The network for 'negative regulation of g1 s transition of mitotic cell cycle' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of g1 s transition of mitotic cell cycle

Any cell cycle regulatory process that prevents the commitment of a cell from G1 to S phase of the mitotic cell cycle.

Homo sapiens
Name Description Probability Func Analog Organism
RB1 retinoblastoma 1 1.000
RBL2 retinoblastoma-like 2 (p130) 0.996
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.993
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.981
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.980
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.948
CDK2 cyclin-dependent kinase 2 0.935
RBL1 retinoblastoma-like 1 (p107) 0.896
CCND1 cyclin D1 0.876
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.868
XIAP X-linked inhibitor of apoptosis 0.769
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.728
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.705
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.643
CDK6 cyclin-dependent kinase 6 0.641
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.637
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.565
E2F1 E2F transcription factor 1 0.554
PAX3 paired box 3 0.537
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.452
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.430
FAS Fas (TNF receptor superfamily, member 6) 0.403
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.369
ARID1A AT rich interactive domain 1A (SWI-like) 0.337
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.302
APAF1 apoptotic peptidase activating factor 1 0.298
RBBP8 retinoblastoma binding protein 8 0.287
EGFR epidermal growth factor receptor 0.283
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.279
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.268
WWOX WW domain containing oxidoreductase 0.259
BRCA1 breast cancer 1, early onset 0.243
LRDD leucine-rich repeats and death domain containing 0.242
IRAK2 interleukin-1 receptor-associated kinase 2 0.241
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.240
BTRC beta-transducin repeat containing 0.236
E2F8 E2F transcription factor 8 0.235
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.221
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.201
BIRC2 baculoviral IAP repeat containing 2 0.174
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.163
PCNA proliferating cell nuclear antigen 0.156
SMAD7 SMAD family member 7 0.154
CCNE1 cyclin E1 0.148
TP53 tumor protein p53 0.146
CFLAR CASP8 and FADD-like apoptosis regulator 0.146
RBBP4 retinoblastoma binding protein 4 0.131
CCND3 cyclin D3 0.127
HBP1 HMG-box transcription factor 1 0.126
RIPK2 receptor-interacting serine-threonine kinase 2 0.124
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.119
IER3 immediate early response 3 0.111
NCOR1 nuclear receptor corepressor 1 0.108
BIRC3 baculoviral IAP repeat containing 3 0.103
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.103
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.097
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.094
UBE3A ubiquitin protein ligase E3A 0.094
YAP1 Yes-associated protein 1 0.094
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.093
NLRC4 NLR family, CARD domain containing 4 0.092
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.091
AR androgen receptor 0.091
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.089
ARRB2 arrestin, beta 2 0.085
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.084
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.082
POU5F1 POU class 5 homeobox 1 0.080
E2F3 E2F transcription factor 3 0.080
NCOA1 nuclear receptor coactivator 1 0.079
ESR1 estrogen receptor 1 0.073
TFDP1 transcription factor Dp-1 0.070
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.068
EP300 E1A binding protein p300 0.068
FADD Fas (TNFRSF6)-associated via death domain 0.068
KRT5 keratin 5 0.063
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.062
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.061
FASLG Fas ligand (TNF superfamily, member 6) 0.061
LIN9 lin-9 homolog (C. elegans) 0.061
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.060
PURA purine-rich element binding protein A 0.060
E2F2 E2F transcription factor 2 0.060
SKP2 S-phase kinase-associated protein 2 (p45) 0.058
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.058
PDE4DIP phosphodiesterase 4D interacting protein 0.056
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.055
POU3F2 POU class 3 homeobox 2 0.053
PTCH1 patched 1 0.051
RAD18 RAD18 homolog (S. cerevisiae) 0.050
STRN3 striatin, calmodulin binding protein 3 0.049
TXNIP thioredoxin interacting protein 0.045
RPA1 replication protein A1, 70kDa 0.045
YY1 YY1 transcription factor 0.044
SMAD5 SMAD family member 5 0.043
PINK1 PTEN induced putative kinase 1 0.043
BCL2 B-cell CLL/lymphoma 2 0.043
IGF1R insulin-like growth factor 1 receptor 0.042
SATB2 SATB homeobox 2 0.041
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.041
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Ras85D Ras oncogene at 85D 0.756
Dp DP transcription factor 0.589
Rbf Retinoblastoma-family protein 0.559
Akt1 CG4006 gene product from transcript CG4006-RA 0.513
yki yorkie 0.399
phl pole hole 0.347
smo smoothened 0.272
CycD Cyclin D 0.217
Mad Mothers against dpp 0.208
Rel Relish 0.170
brm brahma 0.168
D Dichaete 0.160
babo baboon 0.160
sd scalloped 0.152
e(y)3 enhancer of yellow 3 0.137
imd immune deficiency 0.127
Cdk4 Cyclin-dependent kinase 4 0.125
rl rolled 0.119
Su(H) Suppressor of Hairless 0.117
sax saxophone 0.117
Trf2 TATA box binding protein-related factor 2 0.114
p53 CG33336 gene product from transcript CG33336-RB 0.081
Dcr-1 Dicer-1 0.063
rap retina aberrant in pattern 0.062
Cbl CG7037 gene product from transcript CG7037-RB 0.058
wts warts 0.057
cdc2c CG10498 gene product from transcript CG10498-RC 0.057
Tsc1 CG6147 gene product from transcript CG6147-RA 0.054
CG9339 CG9339 gene product from transcript CG9339-RG 0.054
da daughterless 0.051
hep hemipterous 0.048
put punt 0.046
Su(z)12 CG8013 gene product from transcript CG8013-RA 0.046
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.045
nej nejire 0.044
eya eyes absent 0.038
Dap160 Dynamin associated protein 160 0.037
tkv thickveins 0.035
CG5669 CG5669 gene product from transcript CG5669-RA 0.034
gbb glass bottom boat 0.034
RagA CG11968 gene product from transcript CG11968-RA 0.034
mus205 mutagen-sensitive 205 0.033
CycA Cyclin A 0.030
lmg lemming 0.030
pygo pygopus 0.030
Myd88 CG2078 gene product from transcript CG2078-RA 0.029
Tis11 Tis11 homolog 0.029
EcR Ecdysone receptor 0.028
heph hephaestus 0.028
tld tolloid 0.027
MED26 Mediator complex subunit 26 0.026
Nf-YA Nuclear factor Y-box A 0.024
Pc Polycomb 0.024
plu plutonium 0.024
Eps-15 Epidermal growth factor receptor pathway substrate clone 15 0.023
kn knot 0.023
tefu telomere fusion 0.023
CG8455 CG8455 gene product from transcript CG8455-RA 0.023
jub Ajuba LIM protein 0.022
nct nicastrin 0.022
CycG Cyclin G 0.021
emc extra macrochaetae 0.020
simj simjang 0.020
JhI-1 Juvenile hormone-inducible protein 1 0.020
MED17 Mediator complex subunit 17 0.019
eff effete 0.019
swm second mitotic wave missing 0.018
Atg1 Autophagy-specific gene 1 0.018
Imp IGF-II mRNA-binding protein 0.018
flower CG6151 gene product from transcript CG6151-RA 0.018
E2f E2F transcription factor 0.018
Set2 CG1716 gene product from transcript CG1716-RA 0.018
mip120 Myb-interacting protein 120 0.017
mib1 mind bomb 1 0.017
drosha CG8730 gene product from transcript CG8730-RA 0.017
GATAd CG5034 gene product from transcript CG5034-RA 0.017
ush u-shaped 0.016
DNApol-alpha50 DNA polymerase alpha 50kD 0.016
Brca2 Breast cancer 2, early onset homolog 0.016
Axn Axin 0.015
milt milton 0.015
E2f2 E2F transcription factor 2 0.015
sav salvador 0.015
BG4 CG12297 gene product from transcript CG12297-RA 0.015
not non-stop 0.015
Rcd5 Reduction in Cnn dots 5 0.015
Caf1-105 CG12892 gene product from transcript CG12892-RA 0.014
Nup160 Nucleoporin 160 0.014
CycJ Cyclin J 0.014
ari-2 ariadne 2 0.014
MED19 Mediator complex subunit 19 0.014
FBX011 FBX011 ortholog 0.014
CG4973 CG4973 gene product from transcript CG4973-RA 0.014
mip130 Myb-interacting protein 130 0.014
CG18754 CG18754 gene product from transcript CG18754-RB 0.013
CG7358 CG7358 gene product from transcript CG7358-RA 0.013
Kap-alpha3 karyopherin alpha3 0.013
kek5 kekkon5 0.013
nbs CG6754 gene product from transcript CG6754-RC 0.012
boca CG30498 gene product from transcript CG30498-RA 0.012
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.999
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.911
Rb1 retinoblastoma 1 0.897
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.645
Pten phosphatase and tensin homolog 0.613
Arid1b AT rich interactive domain 1B (SWI-like) 0.359
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.301
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.241
Apc adenomatosis polyposis coli 0.220
Nf1 neurofibromatosis 1 0.200
Brca1 breast cancer 1 0.200
Mdm4 transformed mouse 3T3 cell double minute 4 0.184
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.176
E2f1 E2F transcription factor 1 0.159
Arid1a AT rich interactive domain 1A (SWI-like) 0.154
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.148
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.141
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.133
Kit kit oncogene 0.107
Msh2 mutS homolog 2 (E. coli) 0.101
Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.090
Cd80 CD80 antigen 0.090
Ctnnb1 catenin (cadherin associated protein), beta 1 0.076
Tgfb2 transforming growth factor, beta 2 0.068
Ret ret proto-oncogene 0.062
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.057
Aebp2 AE binding protein 2 0.056
Cdk4 cyclin-dependent kinase 4 0.056
Nbn nibrin 0.054
Ptch1 patched homolog 1 0.052
Rbl2 retinoblastoma-like 2 0.050
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.044
Rbl1 retinoblastoma-like 1 (p107) 0.043
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.042
Stk11 serine/threonine kinase 11 0.039
Smad4 MAD homolog 4 (Drosophila) 0.037
Atm ataxia telangiectasia mutated homolog (human) 0.036
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.033
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.033
Braf Braf transforming gene 0.032
Foxo3 forkhead box O3 0.032
Hif1a hypoxia inducible factor 1, alpha subunit 0.030
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.029
Fgfr2 fibroblast growth factor receptor 2 0.028
Bcl2 B-cell leukemia/lymphoma 2 0.028
Cdkn2d cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.027
Bax BCL2-associated X protein 0.027
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.025
Jarid2 jumonji, AT rich interactive domain 2 0.025
Brca2 breast cancer 2 0.024
Xpa xeroderma pigmentosum, complementation group A 0.022
Fgfr1 fibroblast growth factor receptor 1 0.022
Isl1 ISL1 transcription factor, LIM/homeodomain 0.022
Bmpr1a bone morphogenetic protein receptor, type 1A 0.022
Ptpn13 protein tyrosine phosphatase, non-receptor type 13 0.022
Shh sonic hedgehog 0.021
Meox2 mesenchyme homeobox 2 0.020
Mdm2 transformed mouse 3T3 cell double minute 2 0.020
Sin3a transcriptional regulator, SIN3A (yeast) 0.019
Tcf3 transcription factor 3 0.019
Runx1 runt related transcription factor 1 0.019
Nrg1 neuregulin 1 0.018
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.018
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.017
Stk38 serine/threonine kinase 38 0.017
Gja1 gap junction protein, alpha 1 0.017
A930001N09Rik RIKEN cDNA A930001N09 gene 0.017
Zfp830 zinc finger protein 830 0.016
Tfdp2 transcription factor Dp 2 0.016
Lrrc58 leucine rich repeat containing 58 0.016
Skil SKI-like 0.016
Tsc1 tuberous sclerosis 1 0.015
Rara retinoic acid receptor, alpha 0.015
Pdcd1 programmed cell death 1 0.015
Daxx Fas death domain-associated protein 0.015
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.015
Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.015
Osbpl11 oxysterol binding protein-like 11 0.015
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.015
Hdac1 histone deacetylase 1 0.014
Nf2 neurofibromatosis 2 0.014
Cdk2 cyclin-dependent kinase 2 0.014
Cdk6 cyclin-dependent kinase 6 0.014
Numa1 nuclear mitotic apparatus protein 1 0.014
Bak1 BCL2-antagonist/killer 1 0.014
Rxra retinoid X receptor alpha 0.014
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.013
Psen1 presenilin 1 0.013
Kif16b kinesin family member 16B 0.012
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.012
Cbl Casitas B-lineage lymphoma 0.012
Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.012
Shc1 src homology 2 domain-containing transforming protein C1 0.012
Ulk2 Unc-51 like kinase 2 (C. elegans) 0.012
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.012
Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.011
Ntf3 neurotrophin 3 0.011
Hdac2 histone deacetylase 2 0.011
Ccdc117 coiled-coil domain containing 117 0.011
Pcna proliferating cell nuclear antigen 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism