The network for 'positive regulation of immunoglobulin production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of immunoglobulin production

Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.

Mus musculus
Name Description Probability Func Analog Organism
Ifng interferon gamma 0.826
Ccl2 chemokine (C-C motif) ligand 2 0.740
Fyn Fyn proto-oncogene 0.734
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.695
Foxp3 forkhead box P3 0.695
Stat5b signal transducer and activator of transcription 5B 0.669
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.623
Tbx3 T-box 3 0.522
Socs1 suppressor of cytokine signaling 1 0.511
Lyz2 lysozyme 2 0.452
Cd28 CD28 antigen 0.436
Il10 interleukin 10 0.422
Tlr4 toll-like receptor 4 0.415
Pitx1 paired-like homeodomain transcription factor 1 0.400
Csf1 colony stimulating factor 1 (macrophage) 0.385
Pitx2 paired-like homeodomain transcription factor 2 0.345
Ccl7 chemokine (C-C motif) ligand 7 0.330
Ccr2 chemokine (C-C motif) receptor 2 0.317
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.262
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.203
Irf9 interferon regulatory factor 9 0.201
Tnf tumor necrosis factor 0.197
Ccr1 chemokine (C-C motif) receptor 1 0.196
Stat5a signal transducer and activator of transcription 5A 0.181
Stat3 signal transducer and activator of transcription 3 0.178
Pdcd1 programmed cell death 1 0.172
Il6st interleukin 6 signal transducer 0.168
Il6 interleukin 6 0.162
Fasl Fas ligand (TNF superfamily, member 6) 0.147
Wt1 Wilms tumor 1 homolog 0.143
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.139
Tbx5 T-box 5 0.139
Ccr7 chemokine (C-C motif) receptor 7 0.130
Il2 interleukin 2 0.126
Itga3 integrin alpha 3 0.126
Prf1 perforin 1 (pore forming protein) 0.117
Fas Fas (TNF receptor superfamily member 6) 0.103
Il4 interleukin 4 0.098
Ccl8 chemokine (C-C motif) ligand 8 0.096
Hoxa1 homeobox A1 0.094
Noto notochord homolog (Xenopus laevis) 0.083
Ptgs2 prostaglandin-endoperoxide synthase 2 0.082
Tcra T-cell receptor alpha chain 0.076
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.072
Selp selectin, platelet 0.072
Il1r1 interleukin 1 receptor, type I 0.072
Nos2 nitric oxide synthase 2, inducible 0.071
Mmp9 matrix metallopeptidase 9 0.071
Nckap1l NCK associated protein 1 like 0.070
Icos inducible T-cell co-stimulator 0.069
Ccr5 chemokine (C-C motif) receptor 5 0.067
C3ar1 complement component 3a receptor 1 0.067
Batf basic leucine zipper transcription factor, ATF-like 0.067
Fgfr2 fibroblast growth factor receptor 2 0.059
Sall1 sal-like 1 (Drosophila) 0.057
Fgf10 fibroblast growth factor 10 0.056
Cd5 CD5 antigen 0.056
Scn5a sodium channel, voltage-gated, type V, alpha 0.056
Ly9 lymphocyte antigen 9 0.054
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.052
Cxcl2 chemokine (C-X-C motif) ligand 2 0.051
Rag2 recombination activating gene 2 0.051
Il13 interleukin 13 0.049
Mmp3 matrix metallopeptidase 3 0.047
Lcp1 lymphocyte cytosolic protein 1 0.047
Cd7 CD7 antigen 0.046
Rag1 recombination activating gene 1 0.044
Il4ra interleukin 4 receptor, alpha 0.044
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.044
Il10ra interleukin 10 receptor, alpha 0.044
Ccl3 chemokine (C-C motif) ligand 3 0.044
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.042
Il1rl1 interleukin 1 receptor-like 1 0.042
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.041
Ch25h cholesterol 25-hydroxylase 0.040
Pou5f1 POU domain, class 5, transcription factor 1 0.040
Pax2 paired box gene 2 0.040
Lag3 lymphocyte-activation gene 3 0.040
Lta lymphotoxin A 0.038
Nanog Nanog homeobox 0.037
Gja5 gap junction protein, alpha 5 0.036
Sh2d2a SH2 domain protein 2A 0.036
Sall4 sal-like 4 (Drosophila) 0.036
Gzma granzyme A 0.035
Pdcd1lg2 programmed cell death 1 ligand 2 0.035
Rxra retinoid X receptor alpha 0.035
Jak2 Janus kinase 2 0.034
Gzmk granzyme K 0.034
Ccl12 chemokine (C-C motif) ligand 12 0.034
Btk Bruton agammaglobulinemia tyrosine kinase 0.033
Ubd ubiquitin D 0.033
Ifnar2 interferon (alpha and beta) receptor 2 0.032
Il2rb interleukin 2 receptor, beta chain 0.032
Mmp12 matrix metallopeptidase 12 0.031
Was Wiskott-Aldrich syndrome homolog (human) 0.030
Cd247 CD247 antigen 0.030
Lcp2 lymphocyte cytosolic protein 2 0.030
Ctla4 cytotoxic T-lymphocyte-associated protein 4 0.029
Cxcl1 chemokine (C-X-C motif) ligand 1 0.029
Tbx4 T-box 4 0.028
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
IL4R interleukin 4 receptor 0.998
IL2RG interleukin 2 receptor, gamma 0.868
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.258
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.241
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.207
GRAP2 GRB2-related adaptor protein 2 0.199
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.176
TRAF3 TNF receptor-associated factor 3 0.170
ENG endoglin 0.158
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.114
TTR transthyretin 0.095
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.090
IL6R interleukin 6 receptor 0.067
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.065
SMC1A structural maintenance of chromosomes 1A 0.058
C16orf53 chromosome 16 open reading frame 53 0.052
CD22 CD22 molecule 0.050
IL4 interleukin 4 0.044
CD80 CD80 molecule 0.039
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 0.036
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.030
TMEM173 transmembrane protein 173 0.030
TRAF5 TNF receptor-associated factor 5 0.028
TP53BP1 tumor protein p53 binding protein 1 0.028
TGFBR1 transforming growth factor, beta receptor 1 0.026
TRAF2 TNF receptor-associated factor 2 0.026
TRAF1 TNF receptor-associated factor 1 0.025
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.025
IL8 interleukin 8 0.025
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.024
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.023
CD40 CD40 molecule, TNF receptor superfamily member 5 0.023
THBS1 thrombospondin 1 0.022
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.022
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.021
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.021
GATAD2B GATA zinc finger domain containing 2B 0.020
LRMP lymphoid-restricted membrane protein 0.017
SYK spleen tyrosine kinase 0.016
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.015
IL13RA1 interleukin 13 receptor, alpha 1 0.015
LCK lymphocyte-specific protein tyrosine kinase 0.014
PLEK pleckstrin 0.014
SFPQ splicing factor proline/glutamine-rich 0.014
TDP1 tyrosyl-DNA phosphodiesterase 1 0.013
JAK1 Janus kinase 1 0.013
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.013
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.012
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 0.012
LAT linker for activation of T cells 0.012
IL10RA interleukin 10 receptor, alpha 0.012
RCN3 reticulocalbin 3, EF-hand calcium binding domain 0.012
BIRC3 baculoviral IAP repeat containing 3 0.012
ICAM1 intercellular adhesion molecule 1 0.012
PIK3CD phosphoinositide-3-kinase, catalytic, delta polypeptide 0.011
PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide 0.011
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.011
SELPLG selectin P ligand 0.011
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.011
ZFP36L2 zinc finger protein 36, C3H type-like 2 0.010
ACVR2B activin A receptor, type IIB 0.010
TRAF3IP2 TRAF3 interacting protein 2 0.010
NOM1 nucleolar protein with MIF4G domain 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cd37 CD37 molecule 0.578
RT1-Db1 RT1 class II, locus Db1 0.305
Fgg fibrinogen gamma chain 0.296
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.286
Laptm5 lysosomal protein transmembrane 5 0.229
Bin2 bridging integrator 2 0.219
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.184
Hck hemopoietic cell kinase 0.179
Dnase1l3 deoxyribonuclease 1-like 3 0.168
Cxcr4 chemokine (C-X-C motif) receptor 4 0.163
Myh9 myosin, heavy chain 9, non-muscle 0.146
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.144
Anpep alanyl (membrane) aminopeptidase 0.141
Arl5c ADP-ribosylation factor-like 5C 0.139
Sell selectin L 0.133
Casp1 caspase 1 0.117
Ptafr platelet-activating factor receptor 0.116
RT1-Bb RT1 class II, locus Bb 0.114
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.110
Syk spleen tyrosine kinase 0.101
Dnase1 deoxyribonuclease I 0.100
Fgfr1 Fibroblast growth factor receptor 1 0.098
Icam1 intercellular adhesion molecule 1 0.097
Csn1s1 casein alpha s1 0.096
Il10 interleukin 10 0.095
Cd247 Cd247 molecule 0.089
Ctse cathepsin E 0.088
RT1-Ba RT1 class II, locus Ba 0.088
Arhgap9 Rho GTPase activating protein 9 0.084
Ptprc protein tyrosine phosphatase, receptor type, C 0.083
Arhgap25 Rho GTPase activating protein 25 0.083
Tmed10 transmembrane emp24-like trafficking protein 10 (yeast) 0.080
Arhgap4 Rho GTPase activating protein 4 0.080
Cybb cytochrome b-245, beta polypeptide 0.079
Uts2r urotensin 2 receptor 0.079
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.078
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.077
Il2rg interleukin 2 receptor, gamma 0.074
Myo1e myosin IE 0.072
Hbg1 hemoglobin, gamma A 0.072
Olr1278 olfactory receptor 1278 0.071
Il2ra interleukin 2 receptor, alpha 0.070
Pim1 pim-1 oncogene 0.069
Cd79b Cd79b molecule, immunoglobulin-associated beta 0.068
Il1r1 interleukin 1 receptor, type I 0.067
Pglyrp1 peptidoglycan recognition protein 1 0.066
Calcr calcitonin receptor 0.065
Cp ceruloplasmin 0.059
Mca32 mast cell antigen 32 0.057
Gja4 gap junction protein, alpha 4 0.057
Cmklr1 chemokine-like receptor 1 0.053
Fga fibrinogen alpha chain 0.053
Cd2 Cd2 molecule 0.053
Plac8 placenta-specific 8 0.053
C3ar1 complement component 3a receptor 1 0.050
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.050
Igh-6 immunoglobulin heavy chain 6 0.049
Zyx zyxin 0.049
Vav1 vav 1 guanine nucleotide exchange factor 0.048
Il1b interleukin 1 beta 0.048
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.047
Clec9a C-type lectin domain family 9, member a 0.047
Acta2 smooth muscle alpha-actin 0.046
Gdnf glial cell derived neurotrophic factor 0.045
Prl prolactin 0.045
Nos3 nitric oxide synthase 3, endothelial cell 0.045
Mobkl2a MOB1, Mps One Binder kinase activator-like 2A (yeast) 0.044
Mpeg1 macrophage expressed 1 0.044
Srd5a2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 0.044
Vegfc vascular endothelial growth factor C 0.043
Pzp pregnancy-zone protein 0.042
Lcp2 lymphocyte cytosolic protein 2 0.042
Il17ra interleukin 17 receptor A 0.042
Aebp1 AE binding protein 1 0.040
Itgb4 integrin, beta 4 0.040
Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 0.040
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.040
Il4ra interleukin 4 receptor, alpha 0.039
Abcc2 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 0.039
Smad7 SMAD family member 7 0.039
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.038
Aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.038
Ly86 lymphocyte antigen 86 0.038
Smad1 SMAD family member 1 0.038
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.038
Il2rb interleukin 2 receptor, beta 0.038
Sh2b2 SH2B adaptor protein 2 0.037
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.037
Ppapdc1b phosphatidic acid phosphatase type 2 domain containing 1B 0.037
Surf4 surfeit 4 0.037
Fmnl1 formin-like 1 0.036
Tln1 talin 1 0.036
Apob apolipoprotein B 0.035
Lrg1 leucine-rich alpha-2-glycoprotein 1 0.035
Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.034
Fabp2 fatty acid binding protein 2, intestinal 0.033
Ccl5 chemokine (C-C motif) ligand 5 0.033
Socs3 suppressor of cytokine signaling 3 0.033
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.033
Inpp5d inositol polyphosphate-5-phosphatase D 0.032
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism