The network for 'circulatory system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

circulatory system development

The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.

Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 1.000
CAV1 caveolin 1, caveolae protein, 22kDa 1.000
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
CREBBP CREB binding protein 1.000
FN1 fibronectin 1 1.000
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.999
EP300 E1A binding protein p300 0.999
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.999
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.998
NOTCH1 notch 1 0.997
SMAD2 SMAD family member 2 0.997
FGFR1 fibroblast growth factor receptor 1 0.997
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.996
SMAD3 SMAD family member 3 0.996
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.995
FLNA filamin A, alpha 0.993
PLCG1 phospholipase C, gamma 1 0.992
ACTB actin, beta 0.992
JAG1 jagged 1 0.992
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.991
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.990
TRIM63 tripartite motif containing 63 0.984
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.984
YAP1 Yes-associated protein 1 0.984
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.982
FHL2 four and a half LIM domains 2 0.982
JUN jun proto-oncogene 0.980
ESR1 estrogen receptor 1 0.979
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.978
MET met proto-oncogene (hepatocyte growth factor receptor) 0.978
SMAD1 SMAD family member 1 0.977
VEGFA vascular endothelial growth factor A 0.975
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.974
ANXA1 annexin A1 0.972
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.969
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.967
VCAM1 vascular cell adhesion molecule 1 0.965
MYOD1 myogenic differentiation 1 0.965
FBN1 fibrillin 1 0.963
PAX3 paired box 3 0.963
QKI quaking homolog, KH domain RNA binding (mouse) 0.960
NOTCH3 notch 3 0.959
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.958
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.953
TAL1 T-cell acute lymphocytic leukemia 1 0.951
FGF1 fibroblast growth factor 1 (acidic) 0.949
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.948
CTGF connective tissue growth factor 0.947
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.947
THBS1 thrombospondin 1 0.942
FGFR2 fibroblast growth factor receptor 2 0.940
CYR61 cysteine-rich, angiogenic inducer, 61 0.935
STK3 serine/threonine kinase 3 0.933
NRP1 neuropilin 1 0.924
ENG endoglin 0.922
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.917
DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 0.915
LAT linker for activation of T cells 0.915
SP1 Sp1 transcription factor 0.915
TIMP3 TIMP metallopeptidase inhibitor 3 0.912
TTN titin 0.911
GSK3B glycogen synthase kinase 3 beta 0.910
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.907
AR androgen receptor 0.903
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.900
CAV2 caveolin 2 0.891
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.887
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.881
TGFB1 transforming growth factor, beta 1 0.881
LTBP2 latent transforming growth factor beta binding protein 2 0.880
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.880
COL3A1 collagen, type III, alpha 1 0.876
TEK TEK tyrosine kinase, endothelial 0.873
COL6A1 collagen, type VI, alpha 1 0.871
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.866
EPAS1 endothelial PAS domain protein 1 0.865
GRB2 growth factor receptor-bound protein 2 0.865
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.864
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.863
RUNX1 runt-related transcription factor 1 0.860
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.858
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.852
COL4A1 collagen, type IV, alpha 1 0.851
NCK1 NCK adaptor protein 1 0.847
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.846
MEF2C myocyte enhancer factor 2C 0.845
TNNC1 troponin C type 1 (slow) 0.845
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.843
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.842
PECAM1 platelet/endothelial cell adhesion molecule 0.835
SIRT1 sirtuin 1 0.834
COL2A1 collagen, type II, alpha 1 0.833
H2AFX H2A histone family, member X 0.833
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.832
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.831
LMNA lamin A/C 0.830
HOXB5 homeobox B5 0.829
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.826
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.820
BCAR1 breast cancer anti-estrogen resistance 1 0.819
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Mad Mothers against dpp 0.993
Egfr Epidermal growth factor receptor 0.985
ush u-shaped 0.982
twi twist 0.977
wg wingless 0.976
shn schnurri 0.975
eya eyes absent 0.974
Ubx Ultrabithorax 0.973
N Notch 0.968
mys myospheroid 0.953
sd scalloped 0.949
nkd naked cuticle 0.940
tin tinman 0.939
Rho1 CG8416 gene product from transcript CG8416-RB 0.933
srp serpent 0.929
Ras85D Ras oncogene at 85D 0.928
emc extra macrochaetae 0.926
Rac1 CG2248 gene product from transcript CG2248-RA 0.926
slp1 sloppy paired 1 0.925
LanB2 Laminin B2 0.916
G-oalpha47A G protein oalpha 47A 0.906
sr stripe 0.892
bab2 CG9102 gene product from transcript CG9102-RA 0.891
ci cubitus interruptus 0.890
rhea CG6831 gene product from transcript CG6831-RA 0.861
Mhc Myosin heavy chain 0.856
shot short stop 0.842
Doc2 Dorsocross2 0.810
ap apterous 0.790
stumps CG31317 gene product from transcript CG31317-RC 0.789
slou slouch 0.779
lea leak 0.768
spi spitz 0.752
insc inscuteable 0.750
S6k RPS6-p70-protein kinase 0.749
Dll Distal-less 0.733
E2f2 E2F transcription factor 2 0.719
htl heartless 0.706
zfh1 Zn finger homeodomain 1 0.705
Nrg Neuroglian 0.688
LanA Laminin A 0.680
mid midline 0.658
Mrtf Myocardin-related transcription factor 0.651
zip zipper 0.648
nmo nemo 0.646
eve even skipped 0.633
Sema-1a CG18405 gene product from transcript CG18405-RD 0.633
SoxN SoxNeuro 0.630
hth homothorax 0.628
stmA stambha A 0.613
wupA wings up A 0.613
vg vestigial 0.602
stck steamer duck 0.600
mew multiple edematous wings 0.594
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.584
rdx roadkill 0.577
Atpalpha Na pump alpha subunit 0.564
Tsc1 CG6147 gene product from transcript CG6147-RA 0.558
csw corkscrew 0.556
kn knot 0.525
gcm glial cells missing 0.519
Cdc42 CG12530 gene product from transcript CG12530-RA 0.518
dally division abnormally delayed 0.516
dsh dishevelled 0.513
kuz kuzbanian 0.504
NetB Netrin-B 0.491
ex expanded 0.486
Moe Moesin 0.482
gro groucho 0.480
C15 CG7937 gene product from transcript CG7937-RA 0.480
fng fringe 0.477
nau nautilus 0.467
pnr pannier 0.466
dpn deadpan 0.456
Galpha49B G protein alpha49B 0.448
baz bazooka 0.440
hkb huckebein 0.434
en engrailed 0.432
sqz squeeze 0.426
Pka-C1 cAMP-dependent protein kinase 1 0.423
so sine oculis 0.406
abd-A abdominal A 0.399
pdm2 POU domain protein 2 0.399
eIF-4E Eukaryotic initiation factor 4E 0.398
rap retina aberrant in pattern 0.397
Zasp52 Z band alternatively spliced PDZ-motif protein 52 0.384
sns sticks and stones 0.381
Akt1 CG4006 gene product from transcript CG4006-RA 0.380
NFAT NFAT homolog 0.379
tup tailup 0.379
robo roundabout 0.377
dpp decapentaplegic 0.368
pb proboscipedia 0.366
Fmr1 CG6203 gene product from transcript CG6203-RC 0.362
prc pericardin 0.361
O-fut1 O-fucosyltransferase 1 0.358
lbl ladybird late 0.355
LanB1 CG7123 gene product from transcript CG7123-RA 0.355
bi bifid 0.354
Dad Daughters against dpp 0.352
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Fos FBJ osteosarcoma oncogene 0.832
Junb jun B proto-oncogene 0.744
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.679
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.605
Crisp1 cysteine-rich secretory protein 1 0.554
Actc1 actin, alpha, cardiac muscle 1 0.542
Ccl4 chemokine (C-C motif) ligand 4 0.493
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.439
Btg2 BTG family, member 2 0.433
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.429
Acvrl1 activin A receptor type II-like 1 0.412
Id3 inhibitor of DNA binding 3 0.397
Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 0.379
Gnrhr gonadotropin releasing hormone receptor 0.379
Bgn biglycan 0.373
Ccl2 chemokine (C-C motif) ligand 2 0.369
Bcl2 B-cell CLL/lymphoma 2 0.366
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.365
Ednrb endothelin receptor type B 0.361
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.358
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.355
Pfn1 profilin 1 0.349
Prrx1 paired related homeobox 1 0.343
Met met proto-oncogene 0.340
F13a1 coagulation factor XIII, A1 polypeptide 0.327
Myh6 myosin, heavy chain 6, cardiac muscle, alpha 0.327
Strn striatin, calmodulin binding protein 0.326
Trim47 tripartite motif-containing 47 0.319
Col12a1 collagen, type XII, alpha 1 0.319
Egr1 early growth response 1 0.317
Prkch protein kinase C, eta 0.312
Trib1 tribbles homolog 1 (Drosophila) 0.307
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.302
Hand2 heart and neural crest derivatives expressed 2 0.299
Sdc3 syndecan 3 0.296
Ceacam10 carcinoembryonic antigen-related cell adhesion molecule 10 0.295
Rara retinoic acid receptor, alpha 0.294
Twist2 twist homolog 2 (Drosophila) 0.292
Dusp1 dual specificity phosphatase 1 0.289
Myl9 myosin, light chain 9, regulatory 0.288
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.282
Rhoa ras homolog gene family, member A 0.281
Ngf nerve growth factor (beta polypeptide) 0.279
Lama5 laminin, alpha 5 0.273
Egr2 early growth response 2 0.269
Atf3 activating transcription factor 3 0.267
Dmd dystrophin 0.267
Slit3 slit homolog 3 (Drosophila) 0.261
Ptgfr prostaglandin F receptor 0.257
Sell selectin L 0.254
Itgb1 integrin, beta 1 0.249
Utrn utrophin 0.249
Tpm4 tropomyosin 4 0.248
Nos3 nitric oxide synthase 3, endothelial cell 0.246
Apcs amyloid P component, serum 0.246
Acta2 smooth muscle alpha-actin 0.245
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.244
Col10a1 collagen, type X, alpha 1 0.239
Fgfr2 fibroblast growth factor receptor 2 0.239
Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.238
Itgam integrin, alpha M 0.235
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.235
Fgfr1 Fibroblast growth factor receptor 1 0.233
Chrna1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.229
Nexn nexilin (F actin binding protein) 0.227
Jak1 Janus kinase 1 0.225
Dchs1 dachsous 1 (Drosophila) 0.225
Ifi204 interferon activated gene 204 0.224
Rhoj ras homolog gene family, member J 0.222
Notch3 Notch homolog 3 (Drosophila) 0.222
Dab2 disabled homolog 2 (Drosophila) 0.221
Sod3 superoxide dismutase 3, extracellular 0.221
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.213
Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform 0.212
Tgfbr2 transforming growth factor, beta receptor II 0.211
Sec14l3 SEC14-like 3 (S. cerevisiae) 0.208
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.208
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.206
Kdr kinase insert domain receptor 0.203
Agtr1a angiotensin II receptor, type 1a 0.201
Fstl1 follistatin-like 1 0.197
Adora2a adenosine A2a receptor 0.196
Cmklr1 chemokine-like receptor 1 0.195
Lpl lipoprotein lipase 0.194
Ccr3 chemokine (C-C motif) receptor 3 0.190
Aebp1 AE binding protein 1 0.190
Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.189
Col8a1 collagen, type VIII, alpha 1 0.188
F2rl1 coagulation factor II (thrombin) receptor-like 1 0.185
Ccl3 chemokine (C-C motif) ligand 3 0.185
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.180
Eln elastin 0.177
Pdk4 pyruvate dehydrogenase kinase, isozyme 4 0.176
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.176
Ccr5 chemokine (C-C motif) receptor 5 0.174
Pip prolactin induced protein 0.173
Cpxm2 carboxypeptidase X (M14 family), member 2 0.172
Plscr1 phospholipid scramblase 1 0.172
Cd200r1 CD200 receptor 1 0.172
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.171
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism