The network for 'positive regulation of lymphocyte proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of lymphocyte proliferation

Any process that activates or increases the rate or extent of lymphocyte proliferation.

Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 0.999
Ifng interferon gamma 0.998
Tlr4 toll-like receptor 4 0.998
Rnf2 ring finger protein 2 0.988
Fas Fas (TNF receptor superfamily member 6) 0.986
Cd40 CD40 antigen 0.983
Myd88 myeloid differentiation primary response gene 88 0.982
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.975
Lepr leptin receptor 0.975
Il6 interleukin 6 0.971
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.968
Efnb2 ephrin B2 0.924
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.921
Ccl2 chemokine (C-C motif) ligand 2 0.919
Ccr2 chemokine (C-C motif) receptor 2 0.918
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.912
Fasl Fas ligand (TNF superfamily, member 6) 0.903
Icos inducible T-cell co-stimulator 0.896
Cd28 CD28 antigen 0.889
Pdcd1 programmed cell death 1 0.886
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.868
Il4 interleukin 4 0.867
Il1b interleukin 1 beta 0.858
Ccr1 chemokine (C-C motif) receptor 1 0.854
Cd19 CD19 antigen 0.852
Lta lymphotoxin A 0.848
Socs1 suppressor of cytokine signaling 1 0.842
Sh2d2a SH2 domain protein 2A 0.814
Tgfb1 transforming growth factor, beta 1 0.798
Nos2 nitric oxide synthase 2, inducible 0.776
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.757
Il10 interleukin 10 0.745
Gli2 GLI-Kruppel family member GLI2 0.744
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.743
Lyz2 lysozyme 2 0.743
Cd5 CD5 antigen 0.726
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.712
Gzmk granzyme K 0.703
Stat5a signal transducer and activator of transcription 5A 0.696
Ccl4 chemokine (C-C motif) ligand 4 0.696
Cd80 CD80 antigen 0.693
Btk Bruton agammaglobulinemia tyrosine kinase 0.680
C3ar1 complement component 3a receptor 1 0.670
Fyn Fyn proto-oncogene 0.669
Stat3 signal transducer and activator of transcription 3 0.661
Csf1 colony stimulating factor 1 (macrophage) 0.653
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.641
Casp8 caspase 8 0.637
Prf1 perforin 1 (pore forming protein) 0.630
Il2rb interleukin 2 receptor, beta chain 0.617
Fgfr2 fibroblast growth factor receptor 2 0.611
Drd2 dopamine receptor D2 0.606
Pdcd1lg2 programmed cell death 1 ligand 2 0.605
Sykb spleen tyrosine kinase 0.602
Ikzf1 IKAROS family zinc finger 1 0.577
Rybp RING1 and YY1 binding protein 0.576
Foxp3 forkhead box P3 0.574
Gpr132 G protein-coupled receptor 132 0.571
Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 0.556
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.541
Gli3 GLI-Kruppel family member GLI3 0.525
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.520
Il2ra interleukin 2 receptor, alpha chain 0.510
Mmp9 matrix metallopeptidase 9 0.504
Stat5b signal transducer and activator of transcription 5B 0.504
Ubd ubiquitin D 0.502
Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 0.500
Emx2 empty spiracles homolog 2 (Drosophila) 0.497
Pax2 paired box gene 2 0.491
Ntf3 neurotrophin 3 0.486
Ptgs2 prostaglandin-endoperoxide synthase 2 0.486
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.478
Il2rg interleukin 2 receptor, gamma chain 0.477
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.474
Nlrp3 NLR family, pyrin domain containing 3 0.472
Cd96 CD96 antigen 0.455
Lag3 lymphocyte-activation gene 3 0.447
Adora2a adenosine A2a receptor 0.442
Foxc1 forkhead box C1 0.435
Esr1 estrogen receptor 1 (alpha) 0.426
Pax8 paired box gene 8 0.422
Cd247 CD247 antigen 0.419
Ccl3 chemokine (C-C motif) ligand 3 0.416
Nos3 nitric oxide synthase 3, endothelial cell 0.414
Pten phosphatase and tensin homolog 0.412
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.412
Il2 interleukin 2 0.410
Ccr7 chemokine (C-C motif) receptor 7 0.406
Ccr6 chemokine (C-C motif) receptor 6 0.396
Gpr33 G protein-coupled receptor 33 0.390
Traf6 TNF receptor-associated factor 6 0.387
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.385
Otx2 orthodenticle homolog 2 (Drosophila) 0.384
Lck lymphocyte protein tyrosine kinase 0.378
Ccl17 chemokine (C-C motif) ligand 17 0.377
Cd6 CD6 antigen 0.371
Cd7 CD7 antigen 0.370
Il12b interleukin 12b 0.362
Grb10 growth factor receptor bound protein 10 0.360
Tbx21 T-box 21 0.354
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
BCL2 B-cell CLL/lymphoma 2 0.995
LCK lymphocyte-specific protein tyrosine kinase 0.994
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.991
FGFR2 fibroblast growth factor receptor 2 0.981
HLA-DRA major histocompatibility complex, class II, DR alpha 0.965
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.956
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.951
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.948
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.909
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.908
HLA-DMA major histocompatibility complex, class II, DM alpha 0.905
IL1R1 interleukin 1 receptor, type I 0.905
GRB2 growth factor receptor-bound protein 2 0.899
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.891
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.878
ICAM1 intercellular adhesion molecule 1 0.877
CD86 CD86 molecule 0.865
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.848
CCL4 chemokine (C-C motif) ligand 4 0.844
CD80 CD80 molecule 0.843
SYK spleen tyrosine kinase 0.825
VAV1 vav 1 guanine nucleotide exchange factor 0.824
CCR5 chemokine (C-C motif) receptor 5 0.822
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.802
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.802
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.798
BTN3A2 butyrophilin, subfamily 3, member A2 0.790
HLA-DMB major histocompatibility complex, class II, DM beta 0.784
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.758
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.757
GRB7 growth factor receptor-bound protein 7 0.752
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.746
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.741
CD247 CD247 molecule 0.739
CCR7 chemokine (C-C motif) receptor 7 0.688
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.678
BTN3A3 butyrophilin, subfamily 3, member A3 0.677
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.647
CXCL9 chemokine (C-X-C motif) ligand 9 0.624
BTN3A1 butyrophilin, subfamily 3, member A1 0.610
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.565
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.552
CCR1 chemokine (C-C motif) receptor 1 0.519
NLRC4 NLR family, CARD domain containing 4 0.512
IFNG interferon, gamma 0.473
CCL22 chemokine (C-C motif) ligand 22 0.436
IL2RB interleukin 2 receptor, beta 0.434
CCL2 chemokine (C-C motif) ligand 2 0.424
IL8 interleukin 8 0.420
MYD88 myeloid differentiation primary response gene (88) 0.387
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.384
CD28 CD28 molecule 0.378
SOCS3 suppressor of cytokine signaling 3 0.354
IRF4 interferon regulatory factor 4 0.347
BID BH3 interacting domain death agonist 0.344
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.340
JAK1 Janus kinase 1 0.326
STAT4 signal transducer and activator of transcription 4 0.324
LAT linker for activation of T cells 0.316
EGFR epidermal growth factor receptor 0.285
BCL2A1 BCL2-related protein A1 0.281
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.279
CXCL10 chemokine (C-X-C motif) ligand 10 0.277
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.267
HDAC9 histone deacetylase 9 0.256
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.254
TICAM2 toll-like receptor adaptor molecule 2 0.252
IL2RG interleukin 2 receptor, gamma 0.249
IL1B interleukin 1, beta 0.246
SH3BP2 SH3-domain binding protein 2 0.246
IRAK1 interleukin-1 receptor-associated kinase 1 0.246
IGF2 insulin-like growth factor 2 (somatomedin A) 0.242
IL6 interleukin 6 (interferon, beta 2) 0.233
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.231
IL10 interleukin 10 0.226
IL4R interleukin 4 receptor 0.222
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.221
TRAF1 TNF receptor-associated factor 1 0.211
TRAF3 TNF receptor-associated factor 3 0.207
CXCL2 chemokine (C-X-C motif) ligand 2 0.205
IL10RA interleukin 10 receptor, alpha 0.193
CXCL13 chemokine (C-X-C motif) ligand 13 0.192
BAX BCL2-associated X protein 0.190
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.186
INSR insulin receptor 0.179
FASLG Fas ligand (TNF superfamily, member 6) 0.178
FGF1 fibroblast growth factor 1 (acidic) 0.174
FGFR1 fibroblast growth factor receptor 1 0.170
TAL1 T-cell acute lymphocytic leukemia 1 0.170
GRAP2 GRB2-related adaptor protein 2 0.170
BCL2L1 BCL2-like 1 0.162
CCL13 chemokine (C-C motif) ligand 13 0.158
CCL20 chemokine (C-C motif) ligand 20 0.158
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.155
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.154
HCK hemopoietic cell kinase 0.154
TLR2 toll-like receptor 2 0.152
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.150
CD83 CD83 molecule 0.142
SLAMF1 signaling lymphocytic activation molecule family member 1 0.142
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cd37 CD37 molecule 0.617
RT1-Da RT1 class II, locus Da 0.498
RT1-Ba RT1 class II, locus Ba 0.419
Cd247 Cd247 molecule 0.394
RT1-Db1 RT1 class II, locus Db1 0.393
RT1-DMb RT1 class II, locus DMb 0.263
Il10 interleukin 10 0.228
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.176
Cd5 Cd5 molecule 0.169
Calcr calcitonin receptor 0.166
Casp1 caspase 1 0.163
Mmp10 matrix metallopeptidase 10 0.118
Itgb7 integrin, beta 7 0.106
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.103
Serpinb2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.099
Il1b interleukin 1 beta 0.096
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.093
Laptm5 lysosomal protein transmembrane 5 0.092
Nkg7 natural killer cell group 7 sequence 0.091
Ly86 lymphocyte antigen 86 0.078
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.070
Pth parathyroid hormone 0.069
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.067
RT1-Bb RT1 class II, locus Bb 0.066
Cd2 Cd2 molecule 0.065
Napsa napsin A aspartic peptidase 0.064
Ptprc protein tyrosine phosphatase, receptor type, C 0.062
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.060
Kl Klotho 0.058
Plin perilipin 0.057
Lcp1 lymphocyte cytosolic protein 1 0.056
Dnase1l3 deoxyribonuclease 1-like 3 0.055
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.054
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.052
Il1rl1 interleukin 1 receptor-like 1 0.051
Gzmk granzyme K 0.049
Vip vasoactive intestinal peptide 0.048
Cd44 Cd44 molecule 0.047
Met met proto-oncogene 0.045
Plcd4 phospholipase C, delta 4 0.045
Ccr2 chemokine (C-C motif) receptor 2 0.045
Ncr1 natural cytotoxicity triggering receptor 1 0.044
Il6 interleukin 6 0.044
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.042
Prol1 proline rich, lacrimal 1 0.042
Npy5r neuropeptide Y receptor Y5 0.042
Tcrb T-cell receptor beta chain 0.041
Il4 interleukin 4 0.040
Spn sialophorin 0.040
Psg19 pregnancy specific glycoprotein 19 0.039
Cd53 Cd53 molecule 0.039
Reg3b regenerating islet-derived 3 beta 0.039
Dio2 deiodinase, iodothyronine, type II 0.037
Trpm8 transient receptor potential cation channel, subfamily M, member 8 0.037
Oprk1 opioid receptor, kappa 1 0.037
Bcl3 B-cell CLL/lymphoma 3 0.037
Cxcr3 chemokine (C-X-C motif) receptor 3 0.035
Prl8a9 prolactin family 8, subfamily a, member 9 0.035
Ciita class II, major histocompatibility complex, transactivator 0.035
Psp parotid secretory protein 0.033
Inpp5d inositol polyphosphate-5-phosphatase D 0.033
Fam108b1 family with sequence similarity 108, member B1 0.032
Zbp1 Z-DNA binding protein 1 0.031
Ptafr platelet-activating factor receptor 0.031
Faslg Fas ligand (TNF superfamily, member 6) 0.031
Neurog3 neurogenin 3 0.031
Prpg1 proline-rich proteoglycan 1 0.031
Il1r1 interleukin 1 receptor, type I 0.030
Art2 ADP-ribosyltransferase 2 0.030
Prl7a4 prolactin family 7, subfamily a, member 4 0.030
UST4r integral membrane transport protein UST4r 0.029
Reg3g regenerating islet-derived 3 gamma 0.028
Tas2r123 taste receptor, type 2, member 123 0.027
Vom2r27 vomeronasal 2 receptor, 27 0.027
Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 0.026
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.026
Sstr1 somatostatin receptor 1 0.026
Adh6a alcohol dehydrogenase 6A (class V) 0.026
Slc7a9 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 0.025
Mobp myelin-associated oligodendrocyte basic protein 0.025
Svs1 seminal vesicle secretory protein 1 0.024
Slc6a18 solute carrier family 6, member 18 0.024
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.024
Ugt2b7 UDP glucuronosyltransferase 2 family, polypeptide B7 0.024
Lepr leptin receptor 0.024
Cd3g CD3 molecule, gamma 0.024
Olr1500 olfactory receptor 1500 0.024
Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.023
Il6st interleukin 6 signal transducer 0.023
Egr3 early growth response 3 0.023
Hck hemopoietic cell kinase 0.023
Ccl4 chemokine (C-C motif) ligand 4 0.023
Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.022
Clec9a C-type lectin domain family 9, member a 0.022
RGD1310262 hypothetical LOC304650 0.022
Slc36a2 solute carrier family 36 (proton/amino acid symporter), member 2 0.022
LOC100363671 hypothetical protein LOC100363671 0.022
Vom1r90 vomeronasal 1 receptor 90 0.022
Mamdc4 MAM domain containing 4 0.022
Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 0.022
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism