The network for 'regulation of myeloid leukocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of myeloid leukocyte differentiation

Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.

Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 1.000
Ikzf1 IKAROS family zinc finger 1 0.998
Pax8 paired box gene 8 0.996
Csf1 colony stimulating factor 1 (macrophage) 0.996
Trp53 transformation related protein 53 0.993
Gata1 GATA binding protein 1 0.981
Kit kit oncogene 0.967
Robo1 roundabout homolog 1 (Drosophila) 0.964
Ctnnb1 catenin (cadherin associated protein), beta 1 0.964
Kiss1 KiSS-1 metastasis-suppressor 0.940
Esr1 estrogen receptor 1 (alpha) 0.933
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.932
Tgfb1 transforming growth factor, beta 1 0.927
Lyz2 lysozyme 2 0.926
Stat3 signal transducer and activator of transcription 3 0.914
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.895
Thra thyroid hormone receptor alpha 0.837
Ar androgen receptor 0.813
Rxra retinoid X receptor alpha 0.789
Mdm2 transformed mouse 3T3 cell double minute 2 0.787
Notch1 Notch gene homolog 1 (Drosophila) 0.783
Foxc2 forkhead box C2 0.757
Gata4 GATA binding protein 4 0.746
Jun Jun oncogene 0.744
Id1 inhibitor of DNA binding 1 0.738
Id3 inhibitor of DNA binding 3 0.727
Sfrp2 secreted frizzled-related protein 2 0.687
Lhx3 LIM homeobox protein 3 0.680
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.676
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.673
Inpp5d inositol polyphosphate-5-phosphatase D 0.664
Tnf tumor necrosis factor 0.658
Lepr leptin receptor 0.656
Igh immunoglobulin heavy chain complex 0.644
Rara retinoic acid receptor, alpha 0.640
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.629
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.609
Cbl Casitas B-lineage lymphoma 0.607
Rarg retinoic acid receptor, gamma 0.602
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.601
Stat5b signal transducer and activator of transcription 5B 0.589
Neurod1 neurogenic differentiation 1 0.588
Plcg2 phospholipase C, gamma 2 0.585
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.578
Smad3 MAD homolog 3 (Drosophila) 0.572
Il2rg interleukin 2 receptor, gamma chain 0.564
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.563
Duox2 dual oxidase 2 0.551
Vdr vitamin D receptor 0.539
Pparg peroxisome proliferator activated receptor gamma 0.537
Pitx2 paired-like homeodomain transcription factor 2 0.524
Fos FBJ osteosarcoma oncogene 0.519
Otx2 orthodenticle homolog 2 (Drosophila) 0.518
Stat5a signal transducer and activator of transcription 5A 0.518
Pax6 paired box gene 6 0.513
Ghr growth hormone receptor 0.512
Ltb lymphotoxin B 0.510
Rbl2 retinoblastoma-like 2 0.504
Notch2 Notch gene homolog 2 (Drosophila) 0.496
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.493
Rarb retinoic acid receptor, beta 0.481
Fcgr2b Fc receptor, IgG, low affinity IIb 0.475
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.474
Was Wiskott-Aldrich syndrome homolog (human) 0.470
Prlr prolactin receptor 0.463
Inhba inhibin beta-A 0.462
Slit3 slit homolog 3 (Drosophila) 0.459
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.454
Hes1 hairy and enhancer of split 1 (Drosophila) 0.444
Clock circadian locomotor output cycles kaput 0.443
Fgfr2 fibroblast growth factor receptor 2 0.438
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.430
Irs2 insulin receptor substrate 2 0.428
Gli2 GLI-Kruppel family member GLI2 0.426
Fas Fas (TNF receptor superfamily member 6) 0.413
Adam17 a disintegrin and metallopeptidase domain 17 0.412
Nos3 nitric oxide synthase 3, endothelial cell 0.393
Neurog2 neurogenin 2 0.380
Snai1 snail homolog 1 (Drosophila) 0.369
Sox11 SRY-box containing gene 11 0.364
Runx1 runt related transcription factor 1 0.362
Mecom MDS1 and EVI1 complex locus 0.356
Gnrh1 gonadotropin releasing hormone 1 0.349
Slit2 slit homolog 2 (Drosophila) 0.348
Cav1 caveolin 1, caveolae protein 0.348
Il2 interleukin 2 0.348
Il6st interleukin 6 signal transducer 0.347
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.345
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.341
Csf1r colony stimulating factor 1 receptor 0.341
Fgd1 FYVE, RhoGEF and PH domain containing 1 0.338
Rb1 retinoblastoma 1 0.335
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.334
Kl klotho 0.323
Bmpr1a bone morphogenetic protein receptor, type 1A 0.313
Stat6 signal transducer and activator of transcription 6 0.312
Dll1 delta-like 1 (Drosophila) 0.308
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.307
Epor erythropoietin receptor 0.303
Bglap bone gamma carboxyglutamate protein 0.302
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
mpx myeloid-specific peroxidase 0.991
junbl jun B proto-oncogene, like 0.648
nf1a neurofibromin 1a 0.614
lcp1 lymphocyte cytosolic plastin 1 0.559
tal1 T-cell acute lymphocytic leukemia 1 0.528
cmyb transcription factor cmyb 0.449
rag1 recombination activating gene 1 0.322
csf1ra colony stimulating factor 1 receptor, a 0.322
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.285
lyz lysozyme 0.272
spi1l spleen focus forming virus (SFFV) proviral integration oncogene spi1 like 0.239
drl draculin 0.221
LOC100331484 hypothetical protein LOC100331484 0.172
ltk leukocyte tyrosine kinase 0.155
kita kit receptor a 0.124
sc:d812 sc:d812 0.121
foxi3a forkhead box I3a 0.094
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.090
runx1 runt-related transcription factor 1 0.061
smyhc1 slow myosin heavy chain 1 0.061
gata1a GATA binding protein 1a 0.061
wnt8a wingless-type MMTV integration site family, member 8a 0.058
trim71 tripartite motif-containing 71 0.050
csf3r colony stimulating factor 3 receptor (granulocyte) 0.046
tfap2e transcription factor AP-2 epsilon 0.045
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.044
LOC560602 novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6) 0.043
mych myelocytomatosis oncogene homolog 0.039
atp6v0d1 ATPase, H+ transporting, V0 subunit D isoform 1 0.039
rarga retinoic acid receptor gamma a 0.038
mmp13a matrix metalloproteinase 13a 0.037
lmo2 LIM domain only 2 (rhombotin-like 1) 0.035
slc24a5 solute carrier family 24, member 5 0.034
col12a1 collagen, type XII, alpha 1 0.033
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.032
lmo4a LIM domain only 4a 0.028
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.028
irf8 interferon regulatory factor 8 0.028
kcnj13 potassium inwardly-rectifying channel, subfamily J, member 13 0.027
rarab retinoic acid receptor, alpha b 0.026
atf3 activating transcription factor 3 0.024
nf1b neurofibromin 1b 0.024
etv2 ets variant gene 2 0.024
mcoln1 mucolipin 1 0.023
egfl7 EGF-like-domain, multiple 7 0.023
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.022
socs3a suppressor of cytokine signaling 3a 0.022
efnb2a ephrin B2a 0.021
bcl2l10 BCL2-like 10 (apoptosis facilitator) 0.019
vps39 vacuolar protein sorting 39 homolog (S. cerevisiae) 0.019
clic2 chloride intracellular channel 2 0.018
mlphb melanophilin b 0.018
f2r coagulation factor II (thrombin) receptor 0.018
si:rp71-39b20.7 si:rp71-39b20.7 0.017
btg1 B-cell translocation gene 1 0.017
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.017
junb jun B proto-oncogene 0.017
cpox coproporphyrinogen oxidase 0.016
anxa11a annexin A11a 0.016
bnc2 basonuclin 2 0.016
mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.016
zgc:112329 zgc:112329 0.015
tyrp1 tyrosinase-related protein 1 0.015
ednrb1 endothelin receptor B 0.015
tgfbi transforming growth factor, beta-induced 0.014
mmp9 matrix metalloproteinase 9 0.014
zgc:162329 zgc:162329 0.013
tob1a transducer of ERBB2, 1a 0.013
celf1 cugbp, Elav-like family member 1 0.013
mef2cb myocyte enhancer factor 2cb 0.013
tlr3 toll-like receptor 3 0.012
pdcd2 programmed cell death 2 0.012
comta catechol-O-methyltransferase a 0.012
cd247l CD247 antigen like 0.012
jazf1b JAZF zinc finger 1b 0.012
ca15a carbonic anhydrase XV a 0.012
wu:fb80a07 wu:fb80a07 0.012
bcl2 B-cell leukemia/lymphoma 2 0.012
tgfb3 transforming growth factor, beta 3 0.011
LOC100151531 zinc finger protein Gfi-1b-like 0.011
adora2aa adenosine A2a receptor a 0.011
atp6v1h ATPase, H+ transporting, lysosomal, V1 subunit H 0.011
fgf17 fibroblast growth factor 17 0.010
cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.010
slc2a13 solute carrier family 2 (facilitated glucose transporter), member 13 0.010
safb scaffold attachment factor B 0.010
ryk receptor-like tyrosine kinase 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.991
C1QA complement component 1, q subcomponent, A chain 0.980
CCR5 chemokine (C-C motif) receptor 5 0.978
ZNF43 zinc finger protein 43 0.938
BIRC3 baculoviral IAP repeat containing 3 0.894
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.876
IL4R interleukin 4 receptor 0.871
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.868
CCL5 chemokine (C-C motif) ligand 5 0.831
RIPK2 receptor-interacting serine-threonine kinase 2 0.808
CXCL9 chemokine (C-X-C motif) ligand 9 0.799
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.779
CFLAR CASP8 and FADD-like apoptosis regulator 0.777
CXCL10 chemokine (C-X-C motif) ligand 10 0.764
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.744
HOXB5 homeobox B5 0.695
CXCL2 chemokine (C-X-C motif) ligand 2 0.675
CCL4 chemokine (C-C motif) ligand 4 0.671
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.646
ZNF253 zinc finger protein 253 0.644
CD40 CD40 molecule, TNF receptor superfamily member 5 0.625
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.608
IFNG interferon, gamma 0.594
SH2D4A SH2 domain containing 4A 0.564
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.546
IL8 interleukin 8 0.526
FASLG Fas ligand (TNF superfamily, member 6) 0.498
CCR1 chemokine (C-C motif) receptor 1 0.493
FAS Fas (TNF receptor superfamily, member 6) 0.481
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.474
JUND jun D proto-oncogene 0.470
TRAF1 TNF receptor-associated factor 1 0.453
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.435
JUN jun proto-oncogene 0.432
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.417
CXCL11 chemokine (C-X-C motif) ligand 11 0.412
ZNF273 zinc finger protein 273 0.397
CREBBP CREB binding protein 0.380
IRF4 interferon regulatory factor 4 0.376
CCL22 chemokine (C-C motif) ligand 22 0.376
ZNF430 zinc finger protein 430 0.375
RXRA retinoid X receptor, alpha 0.340
CCL8 chemokine (C-C motif) ligand 8 0.340
IL1B interleukin 1, beta 0.339
HOXA10 homeobox A10 0.339
IL2RB interleukin 2 receptor, beta 0.330
PILRA paired immunoglobin-like type 2 receptor alpha 0.319
ZNF675 zinc finger protein 675 0.317
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.313
HOXA5 homeobox A5 0.306
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.302
CCR7 chemokine (C-C motif) receptor 7 0.291
BIRC2 baculoviral IAP repeat containing 2 0.288
CXCL5 chemokine (C-X-C motif) ligand 5 0.278
CCR4 chemokine (C-C motif) receptor 4 0.277
ZNF708 zinc finger protein 708 0.276
CCR2 chemokine (C-C motif) receptor 2 0.272
SH3BP2 SH3-domain binding protein 2 0.268
ZNF93 zinc finger protein 93 0.244
HCK hemopoietic cell kinase 0.242
JUP junction plakoglobin 0.229
ZNF91 zinc finger protein 91 0.228
SOCS3 suppressor of cytokine signaling 3 0.227
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.212
EPOR erythropoietin receptor 0.209
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.207
IL10 interleukin 10 0.203
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.199
CCL7 chemokine (C-C motif) ligand 7 0.196
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.194
IL23A interleukin 23, alpha subunit p19 0.187
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.185
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.179
MEST mesoderm specific transcript homolog (mouse) 0.176
CXCL3 chemokine (C-X-C motif) ligand 3 0.174
CXCL13 chemokine (C-X-C motif) ligand 13 0.168
ZNF680 zinc finger protein 680 0.167
CCL2 chemokine (C-C motif) ligand 2 0.163
CCL13 chemokine (C-C motif) ligand 13 0.154
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.151
CXCR6 chemokine (C-X-C motif) receptor 6 0.149
NOTCH1 notch 1 0.146
FADD Fas (TNFRSF6)-associated via death domain 0.145
TRAF3 TNF receptor-associated factor 3 0.144
CCL11 chemokine (C-C motif) ligand 11 0.140
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.139
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.139
IL16 interleukin 16 (lymphocyte chemoattractant factor) 0.136
CXCR3 chemokine (C-X-C motif) receptor 3 0.136
GSK3B glycogen synthase kinase 3 beta 0.136
HTT huntingtin 0.129
ZNF117 zinc finger protein 117 0.127
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.126
SIRPB1 signal-regulatory protein beta 1 0.123
LRDD leucine-rich repeats and death domain containing 0.122
GHR growth hormone receptor 0.119
C1QC complement component 1, q subcomponent, C chain 0.115
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.115
APAF1 apoptotic peptidase activating factor 1 0.109
ATF2 activating transcription factor 2 0.109
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Rattus norvegicus
Name Description Probability Func Analog Organism
Atf3 activating transcription factor 3 0.208
Ctss cathepsin S 0.081
Dusp1 dual specificity phosphatase 1 0.079
Il2rb interleukin 2 receptor, beta 0.073
Klf4 Kruppel-like factor 4 (gut) 0.071
Junb jun B proto-oncogene 0.054
Egr2 early growth response 2 0.049
Plau plasminogen activator, urokinase 0.045
Fcn1 ficolin (collagen/fibrinogen domain containing) 1 0.041
Cbl Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.039
Il1b interleukin 1 beta 0.038
Cfp complement factor properdin 0.035
Cd86 CD86 molecule 0.028
Ccl4 chemokine (C-C motif) ligand 4 0.027
Btg2 BTG family, member 2 0.023
Jun Jun oncogene 0.023
Ccl3 chemokine (C-C motif) ligand 3 0.023
Zfp36 zinc finger protein 36 0.020
Egr1 early growth response 1 0.018
Reg3b regenerating islet-derived 3 beta 0.018
Ier2 immediate early response 2 0.017
Errfi1 ERBB receptor feedback inhibitor 1 0.017
Galnt5 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5) 0.015
Chrne cholinergic receptor, nicotinic, epsilon 0.015
Myl6l myosin, light polypeptide 6, alkali, smooth muscle and non-muscle-like 0.015
Il8rb interleukin 8 receptor, beta 0.014
Nckap1l NCK associated protein 1 like 0.014
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.013
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.013
RGD1359529 similar to chromosome 1 open reading frame 63 0.013
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.013
Nhp2 NHP2 ribonucleoprotein homolog (yeast) 0.012
Klf6 Kruppel-like factor 6 0.012
Prrx1 paired related homeobox 1 0.012
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.012
Laptm5 lysosomal protein transmembrane 5 0.012
Hspa1a heat shock 70kD protein 1A 0.012
Rgs1 regulator of G-protein signaling 1 0.011
Arhgap4 Rho GTPase activating protein 4 0.011
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.011
Il1a interleukin 1 alpha 0.011
Notch2 Notch homolog 2 (Drosophila) 0.011
Cd247 Cd247 molecule 0.011
Cd83 CD83 molecule 0.011
Acacb acetyl-Coenzyme A carboxylase beta 0.011
Tcf12 transcription factor 12 0.011
Ccl2 chemokine (C-C motif) ligand 2 0.010
Eif5a eukaryotic translation initiation factor 5A 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism