The network for 'germ line stem cell division' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

germ line stem cell division

The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.

Mus musculus
Name Description Probability Func Analog Organism
Smad4 MAD homolog 4 (Drosophila) 1.000
Ctnnb1 catenin (cadherin associated protein), beta 1 1.000
Bmpr1a bone morphogenetic protein receptor, type 1A 0.999
Shh sonic hedgehog 0.999
Fgfr2 fibroblast growth factor receptor 2 0.998
Apc adenomatosis polyposis coli 0.996
Foxc1 forkhead box C1 0.988
Smad3 MAD homolog 3 (Drosophila) 0.984
Nodal nodal 0.966
Jarid2 jumonji, AT rich interactive domain 2 0.934
Ptch1 patched homolog 1 0.926
Sox9 SRY-box containing gene 9 0.926
Grb10 growth factor receptor bound protein 10 0.913
Gli3 GLI-Kruppel family member GLI3 0.910
Tgfbr2 transforming growth factor, beta receptor II 0.907
Pten phosphatase and tensin homolog 0.905
Mtf2 metal response element binding transcription factor 2 0.885
Fgfr1 fibroblast growth factor receptor 1 0.872
Smad2 MAD homolog 2 (Drosophila) 0.870
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.866
Acvr1 activin A receptor, type 1 0.863
Fgfr3 fibroblast growth factor receptor 3 0.827
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.755
Bmp7 bone morphogenetic protein 7 0.748
Meox2 mesenchyme homeobox 2 0.725
Tgfb2 transforming growth factor, beta 2 0.717
Fgf8 fibroblast growth factor 8 0.674
Hand2 heart and neural crest derivatives expressed transcript 2 0.659
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.619
Ednra endothelin receptor type A 0.601
Psen1 presenilin 1 0.597
Prrx1 paired related homeobox 1 0.569
Chrd chordin 0.539
Smad1 MAD homolog 1 (Drosophila) 0.538
Gata4 GATA binding protein 4 0.535
Pbx1 pre B-cell leukemia transcription factor 1 0.535
Notch1 Notch gene homolog 1 (Drosophila) 0.501
Eed embryonic ectoderm development 0.484
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.468
Stk38 serine/threonine kinase 38 0.437
Gpc3 glypican 3 0.410
Hand1 heart and neural crest derivatives expressed transcript 1 0.409
Nf1 neurofibromatosis 1 0.385
Egfr epidermal growth factor receptor 0.374
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.369
Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.359
Vegfa vascular endothelial growth factor A 0.340
Pitx2 paired-like homeodomain transcription factor 2 0.327
Runx2 runt related transcription factor 2 0.327
Gja1 gap junction protein, alpha 1 0.323
Irs1 insulin receptor substrate 1 0.322
Lrp6 low density lipoprotein receptor-related protein 6 0.299
Hes1 hairy and enhancer of split 1 (Drosophila) 0.292
Insr insulin receptor 0.289
Ghr growth hormone receptor 0.282
Otx2 orthodenticle homolog 2 (Drosophila) 0.274
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.266
Irs2 insulin receptor substrate 2 0.256
Bptf bromodomain PHD finger transcription factor 0.247
Smo smoothened homolog (Drosophila) 0.245
Gsk3b glycogen synthase kinase 3 beta 0.237
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.235
Prrx2 paired related homeobox 2 0.231
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.227
Msx1 homeobox, msh-like 1 0.226
Npc1 Niemann Pick type C1 0.224
Gli2 GLI-Kruppel family member GLI2 0.223
Amhr2 anti-Mullerian hormone type 2 receptor 0.218
Tgfbr1 transforming growth factor, beta receptor I 0.213
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.205
Tgfbr3 transforming growth factor, beta receptor III 0.203
Hoxd13 homeobox D13 0.202
Aebp2 AE binding protein 2 0.198
Prkg1 protein kinase, cGMP-dependent, type I 0.192
Igf1r insulin-like growth factor I receptor 0.192
Jag1 jagged 1 0.188
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.183
Zeb1 zinc finger E-box binding homeobox 1 0.177
Esr1 estrogen receptor 1 (alpha) 0.171
Rbbp4 retinoblastoma binding protein 4 0.164
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.158
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.157
Col2a1 collagen, type II, alpha 1 0.154
Htt huntingtin 0.152
Tcfap2a transcription factor AP-2, alpha 0.147
Nos3 nitric oxide synthase 3, endothelial cell 0.139
Prop1 paired like homeodomain factor 1 0.134
Bmp2 bone morphogenetic protein 2 0.133
Tdgf1 teratocarcinoma-derived growth factor 1 0.132
Bmp4 bone morphogenetic protein 4 0.130
Twsg1 twisted gastrulation homolog 1 (Drosophila) 0.127
Smad6 MAD homolog 6 (Drosophila) 0.125
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.125
Hoxa11 homeobox A11 0.123
Bmper BMP-binding endothelial regulator 0.123
Alx4 aristaless-like homeobox 4 0.117
Thra thyroid hormone receptor alpha 0.116
Hoxd11 homeobox D11 0.115
Erbb2ip Erbb2 interacting protein 0.112
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.110
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
glh-4 Protein GLH-4 0.417
glh-1 Protein GLH-1 0.268
pgl-1 Protein PGL-1 0.155
csr-1 Protein CSR-1 0.146
hpo-40 Protein HPO-40 0.102
rod-1 Protein ROD-1 0.085
mcm-2 Protein MCM-2 0.079
coh-3 Protein COH-3 0.069
syp-4 Protein SYP-4 0.061
htp-3 Protein HTP-3 0.054
D2096.11 Protein D2096.11 0.049
lst-3 Protein LST-3 0.045
sma-6 Protein SMA-6 0.039
klp-10 Protein KLP-10 0.039
ZK1127.6 Protein ZK1127.6 0.038
K07H8.10 Protein K07H8.10 0.037
C28A5.1 Protein C28A5.1 0.036
mcm-7 Protein MCM-7 0.035
glh-2 Protein GLH-2 0.034
CELE_C34D4.10 Protein C34D4.10 0.032
B0261.1 Protein B0261.1 0.031
zwl-1 Protein ZWL-1 0.029
scc-3 Protein SCC-3 0.029
xpo-1 Protein XPO-1 0.028
cgh-1 Protein CGH-1 0.028
CELE_W03F9.10 Protein W03F9.10 0.027
daf-14 Protein DAF-14 0.026
spr-5 Protein SPR-5 0.026
klp-18 Protein KLP-18 0.026
npp-12 Protein NPP-12 0.025
npp-9 Protein NPP-9 0.024
mrp-7 Protein MRP-7 0.024
mut-7 Protein MUT-7 0.022
CELE_Y48B6A.1 Protein Y48B6A.1 0.022
mcm-3 Protein MCM-3 0.022
prg-1 Protein PRG-1 0.022
fkb-6 Protein FKB-6 0.022
ppw-2 Protein PPW-2 0.021
npp-21 Protein NPP-21 0.021
F57B10.4 Protein F57B10.4 0.021
rad-50 Protein RAD-50 0.021
ani-2 Protein ANI-2 0.020
fbf-1 Protein FBF-1 0.019
toca-2 Protein TOCA-2 0.019
tba-1 Protein TBA-1 0.019
sel-8 Protein SEL-8 0.019
cdc-48.1 Protein CDC-48.1 0.019
dpf-3 Protein DPF-3 0.018
chl-1 Protein CHL-1 0.018
bath-7 Protein BATH-7 0.018
F31C3.3 Protein F31C3.3 0.018
isw-1 Protein ISW-1 0.017
D1081.7 Protein D1081.7 0.017
btf-1 Protein BTF-1 0.017
C30G12.6 Protein C30G12.6 0.017
hpo-10 Protein HPO-10 0.016
M01E11.3 Protein M01E11.3 0.016
CELE_K08F4.2 Protein K08F4.2 0.015
T14B4.1 Protein T14B4.1 0.015
mcm-5 Protein MCM-5 0.015
tbc-2 Protein TBC-2 0.015
ucr-2.3 Protein UCR-2.3 0.015
rpn-2 Protein RPN-2 0.014
eef-1A.1 Protein EEF-1A.1 0.014
skp-1 Protein SKP-1 0.014
sec-6 Protein SEC-6 0.014
K06A5.1 Protein K06A5.1 0.014
crm-1 Protein CRM-1 0.014
glh-3 Protein GLH-3 0.014
mre-11 Protein MRE-11 0.013
atl-1 Protein ATL-1 0.013
mes-2 Protein MES-2 0.013
mcm-4 Protein MCM-4 0.013
egl-18 Protein EGL-18 0.013
ego-1 Protein EGO-1 0.013
sacy-1 Protein SACY-1 0.013
T27A3.2 Protein T27A3.2 0.013
trcs-2 Protein TRCS-2 0.013
wago-9 Protein WAGO-9 0.013
F33G12.3 Protein F33G12.3 0.012
pqn-85 Protein PQN-85 0.012
dsh-2 Protein DSH-2 0.012
C16A11.5 Protein C16A11.5 0.012
CELE_F54D5.9 Protein F54D5.9 0.012
tbb-2 Protein TBB-2 0.012
rbc-1 Protein RBC-1 0.012
R05H10.3 Protein R05H10.3 0.012
rsp-7 Protein RSP-7 0.012
lin-12 Protein LIN-12 0.012
sago-2 Protein SAGO-2 0.012
ife-3 Protein IFE-3 0.012
mat-3 Protein MAT-3 0.012
rpl-11.1 Protein RPL-11.1 0.011
CELE_F25B4.5 Protein F25B4.5 0.011
got-2.1 Protein GOT-2.1 0.011
hum-2 Protein HUM-2 0.011
tba-2 Protein TBA-2 0.011
B0035.6 Protein B0035.6 0.011
C53H9.2 Protein C53H9.2 0.011
B0412.3 Protein B0412.3 0.011
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 1.000
nanos3 nanos homolog 3 0.988
bmp4 bone morphogenetic protein 4 0.987
tbx1 T-box 1 0.958
vasa vasa homolog 0.753
igf1rb insulin-like growth factor 1b receptor 0.746
gro1 groucho 1 0.692
tbx5a T-box 5a 0.590
chd chordin 0.583
gro2 groucho 2 0.582
acvr1l activin A receptor, type I like 0.569
ripk2 receptor-interacting serine-threonine kinase 2 0.425
ndr1 nodal-related 1 0.423
tp53 tumor protein p53 0.400
ca15b carbonic anhydrase XV b 0.343
mmp2 matrix metalloproteinase 2 0.315
ptprb protein tyrosine phosphatase, receptor type, b 0.297
brca2 breast cancer 2, early onset 0.284
eomesa eomesodermin homolog a 0.265
wls wntless homolog (Drosophila) 0.178
fgf8a fibroblast growth factor 8 a 0.173
smad5 MAD homolog 5 (Drosophila) 0.169
chsy1 chondroitin sulfate synthase 1 0.159
lpp LIM domain containing preferred translocation partner in lipoma 0.158
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.156
insrb insulin receptor b 0.136
foxi1 forkhead box I1 0.134
per3 period homolog 3 (Drosophila) 0.131
pou5f1 POU domain, class 5, transcription factor 1 0.130
mapk3 mitogen-activated protein kinase 3 0.125
cx30.3 connexin 30.3 0.118
wnt5b wingless-type MMTV integration site family, member 5b 0.117
rcn1 reticulocalbin 1, EF-hand calcium binding domain 0.114
bokb BCL2-related ovarian killer b 0.113
vdra vitamin D receptor a 0.105
tdrd1 tudor domain containing 1 0.103
bmp2a bone morphogenetic protein 2a 0.102
spns2 spinster homolog 2 (Drosophila) 0.099
lats1 LATS, large tumor suppressor, homolog 1 (Drosophila) 0.096
fancl Fanconi anemia, complementation group L 0.092
sdc2 syndecan 2 0.091
msxd muscle segment homeobox D 0.089
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.085
esyt3 extended synaptotagmin-like protein 3 0.083
tbx16 T-box gene 16 0.082
tmem2 transmembrane protein 2 0.080
c11orf2 c11orf2 homolog (H. sapiens) 0.075
zorba Orb/CPEB-related RNA-binding protein 0.074
aldh1l1 aldehyde dehydrogenase 1 family, member L1 0.073
tgfb3 transforming growth factor, beta 3 0.071
shdb Src homology 2 domain containing transforming protein D, b 0.070
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.070
retsatl retinol saturase (all-trans-retinol 13,14-reductase) like 0.070
rbpms2 RNA binding protein with multiple splicing 2 0.069
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.069
sox19b SRY-box containing gene 19b 0.069
oep one-eyed pinhead 0.068
acvr1b activin A receptor, type IB 0.068
kif23 kinesin family member 23 0.066
tbpl2 TATA box binding protein like 2 0.061
pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.060
trim3a tripartite motif-containing 3a 0.060
spry2 sprouty homolog 2 0.059
foxh1 forkhead box H1 0.058
LOC567678 avidin-like 0.058
ror2 receptor tyrosine kinase-like orphan receptor 2 0.058
sox9a SRY-box containing gene 9a 0.058
rtf1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.057
zgc:77836 zgc:77836 0.056
supt6h suppressor of Ty 6 homolog 0.053
rhpn2 rhophilin, Rho GTPase binding protein 2 0.053
h1m linker histone H1M 0.053
axin1 axin 1 0.052
zbtb4 zinc finger and BTB domain containing 4 0.052
bmpr1ab bone morphogenetic protein receptor, type 1ab 0.052
mtmr8 myotubularin related protein 8 0.051
szl sizzled 0.051
antxr2a anthrax toxin receptor 2a 0.051
capn9 calpain 9 0.051
tll1 tolloid-like 1 0.050
polr2a polymerase (RNA) II (DNA directed) polypeptide A 0.050
fancd2 Fanconi anemia, complementation group D2 0.049
ptgs1 prostaglandin-endoperoxide synthase 1 0.049
cul1b cullin 1b 0.047
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.047
slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 0.046
plxnb2a plexin b2a 0.046
st3gal2l ST3 beta-galactoside alpha-2,3-sialyltransferase 2, like 0.046
pld1a phospholipase D1a 0.046
tgfbr2 transforming growth factor, beta receptor II 0.045
cyp11a1 cytochrome P450, subfamily XIA, polypeptide 1 0.045
shmt2 serine hydroxymethyltransferase 2 (mitochondrial) 0.045
vps35 vacuolar protein sorting 35 (yeast) 0.045
odc1 ornithine decarboxylase 1 0.045
furina furin (paired basic amino acid cleaving enzyme) a 0.044
ptpra protein tyrosine phosphatase, receptor type, A 0.044
wnt8a wingless-type MMTV integration site family, member 8a 0.044
phex phosphate regulating gene with homologues to endopeptidases on the X chromosome 0.043
piwil1 piwi-like 1 (Drosophila) 0.043
grk5 G protein-coupled receptor kinase 5 0.043
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Mad Mothers against dpp 1.000
sax saxophone 0.997
tkv thickveins 0.994
InR Insulin-like receptor 0.974
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.964
brat brain tumor 0.963
Fmr1 CG6203 gene product from transcript CG6203-RC 0.945
piwi CG6122 gene product from transcript CG6122-RA 0.939
vas vasa 0.831
Ras85D Ras oncogene at 85D 0.743
twin CG31137 gene product from transcript CG31137-RB 0.692
Akt1 CG4006 gene product from transcript CG4006-RA 0.666
Src64B Src oncogene at 64B 0.629
bgcn benign gonial cell neoplasm 0.588
hts hu li tai shao 0.578
Dl Delta 0.556
AGO1 Argonaute-1 0.518
nos nanos 0.518
dap dacapo 0.435
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.418
dally division abnormally delayed 0.410
Pabp2 CG2163 gene product from transcript CG2163-RA 0.388
EcR Ecdysone receptor 0.376
CG4771 CG4771 gene product from transcript CG4771-RA 0.355
mael maelstrom 0.330
chic chickadee 0.317
pho pleiohomeotic 0.301
aub aubergine 0.297
Med Medea 0.286
zpg zero population growth 0.279
asp abnormal spindle 0.261
CG8443 CG8443 gene product from transcript CG8443-RA 0.256
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.241
FBX011 FBX011 ortholog 0.235
scny scrawny 0.231
slmb supernumerary limbs 0.228
enok enoki mushroom 0.214
CSN4 COP9 complex homolog subunit 4 0.211
loqs loquacious 0.202
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.201
eff effete 0.193
Rac1 CG2248 gene product from transcript CG2248-RA 0.192
Su(H) Suppressor of Hairless 0.189
pUf68 poly U binding factor 68kD 0.171
hh hedgehog 0.163
spn-E spindle E 0.156
hpo hippo 0.153
trc tricornered 0.146
stwl stonewall 0.144
dm diminutive 0.142
jeb jelly belly 0.136
gbb glass bottom boat 0.136
Top1 Topoisomerase 1 0.133
Stat92E Signal-transducer and activator of transcription protein at 92E 0.129
chb chromosome bows 0.127
eya eyes absent 0.126
Lis-1 Lissencephaly-1 0.123
Dad Daughters against dpp 0.110
polo CG12306 gene product from transcript CG12306-RA 0.109
put punt 0.105
egg eggless 0.101
gig gigas 0.096
Parg Poly(ADP-ribose) glycohydrolase 0.094
otu ovarian tumor 0.085
Scm Sex comb on midleg 0.082
CycA Cyclin A 0.082
Dhc64C Dynein heavy chain 64C 0.080
Irk2 Inwardly rectifying potassium channel 2 0.074
Cap-G CG34438 gene product from transcript CG34438-RF 0.073
stet stem cell tumor 0.071
26-29-p 26-29kD-proteinase 0.071
wcd wicked 0.065
babo baboon 0.065
yki yorkie 0.063
sd scalloped 0.056
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.055
bam bag of marbles 0.054
fzy fizzy 0.052
aret arrest 0.050
Cdc42 CG12530 gene product from transcript CG12530-RA 0.048
phl pole hole 0.045
pasha partner of drosha 0.045
CycE Cyclin E 0.044
armi armitage 0.044
BicD Bicaudal D 0.043
Ser Serrate 0.042
Snoo Sno oncogene 0.042
arm armadillo 0.042
CG2926 CG2926 gene product from transcript CG2926-RA 0.042
gpp grappa 0.041
bel belle 0.039
ro rough 0.038
Nup154 Nucleoporin 154 0.037
Pk61C Protein kinase 61C 0.037
CG42709 CG42709 gene product from transcript CG42709-RC 0.036
stl stall 0.035
Atx2 Ataxin-2 0.035
Egfr Epidermal growth factor receptor 0.034
Notum CG13076 gene product from transcript CG13076-RB 0.033
Pc Polycomb 0.032
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Homo sapiens
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism