The network for 'immune response activating cell surface receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

immune response activating cell surface receptor signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response.

Mus musculus
Name Description Probability Func Analog Organism
Cd19 CD19 antigen 1.000
Inpp5d inositol polyphosphate-5-phosphatase D 1.000
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.998
Ikzf1 IKAROS family zinc finger 1 0.998
Cd22 CD22 antigen 0.998
Icos inducible T-cell co-stimulator 0.997
Itk IL2-inducible T-cell kinase 0.997
Ptprc protein tyrosine phosphatase, receptor type, C 0.996
Fyn Fyn proto-oncogene 0.996
Lat linker for activation of T cells 0.996
Ccr2 chemokine (C-C motif) receptor 2 0.993
Ptk2 PTK2 protein tyrosine kinase 2 0.992
Vav1 vav 1 oncogene 0.984
Dok1 docking protein 1 0.982
Tnf tumor necrosis factor 0.978
Fasl Fas ligand (TNF superfamily, member 6) 0.978
Sykb spleen tyrosine kinase 0.978
Grb2 growth factor receptor bound protein 2 0.965
Pten phosphatase and tensin homolog 0.955
Il2rb interleukin 2 receptor, beta chain 0.953
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.953
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.943
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.942
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.920
Itgax integrin alpha X 0.919
Fas Fas (TNF receptor superfamily member 6) 0.917
Lck lymphocyte protein tyrosine kinase 0.909
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.901
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.901
Lta lymphotoxin A 0.895
Plcg1 phospholipase C, gamma 1 0.889
Itgal integrin alpha L 0.887
Was Wiskott-Aldrich syndrome homolog (human) 0.885
Blk B lymphoid kinase 0.885
Sfpi1 SFFV proviral integration 1 0.874
Il2rg interleukin 2 receptor, gamma chain 0.871
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.871
Ccr6 chemokine (C-C motif) receptor 6 0.870
Ly9 lymphocyte antigen 9 0.869
Fcgr2b Fc receptor, IgG, low affinity IIb 0.865
Igh immunoglobulin heavy chain complex 0.864
Cdh5 cadherin 5 0.863
Cd247 CD247 antigen 0.852
Il10ra interleukin 10 receptor, alpha 0.842
Btk Bruton agammaglobulinemia tyrosine kinase 0.828
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.816
Prdm1 PR domain containing 1, with ZNF domain 0.813
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.813
Gata4 GATA binding protein 4 0.810
Zap70 zeta-chain (TCR) associated protein kinase 0.805
Ccr7 chemokine (C-C motif) receptor 7 0.804
Cd7 CD7 antigen 0.800
Ltb lymphotoxin B 0.789
Pou2af1 POU domain, class 2, associating factor 1 0.776
Dok2 docking protein 2 0.771
Il10 interleukin 10 0.767
Card11 caspase recruitment domain family, member 11 0.765
Il7r interleukin 7 receptor 0.764
Fcrla Fc receptor-like A 0.756
Ikzf3 IKAROS family zinc finger 3 0.754
Ctla4 cytotoxic T-lymphocyte-associated protein 4 0.743
Cd2 CD2 antigen 0.741
Cd5 CD5 antigen 0.741
Slamf6 SLAM family member 6 0.738
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.737
Cxcr3 chemokine (C-X-C motif) receptor 3 0.736
Cd4 CD4 antigen 0.734
Cd3g CD3 antigen, gamma polypeptide 0.732
Cbl Casitas B-lineage lymphoma 0.730
Sh2d1a SH2 domain protein 1A 0.725
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.707
Stat3 signal transducer and activator of transcription 3 0.701
Aoah acyloxyacyl hydrolase 0.699
Slamf1 signaling lymphocytic activation molecule family member 1 0.697
Cd6 CD6 antigen 0.689
Rxra retinoid X receptor alpha 0.688
Notch2 Notch gene homolog 2 (Drosophila) 0.685
Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide 0.678
Nkg7 natural killer cell group 7 sequence 0.668
Cd96 CD96 antigen 0.665
Foxp3 forkhead box P3 0.664
Cd80 CD80 antigen 0.662
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.661
Ncf1 neutrophil cytosolic factor 1 0.654
Ncr1 natural cytotoxicity triggering receptor 1 0.632
Sell selectin, lymphocyte 0.632
Cd3e CD3 antigen, epsilon polypeptide 0.629
Tlr7 toll-like receptor 7 0.615
Cd28 CD28 antigen 0.607
Ifng interferon gamma 0.605
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.603
Ncoa3 nuclear receptor coactivator 3 0.598
Flt1 FMS-like tyrosine kinase 1 0.597
Ticam1 toll-like receptor adaptor molecule 1 0.594
Gimap7 GTPase, IMAP family member 7 0.591
Lrmp lymphoid-restricted membrane protein 0.590
Rhoh ras homolog gene family, member H 0.590
Lyz2 lysozyme 2 0.574
Ctsw cathepsin W 0.572
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.551
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.000
GRB2 growth factor receptor-bound protein 2 0.999
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.998
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.996
LCK lymphocyte-specific protein tyrosine kinase 0.996
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.995
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.993
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.993
SYK spleen tyrosine kinase 0.983
PTK2 PTK2 protein tyrosine kinase 2 0.983
LAT linker for activation of T cells 0.981
CD80 CD80 molecule 0.969
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.969
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.963
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.949
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.949
BCL2 B-cell CLL/lymphoma 2 0.948
CD247 CD247 molecule 0.947
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.942
BTK Bruton agammaglobulinemia tyrosine kinase 0.893
BTN3A2 butyrophilin, subfamily 3, member A2 0.888
GHR growth hormone receptor 0.881
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.860
FYB FYN binding protein 0.848
CD2 CD2 molecule 0.836
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.829
TFF1 trefoil factor 1 0.827
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.827
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.820
BIRC3 baculoviral IAP repeat containing 3 0.815
BLNK B-cell linker 0.813
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.761
BCL2L1 BCL2-like 1 0.743
SH3BP2 SH3-domain binding protein 2 0.736
BAX BCL2-associated X protein 0.705
TRAF3 TNF receptor-associated factor 3 0.697
EGFR epidermal growth factor receptor 0.692
MPDZ multiple PDZ domain protein 0.678
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.677
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.677
CD79A CD79a molecule, immunoglobulin-associated alpha 0.659
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.657
BTN3A3 butyrophilin, subfamily 3, member A3 0.639
RNF31 ring finger protein 31 0.628
CARD11 caspase recruitment domain family, member 11 0.533
TRAF1 TNF receptor-associated factor 1 0.493
CD40 CD40 molecule, TNF receptor superfamily member 5 0.492
SLA Src-like-adaptor 0.466
MICA MHC class I polypeptide-related sequence A 0.438
BTN3A1 butyrophilin, subfamily 3, member A1 0.435
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.416
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.412
BID BH3 interacting domain death agonist 0.407
VAV1 vav 1 guanine nucleotide exchange factor 0.401
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.390
SQSTM1 sequestosome 1 0.388
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.313
CD79B CD79b molecule, immunoglobulin-associated beta 0.311
MAPK3 mitogen-activated protein kinase 3 0.307
C19orf50 chromosome 19 open reading frame 50 0.303
NCK2 NCK adaptor protein 2 0.275
LPXN leupaxin 0.274
NUMBL numb homolog (Drosophila)-like 0.267
CTNND1 catenin (cadherin-associated protein), delta 1 0.250
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.250
UBASH3B ubiquitin associated and SH3 domain containing B 0.248
HDAC7 histone deacetylase 7 0.246
GRAP2 GRB2-related adaptor protein 2 0.240
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.240
FYN FYN oncogene related to SRC, FGR, YES 0.234
CD163 CD163 molecule 0.233
BAD BCL2-associated agonist of cell death 0.231
PXN paxillin 0.227
CD19 CD19 molecule 0.222
GRB7 growth factor receptor-bound protein 7 0.215
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.209
ACTB actin, beta 0.207
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.203
GAS7 growth arrest-specific 7 0.195
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.191
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.185
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.180
CCR1 chemokine (C-C motif) receptor 1 0.176
RNF11 ring finger protein 11 0.175
FASLG Fas ligand (TNF superfamily, member 6) 0.174
VAV2 vav 2 guanine nucleotide exchange factor 0.173
YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.172
SPRR2A small proline-rich protein 2A 0.162
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.158
MET met proto-oncogene (hepatocyte growth factor receptor) 0.156
BLK B lymphoid tyrosine kinase 0.150
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.148
HCK hemopoietic cell kinase 0.148
WIPF1 WAS/WASL interacting protein family, member 1 0.146
CD22 CD22 molecule 0.141
PSEN2 presenilin 2 (Alzheimer disease 4) 0.137
FHL2 four and a half LIM domains 2 0.135
PTPRC protein tyrosine phosphatase, receptor type, C 0.134
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.134
SH2D2A SH2 domain containing 2A 0.124
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Rattus norvegicus
Name Description Probability Func Analog Organism
Il2rg interleukin 2 receptor, gamma 0.081
Sash3 SAM and SH3 domain containing 3 0.043
Cd37 CD37 molecule 0.033
Syk spleen tyrosine kinase 0.021
Cfp complement factor properdin 0.020
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.019
Vav1 vav 1 guanine nucleotide exchange factor 0.019
Sirpa signal-regulatory protein alpha 0.018
Cd86 CD86 molecule 0.017
Myo1f myosin IF 0.016
Cd3g CD3 molecule, gamma 0.016
Ccr5 chemokine (C-C motif) receptor 5 0.015
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.014
Cybb cytochrome b-245, beta polypeptide 0.012
Stk10 serine/threonine kinase 10 0.012
Ptprc protein tyrosine phosphatase, receptor type, C 0.012
Inpp5d inositol polyphosphate-5-phosphatase D 0.012
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.011
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.011
Igsf6 immunoglobulin superfamily, member 6 0.011
Casp1 caspase 1 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism