The network for 'cellular response to mechanical stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to mechanical stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.

Homo sapiens
Name Description Probability Func Analog Organism
BCL2 B-cell CLL/lymphoma 2 0.999
CFLAR CASP8 and FADD-like apoptosis regulator 0.998
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.997
BCL2L1 BCL2-like 1 0.996
TRAF1 TNF receptor-associated factor 1 0.990
MAPK14 mitogen-activated protein kinase 14 0.988
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.986
FADD Fas (TNFRSF6)-associated via death domain 0.983
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.975
MYD88 myeloid differentiation primary response gene (88) 0.971
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.915
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.913
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.893
XIAP X-linked inhibitor of apoptosis 0.860
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.859
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.822
FAS Fas (TNF receptor superfamily, member 6) 0.759
IL1R1 interleukin 1 receptor, type I 0.758
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.713
BCL3 B-cell CLL/lymphoma 3 0.687
APAF1 apoptotic peptidase activating factor 1 0.664
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.653
ATF2 activating transcription factor 2 0.643
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.643
MAPK8 mitogen-activated protein kinase 8 0.636
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.588
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.508
BID BH3 interacting domain death agonist 0.502
BMPR1A bone morphogenetic protein receptor, type IA 0.458
PLAUR plasminogen activator, urokinase receptor 0.429
GADD45A growth arrest and DNA-damage-inducible, alpha 0.428
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.402
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.379
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.376
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.362
TP53 tumor protein p53 0.350
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.345
GBP2 guanylate binding protein 2, interferon-inducible 0.340
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.337
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.328
TRAF5 TNF receptor-associated factor 5 0.324
CD40 CD40 molecule, TNF receptor superfamily member 5 0.321
BAK1 BCL2-antagonist/killer 1 0.316
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0.303
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.302
NLRC4 NLR family, CARD domain containing 4 0.297
IRF1 interferon regulatory factor 1 0.295
STAT2 signal transducer and activator of transcription 2, 113kDa 0.294
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.288
PLAU plasminogen activator, urokinase 0.283
TRADD TNFRSF1A-associated via death domain 0.270
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.269
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.267
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.256
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.250
NOSTRIN nitric oxide synthase trafficker 0.245
PRKD2 protein kinase D2 0.244
HSPB8 heat shock 22kDa protein 8 0.242
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.241
LRDD leucine-rich repeats and death domain containing 0.236
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.214
ARRB2 arrestin, beta 2 0.212
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.204
TLR2 toll-like receptor 2 0.201
LRRK2 leucine-rich repeat kinase 2 0.199
SOCS3 suppressor of cytokine signaling 3 0.199
KCNIP2 Kv channel interacting protein 2 0.194
BAX BCL2-associated X protein 0.184
IL8 interleukin 8 0.179
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.178
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.170
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.159
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.159
MAP2K4 mitogen-activated protein kinase kinase 4 0.156
MAPK9 mitogen-activated protein kinase 9 0.155
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.154
DUSP1 dual specificity phosphatase 1 0.151
C9orf89 chromosome 9 open reading frame 89 0.151
LY96 lymphocyte antigen 96 0.148
JUN jun proto-oncogene 0.147
CHUK conserved helix-loop-helix ubiquitous kinase 0.138
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.136
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.132
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.125
BAD BCL2-associated agonist of cell death 0.121
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.119
TLR4 toll-like receptor 4 0.118
FAM101B family with sequence similarity 101, member B 0.118
TRAF2 TNF receptor-associated factor 2 0.115
VAC14 Vac14 homolog (S. cerevisiae) 0.108
FLNA filamin A, alpha 0.106
HSPB1 heat shock 27kDa protein 1 0.105
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.100
ICAM1 intercellular adhesion molecule 1 0.099
HSPA1B heat shock 70kDa protein 1B 0.093
CRYAB crystallin, alpha B 0.092
AR androgen receptor 0.091
KAT2B K(lysine) acetyltransferase 2B 0.090
PIAS4 protein inhibitor of activated STAT, 4 0.084
TRIM21 tripartite motif containing 21 0.083
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rel Relish 0.314
18w 18 wheeler 0.259
egr eiger 0.143
ird5 immune response deficient 5 0.128
BG4 CG12297 gene product from transcript CG12297-RA 0.127
cathD CG1548 gene product from transcript CG1548-RA 0.106
Cat Catalase 0.083
plx pollux 0.082
amos absent MD neurons and olfactory sensilla 0.075
fz2 frizzled 2 0.069
cv-2 crossveinless 2 0.057
Irk3 Inwardly rectifying potassium channel 3 0.056
Irk2 Inwardly rectifying potassium channel 2 0.056
imd immune deficiency 0.052
Atg9 Autophagy-specific gene 9 0.051
S6k RPS6-p70-protein kinase 0.048
Spn27A Serpin 27A 0.045
crp cropped 0.045
Nipped-B CG17704 gene product from transcript CG17704-RI 0.043
ec echinus 0.042
zetaTry zetaTrypsin 0.042
Dredd Death related ced-3/Nedd2-like protein 0.042
bnl branchless 0.041
Pkc98E Protein C kinase 98E 0.041
Pink1 PTEN-induced putative kinase 1 0.040
Sox14 Sox box protein 14 0.039
na narrow abdomen 0.038
CG4168 CG4168 gene product from transcript CG4168-RA 0.037
whd withered 0.037
Sap-r Saposin-related 0.036
B-H1 BarH1 0.035
ST6Gal Sialyltransferase 0.034
PRL-1 CG4993 gene product from transcript CG4993-RB 0.034
dan distal antenna 0.033
Cyp6g1 CG8453 gene product from transcript CG8453-RA 0.033
Myd88 CG2078 gene product from transcript CG2078-RA 0.033
tsh teashirt 0.032
NPFR1 neuropeptide F receptor 0.032
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.031
th thread 0.030
CG42369 CG42369 gene product from transcript CG42369-RA 0.028
Eaat1 Excitatory amino acid transporter 1 0.027
Ilp6 Insulin-like peptide 6 0.027
PGRP-LF Peptidoglycan recognition protein LF 0.027
shd shade 0.026
disco disconnected 0.026
Thor CG8846 gene product from transcript CG8846-RA 0.025
Ubqn Ubiquilin 0.025
ple pale 0.024
CycJ Cyclin J 0.023
Wnt2 Wnt oncogene analog 2 0.023
nub nubbin 0.023
Cyp12d1-p CG30489 gene product from transcript CG30489-RA 0.022
fng fringe 0.022
Ppat-Dpck Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase 0.021
l(3)82Fd CG32464 gene product from transcript CG32464-RR 0.021
Poxn Pox neuro 0.021
Sp1 CG1343 gene product from transcript CG1343-RB 0.021
pxb CG33207 gene product from transcript CG33207-RB 0.020
NLaz Neural Lazarillo 0.020
CG5195 CG5195 gene product from transcript CG5195-RA 0.020
Toll-7 CG8595 gene product from transcript CG8595-RA 0.020
insc inscuteable 0.020
ci cubitus interruptus 0.020
foxo forkhead box, sub-group O 0.020
ro rough 0.020
fred friend of echinoid 0.020
CG5890 CG5890 gene product from transcript CG5890-RB 0.019
Tollo CG6890 gene product from transcript CG6890-RA 0.019
Cp1 Cysteine proteinase-1 0.019
PGRP-LC Peptidoglycan recognition protein LC 0.019
CG3759 CG3759 gene product from transcript CG3759-RB 0.019
nab CG33545 gene product from transcript CG33545-RC 0.019
CG12187 CG12187 gene product from transcript CG12187-RA 0.019
IP3K1 Inositol 1,4,5-triphosphate kinase 1 0.018
Pfrx 6-phosphofructo-2-kinase 0.018
Hnf4 Hepatocyte nuclear factor 4 0.018
GLaz Glial Lazarillo 0.018
rg rugose 0.018
noc no ocelli 0.018
CG13784 CG13784 gene product from transcript CG13784-RC 0.018
Toll-6 CG7250 gene product from transcript CG7250-RA 0.018
Ace Acetylcholine esterase 0.018
Syn2 Syntrophin-like 2 0.018
Doa Darkener of apricot 0.018
DJ-1alpha CG6646 gene product from transcript CG6646-RA 0.017
rpr reaper 0.017
dys dysfusion 0.017
Hsp68 Heat shock protein 68 0.017
Tango2 Transport and Golgi organization 2 0.017
CREG Cellular Repressor of E1A-stimulated Genes 0.017
vvl ventral veins lacking 0.017
CG14545 CG14545 gene product from transcript CG14545-RA 0.017
Rfx CG6312 gene product from transcript CG6312-RA 0.017
CG3011 CG3011 gene product from transcript CG3011-RA 0.017
CG10200 CG10200 gene product from transcript CG10200-RB 0.016
CG3967 CG3967 gene product from transcript CG3967-RC 0.016
gfA giant fibre A 0.016
RpS28a Ribosomal protein S28a 0.016
kibra kibra ortholog 0.016
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Mus musculus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 0.553
Ctnnb1 catenin (cadherin associated protein), beta 1 0.277
Runx2 runt related transcription factor 2 0.271
Pax3 paired box gene 3 0.183
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.137
Pax6 paired box gene 6 0.107
Fas Fas (TNF receptor superfamily member 6) 0.088
Tnf tumor necrosis factor 0.081
Col3a1 collagen, type III, alpha 1 0.074
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.072
Neurod1 neurogenic differentiation 1 0.064
Col1a2 collagen, type I, alpha 2 0.063
Ptgs2 prostaglandin-endoperoxide synthase 2 0.061
Lmna lamin A 0.058
Col6a2 collagen, type VI, alpha 2 0.046
Ren1 renin 1 structural 0.044
Vegfa vascular endothelial growth factor A 0.042
Otx2 orthodenticle homolog 2 (Drosophila) 0.041
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.039
Shh sonic hedgehog 0.038
Nos2 nitric oxide synthase 2, inducible 0.038
Gdnf glial cell line derived neurotrophic factor 0.037
Pten phosphatase and tensin homolog 0.033
Col5a2 collagen, type V, alpha 2 0.033
Fgfr2 fibroblast growth factor receptor 2 0.032
Meox2 mesenchyme homeobox 2 0.030
Il6 interleukin 6 0.029
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.026
Col6a1 collagen, type VI, alpha 1 0.025
Dlx6 distal-less homeobox 6 0.025
Tcfap2a transcription factor AP-2, alpha 0.024
Foxc2 forkhead box C2 0.024
Tlr4 toll-like receptor 4 0.023
Isl1 ISL1 transcription factor, LIM/homeodomain 0.022
Prrx1 paired related homeobox 1 0.021
Aplnr apelin receptor 0.021
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.021
Col6a3 collagen, type VI, alpha 3 0.020
Foxc1 forkhead box C1 0.020
Msx1 homeobox, msh-like 1 0.020
Lhx3 LIM homeobox protein 3 0.019
Apc adenomatosis polyposis coli 0.019
Gli3 GLI-Kruppel family member GLI3 0.018
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.018
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.018
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.017
Tgfb1 transforming growth factor, beta 1 0.017
Atoh7 atonal homolog 7 (Drosophila) 0.017
Smo smoothened homolog (Drosophila) 0.016
Mecom MDS1 and EVI1 complex locus 0.016
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.016
Lepr leptin receptor 0.016
Mmp9 matrix metallopeptidase 9 0.015
Prrx2 paired related homeobox 2 0.015
Hand1 heart and neural crest derivatives expressed transcript 1 0.015
Lyz2 lysozyme 2 0.015
Pou4f2 POU domain, class 4, transcription factor 2 0.014
Sparc secreted acidic cysteine rich glycoprotein 0.014
Il9r interleukin 9 receptor 0.014
She src homology 2 domain-containing transforming protein E 0.014
Fgf8 fibroblast growth factor 8 0.014
Slc12a1 solute carrier family 12, member 1 0.014
Agtr1a angiotensin II receptor, type 1a 0.014
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.013
Trp53 transformation related protein 53 0.013
Plxnd1 plexin D1 0.012
Prph2 peripherin 2 0.012
Nos3 nitric oxide synthase 3, endothelial cell 0.012
Casp8 caspase 8 0.012
Cldn5 claudin 5 0.012
Cd44 CD44 antigen 0.011
Il10 interleukin 10 0.011
Btbd17 BTB (POZ) domain containing 17 0.011
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.011
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.011
Hand2 heart and neural crest derivatives expressed transcript 2 0.011
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.011
Col15a1 collagen, type XV, alpha 1 0.011
Adamts2 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 0.011
Mef2d myocyte enhancer factor 2D 0.011
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.010
Bgn biglycan 0.010
Col5a1 collagen, type V, alpha 1 0.010
Cd19 CD19 antigen 0.010
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.010
Fstl1 follistatin-like 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 0.396
Col10a1 collagen, type X, alpha 1 0.178
Inhba inhibin beta-A 0.170
Col3a1 collagen, type III, alpha 1 0.169
Col1a2 collagen, type I, alpha 2 0.158
Fgf16 fibroblast growth factor 16 0.153
LOC100362824 caveolin 2-like 0.150
Flt1 FMS-related tyrosine kinase 1 0.148
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.144
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.143
Hspb7 heat shock protein family, member 7 (cardiovascular) 0.128
Col4a2 collagen, type IV, alpha 2 0.114
Gja1 gap junction protein, alpha 1 0.110
Adrb1 adrenergic, beta-1-, receptor 0.109
Tcf21 transcription factor 21 0.105
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.099
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.094
Obscn obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.092
Ctsd cathepsin D 0.089
Sftpa1 surfactant protein A1 0.088
Egr1 early growth response 1 0.084
Vdac1 voltage-dependent anion channel 1 0.083
Ppard peroxisome proliferator-activated receptor delta 0.077
Gja5 gap junction protein, alpha 5 0.071
Apba1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.070
Litaf lipopolysaccharide-induced TNF factor 0.069
Col5a1 collagen, type V, alpha 1 0.068
Igfals insulin-like growth factor binding protein, acid labile subunit 0.068
C5ar1 complement component 5a receptor 1 0.067
Syt10 synaptotagmin X 0.067
Ahsg alpha-2-HS-glycoprotein 0.067
Cav2 caveolin 2 0.066
Ccl4 chemokine (C-C motif) ligand 4 0.064
Cabp1 calcium binding protein 1 0.064
Prss1 protease, serine, 1 (trypsin 1) 0.061
Sult1c3 sulfotransferase family, cytosolic, 1C, member 3 0.060
A2m alpha-2-macroglobulin 0.057
Fgf2 fibroblast growth factor 2 0.056
Il1a interleukin 1 alpha 0.056
Egr2 early growth response 2 0.055
Plcb2 phospholipase C, beta 2 0.055
Apoh apolipoprotein H (beta-2-glycoprotein I) 0.055
Kcnd3 potassium voltage-gated channel, Shal-related subfamily, member 3 0.054
Adora2a adenosine A2a receptor 0.054
Il6 interleukin 6 0.054
LOC687856 similar to Myeloid cell surface antigen CD33 precursor (Siglec-3) 0.052
Spink1 serine peptidase inhibitor, Kazal type 1 0.052
Pzp pregnancy-zone protein 0.051
Fos FBJ osteosarcoma oncogene 0.050
Vat1 vesicle amine transport protein 1 homolog (T californica) 0.050
Syngr2 synaptogyrin 2 0.049
Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.048
Cdh17 cadherin 17 0.048
Il1rl1 interleukin 1 receptor-like 1 0.048
Rara retinoic acid receptor, alpha 0.047
Aqp8 aquaporin 8 0.046
Vcan versican 0.046
Mbl1 mannose-binding lectin (protein A) 1 0.046
Postn periostin, osteoblast specific factor 0.046
Dab2 disabled homolog 2 (Drosophila) 0.046
Fndc1 fibronectin type III domain containing 1 0.045
Cfi complement factor I 0.045
Bgn biglycan 0.044
Nos3 nitric oxide synthase 3, endothelial cell 0.044
Ptprc protein tyrosine phosphatase, receptor type, C 0.043
Crhbp corticotropin releasing hormone binding protein 0.043
Eln elastin 0.042
Ednrb endothelin receptor type B 0.042
Lum lumican 0.042
Arc activity-regulated cytoskeleton-associated protein 0.041
Stat6 signal transducer and activator of transcription 6 0.041
Ier2 immediate early response 2 0.040
Aqp4 aquaporin 4 0.040
Fcgr1a Fc fragment of IgG, high affinity Ia, receptor (CD64) 0.040
Psp parotid secretory protein 0.039
Ngf nerve growth factor (beta polypeptide) 0.039
Wt1 Wilms tumor 1 0.038
Junb jun B proto-oncogene 0.038
Thbd thrombomodulin 0.038
Clic4 chloride intracellular channel 4 0.038
Col15a1 collagen, type XV, alpha 1 0.038
Ampd1 adenosine monophosphate deaminase 1 (isoform M) 0.037
Lepr leptin receptor 0.037
Cmklr1 chemokine-like receptor 1 0.037
Rab32 RAB32, member RAS oncogene family 0.037
F10 coagulation factor X 0.037
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.037
Cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.037
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.037
S1pr2 sphingosine-1-phosphate receptor 2 0.036
Myh6 myosin, heavy chain 6, cardiac muscle, alpha 0.036
Pbsn probasin 0.036
Tbxa2r thromboxane A2 receptor 0.036
Hbg1 hemoglobin, gamma A 0.036
Mmp12 matrix metallopeptidase 12 0.035
Agtr1a angiotensin II receptor, type 1a 0.035
Dusp6 dual specificity phosphatase 6 0.035
P2ry2 purinergic receptor P2Y, G-protein coupled, 2 0.035
Cspg4 chondroitin sulfate proteoglycan 4 0.034
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.034
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism