The network for 'response to cytokine' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to cytokine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.

Homo sapiens
Name Description Probability Func Analog Organism
CREBBP CREB binding protein 1.000
STAT1 signal transducer and activator of transcription 1, 91kDa 1.000
EGFR epidermal growth factor receptor 1.000
RIPK2 receptor-interacting serine-threonine kinase 2 1.000
TRAF6 TNF receptor-associated factor 6 1.000
PML promyelocytic leukemia 0.999
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.999
IRAK1 interleukin-1 receptor-associated kinase 1 0.999
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.998
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.998
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.998
MYD88 myeloid differentiation primary response gene (88) 0.996
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.996
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.995
MAPK14 mitogen-activated protein kinase 14 0.993
IL1B interleukin 1, beta 0.992
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.991
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.989
RUNX1 runt-related transcription factor 1 0.988
CXCL10 chemokine (C-X-C motif) ligand 10 0.988
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.986
CAV1 caveolin 1, caveolae protein, 22kDa 0.985
GHR growth hormone receptor 0.985
BIRC3 baculoviral IAP repeat containing 3 0.983
DUSP1 dual specificity phosphatase 1 0.982
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.982
MT1H metallothionein 1H 0.981
TRAF1 TNF receptor-associated factor 1 0.980
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.979
SOCS3 suppressor of cytokine signaling 3 0.979
CCR7 chemokine (C-C motif) receptor 7 0.976
CXCL9 chemokine (C-X-C motif) ligand 9 0.973
FAS Fas (TNF receptor superfamily, member 6) 0.973
MT2A metallothionein 2A 0.972
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.971
JAK2 Janus kinase 2 0.968
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.966
BIRC2 baculoviral IAP repeat containing 2 0.963
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.961
IL8 interleukin 8 0.957
EP300 E1A binding protein p300 0.951
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.944
IL1R1 interleukin 1 receptor, type I 0.944
ZNF43 zinc finger protein 43 0.943
IFI44L interferon-induced protein 44-like 0.940
NCOR1 nuclear receptor corepressor 1 0.940
IFI44 interferon-induced protein 44 0.937
PLSCR1 phospholipid scramblase 1 0.933
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.929
CCR5 chemokine (C-C motif) receptor 5 0.928
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.926
PTPRJ protein tyrosine phosphatase, receptor type, J 0.924
JUN jun proto-oncogene 0.923
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.922
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.922
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.921
PARP9 poly (ADP-ribose) polymerase family, member 9 0.918
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.917
CCL22 chemokine (C-C motif) ligand 22 0.917
UBC ubiquitin C 0.912
NCF1 neutrophil cytosolic factor 1 0.909
TAL1 T-cell acute lymphocytic leukemia 1 0.908
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.905
NAMPT nicotinamide phosphoribosyltransferase 0.905
IRAK2 interleukin-1 receptor-associated kinase 2 0.901
ICAM1 intercellular adhesion molecule 1 0.901
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.893
CCL2 chemokine (C-C motif) ligand 2 0.892
APOE apolipoprotein E 0.890
COL1A1 collagen, type I, alpha 1 0.890
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.889
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.889
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.886
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.879
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.877
IL2RB interleukin 2 receptor, beta 0.876
LAT linker for activation of T cells 0.875
IFIH1 interferon induced with helicase C domain 1 0.872
CCL4 chemokine (C-C motif) ligand 4 0.871
BCL2 B-cell CLL/lymphoma 2 0.870
TRAF5 TNF receptor-associated factor 5 0.869
NCOR2 nuclear receptor corepressor 2 0.862
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.860
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.859
C1QA complement component 1, q subcomponent, A chain 0.848
JAK1 Janus kinase 1 0.847
STAT5A signal transducer and activator of transcription 5A 0.843
BCL2L1 BCL2-like 1 0.842
TRAF2 TNF receptor-associated factor 2 0.841
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.839
CD40 CD40 molecule, TNF receptor superfamily member 5 0.836
IL6 interleukin 6 (interferon, beta 2) 0.832
CFLAR CASP8 and FADD-like apoptosis regulator 0.827
MX2 myxovirus (influenza virus) resistance 2 (mouse) 0.821
CDK2 cyclin-dependent kinase 2 0.821
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.814
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.811
MAPK1 mitogen-activated protein kinase 1 0.805
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.798
BCL3 B-cell CLL/lymphoma 3 0.798
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.125
col1a2 collagen, type I, alpha 2 0.097
bcl2l1 bcl2-like 1 0.075
junb jun B proto-oncogene 0.063
cxcr4b chemokine (C-X-C motif), receptor 4b 0.056
spry4 sprouty (Drosophila) homolog 4 0.043
mmp9 matrix metalloproteinase 9 0.043
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.027
ef1a elongation factor 1-alpha 0.025
tlr3 toll-like receptor 3 0.025
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.024
stat1b signal transducer and activator of transcription 1b 0.024
mcl1a myeloid cell leukemia sequence 1a 0.022
socs3a suppressor of cytokine signaling 3a 0.021
anxa1a annexin A1a 0.021
rspo1 R-spondin homolog (Xenopus laevis) 0.021
rag1 recombination activating gene 1 0.021
tlr21 toll-like receptor 21 0.020
apoeb apolipoprotein Eb 0.018
krt4 keratin 4 0.017
mapk3 mitogen-activated protein kinase 3 0.017
pcsk5a proprotein convertase subtilisin/kexin type 5a 0.017
stc1l stanniocalcin 1, like 0.017
nrp2b neuropilin 2b 0.016
igf2a insulin-like growth factor 2a 0.016
col1a1a collagen, type I, alpha 1a 0.016
cldne claudin e 0.016
bcl2l10 BCL2-like 10 (apoptosis facilitator) 0.016
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.015
met met proto-oncogene (hepatocyte growth factor receptor) 0.014
pycard PYD and CARD domain containing 0.014
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.013
junbl jun B proto-oncogene, like 0.012
runx1 runt-related transcription factor 1 0.012
hgfa hepatocyte growth factor a 0.012
tbpl2 TATA box binding protein like 2 0.011
fgf3 fibroblast growth factor 3 0.011
sox9a SRY-box containing gene 9a 0.011
mapk6 mitogen-activated protein kinase 6 0.011
cish cytokine inducible SH2-containing protein 0.011
stat3 signal transduction and activation of transcription 3 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cxcl10 chemokine (C-X-C motif) ligand 10 0.933
Il1r1 interleukin 1 receptor, type I 0.913
Runx1 runt-related transcription factor 1 0.798
Sell selectin L 0.760
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.757
Ccl2 chemokine (C-C motif) ligand 2 0.751
Cxcl2 chemokine (C-X-C motif) ligand 2 0.750
Col1a1 collagen, type I, alpha 1 0.748
Lgals9 lectin, galactoside-binding, soluble, 9 0.742
C1s complement component 1, s subcomponent 0.742
Fgf16 fibroblast growth factor 16 0.722
Col3a1 collagen, type III, alpha 1 0.720
Irf7 interferon regulatory factor 7 0.711
Il8rb interleukin 8 receptor, beta 0.711
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.699
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.698
Icam1 intercellular adhesion molecule 1 0.693
Socs3 suppressor of cytokine signaling 3 0.679
Lepr leptin receptor 0.672
Orm1 orosomucoid 1 0.642
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.642
Bcl2 B-cell CLL/lymphoma 2 0.625
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.583
Oas1a 2'-5' oligoadenylate synthetase 1A 0.581
Mx1 myxovirus (influenza virus) resistance 1 0.573
Gfap glial fibrillary acidic protein 0.570
RGD1564599 RGD1564599 0.557
Anxa1 annexin A1 0.557
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.555
Rap1b RAP1B, member of RAS oncogene family 0.543
Lgals5 lectin, galactose binding, soluble 5 0.537
Il6 interleukin 6 0.531
A2m alpha-2-macroglobulin 0.522
Myo1b myosin Ib 0.516
Ifitm3 interferon induced transmembrane protein 3 0.515
Ccr5 chemokine (C-C motif) receptor 5 0.514
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.512
Igfals insulin-like growth factor binding protein, acid labile subunit 0.505
Il1b interleukin 1 beta 0.494
Eif5a eukaryotic translation initiation factor 5A 0.487
Il4ra interleukin 4 receptor, alpha 0.479
Arpc1b actin related protein 2/3 complex, subunit 1B 0.474
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.466
Bdkrb1 bradykinin receptor B1 0.460
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.459
Vcam1 vascular cell adhesion molecule 1 0.456
Oasl 2'-5'-oligoadenylate synthetase-like 0.455
Cd44 Cd44 molecule 0.454
Usp18 ubiquitin specific peptidase 18 0.447
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.445
Mmp3 matrix metallopeptidase 3 0.444
LOC100363783 rCG53773-like 0.443
Ggt1 gamma-glutamyltransferase 1 0.441
Testin testin gene 0.439
Itgam integrin, alpha M 0.428
Pcolce procollagen C-endopeptidase enhancer 0.422
Ccl4 chemokine (C-C motif) ligand 4 0.419
Rhd Rh blood group, D antigen 0.417
Crisp2 cysteine-rich secretory protein 2 0.416
Mef2d myocyte enhancer factor 2D 0.406
Gpr182 G protein-coupled receptor 182 0.406
Ppard peroxisome proliferator-activated receptor delta 0.401
S1pr2 sphingosine-1-phosphate receptor 2 0.400
Nos2 nitric oxide synthase 2, inducible 0.397
Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 0.396
Fos FBJ osteosarcoma oncogene 0.392
RT1-Da RT1 class II, locus Da 0.392
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.390
Klf6 Kruppel-like factor 6 0.387
Junb jun B proto-oncogene 0.386
Atp4b ATPase, H+/K+ exchanging, beta polypeptide 0.384
Hck hemopoietic cell kinase 0.383
Igf2 insulin-like growth factor 2 0.382
Jak1 Janus kinase 1 0.381
Thbd thrombomodulin 0.380
Stat1 signal transducer and activator of transcription 1 0.365
Cd38 CD38 molecule 0.360
Jun Jun oncogene 0.360
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.358
Ncr1 natural cytotoxicity triggering receptor 1 0.358
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.355
Tgfbr3 transforming growth factor, beta receptor III 0.352
Prph2 peripherin 2 0.351
Bgn biglycan 0.348
RT1-Ba RT1 class II, locus Ba 0.345
LOC100364500 RT1 class I, locus CE11-like 0.340
Cuzd1 CUB and zona pellucida-like domains 1 0.339
Stc1 stanniocalcin 1 0.329
Cd14 CD14 molecule 0.326
Ccl3 chemokine (C-C motif) ligand 3 0.324
Timp2 TIMP metallopeptidase inhibitor 2 0.323
Klf4 Kruppel-like factor 4 (gut) 0.318
Il2rb interleukin 2 receptor, beta 0.317
Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 0.314
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.313
RGD1310262 hypothetical LOC304650 0.313
Plau plasminogen activator, urokinase 0.311
Rhox5 reproductive homeobox 5 0.309
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.309
Ctdsp1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 0.308
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism