frizzled homolog 7a	0.055
sox32	SRY-box containing gene 32	0.055
fzd8a	frizzled homolog 8a	0.054
msxc	muscle segment homeobox C	0.054
shhb	sonic hedgehog b	0.053	Fly
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.051
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.051
tbx2b	T-box 2b	0.050	Zebrafish
lhx1a	LIM homeobox 1a	0.050
pax6a	paired box gene 6a	0.050
ptch1	patched 1	0.049
arx	aristaless related homeobox	0.049
igfbp3	insulin-like growth factor binding protein 3	0.049
slit1b	slit homolog 1b (Drosophila)	0.048	Zebrafish
znf703	zinc finger protein 703	0.048
myl7	myosin, light polypeptide 7, regulatory	0.047
rspo3	R-spondin 3 homolog (Xenopus laevis)	0.047
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.046
aplnrb	apelin receptor b	0.045
vasa	vasa homolog	0.045
tbpl2	TATA box binding protein like 2	0.045
ptch2	patched 2	0.045
boc	brother of CDO	0.044
edn1	endothelin 1	0.044
wnt8b	wingless-type MMTV integration site family, member 8b	0.044
bmp2a	bone morphogenetic protein 2a	0.043
otx1a	orthodenticle homolog 1a	0.043
vax1	ventral anterior homeobox 1	0.043
dlx1a	distal-less homeobox gene 1a	0.041
slc6a8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	0.041
wnt7ba	wingless-type MMTV integration site family, member 7Ba	0.041
mespa	mesoderm posterior a	0.040	Mouse
bon	bonnie and clyde	0.040
rx3	retinal homeobox gene 3	0.040
prdm1a	PR domain containing 1a, with ZNF domain	0.039
vcanb	versican b	0.039
foxd3	forkhead box D3	0.039
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.039
klf2a	Kruppel-like factor 2a	0.039
pbx4	pre-B-cell leukemia transcription factor 4	0.039
lhx3	LIM homeobox 3	0.038
fezf2	FEZ family zinc finger 2	0.038
hhex	hematopoietically expressed homeobox	0.037
fli1a	friend leukemia integration 1a	0.037
slit3	slit (Drosophila) homolog 3	0.037	Zebrafish
vax2	ventral anterior homeobox 2	0.036
her5	hairy-related 5	0.036
hoxa13a	homeo box A13a	0.036
irx3a	iroquois homeobox protein 3a	0.035
sox19b	SRY-box containing gene 19b	0.035	Zebrafish
waca	WW domain containing adaptor with coiled-coil a	0.035
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.035
cdh5	cadherin 5	0.034
drl	draculin	0.034
rest	RE1-silencing transcription factor	0.034
mef2ca	myocyte enhancer factor 2ca	0.034
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.033
hand2	heart and neural crest derivatives expressed transcript 2	0.033	Mouse
tcf12	transcription factor 12	0.033
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.033
robo1	roundabout homolog 1	0.032
zic5	zic family member 5 (odd-paired homolog, Drosophila)	0.031
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.031
tp63	tumor protein p63	0.031
vangl2	vang-like 2 (van gogh, Drosophila)	0.030
six4a	sine oculis homeobox homolog 4a	0.030
map2k4a	mitogen-activated protein kinase kinase 4a	0.030
isl2a	islet2a	0.029
col2a1a	collagen type II, alpha-1a	0.028
mos	v-mos Moloney murine sarcoma viral oncogene homolog	0.028
msxb	muscle segment homeobox B	0.028
ifnphi1	interferon phi 1	0.028
foxp2	forkhead box P2	0.028
osr2	odd-skipped related 2 (Drosophila)	0.028
arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.027
notch1b	notch homolog 1b	0.027	Rat
igf1ra	insulin-like growth factor 1a receptor	0.027
gli3	GLI-Kruppel family member GLI3	0.027
hmgcrb	3-hydroxy-3-methylglutaryl-Coenzyme A reductase b	0.026
gpc4	glypican 4	0.026
fgf17	fibroblast growth factor 17	0.026
nrp1a	neuropilin 1a	0.026
sox9a	SRY-box containing gene 9a	0.026	Zebrafish
wnt10a	wingless-type MMTV integration site family, member 10a	0.025
nppa	natriuretic peptide precursor A	0.025
foxd5	forkhead box D5	0.025
robo4	roundabout homolog 4	0.025	Zebrafish
thsd7a	thrombospondin, type I, domain containing 7A	0.025
tbx6	T-box gene 6	0.024	Zebrafish
gja3	gap junction protein, alpha 3	0.024
dharma	dharma	0.024
tmem88a	transmembrane protein 88 a	0.024
chrm2a	cholinergic receptor, muscarinic 2a	0.023
prrx1a	paired related homeobox 1a	0.023
egr1	early growth response 1	0.023
gro2	groucho 2	0.022
dla	deltaA	0.022
zic1	zic family member 1 (odd-paired homolog, Drosophila)	0.022
dvl3	dishevelled, dsh homolog 3 (Drosophila)	0.022	Fly
barhl2	BarH-like 2	0.021
unc5b	unc-5 homolog B (C. elegans)	0.021
jag1b	jagged 1b	0.021
zgc:66100	zgc:66100	0.021
nr2f1a	nuclear receptor subfamily 2, group F, member 1a	0.021
aplnra	apelin receptor a	0.021
cftr	cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)	0.021
ihha	Indian hedgehog homolog a	0.021	Fly
lmo2	LIM domain only 2 (rhombotin-like 1)	0.020
foxp1b	forkhead box P1b	0.020
nrg2a	neuregulin 2a	0.020
si:ch211-212m21.5	si:ch211-212m21.5	0.020
nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.020
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.019
pacsin3	protein kinase C and casein kinase substrate in neurons 3	0.019
krt4	keratin 4	0.019
ephb4b	eph receptor B4b	0.019
sall4	sal-like 4 (Drosophila)	0.019
wt1a	wilms tumor 1a	0.019
fzd8b	frizzled homolog 8b	0.019
ebf3	early B-cell factor 3	0.018
lama4	laminin, alpha 4	0.018
dusp6	dual specificity phosphatase 6	0.018
lhx2b	LIM homeobox 2b	0.018
plagl2	pleiomorphic adenoma gene-like 2	0.018
ctsk	cathepsin K	0.018
foxh1	forkhead box H1	0.018	Mouse
cd99l2	CD99 antigen-like 2	0.018
foxa2	forkhead box A2	0.018
efnb1	ephrin B1	0.018
smad9	MAD homolog 9 (Drosophila)	0.018
wnt8a	wingless-type MMTV integration site family, member 8a	0.018
hoxa9a	homeo box A9a	0.018
ptprfb	protein tyrosine phosphatase, receptor type, f, b	0.018
mesp2	mesoderm posterior 2 homolog (mouse)	0.018
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.017
fzd5	frizzled homolog 5	0.017
sp5l	Sp5 transcription factor-like	0.017
neurod4	neurogenic differentiation 4	0.017
irx1b	iroquois homeobox protein 1, b	0.017
cdh23	cadherin-like 23	0.017
gng13a	guanine nucleotide binding protein (G protein), gamma 13a	0.017
fgfr2	fibroblast growth factor receptor 2	0.017
otx1b	orthodenticle homolog 1b	0.017
stau2	staufen, RNA binding protein, homolog 2 (Drosophila)	0.017
alcama	activated leukocyte cell adhesion molecule a	0.017
gsna	gelsolin a	0.017
hdac4	histone deacetylase 4	0.017
flt4	fms-related tyrosine kinase 4	0.016
rhoua	ras homolog gene family, member Ua	0.016
tgfbi	transforming growth factor, beta-induced	0.016
cdk8	cyclin-dependent kinase 8	0.016
foxc1a	forkhead box C1a	0.016
prtga	protogenin homolog a (Gallus gallus)	0.016
tnnc1a	troponin C type 1a (slow)	0.016
nog2	noggin 2	0.016
flt1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.016
six2a	sine oculis-related homeobox 2a	0.016
rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.016
tmem2	transmembrane protein 2	0.016
wnt9b	wingless-type MMTV integration site family, member 9B	0.015
fgfr1a	fibroblast growth factor receptor 1a	0.015
fgf4	fibroblast growth factor 4	0.015
atp1a2a	ATPase, Na+/K+ transporting, alpha 2a polypeptide	0.015
myf5	myogenic factor 5	0.015
her11	hairy-related 11	0.015
mapk3	mitogen-activated protein kinase 3	0.015
twist1a	twist1a	0.015
meis3	myeloid ecotropic viral integration site 3	0.015
barx1	BarH-like homeobox 1	0.015
apc	adenomatosis polyposis coli	0.015
fgfrl1b	fibroblast growth factor receptor-like 1b	0.015
prox1	prospero-related homeobox gene 1	0.014
dlx4b	distal-less homeobox gene 4b	0.014
apoa4	apolipoprotein A-IV	0.014
mespb	mesoderm posterior b	0.014	Mouse
msgn1	mesogenin 1	0.014
tnnt2a	troponin T2a, cardiac	0.014
twist3	twist3	0.014
dkk1b	dickkopf 1b	0.014
pea3	ETS-domain transcription factor pea3	0.014
smad3b	MAD, mothers against decapentaplegic homolog 3b (Drosophila)	0.014
per3	period homolog 3 (Drosophila)	0.014
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.014
hlxb9la	homeo box HB9 like a	0.014
prickle1a	prickle-like 1 (Drosophila) a	0.013
nr2f2	nuclear receptor subfamily 2, group F, member 2	0.013
mib2	mind bomb 2	0.013
nkd2	naked cuticle homolog 2 and naked 2a	0.013
tie1	endothelium-specific receptor tyrosine kinase 1	0.013
vcana	versican a	0.013
ihhb	Indian hedgehog homolog b	0.013	Fly
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.013
rbm24a	RNA binding motif protein 24a	0.013
mmp14a	matrix metalloproteinase 14a (membrane-inserted)	0.013
nanos3	nanos homolog 3	0.013
furina	furin (paired basic amino acid cleaving enzyme) a	0.013
wif1	wnt inhibitory factor 1	0.013
dbx1a	developing brain homeobox 1a	0.013
auts2	autism susceptibility candidate 2	0.013
cx39.9	connexin 39.9	0.012
apob	apolipoprotein B	0.012
pax6b	paired box gene 6b	0.012
im:7137555	im:7137555	0.012
dmrta2	doublesex and mab-3 related transcription factor like family A2	0.012
npy8ar	neuropeptide Y receptor Y8a	0.012
ism1	isthmin 1	0.012
rgma	RGM domain family, member A	0.012
gmds	GDP-mannose 4,6-dehydratase	0.012
six3b	sine oculis homeobox homolog 3b	0.012
notch2	notch homolog 2	0.012
hbae3	hemoglobin alpha embryonic-3	0.012
trim3a	tripartite motif-containing 3a	0.012
pth2	parathyroid hormone 2	0.012
dcc	deleted in colorectal carcinoma	0.012
nkx2.2a	NK2 transcription factor related 2a	0.012
nkx2.1b	NK2 homeobox 1b	0.012
six3a	sine oculis homeobox homolog 3a	0.011
nog1	noggin 1	0.011
zgc:158603	zgc:158603	0.011
hlxb9lb	homeo box HB9 like b	0.011
hoxc8a	homeo box C8a	0.011
hspb7	heat shock protein family, alpha-crystallin-related, b7	0.011
col8a1a	collagen, type VIII, alpha 1a	0.011
ckap5	cytoskeleton associated protein 5	0.011
runx2a	runt-related transcription factor 2a	0.011
lims1	LIM and senescent cell antigen-like domains 1	0.011
og9x	OG9 homeobox gene	0.011
slit1a	slit homolog 1a (Drosophila)	0.011	Zebrafish
otpb	orthopedia homolog b	0.011
h1m	linker histone H1M	0.011
dvl2	dishevelled, dsh homolog 2 (Drosophila)	0.011	Fly
tll1	tolloid-like 1	0.011
pcdh18a	protocadherin 18a	0.011
pdx1	pancreatic and duodenal homeobox 1	0.011
xylt1	xylosyltransferase 1	0.011
kcnn1	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1	0.011
prox1b	prospero-related homeobox gene 1b	0.011
LOC566708	FL cytokine receptor-like	0.011
slc25a37	solute carrier family 25, member 37	0.011
fbln1	fibulin 1	0.011
zeb2a	zinc finger E-box binding homeobox 2a	0.011
gli1	GLI-Kruppel family member 1	0.011	Fly
rargb	retinoic acid receptor, gamma b	0.010
ins	preproinsulin	0.010
eya4	eyes absent homolog 4 (Drosophila)	0.010
gng2	guanine nucleotide binding protein (G protein), gamma 2	0.010
rarab	retinoic acid receptor, alpha b	0.010
rbpja	recombination signal binding protein for immunoglobulin kappa J region a	0.010	Mouse
ddx26b	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	0.010
vdra	vitamin D receptor a	0.010
has3	hyaluronan synthase 3	0.010
emx3	empty spiracles homeobox 3	0.010
slit2	slit (Drosophila) homolog 2	0.010