The network for 'response to alcohol' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to alcohol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus.

Mus musculus
Name Description Probability Func Analog Organism
Lepr leptin receptor 0.999
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.999
Nos3 nitric oxide synthase 3, endothelial cell 0.998
Drd2 dopamine receptor D2 0.994
Apc adenomatosis polyposis coli 0.985
Esr1 estrogen receptor 1 (alpha) 0.983
Pten phosphatase and tensin homolog 0.967
Ar androgen receptor 0.965
Fshr follicle stimulating hormone receptor 0.952
Tgfb1 transforming growth factor, beta 1 0.950
Lep leptin 0.949
Stat3 signal transducer and activator of transcription 3 0.934
Ptgs2 prostaglandin-endoperoxide synthase 2 0.906
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.883
Nos1 nitric oxide synthase 1, neuronal 0.850
Csf1 colony stimulating factor 1 (macrophage) 0.815
Ccl2 chemokine (C-C motif) ligand 2 0.812
Bglap bone gamma carboxyglutamate protein 0.737
Prlr prolactin receptor 0.733
Robo1 roundabout homolog 1 (Drosophila) 0.697
Agtr1a angiotensin II receptor, type 1a 0.689
Pgr progesterone receptor 0.658
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.608
Slc12a1 solute carrier family 12, member 1 0.604
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.587
Prkce protein kinase C, epsilon 0.580
Smad3 MAD homolog 3 (Drosophila) 0.575
Fgfr2 fibroblast growth factor receptor 2 0.566
Cdk4 cyclin-dependent kinase 4 0.552
Amhr2 anti-Mullerian hormone type 2 receptor 0.551
Ren1 renin 1 structural 0.550
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.534
Fst follistatin 0.512
Tlr4 toll-like receptor 4 0.506
Ifng interferon gamma 0.497
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.490
Tgfbr2 transforming growth factor, beta receptor II 0.487
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.473
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.462
Ptk2 PTK2 protein tyrosine kinase 2 0.457
Insr insulin receptor 0.430
Bmpr1a bone morphogenetic protein receptor, type 1A 0.422
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.418
Pomc pro-opiomelanocortin-alpha 0.416
Sox4 SRY-box containing gene 4 0.410
Cd44 CD44 antigen 0.401
Kl klotho 0.400
Pthlh parathyroid hormone-like peptide 0.382
Ldb3 LIM domain binding 3 0.379
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.377
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.374
Nos2 nitric oxide synthase 2, inducible 0.354
Clock circadian locomotor output cycles kaput 0.349
Gdnf glial cell line derived neurotrophic factor 0.348
Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 0.337
Vegfa vascular endothelial growth factor A 0.332
Rxra retinoid X receptor alpha 0.327
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.318
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.312
Nf1 neurofibromatosis 1 0.299
Ptprc protein tyrosine phosphatase, receptor type, C 0.296
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.296
Ccr2 chemokine (C-C motif) receptor 2 0.281
Ghr growth hormone receptor 0.272
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.267
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.262
Mef2a myocyte enhancer factor 2A 0.254
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.252
Tgfbr1 transforming growth factor, beta receptor I 0.251
Smad4 MAD homolog 4 (Drosophila) 0.248
Rarg retinoic acid receptor, gamma 0.248
Keg1 kidney expressed gene 1 0.244
Agtr2 angiotensin II receptor, type 2 0.235
Blnk B-cell linker 0.231
Thrb thyroid hormone receptor beta 0.225
F2r coagulation factor II (thrombin) receptor 0.223
Src Rous sarcoma oncogene 0.219
Gli2 GLI-Kruppel family member GLI2 0.216
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.215
Rara retinoic acid receptor, alpha 0.214
Fas Fas (TNF receptor superfamily member 6) 0.214
Mas1 MAS1 oncogene 0.213
Foxa2 forkhead box A2 0.213
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.211
Smyd1 SET and MYND domain containing 1 0.198
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.196
Bmi1 Bmi1 polycomb ring finger oncogene 0.194
Isl1 ISL1 transcription factor, LIM/homeodomain 0.193
Pax8 paired box gene 8 0.193
Cdk6 cyclin-dependent kinase 6 0.192
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.191
Adm adrenomedullin 0.188
Myod1 myogenic differentiation 1 0.186
Stat5b signal transducer and activator of transcription 5B 0.177
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.173
Icam1 intercellular adhesion molecule 1 0.172
Stat5a signal transducer and activator of transcription 5A 0.171
Il1b interleukin 1 beta 0.171
S100a8 S100 calcium binding protein A8 (calgranulin A) 0.163
Lyz2 lysozyme 2 0.161
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
apoeb apolipoprotein Eb 0.481
shha sonic hedgehog a 0.413
inhbaa inhibin, beta Aa 0.389
socs3a suppressor of cytokine signaling 3a 0.375
nrp2b neuropilin 2b 0.313
sox11a SRY-box containing gene 11a 0.199
ptgs2a prostaglandin-endoperoxide synthase 2a 0.178
slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.143
col1a1a collagen, type I, alpha 1a 0.142
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.136
ptprf protein tyrosine phosphatase, receptor type, F 0.089
otx2 orthodenticle homolog 2 0.089
dag1 dystroglycan 1 0.081
dcn decorin 0.077
gpr126 G protein-coupled receptor 126 0.075
acvr2a activin receptor IIa 0.073
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.072
esrrga estrogen-related receptor gamma a 0.070
uts1 urotensin 1 0.070
esr1 estrogen receptor 1 0.068
per2 period homolog 2 (Drosophila) 0.066
ca2 carbonic anhydrase II 0.061
evx1 even-skipped homeobox 1 0.061
alcama activated leukocyte cell adhesion molecule a 0.057
igf3 insulin-like growth factor 3 0.055
gdf11 growth differentiation factor 11 0.054
cbr1l carbonyl reductase 1-like 0.053
cyp3a65 cytochrome P450, family 3, subfamily A, polypeptide 65 0.052
itgb1a integrin, beta 1a 0.050
robo2 roundabout homolog 2 0.050
pcna proliferating cell nuclear antigen 0.049
gcm2 glial cells missing homolog 2 (Drosophila) 0.048
ctsba cathepsin B, a 0.048
mao monoamine oxidase 0.045
dab1a disabled homolog 1a (Drosophila) 0.045
ca8 carbonic anhydrase VIII 0.045
ppargc1al peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like 0.044
fzd7a frizzled homolog 7a 0.044
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.041
pdia4 protein disulfide isomerase associated 4 0.040
rc3 rabconnectin 3 0.040
igf2b insulin-like growth factor 2b 0.039
paqr7b progestin and adipoQ receptor family member VII, b 0.038
pcp4a Purkinje cell protein 4a 0.038
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.038
ripk2 receptor-interacting serine-threonine kinase 2 0.037
cry1a cryptochrome 1a 0.037
spry4 sprouty (Drosophila) homolog 4 0.037
inha inhibin, alpha 0.037
cadm1b cell adhesion molecule 1b 0.037
cry3 cryptochrome 3 0.037
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.036
chrm2a cholinergic receptor, muscarinic 2a 0.035
fgf3 fibroblast growth factor 3 0.035
bcl2 B-cell leukemia/lymphoma 2 0.034
sept9a septin 9a 0.034
tgfbr2 transforming growth factor, beta receptor II 0.033
hsp90a.1 heat shock protein 90-alpha 1 0.033
mmp9 matrix metalloproteinase 9 0.032
gdf9 growth differentiation factor 9 0.032
bcl2l1 bcl2-like 1 0.031
foxi1 forkhead box I1 0.031
mmp2 matrix metalloproteinase 2 0.031
gfra1a gdnf family receptor alpha 1a 0.031
myca myelocytomatosis oncogene a 0.030
nr2f1b nuclear receptor subfamily 2, group F, member 1b 0.030
th2 tyrosine hydroxylase 2 0.030
zgc:85866 zgc:85866 0.030
mapk1 mitogen-activated protein kinase 1 0.030
epas1b endothelial PAS domain protein 1b 0.029
ahi1 Abelson helper integration site 1 0.029
nrg1 neuregulin 1 0.028
robo3 roundabout homolog 3 0.028
calr calreticulin and calreticulin 0.028
th tyrosine hydroxylase 0.027
ctsz cathepsin Z 0.027
glud1a glutamate dehydrogenase 1a 0.027
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.027
nr1d1 nuclear receptor subfamily 1, group d, member 1 0.027
mef2d myocyte enhancer factor 2d 0.026
junb jun B proto-oncogene 0.025
fzd8b frizzled homolog 8b 0.025
avpl arginine vasopressin-like 0.025
wnt10a wingless-type MMTV integration site family, member 10a 0.025
kif5c kinesin family member 5C 0.025
ptgs1 prostaglandin-endoperoxide synthase 1 0.025
slit3 slit (Drosophila) homolog 3 0.025
cyp11a1 cytochrome P450, subfamily XIA, polypeptide 1 0.025
bhmt betaine-homocysteine methyltransferase 0.025
tfap2a transcription factor AP-2 alpha 0.025
lhx3 LIM homeobox 3 0.024
chrna4 cholinergic receptor, nicotinic, alpha 4 0.024
fgfr4 fibroblast growth factor receptor 4 0.024
zgc:153997 zgc:153997 0.024
zbtb10 zinc finger and BTB domain containing 10 0.024
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.024
atp1b2a ATPase, Na+/K+ transporting, beta 2a polypeptide 0.024
dbh dopamine beta hydroxylase 0.023
quo quattro 0.023
wif1 wnt inhibitory factor 1 0.023
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Drosophila melanogaster
Name Description Probability Func Analog Organism
TBPH CG10327 gene product from transcript CG10327-RC 0.971
brk brinker 0.857
Fas2 Fasciclin 2 0.826
EcR Ecdysone receptor 0.825
mew multiple edematous wings 0.805
Ras85D Ras oncogene at 85D 0.780
ttk tramtrack 0.723
Egfr Epidermal growth factor receptor 0.712
pan pangolin 0.655
rg rugose 0.622
argos CG4531 gene product from transcript CG4531-RA 0.613
Ced-12 CG5336 gene product from transcript CG5336-RA 0.603
hep hemipterous 0.538
Mer Merlin 0.527
CG7998 CG7998 gene product from transcript CG7998-RA 0.526
bves CG32513 gene product from transcript CG32513-RA 0.493
tll tailless 0.476
InR Insulin-like receptor 0.473
S6k RPS6-p70-protein kinase 0.453
spir spire 0.443
SoxN SoxNeuro 0.430
Sir2 CG5216 gene product from transcript CG5216-RA 0.423
ph-p polyhomeotic proximal 0.422
fu fused 0.410
Jhe Juvenile hormone esterase 0.373
kto kohtalo 0.347
CG17734 CG17734 gene product from transcript CG17734-RA 0.343
W Wrinkled 0.335
pros prospero 0.330
Nrg Neuroglian 0.329
sax saxophone 0.328
Dscam Down syndrome cell adhesion molecule 0.318
drk downstream of receptor kinase 0.312
btl breathless 0.311
eve even skipped 0.310
Rel Relish 0.308
usp ultraspiracle 0.304
insc inscuteable 0.296
Pkc98E Protein C kinase 98E 0.295
Nmdar1 NMDA receptor 1 0.292
NPFR1 neuropeptide F receptor 0.286
trx trithorax 0.274
drl derailed 0.265
pum pumilio 0.263
milt milton 0.263
eas easily shocked 0.263
if inflated 0.262
gcm glial cells missing 0.258
BRWD3 CG31132 gene product from transcript CG31132-RA 0.253
mmd mind-meld 0.250
disco disconnected 0.240
cmet CENP-meta 0.239
CG13253 CG13253 gene product from transcript CG13253-RB 0.238
Sulf1 Sulfated 0.235
gfA giant fibre A 0.234
tau CG31057 gene product from transcript CG31057-RA 0.233
Gem3 Gemin3 0.230
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.224
sty sprouty 0.220
Cat Catalase 0.219
Ubx Ultrabithorax 0.219
egr eiger 0.217
yu CG3249 gene product from transcript CG3249-RA 0.216
Spn27A Serpin 27A 0.214
vsg visgun 0.212
pnt pointed 0.211
sim single-minded 0.207
mbm mushroom body miniature 0.206
Rac1 CG2248 gene product from transcript CG2248-RA 0.204
CG3011 CG3011 gene product from transcript CG3011-RA 0.202
arr arrow 0.198
arm armadillo 0.194
ap apterous 0.192
Tbh Tyramine beta hydroxylase 0.183
spi spitz 0.183
Mf Myofilin 0.183
fru fruitless 0.179
Akap200 A kinase anchor protein 200 0.177
Tao-1 CG14217 gene product from transcript CG14217-RF 0.175
tutl turtle 0.173
crc cryptocephal 0.172
2mit CG42573 gene product from transcript CG42573-RA 0.171
Trh Tryptophan hydroxylase 0.169
AcCoAS Acetyl Coenzyme A synthase 0.169
Patr-1 Protein associated with topo II related - 1 0.168
mura murashka 0.168
CG8773 CG8773 gene product from transcript CG8773-RB 0.164
rictor rapamycin-insensitive companion of Tor 0.164
hb hunchback 0.164
Or83b Odorant receptor 83b 0.162
osk oskar 0.159
lab labial 0.155
slo slowpoke 0.154
Mtp Microsomal triacylglycerol transfer protein 0.151
Nf-YC Nuclear factor Y-box C 0.150
CG34168 CG34168 gene product from transcript CG34168-RA 0.150
Hop Hsp70/Hsp90 organizing protein homolog 0.149
nej nejire 0.149
drpr draper 0.147
vvl ventral veins lacking 0.143
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Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 0.994
ESR1 estrogen receptor 1 0.992
RARA retinoic acid receptor, alpha 0.919
IL8 interleukin 8 0.849
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.845
RXRA retinoid X receptor, alpha 0.814
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.773
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.773
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.766
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.755
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.746
SMAD2 SMAD family member 2 0.741
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.727
AR androgen receptor 0.672
IL2RB interleukin 2 receptor, beta 0.668
CCL5 chemokine (C-C motif) ligand 5 0.637
DLG4 discs, large homolog 4 (Drosophila) 0.629
FGFR2 fibroblast growth factor receptor 2 0.594
CCR5 chemokine (C-C motif) receptor 5 0.540
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.494
NCOA1 nuclear receptor coactivator 1 0.474
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.472
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.470
BCL2 B-cell CLL/lymphoma 2 0.469
IL6 interleukin 6 (interferon, beta 2) 0.466
THBS1 thrombospondin 1 0.451
EGR1 early growth response 1 0.434
FN1 fibronectin 1 0.426
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.423
CAV1 caveolin 1, caveolae protein, 22kDa 0.416
CREBBP CREB binding protein 0.413
GSK3B glycogen synthase kinase 3 beta 0.409
SMAD1 SMAD family member 1 0.398
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.392
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.391
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.380
NRP1 neuropilin 1 0.380
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.368
NCF1 neutrophil cytosolic factor 1 0.347
EPOR erythropoietin receptor 0.345
CCL2 chemokine (C-C motif) ligand 2 0.326
CCL4 chemokine (C-C motif) ligand 4 0.305
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.301
CRHR1 corticotropin releasing hormone receptor 1 0.300
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.298
HDAC1 histone deacetylase 1 0.294
DAXX death-domain associated protein 0.288
SLMAP sarcolemma associated protein 0.273
PPARA peroxisome proliferator-activated receptor alpha 0.263
SMAD7 SMAD family member 7 0.263
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.262
NCOR1 nuclear receptor corepressor 1 0.262
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.253
CCL22 chemokine (C-C motif) ligand 22 0.247
HNF4A hepatocyte nuclear factor 4, alpha 0.243
CXCL9 chemokine (C-X-C motif) ligand 9 0.239
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.230
ACACA acetyl-CoA carboxylase alpha 0.227
HSPB1 heat shock 27kDa protein 1 0.224
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.222
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.220
IL4R interleukin 4 receptor 0.219
BMP2 bone morphogenetic protein 2 0.211
TP53 tumor protein p53 0.210
FSTL1 follistatin-like 1 0.208
SIRT1 sirtuin 1 0.208
TGFB1 transforming growth factor, beta 1 0.202
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.200
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.198
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.196
BRCA1 breast cancer 1, early onset 0.192
XIAP X-linked inhibitor of apoptosis 0.192
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.188
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.179
IFNG interferon, gamma 0.176
VCAM1 vascular cell adhesion molecule 1 0.174
CCND1 cyclin D1 0.169
JAK2 Janus kinase 2 0.167
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.166
TBX5 T-box 5 0.165
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.165
TNF tumor necrosis factor 0.159
PAX8 paired box 8 0.157
NRIP1 nuclear receptor interacting protein 1 0.156
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.149
ARRB1 arrestin, beta 1 0.148
ADNP activity-dependent neuroprotector homeobox 0.148
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.146
MAPK14 mitogen-activated protein kinase 14 0.143
MAPK8 mitogen-activated protein kinase 8 0.140
JAK1 Janus kinase 1 0.139
BAX BCL2-associated X protein 0.134
ATF2 activating transcription factor 2 0.133
JUN jun proto-oncogene 0.133
MAPK3 mitogen-activated protein kinase 3 0.129
APAF1 apoptotic peptidase activating factor 1 0.126
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.126
SOCS5 suppressor of cytokine signaling 5 0.125
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.124
PLAU plasminogen activator, urokinase 0.121
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism