The network for 'negative regulation of cytoplasmic transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cytoplasmic transport

Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport.

Homo sapiens
Name Description Probability Func Analog Organism
GSK3B glycogen synthase kinase 3 beta 0.659
CREBBP CREB binding protein 0.630
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.475
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.463
AXIN1 axin 1 0.419
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.399
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.381
BTRC beta-transducin repeat containing 0.376
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.298
IGF1R insulin-like growth factor 1 receptor 0.292
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.276
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.270
SMAD7 SMAD family member 7 0.254
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.212
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.169
MMS22L MMS22-like, DNA repair protein 0.149
HIPK2 homeodomain interacting protein kinase 2 0.141
CHUK conserved helix-loop-helix ubiquitous kinase 0.137
ZNF260 zinc finger protein 260 0.130
FBXW11 F-box and WD repeat domain containing 11 0.116
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.112
TGFBR1 transforming growth factor, beta receptor 1 0.110
PAX3 paired box 3 0.101
CKAP5 cytoskeleton associated protein 5 0.096
PML promyelocytic leukemia 0.093
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.085
YAP1 Yes-associated protein 1 0.085
ACVR1B activin A receptor, type IB 0.081
SREBF2 sterol regulatory element binding transcription factor 2 0.081
POU3F2 POU class 3 homeobox 2 0.075
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.073
SKP1 S-phase kinase-associated protein 1 0.070
LZTS2 leucine zipper, putative tumor suppressor 2 0.069
POU5F1 POU class 5 homeobox 1 0.068
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.063
PARP14 poly (ADP-ribose) polymerase family, member 14 0.062
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.060
ERBB2IP erbb2 interacting protein 0.059
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.058
DTX3L deltex 3-like (Drosophila) 0.057
SMAD2 SMAD family member 2 0.057
NXF1 nuclear RNA export factor 1 0.052
ZNF585A zinc finger protein 585A 0.052
SP100 SP100 nuclear antigen 0.052
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.050
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.049
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.049
SOD1 superoxide dismutase 1, soluble 0.048
NEK9 NIMA (never in mitosis gene a)- related kinase 9 0.047
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.047
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.047
HIPK3 homeodomain interacting protein kinase 3 0.046
KPNB1 karyopherin (importin) beta 1 0.046
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.045
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.044
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.043
APC adenomatous polyposis coli 0.042
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.042
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.042
IRS1 insulin receptor substrate 1 0.041
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.040
FBXW7 F-box and WD repeat domain containing 7 0.040
MAPK14 mitogen-activated protein kinase 14 0.039
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.039
ZNF567 zinc finger protein 567 0.039
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 0.039
ZNF84 zinc finger protein 84 0.039
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.038
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.038
RANBP3 RAN binding protein 3 0.038
CASP8AP2 caspase 8 associated protein 2 0.038
C3orf15 chromosome 3 open reading frame 15 0.038
PROX1 prospero homeobox 1 0.036
PRDX1 peroxiredoxin 1 0.036
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 0.036
PRKCZ protein kinase C, zeta 0.035
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.035
IRS2 insulin receptor substrate 2 0.035
GRB10 growth factor receptor-bound protein 10 0.034
FOXD3 forkhead box D3 0.033
CUL1 cullin 1 0.031
RANBP2 RAN binding protein 2 0.031
GLI1 GLI family zinc finger 1 0.031
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 0.031
FBXO33 F-box protein 33 0.030
CDC34 cell division cycle 34 homolog (S. cerevisiae) 0.029
RARA retinoic acid receptor, alpha 0.029
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.028
SETD7 SET domain containing (lysine methyltransferase) 7 0.028
DCAF7 DDB1 and CUL4 associated factor 7 0.028
LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila) 0.028
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.028
FAS Fas (TNF receptor superfamily, member 6) 0.027
INSR insulin receptor 0.027
STX8 syntaxin 8 0.027
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.026
CSNK1E casein kinase 1, epsilon 0.026
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.026
MED24 mediator complex subunit 24 0.026
ENG endoglin 0.026
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
nf1a neurofibromin 1a 0.529
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.323
mad2l1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.248
cd63 Cd63 antigen 0.226
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.189
LOC100535549 cytoplasmic polyadenylation element-binding protein 4-like 0.179
zgc:101761 zgc:101761 0.178
actr1 ARP1 actin-related protein 1, centractin (yeast) 0.157
ptprf protein tyrosine phosphatase, receptor type, F 0.154
neo1 neogenin 1 0.154
fbn2b fibrillin 2b 0.152
LOC567452 G protein-coupled receptor kinase 5-like 0.151
wnt10a wingless-type MMTV integration site family, member 10a 0.148
thraa thyroid hormone receptor alpha a 0.142
kif5bb kinesin family member 5B, b 0.132
rarga retinoic acid receptor gamma a 0.129
ppp2r5d protein phosphatase 2, regulatory subunit B', delta 0.122
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.121
insrb insulin receptor b 0.114
cyp51 cytochrome P450, family 51 0.111
akt2 v-akt murine thymoma viral oncogene homolog 2 0.110
cdc20 cell division cycle 20 homolog 0.108
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.108
cltcb clathrin, heavy polypeptide b (Hc) 0.108
gdf6a growth differentiation factor 6a 0.107
zgc:92027 zgc:92027 0.104
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.103
epas1b endothelial PAS domain protein 1b 0.102
nf1b neurofibromin 1b 0.102
insra insulin receptor a 0.097
kdm5c lysine (K)-specific demethylase 5C 0.096
vgll4l vestigial like 4 like 0.094
vdra vitamin D receptor a 0.092
bmp1a bone morphogenetic protein 1a 0.091
ddx3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 0.091
igf1rb insulin-like growth factor 1b receptor 0.091
pdlim1 PDZ and LIM domain 1 (elfin) 0.090
psmd11b proteasome (prosome, macropain) 216S subunit, non-ATPase, 11b 0.089
cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.089
tll1 tolloid-like 1 0.086
akap12b A kinase (PRKA) anchor protein (gravin) 12b 0.085
kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.083
slc16a8 solute carrier family 16 (monocarboxylic acid transporters), member 8 0.083
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.082
ankrd6 ankyrin repeat domain 6 0.082
nuf2 NUF2, NDC80 kinetochore complex component, homolog 0.081
col27a1a collagen, type XXVII, alpha 1a 0.081
furinb furin (paired basic amino acid cleaving enzyme) b 0.080
LOC100000332 e3 ubiquitin-protein ligase RNF182-like 0.080
lef1 lymphocyte enhancer binding factor 1 0.076
frem2a Fras1 related extracellular matrix protein 2a 0.075
fgf20a fibroblast growth factor 20a 0.074
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.072
litaf lipopolysaccharide-induced TNF factor 0.072
LOC100004296 novel protein similar to murine T brachyury (T) 0.072
wu:fc23b05 wu:fc23b05 0.072
ext2 exostoses (multiple) 2 0.071
ptpra protein tyrosine phosphatase, receptor type, A 0.069
gstp1 glutathione S-transferase pi 0.068
gro2 groucho 2 0.067
tubg1 tubulin, gamma 1 0.065
im:7163520 im:7163520 0.065
mapk6 mitogen-activated protein kinase 6 0.065
plk1 polo-like kinase 1 (Drosophila) 0.064
cdh1 cadherin 1, epithelial 0.064
zgc:56576 zgc:56576 0.064
furina furin (paired basic amino acid cleaving enzyme) a 0.064
mcl1a myeloid cell leukemia sequence 1a 0.064
szl sizzled 0.063
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.062
zgc:73328 zgc:73328 0.062
itga3b integrin, alpha 3b 0.062
spry2 sprouty homolog 2 0.062
zgc:172136 zgc:172136 0.062
klhl11 kelch-like 11 (Drosophila) 0.061
usp4 ubiquitin specific protease 4 (proto-oncogene) 0.061
irx5a iroquois homeobox protein 5a 0.060
lsm8 LSM8 homolog, U6 small nuclear RNA associated 0.059
hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) 0.059
zgc:55307 zgc:55307 0.058
thrab thyroid hormone receptor alpha b 0.058
tsc22d1 TSC22 domain family, member 1 0.058
clic1 chloride intracellular channel 1 0.058
kif23 kinesin family member 23 0.058
sdf4 stromal cell derived factor 4 0.057
zgc:56530 zgc:56530 0.057
ldb1a LIM-domain binding factor 1a 0.056
optn optineurin 0.056
hmcn1 hemicentin 1 0.056
axin1 axin 1 0.055
elovl1b elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b 0.055
pim1 pim-1 oncogene 0.054
mmp15b matrix metallopeptidase 15b 0.054
kif11 kinesin family member 11 0.054
id:ibd1152 id:ibd1152 0.054
clasp2 cytoplasmic linker associated protein 2 0.053
ints6 integrator complex subunit 6 0.053
vps26bl vacuolar protein sorting 26 homolog B, like 0.053
ncoa2 nuclear receptor coactivator 2 0.052
npnt nephronectin 0.052
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
kis kismet 0.181
Akt1 CG4006 gene product from transcript CG4006-RA 0.049
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.031
chico CG5686 gene product from transcript CG5686-RB 0.018
Gap1 GTPase-activating protein 1 0.017
Zyx102EF CG32018 gene product from transcript CG32018-RA 0.014
Ras85D Ras oncogene at 85D 0.014
mub mushroom-body expressed 0.012
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.903
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.863
Ctnnb1 catenin (cadherin associated protein), beta 1 0.716
Bcl2 B-cell leukemia/lymphoma 2 0.605
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.520
Gbp2 guanylate binding protein 2 0.425
Rara retinoic acid receptor, alpha 0.404
Rxra retinoid X receptor alpha 0.313
Yap1 yes-associated protein 1 0.300
Bax BCL2-associated X protein 0.292
Casp1 caspase 1 0.230
Iigp1 interferon inducible GTPase 1 0.225
Axin1 axin 1 0.225
Apc adenomatosis polyposis coli 0.191
Gbp7 guanylate binding protein 7 0.179
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.169
Fgfr2 fibroblast growth factor receptor 2 0.165
Grb10 growth factor receptor bound protein 10 0.154
Fzd8 frizzled homolog 8 (Drosophila) 0.143
Il6st interleukin 6 signal transducer 0.141
Gli3 GLI-Kruppel family member GLI3 0.136
Irgm2 immunity-related GTPase family M member 2 0.129
Gbp3 guanylate binding protein 3 0.113
Igtp interferon gamma induced GTPase 0.102
Irgm1 immunity-related GTPase family M member 1 0.098
Pycard PYD and CARD domain containing 0.093
Aim2 absent in melanoma 2 0.093
Dlg2 discs, large homolog 2 (Drosophila) 0.093
Gopc golgi associated PDZ and coiled-coil motif containing 0.092
Usp18 ubiquitin specific peptidase 18 0.091
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.090
Gbp6 guanylate binding protein 6 0.087
Smad3 MAD homolog 3 (Drosophila) 0.084
Fgfr1 fibroblast growth factor receptor 1 0.082
Ifih1 interferon induced with helicase C domain 1 0.080
Wnt5a wingless-related MMTV integration site 5A 0.078
Thra thyroid hormone receptor alpha 0.075
Tgtp2 T-cell specific GTPase 2 0.075
Pbx1 pre B-cell leukemia transcription factor 1 0.074
Vps29 vacuolar protein sorting 29 (S. pombe) 0.074
Ifit2 interferon-induced protein with tetratricopeptide repeats 2 0.071
Vegfa vascular endothelial growth factor A 0.070
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.065
Casp12 caspase 12 0.064
Mndal myeloid nuclear differentiation antigen like 0.064
Ncoa3 nuclear receptor coactivator 3 0.064
Ret ret proto-oncogene 0.062
Ifi47 interferon gamma inducible protein 47 0.061
Mdm2 transformed mouse 3T3 cell double minute 2 0.058
Vhl von Hippel-Lindau tumor suppressor 0.057
Serpinb9 serine (or cysteine) peptidase inhibitor, clade B, member 9 0.054
Gbp10 guanylate-binding protein 10 0.052
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.051
Ghr growth hormone receptor 0.050
Ifit1 interferon-induced protein with tetratricopeptide repeats 1 0.049
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.048
Ikbkb inhibitor of kappaB kinase beta 0.048
Rarg retinoic acid receptor, gamma 0.048
Nmi N-myc (and STAT) interactor 0.046
Trp63 transformation related protein 63 0.045
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.045
Bak1 BCL2-antagonist/killer 1 0.045
Vps26a vacuolar protein sorting 26 homolog A (yeast) 0.044
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.043
Notch2 Notch gene homolog 2 (Drosophila) 0.040
Smad6 MAD homolog 6 (Drosophila) 0.040
Arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.040
Stat1 signal transducer and activator of transcription 1 0.040
Oasl2 2'-5' oligoadenylate synthetase-like 2 0.040
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.038
Bicc1 bicaudal C homolog 1 (Drosophila) 0.038
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.038
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.038
Fam96a family with sequence similarity 96, member A 0.036
Rnf115 ring finger protein 115 0.035
Mapkap1 mitogen-activated protein kinase associated protein 1 0.034
Hoxb3 homeobox B3 0.034
Trim30a tripartite motif-containing 30A 0.034
Lrp5 low density lipoprotein receptor-related protein 5 0.034
Fas Fas (TNF receptor superfamily member 6) 0.031
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.031
Bcl3 B-cell leukemia/lymphoma 3 0.030
Irf1 interferon regulatory factor 1 0.030
Tbx3 T-box 3 0.030
Htt huntingtin 0.030
Acvr1 activin A receptor, type 1 0.029
Fzd2 frizzled homolog 2 (Drosophila) 0.029
Ece1 endothelin converting enzyme 1 0.029
Cdh5 cadherin 5 0.029
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.029
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.029
Gli2 GLI-Kruppel family member GLI2 0.029
Commd6 COMM domain containing 6 0.028
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.028
Skp1a S-phase kinase-associated protein 1A 0.028
Tef thyrotroph embryonic factor 0.028
Per1 period homolog 1 (Drosophila) 0.027
Sap18 Sin3-associated polypeptide 18 0.027
Kitl kit ligand 0.027
Tgfb2 transforming growth factor, beta 2 0.027
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism