The network for 'regulation of alpha beta t cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of alpha beta t cell activation

Any process that modulates the frequency, rate or extent of alpha-beta T cell activation.

Mus musculus
Name Description Probability Func Analog Organism
Foxp3 forkhead box P3 0.967
Stat3 signal transducer and activator of transcription 3 0.949
Cd40 CD40 antigen 0.945
Sox9 SRY-box containing gene 9 0.930
Gli2 GLI-Kruppel family member GLI2 0.913
Fas Fas (TNF receptor superfamily member 6) 0.908
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.903
Ccl2 chemokine (C-C motif) ligand 2 0.898
Fyn Fyn proto-oncogene 0.860
Stat5a signal transducer and activator of transcription 5A 0.860
Il2rb interleukin 2 receptor, beta chain 0.857
Il27ra interleukin 27 receptor, alpha 0.856
Socs1 suppressor of cytokine signaling 1 0.853
Itk IL2-inducible T-cell kinase 0.816
Irf4 interferon regulatory factor 4 0.809
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.802
Batf basic leucine zipper transcription factor, ATF-like 0.793
Ccr2 chemokine (C-C motif) receptor 2 0.765
Ccl3 chemokine (C-C motif) ligand 3 0.736
Ifng interferon gamma 0.735
Icos inducible T-cell co-stimulator 0.728
Irf5 interferon regulatory factor 5 0.725
Cd28 CD28 antigen 0.724
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.724
Jak2 Janus kinase 2 0.697
Traf6 TNF receptor-associated factor 6 0.670
Rarg retinoic acid receptor, gamma 0.650
Prdm1 PR domain containing 1, with ZNF domain 0.648
Il1r1 interleukin 1 receptor, type I 0.624
Zap70 zeta-chain (TCR) associated protein kinase 0.619
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.615
Myd88 myeloid differentiation primary response gene 88 0.586
Stat5b signal transducer and activator of transcription 5B 0.585
Ccl8 chemokine (C-C motif) ligand 8 0.580
Bcl3 B-cell leukemia/lymphoma 3 0.529
Casp8 caspase 8 0.524
H2-Aa histocompatibility 2, class II antigen A, alpha 0.519
Ikzf1 IKAROS family zinc finger 1 0.502
Cd86 CD86 antigen 0.476
Fasl Fas ligand (TNF superfamily, member 6) 0.466
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.462
Lat linker for activation of T cells 0.460
Sh2d2a SH2 domain protein 2A 0.454
Il4ra interleukin 4 receptor, alpha 0.452
Sfpi1 SFFV proviral integration 1 0.444
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.436
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.433
Ar androgen receptor 0.432
Lta lymphotoxin A 0.425
Rc3h1 RING CCCH (C3H) domains 1 0.421
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.419
Pdcd1 programmed cell death 1 0.411
Zeb1 zinc finger E-box binding homeobox 1 0.409
Gata4 GATA binding protein 4 0.383
Cd5 CD5 antigen 0.382
Lck lymphocyte protein tyrosine kinase 0.378
Cd7 CD7 antigen 0.375
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.365
Tbx21 T-box 21 0.359
Cish cytokine inducible SH2-containing protein 0.340
Ccr1 chemokine (C-C motif) receptor 1 0.333
Lag3 lymphocyte-activation gene 3 0.324
Ren1 renin 1 structural 0.322
Ch25h cholesterol 25-hydroxylase 0.320
Gab2 growth factor receptor bound protein 2-associated protein 2 0.311
Gli3 GLI-Kruppel family member GLI3 0.310
Pnp2 purine-nucleoside phosphorylase 2 0.308
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.281
Cd44 CD44 antigen 0.276
Ctla4 cytotoxic T-lymphocyte-associated protein 4 0.275
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.268
Lepr leptin receptor 0.267
Cd6 CD6 antigen 0.266
Gzmb granzyme B 0.256
Fgf10 fibroblast growth factor 10 0.255
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.252
Il6st interleukin 6 signal transducer 0.251
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.245
Ctsw cathepsin W 0.245
Itgax integrin alpha X 0.244
Csf1 colony stimulating factor 1 (macrophage) 0.240
Xcl1 chemokine (C motif) ligand 1 0.231
Mmp9 matrix metallopeptidase 9 0.219
Smad4 MAD homolog 4 (Drosophila) 0.213
Sfn stratifin 0.212
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.211
H2-Eb1 histocompatibility 2, class II antigen E beta 0.205
Stat2 signal transducer and activator of transcription 2 0.202
Smad6 MAD homolog 6 (Drosophila) 0.200
Foxn1 forkhead box N1 0.200
Ccl4 chemokine (C-C motif) ligand 4 0.198
Snai1 snail homolog 1 (Drosophila) 0.195
Cyld cylindromatosis (turban tumor syndrome) 0.194
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.193
C3ar1 complement component 3a receptor 1 0.190
Creb1 cAMP responsive element binding protein 1 0.190
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.190
Il1rn interleukin 1 receptor antagonist 0.185
Tnf tumor necrosis factor 0.181
Inhba inhibin beta-A 0.181
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CD247 CD247 molecule 0.902
LCK lymphocyte-specific protein tyrosine kinase 0.888
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.874
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.546
IL4R interleukin 4 receptor 0.514
TRAF1 TNF receptor-associated factor 1 0.492
CCR5 chemokine (C-C motif) receptor 5 0.467
LAT linker for activation of T cells 0.415
CCL4 chemokine (C-C motif) ligand 4 0.401
SYK spleen tyrosine kinase 0.394
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.375
RXRA retinoid X receptor, alpha 0.366
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.338
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.268
LIN9 lin-9 homolog (C. elegans) 0.246
CD2 CD2 molecule 0.246
CXCL9 chemokine (C-X-C motif) ligand 9 0.242
IL1B interleukin 1, beta 0.212
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.198
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.196
GRAP2 GRB2-related adaptor protein 2 0.192
CD86 CD86 molecule 0.174
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.167
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.155
NCOR2 nuclear receptor corepressor 2 0.150
HK3 hexokinase 3 (white cell) 0.150
SH3KBP1 SH3-domain kinase binding protein 1 0.141
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.141
PILRA paired immunoglobin-like type 2 receptor alpha 0.139
CCR1 chemokine (C-C motif) receptor 1 0.136
TFF1 trefoil factor 1 0.135
IDE insulin-degrading enzyme 0.125
CXCL2 chemokine (C-X-C motif) ligand 2 0.118
RARA retinoic acid receptor, alpha 0.101
IL2RG interleukin 2 receptor, gamma 0.097
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.096
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.087
SIGLEC7 sialic acid binding Ig-like lectin 7 0.085
IL4 interleukin 4 0.064
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.063
CCR7 chemokine (C-C motif) receptor 7 0.058
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.058
DRD2 dopamine receptor D2 0.053
TGIF1 TGFB-induced factor homeobox 1 0.051
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.051
MED25 mediator complex subunit 25 0.048
ICAM1 intercellular adhesion molecule 1 0.048
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.048
IFNG interferon, gamma 0.046
IL23A interleukin 23, alpha subunit p19 0.044
CD40 CD40 molecule, TNF receptor superfamily member 5 0.044
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.042
IL8 interleukin 8 0.042
SH2D1A SH2 domain containing 1A 0.041
CD48 CD48 molecule 0.039
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.037
CCL2 chemokine (C-C motif) ligand 2 0.035
CCL13 chemokine (C-C motif) ligand 13 0.035
CD163 CD163 molecule 0.035
NAMPT nicotinamide phosphoribosyltransferase 0.034
IL2RB interleukin 2 receptor, beta 0.033
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.033
CCL5 chemokine (C-C motif) ligand 5 0.033
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.033
PTAFR platelet-activating factor receptor 0.033
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.032
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.031
CXCL10 chemokine (C-X-C motif) ligand 10 0.030
SOCS3 suppressor of cytokine signaling 3 0.030
CREBBP CREB binding protein 0.030
CD80 CD80 molecule 0.026
PTPRC protein tyrosine phosphatase, receptor type, C 0.026
TRAF5 TNF receptor-associated factor 5 0.026
IL7R interleukin 7 receptor 0.026
SH3BP2 SH3-domain binding protein 2 0.026
TYMP thymidine phosphorylase 0.025
CCL8 chemokine (C-C motif) ligand 8 0.025
PPARA peroxisome proliferator-activated receptor alpha 0.025
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.025
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.024
ADAM15 ADAM metallopeptidase domain 15 0.024
NOD2 nucleotide-binding oligomerization domain containing 2 0.024
IL16 interleukin 16 (lymphocyte chemoattractant factor) 0.023
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.023
TGFB1 transforming growth factor, beta 1 0.022
SKI v-ski sarcoma viral oncogene homolog (avian) 0.022
SH2D2A SH2 domain containing 2A 0.022
VAV1 vav 1 guanine nucleotide exchange factor 0.022
CD33 CD33 molecule 0.022
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.021
IL6R interleukin 6 receptor 0.020
LIN54 lin-54 homolog (C. elegans) 0.020
PML promyelocytic leukemia 0.020
CD28 CD28 molecule 0.019
TGFB3 transforming growth factor, beta 3 0.018
CCL19 chemokine (C-C motif) ligand 19 0.018
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 0.017
CCL22 chemokine (C-C motif) ligand 22 0.017
IL1RN interleukin 1 receptor antagonist 0.017
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.016
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Ba RT1 class II, locus Ba 0.536
RT1-Db1 RT1 class II, locus Db1 0.291
Cd37 CD37 molecule 0.163
RT1-Da RT1 class II, locus Da 0.090
Itgb7 integrin, beta 7 0.085
Prkch protein kinase C, eta 0.076
Calcrl calcitonin receptor-like 0.069
Gja4 gap junction protein, alpha 4 0.060
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.055
Gimap4 GTPase, IMAP family member 4 0.054
Cd2 Cd2 molecule 0.052
Pecam1 platelet/endothelial cell adhesion molecule 1 0.052
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.051
Bin2 bridging integrator 2 0.050
Il2rb interleukin 2 receptor, beta 0.050
Il2rg interleukin 2 receptor, gamma 0.046
Sh2d1a SH2 domain protein 1A 0.043
Ptafr platelet-activating factor receptor 0.043
Rcsd1 RCSD domain containing 1 0.042
Spn sialophorin 0.038
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.036
Slfn2 schlafen 2 0.035
Tcrb T-cell receptor beta chain 0.032
Ccl5 chemokine (C-C motif) ligand 5 0.027
Cxcr4 chemokine (C-X-C motif) receptor 4 0.027
Hmha1 histocompatibility (minor) HA-1 0.026
Csk c-src tyrosine kinase 0.026
Nfat5 nuclear factor of activated T-cells 5 0.025
RT1-Bb RT1 class II, locus Bb 0.025
Cd8b CD8b molecule 0.025
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.025
Ceacam10 carcinoembryonic antigen-related cell adhesion molecule 10 0.024
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.024
Stk10 serine/threonine kinase 10 0.024
Cd4 Cd4 molecule 0.023
Lilrb3l leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like 0.023
Itgam integrin, alpha M 0.023
Emcn endomucin 0.023
Arhgap4 Rho GTPase activating protein 4 0.023
Anpep alanyl (membrane) aminopeptidase 0.022
Cd3g CD3 molecule, gamma 0.022
Klra5 killer cell lectin-like receptor, subfamily A, member 5 0.020
Bmp7 bone morphogenetic protein 7 0.020
Sox18 SRY (sex determining region Y)-box 18 0.019
Nfic nuclear factor I/C 0.019
Ralgds ral guanine nucleotide dissociation stimulator 0.019
Ly6c Ly6-C antigen 0.019
Lrg1 leucine-rich alpha-2-glycoprotein 1 0.019
Cdc2l6 cell division cycle 2-like 6 (CDK8-like) 0.018
Il1b interleukin 1 beta 0.018
Cfp complement factor properdin 0.018
Svs1 seminal vesicle secretory protein 1 0.018
Cd6 Cd6 molecule 0.018
Mov10 Moloney leukemia virus 10 0.018
Rxra retinoid X receptor alpha 0.017
Stat3 signal transducer and activator of transcription 3 0.016
Fgf16 fibroblast growth factor 16 0.016
Sdc3 syndecan 3 0.016
Cybb cytochrome b-245, beta polypeptide 0.016
Tgfbr3 transforming growth factor, beta receptor III 0.016
Il1rn interleukin 1 receptor antagonist 0.016
H2afy H2A histone family, member Y 0.016
Abi3 ABI family, member 3 0.016
Dmgdh dimethylglycine dehydrogenase 0.016
Sorbs1 sorbin and SH3 domain containing 1 0.016
Il7r interleukin 7 receptor 0.016
Fut4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.016
LOC60591 calcium-activated potassium channel beta subunit 0.016
Cd5 Cd5 molecule 0.015
Laptm5 lysosomal protein transmembrane 5 0.015
Cd8a CD8a molecule 0.015
Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 0.015
Gpsm3 G-protein signaling modulator 3 (AGS3-like, C. elegans) 0.015
Aqp2 aquaporin 2 (collecting duct) 0.015
Apol3 apolipoprotein L, 3 0.015
Egfl7 EGF-like-domain, multiple 7 0.015
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.015
Sept1 septin 1 0.014
Ctsc cathepsin C 0.014
Epn1 Epsin 1 0.014
Hcst hematopoietic cell signal transducer 0.014
Tfec transcription factor EC 0.014
Igh-6 immunoglobulin heavy chain 6 0.014
Mapk7 mitogen-activated protein kinase 7 0.014
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.014
Prickle3 prickle homolog 3 (Drosophila) 0.014
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.014
Myoc myocilin 0.014
Enpep glutamyl aminopeptidase 0.014
Gpr182 G protein-coupled receptor 182 0.014
Arhgap25 Rho GTPase activating protein 25 0.014
Hdac7 histone deacetylase 7 0.013
Pparg peroxisome proliferator-activated receptor gamma 0.013
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.013
Stx2 syntaxin 2 0.013
Sox7 SRY (sex determining region Y)-box 7 0.013
Lect1 leukocyte cell derived chemotaxin 1 0.013
Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha 0.013
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.013
Zfp36 zinc finger protein 36 0.013
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism