The network for 'lymphocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lymphocyte differentiation

The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.

Homo sapiens
Name Description Probability Func Analog Organism
LCK lymphocyte-specific protein tyrosine kinase 0.998
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.948
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.810
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.810
EGFR epidermal growth factor receptor 0.802
B2M beta-2-microglobulin 0.757
LAT linker for activation of T cells 0.741
RUNX1 runt-related transcription factor 1 0.690
HLA-G major histocompatibility complex, class I, G 0.687
NCOR2 nuclear receptor corepressor 2 0.677
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.623
PML promyelocytic leukemia 0.556
NOTCH1 notch 1 0.547
GRB2 growth factor receptor-bound protein 2 0.534
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.528
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.474
IL4R interleukin 4 receptor 0.463
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.461
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.454
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.441
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.438
HLA-A major histocompatibility complex, class I, A 0.395
HLA-B major histocompatibility complex, class I, B 0.394
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.384
PLCG1 phospholipase C, gamma 1 0.383
TGIF1 TGFB-induced factor homeobox 1 0.377
TAL1 T-cell acute lymphocytic leukemia 1 0.371
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.357
HLA-C major histocompatibility complex, class I, C 0.355
ESR1 estrogen receptor 1 0.355
ZFYVE9 zinc finger, FYVE domain containing 9 0.348
TP53 tumor protein p53 0.345
PPARA peroxisome proliferator-activated receptor alpha 0.333
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.282
HCK hemopoietic cell kinase 0.261
VAV1 vav 1 guanine nucleotide exchange factor 0.251
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.250
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.248
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.237
HLA-F major histocompatibility complex, class I, F 0.234
CDK6 cyclin-dependent kinase 6 0.206
BIRC3 baculoviral IAP repeat containing 3 0.201
CD247 CD247 molecule 0.200
NOTCH3 notch 3 0.199
NCOR1 nuclear receptor corepressor 1 0.190
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.181
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.179
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.174
FYN FYN oncogene related to SRC, FGR, YES 0.170
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.168
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.165
SLA Src-like-adaptor 0.157
HLA-E major histocompatibility complex, class I, E 0.154
CTBP2 C-terminal binding protein 2 0.150
IL2RG interleukin 2 receptor, gamma 0.149
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.148
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.145
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.144
CD86 CD86 molecule 0.143
CCR7 chemokine (C-C motif) receptor 7 0.142
ICAM1 intercellular adhesion molecule 1 0.139
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.137
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.131
SYK spleen tyrosine kinase 0.129
DLG1 discs, large homolog 1 (Drosophila) 0.124
GRB7 growth factor receptor-bound protein 7 0.123
APLF aprataxin and PNKP like factor 0.122
GHR growth hormone receptor 0.118
PILRA paired immunoglobin-like type 2 receptor alpha 0.107
CD80 CD80 molecule 0.103
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.101
IRF4 interferon regulatory factor 4 0.101
FOS FBJ murine osteosarcoma viral oncogene homolog 0.099
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.098
CXCR4 chemokine (C-X-C motif) receptor 4 0.097
RUNX3 runt-related transcription factor 3 0.097
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.097
SMAD2 SMAD family member 2 0.095
CTBP1 C-terminal binding protein 1 0.092
RXRA retinoid X receptor, alpha 0.091
BMPR1A bone morphogenetic protein receptor, type IA 0.086
HIPK2 homeodomain interacting protein kinase 2 0.083
TCF12 transcription factor 12 0.082
CD3D CD3d molecule, delta (CD3-TCR complex) 0.081
IL2RB interleukin 2 receptor, beta 0.081
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.080
SOCS3 suppressor of cytokine signaling 3 0.079
PTPRC protein tyrosine phosphatase, receptor type, C 0.079
IL4 interleukin 4 0.077
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.075
CD8A CD8a molecule 0.074
BID BH3 interacting domain death agonist 0.074
ITK IL2-inducible T-cell kinase 0.073
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.071
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.070
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.070
EP300 E1A binding protein p300 0.068
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.066
BCL2L1 BCL2-like 1 0.065
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.064
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cmyb transcription factor cmyb 0.964
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.719
bmp2b bone morphogenetic protein 2b 0.664
rag1 recombination activating gene 1 0.519
tp53 tumor protein p53 0.495
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.445
cdx4 caudal type homeo box transcription factor 4 0.412
bcl2 B-cell leukemia/lymphoma 2 0.394
lcp1 lymphocyte cytosolic plastin 1 0.358
trim33 tripartite motif-containing 33 0.329
runx3 runt-related transcription factor 3 0.317
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.293
bmper BMP binding endothelial regulator 0.289
il7r interleukin 7 receptor 0.286
flh floating head 0.259
slc30a7 solute carrier family 30 (zinc transporter), member 7 0.231
ccnd1 cyclin D1 0.225
gata1a GATA binding protein 1a 0.224
chd chordin 0.203
lef1 lymphocyte enhancer binding factor 1 0.200
tbx1 T-box 1 0.195
cobl cordon-bleu homolog (mouse) 0.192
ptger4a prostaglandin E receptor 4 (subtype EP4) a 0.188
spns2 spinster homolog 2 (Drosophila) 0.185
wnt8a wingless-type MMTV integration site family, member 8a 0.184
dlc deltaC 0.173
runx1 runt-related transcription factor 1 0.171
nrp2b neuropilin 2b 0.166
hoxa2b homeo box A2b 0.158
zgc:64115 zgc:64115 0.152
runx2a runt-related transcription factor 2a 0.149
coro1a coronin, actin binding protein, 1A 0.136
fgf3 fibroblast growth factor 3 0.134
fzd5 frizzled homolog 5 0.124
kita kit receptor a 0.120
anxa11a annexin A11a 0.119
smoc2 secreted modular calcium binding protein 2 0.114
fgf4 fibroblast growth factor 4 0.112
mmp9 matrix metalloproteinase 9 0.111
rad21 RAD21 homolog (S. pombe) 0.100
id1 inhibitor of DNA binding 1 0.095
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.095
egr2b early growth response 2b 0.095
rest RE1-silencing transcription factor 0.082
cd247l CD247 antigen like 0.082
ncor1 nuclear receptor co-repressor 1 0.081
tgfb3 transforming growth factor, beta 3 0.078
rpl23a ribosomal protein L23a 0.077
dnmt4 DNA (cytosine-5-)-methyltransferase 4 0.076
pdlim3a PDZ and LIM domain 3a 0.075
shhb sonic hedgehog b 0.072
tal1 T-cell acute lymphocytic leukemia 1 0.071
pax5 paired box gene 5 0.070
elk4 ELK4, ETS-domain protein 0.070
jag1b jagged 1b 0.069
dld deltaD 0.067
plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.065
pcdh18b protocadherin 18b 0.056
lfng lunatic fringe homolog 0.055
rag2 recombination activating gene 2 0.055
krt5 keratin 5 0.055
fzd8a frizzled homolog 8a 0.054
dntt deoxynucleotidyltransferase, terminal 0.054
gsc goosecoid 0.053
tp63 tumor protein p63 0.051
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.051
nme2b.1 non-metastatic cells 2b.1, protein (NM23B) expressed in 0.049
jak3 Janus kinase 3 (a protein tyrosine kinase, leukocyte) 0.047
cxcr4b chemokine (C-X-C motif), receptor 4b 0.044
gfi1.1 growth factor independent 1.1 0.043
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.043
myca myelocytomatosis oncogene a 0.043
znf703 zinc finger protein 703 0.042
tfe3a transcription factor binding to IGHM enhancer 3a 0.042
tbx2b T-box 2b 0.041
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.039
alk anaplastic lymphoma kinase (Ki-1) 0.036
sfrp5 secreted frizzled-related protein 5 0.036
eomesb eomesodermin homolog b 0.033
rarga retinoic acid receptor gamma a 0.032
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.031
pdcd2 programmed cell death 2 0.030
gata3 GATA-binding protein 3 0.029
msxb muscle segment homeobox B 0.028
baxa bcl2-associated X protein, a 0.028
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.028
rpl7a ribosomal protein L7a 0.027
mitfa microphthalmia-associated transcription factor a 0.027
tfec transcription factor EC 0.027
rhoab ras homolog gene family, member Ab 0.026
crip2 cysteine-rich protein 2 0.026
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.026
hlxb9la homeo box HB9 like a 0.026
fn1 fibronectin 1 0.024
dusp6 dual specificity phosphatase 6 0.024
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.024
zgc:123327 zgc:123327 0.024
zbtb4 zinc finger and BTB domain containing 4 0.024
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.024
capns1b calpain, small subunit 1 b 0.024
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Ikzf1 IKAROS family zinc finger 1 1.000
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 1.000
Pten phosphatase and tensin homolog 1.000
Igh immunoglobulin heavy chain complex 1.000
Gli2 GLI-Kruppel family member GLI2 1.000
Gli3 GLI-Kruppel family member GLI3 0.999
Cd19 CD19 antigen 0.997
Sox2 SRY-box containing gene 2 0.997
Pax2 paired box gene 2 0.997
Socs1 suppressor of cytokine signaling 1 0.996
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.996
Sox9 SRY-box containing gene 9 0.996
Fas Fas (TNF receptor superfamily member 6) 0.996
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.995
Fgfr2 fibroblast growth factor receptor 2 0.995
Trp53 transformation related protein 53 0.995
Tnf tumor necrosis factor 0.995
Runx1 runt related transcription factor 1 0.993
Stat3 signal transducer and activator of transcription 3 0.992
Bcl2 B-cell leukemia/lymphoma 2 0.992
Ctnnb1 catenin (cadherin associated protein), beta 1 0.992
Cd40 CD40 antigen 0.992
Tgfb1 transforming growth factor, beta 1 0.991
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.989
Jak2 Janus kinase 2 0.989
Lck lymphocyte protein tyrosine kinase 0.989
Fgfr1 fibroblast growth factor receptor 1 0.989
Lta lymphotoxin A 0.988
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.988
Ntf3 neurotrophin 3 0.986
Icos inducible T-cell co-stimulator 0.985
Shh sonic hedgehog 0.980
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.978
Emx1 empty spiracles homolog 1 (Drosophila) 0.977
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.973
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.973
Nf1 neurofibromatosis 1 0.968
Tcf3 transcription factor 3 0.968
Ptprc protein tyrosine phosphatase, receptor type, C 0.959
Zeb1 zinc finger E-box binding homeobox 1 0.959
Notch1 Notch gene homolog 1 (Drosophila) 0.959
Ptf1a pancreas specific transcription factor, 1a 0.958
Smad4 MAD homolog 4 (Drosophila) 0.957
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.956
Bmi1 Bmi1 polycomb ring finger oncogene 0.956
Rnf2 ring finger protein 2 0.955
Jag1 jagged 1 0.952
Hes1 hairy and enhancer of split 1 (Drosophila) 0.950
Foxc1 forkhead box C1 0.947
Hoxa1 homeobox A1 0.947
Pax6 paired box gene 6 0.945
Dll1 delta-like 1 (Drosophila) 0.944
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.942
Lat linker for activation of T cells 0.939
Hic1 hypermethylated in cancer 1 0.938
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.936
Hoxd13 homeobox D13 0.931
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.930
Batf basic leucine zipper transcription factor, ATF-like 0.929
Rb1 retinoblastoma 1 0.929
Ltb lymphotoxin B 0.929
Eya1 eyes absent 1 homolog (Drosophila) 0.928
Cd22 CD22 antigen 0.927
Sfpi1 SFFV proviral integration 1 0.926
Irf8 interferon regulatory factor 8 0.926
Efnb2 ephrin B2 0.919
Rarg retinoic acid receptor, gamma 0.919
Csf1 colony stimulating factor 1 (macrophage) 0.918
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.915
Apc adenomatosis polyposis coli 0.915
Pbx1 pre B-cell leukemia transcription factor 1 0.914
Irf4 interferon regulatory factor 4 0.913
Ccr6 chemokine (C-C motif) receptor 6 0.911
Il2rb interleukin 2 receptor, beta chain 0.907
Bmp4 bone morphogenetic protein 4 0.906
Irf5 interferon regulatory factor 5 0.906
Fzd8 frizzled homolog 8 (Drosophila) 0.906
Ar androgen receptor 0.905
Vangl2 vang-like 2 (van gogh, Drosophila) 0.894
Bcl6 B-cell leukemia/lymphoma 6 0.891
Il2 interleukin 2 0.887
Foxp3 forkhead box P3 0.884
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.883
Pdcd1 programmed cell death 1 0.881
Tcrb T-cell receptor beta chain 0.879
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.878
Gata3 GATA binding protein 3 0.873
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.871
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.865
Rybp RING1 and YY1 binding protein 0.864
Onecut1 one cut domain, family member 1 0.863
Esr1 estrogen receptor 1 (alpha) 0.857
Twist2 twist homolog 2 (Drosophila) 0.855
Axl AXL receptor tyrosine kinase 0.851
Hoxa11 homeobox A11 0.851
Ccl2 chemokine (C-C motif) ligand 2 0.850
Fyn Fyn proto-oncogene 0.849
Lepr leptin receptor 0.846
H2-Aa histocompatibility 2, class II antigen A, alpha 0.842
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.839
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Da RT1 class II, locus Da 0.364
RT1-Ba RT1 class II, locus Ba 0.254
Cd247 Cd247 molecule 0.134
Cd37 CD37 molecule 0.126
Tcrb T-cell receptor beta chain 0.072
RT1-Db1 RT1 class II, locus Db1 0.068
Cd2 Cd2 molecule 0.067
Igh-6 immunoglobulin heavy chain 6 0.033
Cd5 Cd5 molecule 0.032
Cfp complement factor properdin 0.030
Stat4 signal transducer and activator of transcription 4 0.029
Map4k1 mitogen activated protein kinase kinase kinase kinase 1 0.028
Gpsm3 G-protein signaling modulator 3 (AGS3-like, C. elegans) 0.025
Bin2 bridging integrator 2 0.025
Il2rb interleukin 2 receptor, beta 0.021
Lyz2 lysozyme 2 0.019
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.017
Laptm5 lysosomal protein transmembrane 5 0.016
Stat6 signal transducer and activator of transcription 6 0.015
Cd3g CD3 molecule, gamma 0.015
Plcg2 phospholipase C, gamma 2 0.015
Tgfbr2 transforming growth factor, beta receptor II 0.014
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.014
RT1-DMb RT1 class II, locus DMb 0.013
Cd4 Cd4 molecule 0.013
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.012
Ccr5 chemokine (C-C motif) receptor 5 0.012
RT1-Bb RT1 class II, locus Bb 0.012
Creb1 cAMP responsive element binding protein 1 0.012
Arhgap4 Rho GTPase activating protein 4 0.012
Ccl5 chemokine (C-C motif) ligand 5 0.011
Cd3e CD3 molecule, epsilon 0.011
Lilrb3l leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like 0.011
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.011
Spn sialophorin 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism