The network for 'regulation of osteoclast differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of osteoclast differentiation

Any process that modulates the frequency, rate or extent of osteoclast differentiation.

Mus musculus
Name Description Probability Func Analog Organism
Csf1 colony stimulating factor 1 (macrophage) 0.973
Pten phosphatase and tensin homolog 0.968
Trp53 transformation related protein 53 0.869
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.860
Tnf tumor necrosis factor 0.842
Tgfb1 transforming growth factor, beta 1 0.835
Egr1 early growth response 1 0.685
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.669
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.627
Ctnnb1 catenin (cadherin associated protein), beta 1 0.584
Robo1 roundabout homolog 1 (Drosophila) 0.574
Ctsk cathepsin K 0.549
Esr1 estrogen receptor 1 (alpha) 0.523
Lepr leptin receptor 0.512
Psen1 presenilin 1 0.473
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.442
Mdm2 transformed mouse 3T3 cell double minute 2 0.430
Vdr vitamin D receptor 0.429
Jun Jun oncogene 0.415
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.362
Notch1 Notch gene homolog 1 (Drosophila) 0.350
Ifng interferon gamma 0.338
Sfrp2 secreted frizzled-related protein 2 0.337
Notch2 Notch gene homolog 2 (Drosophila) 0.333
Pparg peroxisome proliferator activated receptor gamma 0.328
Pax8 paired box gene 8 0.315
Thra thyroid hormone receptor alpha 0.312
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.274
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.234
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.221
Robo2 roundabout homolog 2 (Drosophila) 0.215
Ccr2 chemokine (C-C motif) receptor 2 0.212
Slit3 slit homolog 3 (Drosophila) 0.210
Braf Braf transforming gene 0.203
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.202
Runx2 runt related transcription factor 2 0.197
Smad3 MAD homolog 3 (Drosophila) 0.196
Il10 interleukin 10 0.193
Lyz2 lysozyme 2 0.191
Col1a1 collagen, type I, alpha 1 0.188
Ncoa3 nuclear receptor coactivator 3 0.186
Slit2 slit homolog 2 (Drosophila) 0.168
Runx1 runt related transcription factor 1 0.165
Dll1 delta-like 1 (Drosophila) 0.162
Duox2 dual oxidase 2 0.162
Bglap bone gamma carboxyglutamate protein 0.160
Sfrp1 secreted frizzled-related protein 1 0.156
Dusp1 dual specificity phosphatase 1 0.154
Cav1 caveolin 1, caveolae protein 0.149
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.143
Nos2 nitric oxide synthase 2, inducible 0.142
Btk Bruton agammaglobulinemia tyrosine kinase 0.140
Atf3 activating transcription factor 3 0.134
Kl klotho 0.132
Il4 interleukin 4 0.130
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.128
Hif1a hypoxia inducible factor 1, alpha subunit 0.126
Efnb2 ephrin B2 0.119
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.118
Ikzf1 IKAROS family zinc finger 1 0.114
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.112
Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta 0.109
Ccl3 chemokine (C-C motif) ligand 3 0.108
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.107
Ccr1 chemokine (C-C motif) receptor 1 0.107
Kiss1r KISS1 receptor 0.102
Nos3 nitric oxide synthase 3, endothelial cell 0.097
Cbl Casitas B-lineage lymphoma 0.097
Cd160 CD160 antigen 0.095
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.094
Runx3 runt related transcription factor 3 0.094
Hipk1 homeodomain interacting protein kinase 1 0.094
Shc1 src homology 2 domain-containing transforming protein C1 0.094
Cd40 CD40 antigen 0.093
Il12b interleukin 12b 0.089
Cd244 CD244 natural killer cell receptor 2B4 0.087
Ccl4 chemokine (C-C motif) ligand 4 0.085
Adam17 a disintegrin and metallopeptidase domain 17 0.084
Il6st interleukin 6 signal transducer 0.083
Trem3 triggering receptor expressed on myeloid cells 3 0.082
Itgb3 integrin beta 3 0.080
Mmp9 matrix metallopeptidase 9 0.080
Pdcd1 programmed cell death 1 0.079
Il10ra interleukin 10 receptor, alpha 0.077
Fgfr2 fibroblast growth factor receptor 2 0.076
Lta lymphotoxin A 0.076
Psen2 presenilin 2 0.076
Ccr5 chemokine (C-C motif) receptor 5 0.075
Fos FBJ osteosarcoma oncogene 0.075
Nfil3 nuclear factor, interleukin 3, regulated 0.073
Kiss1 KiSS-1 metastasis-suppressor 0.073
Tlr4 toll-like receptor 4 0.072
Vangl2 vang-like 2 (van gogh, Drosophila) 0.071
Bmp4 bone morphogenetic protein 4 0.071
Rel reticuloendotheliosis oncogene 0.071
AF251705 cDNA sequence AF251705 0.071
Kitl kit ligand 0.066
Kit kit oncogene 0.066
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.065
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.064
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
ZNF43 zinc finger protein 43 0.999
IL4R interleukin 4 receptor 0.991
ZNF273 zinc finger protein 273 0.990
CCR5 chemokine (C-C motif) receptor 5 0.983
ZNF253 zinc finger protein 253 0.973
TRAF1 TNF receptor-associated factor 1 0.951
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.947
ZNF675 zinc finger protein 675 0.912
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.864
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.857
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.825
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.791
PILRA paired immunoglobin-like type 2 receptor alpha 0.772
CCL22 chemokine (C-C motif) ligand 22 0.755
CD40 CD40 molecule, TNF receptor superfamily member 5 0.715
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.656
IFNG interferon, gamma 0.644
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.623
CXCL9 chemokine (C-X-C motif) ligand 9 0.608
TRAF2 TNF receptor-associated factor 2 0.598
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.564
ZNF117 zinc finger protein 117 0.479
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.465
ZNF85 zinc finger protein 85 0.448
ZNF91 zinc finger protein 91 0.433
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.429
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.417
CCL4 chemokine (C-C motif) ligand 4 0.409
CCL5 chemokine (C-C motif) ligand 5 0.400
TRADD TNFRSF1A-associated via death domain 0.393
TRAF3 TNF receptor-associated factor 3 0.388
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.387
ZNF93 zinc finger protein 93 0.368
CCR4 chemokine (C-C motif) receptor 4 0.347
CCR7 chemokine (C-C motif) receptor 7 0.343
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.342
CD14 CD14 molecule 0.324
ZNF254 zinc finger protein 254 0.311
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.311
FASLG Fas ligand (TNF superfamily, member 6) 0.308
CCR1 chemokine (C-C motif) receptor 1 0.298
IL2RB interleukin 2 receptor, beta 0.268
IL10 interleukin 10 0.241
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.232
CCL8 chemokine (C-C motif) ligand 8 0.229
PTAFR platelet-activating factor receptor 0.224
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.211
SH2D1A SH2 domain containing 1A 0.202
IL23A interleukin 23, alpha subunit p19 0.199
IRF4 interferon regulatory factor 4 0.195
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.172
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.166
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.154
SIRPB1 signal-regulatory protein beta 1 0.145
SIGLEC7 sialic acid binding Ig-like lectin 7 0.143
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.140
CXCL13 chemokine (C-X-C motif) ligand 13 0.135
CCL7 chemokine (C-C motif) ligand 7 0.134
CD40LG CD40 ligand 0.134
HK3 hexokinase 3 (white cell) 0.114
ZNF708 zinc finger protein 708 0.107
TGFB1 transforming growth factor, beta 1 0.106
CCR2 chemokine (C-C motif) receptor 2 0.104
CCL13 chemokine (C-C motif) ligand 13 0.097
IL1B interleukin 1, beta 0.096
TNF tumor necrosis factor 0.093
TRAF5 TNF receptor-associated factor 5 0.092
ZNF430 zinc finger protein 430 0.089
CD86 CD86 molecule 0.087
SLAMF7 SLAM family member 7 0.083
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.081
SH3BP2 SH3-domain binding protein 2 0.078
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.075
CCL2 chemokine (C-C motif) ligand 2 0.075
CFLAR CASP8 and FADD-like apoptosis regulator 0.067
FAS Fas (TNF receptor superfamily, member 6) 0.066
ARRB1 arrestin, beta 1 0.065
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.062
SLAMF1 signaling lymphocytic activation molecule family member 1 0.061
ZNF680 zinc finger protein 680 0.059
RIPK2 receptor-interacting serine-threonine kinase 2 0.057
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.055
CD80 CD80 molecule 0.053
ZMYND11 zinc finger, MYND-type containing 11 0.053
CXCR6 chemokine (C-X-C motif) receptor 6 0.053
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 0.052
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.052
ZNF682 zinc finger protein 682 0.052
BIRC3 baculoviral IAP repeat containing 3 0.052
PDPK1 3-phosphoinositide dependent protein kinase-1 0.048
DOCK7 dedicator of cytokinesis 7 0.048
IL10RA interleukin 10 receptor, alpha 0.045
CCR3 chemokine (C-C motif) receptor 3 0.044
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.044
SMAD1 SMAD family member 1 0.044
CD28 CD28 molecule 0.043
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.042
ZNF107 zinc finger protein 107 0.041
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.040
ZNF512B zinc finger protein 512B 0.039
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Rattus norvegicus
Name Description Probability Func Analog Organism
Junb jun B proto-oncogene 0.415
Egr2 early growth response 2 0.130
Ccl3 chemokine (C-C motif) ligand 3 0.121
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.096
Zfp36 zinc finger protein 36 0.064
Il2rb interleukin 2 receptor, beta 0.060
Ccl4 chemokine (C-C motif) ligand 4 0.059
Adcy10 adenylate cyclase 10 (soluble) 0.044
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.040
Il8rb interleukin 8 receptor, beta 0.036
Dusp1 dual specificity phosphatase 1 0.036
Atf3 activating transcription factor 3 0.031
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.030
Klf4 Kruppel-like factor 4 (gut) 0.029
Fcn1 ficolin (collagen/fibrinogen domain containing) 1 0.026
Jun Jun oncogene 0.024
Grm3 glutamate receptor, metabotropic 3 0.024
Btg2 BTG family, member 2 0.023
Gzmb granzyme B 0.023
Cd247 Cd247 molecule 0.022
Il1a interleukin 1 alpha 0.022
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.021
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.021
Cd86 CD86 molecule 0.021
Cbl Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.019
Cd83 CD83 molecule 0.018
Reg3b regenerating islet-derived 3 beta 0.017
Tcrb T-cell receptor beta chain 0.016
Axl Axl receptor tyrosine kinase 0.014
Sell selectin L 0.014
Ccr2 chemokine (C-C motif) receptor 2 0.014
Nkg7 natural killer cell group 7 sequence 0.014
Il1b interleukin 1 beta 0.014
Prf1 perforin 1 (pore forming protein) 0.012
Cd8b CD8b molecule 0.011
Prrx1 paired related homeobox 1 0.011
Mrc1 mannose receptor, C type 1 0.011
Cd8a CD8a molecule 0.011
Ddr2 discoidin domain receptor tyrosine kinase 2 0.011
Ccr5 chemokine (C-C motif) receptor 5 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism