IMP

Process View

Homo sapiens

25 genes annotated in human

positive regulation of cytokine biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of cytokine biosynthetic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of cytokine biosynthetic process" (in gray)

Name	Description	Probability	Func Analog Organism
LCK	lymphocyte-specific protein tyrosine kinase	0.956
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.899
BCL3	B-cell CLL/lymphoma 3	0.802	Mouse
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.727
TRAF1	TNF receptor-associated factor 1	0.716
IRAK2	interleukin-1 receptor-associated kinase 2	0.700
MYD88	myeloid differentiation primary response gene (88)	0.692	Mouse
BIRC3	baculoviral IAP repeat containing 3	0.659
CD80	CD80 molecule	0.654
BTN3A1	butyrophilin, subfamily 3, member A1	0.569	Human
IL1R1	interleukin 1 receptor, type I	0.515
BTN3A3	butyrophilin, subfamily 3, member A3	0.435	Human
BCL10	B-cell CLL/lymphoma 10	0.360
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.353
TRAF6	TNF receptor-associated factor 6	0.346	Mouse
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.311
BTN3A2	butyrophilin, subfamily 3, member A2	0.300	Human
TICAM2	toll-like receptor adaptor molecule 2	0.277
IL4R	interleukin 4 receptor	0.270
SYK	spleen tyrosine kinase	0.269	Mouse
TLR4	toll-like receptor 4	0.257
BTK	Bruton agammaglobulinemia tyrosine kinase	0.226
TRAF5	TNF receptor-associated factor 5	0.220
TRAF2	TNF receptor-associated factor 2	0.220
LAT	linker for activation of T cells	0.205
CD86	CD86 molecule	0.190	Human
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.164
IL2RB	interleukin 2 receptor, beta	0.158
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.154
IL1RAP	interleukin 1 receptor accessory protein	0.130
IRAK1	interleukin-1 receptor-associated kinase 1	0.123
TRAF3	TNF receptor-associated factor 3	0.113
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.113
DDIT3	DNA-damage-inducible transcript 3	0.110
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.103
CD247	CD247 molecule	0.101
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.101
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.099
BTN2A2	butyrophilin, subfamily 2, member A2	0.094	Human
CARD11	caspase recruitment domain family, member 11	0.094	Mouse
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.092
TLR2	toll-like receptor 2	0.091
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.077
CD40	CD40 molecule, TNF receptor superfamily member 5	0.070
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.066
INSR	insulin receptor	0.058
TRADD	TNFRSF1A-associated via death domain	0.054
JAK1	Janus kinase 1	0.052
IRAK3	interleukin-1 receptor-associated kinase 3	0.051
STAP2	signal transducing adaptor family member 2	0.050
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.050
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.048	Human
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.048
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.046
BTN2A1	butyrophilin, subfamily 2, member A1	0.045	Human
BAG3	BCL2-associated athanogene 3	0.045
GRAP2	GRB2-related adaptor protein 2	0.041
JAK2	Janus kinase 2	0.041
MPO	myeloperoxidase	0.040
AZI2	5-azacytidine induced 2	0.038
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.038
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.038
TNIP1	TNFAIP3 interacting protein 1	0.037
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	0.036
TNF	tumor necrosis factor	0.036
CYBB	cytochrome b-245, beta polypeptide	0.035
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.035
IRF4	interferon regulatory factor 4	0.034
IL8	interleukin 8	0.033
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.033
TRIM21	tripartite motif containing 21	0.031
CD83	CD83 molecule	0.031
CXCR6	chemokine (C-X-C motif) receptor 6	0.031
CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	0.030
TANK	TRAF family member-associated NFKB activator	0.030
ZC3H12A	zinc finger CCCH-type containing 12A	0.030
PIAS4	protein inhibitor of activated STAT, 4	0.029
UBA7	ubiquitin-like modifier activating enzyme 7	0.028
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.028
IRAK4	interleukin-1 receptor-associated kinase 4	0.028
CCR7	chemokine (C-C motif) receptor 7	0.028
FZD1	frizzled homolog 1 (Drosophila)	0.028
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.027	Human
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.027
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.027
CTSG	cathepsin G	0.026
C9orf89	chromosome 9 open reading frame 89	0.026
IL10	interleukin 10	0.026
ICAM1	intercellular adhesion molecule 1	0.025
IRF9	interferon regulatory factor 9	0.025
TLR7	toll-like receptor 7	0.025
IL2RG	interleukin 2 receptor, gamma	0.024
STAT5A	signal transducer and activator of transcription 5A	0.024	Mouse
PELI3	pellino homolog 3 (Drosophila)	0.024
ELANE	elastase, neutrophil expressed	0.023
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.023
PRKCQ	protein kinase C, theta	0.022	Mouse
IFNG	interferon, gamma	0.022
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.022
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.022
CD1C	CD1c molecule	0.022
STAT2	signal transducer and activator of transcription 2, 113kDa	0.022
AZU1	azurocidin 1	0.022
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.022
IL1R2	interleukin 1 receptor, type II	0.021
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.021
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.021
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.020
IRF1	interferon regulatory factor 1	0.020	Human Mouse
KAT2B	K(lysine) acetyltransferase 2B	0.019
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.019	Mouse
RIPK2	receptor-interacting serine-threonine kinase 2	0.019
HSPB8	heat shock 22kDa protein 8	0.018
LY9	lymphocyte antigen 9	0.018
PRTN3	proteinase 3	0.018	Human
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.018
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.018	Mouse
CRYAB	crystallin, alpha B	0.017
TRAF3IP3	TRAF3 interacting protein 3	0.017
LY96	lymphocyte antigen 96	0.017
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.017
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.017
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.017
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.017
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.017
CD2	CD2 molecule	0.017
IL15RA	interleukin 15 receptor, alpha	0.017
MS4A3	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	0.016
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.016
IRF3	interferon regulatory factor 3	0.016
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.016
CTBP2	C-terminal binding protein 2	0.016
KMO	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	0.016
RNASE3	ribonuclease, RNase A family, 3	0.016
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.015
FGL2	fibrinogen-like 2	0.015
CD6	CD6 molecule	0.015
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.015
BATF	basic leucine zipper transcription factor, ATF-like	0.015
CLC	Charcot-Leyden crystal protein	0.015
IRF8	interferon regulatory factor 8	0.015	Human
HCP5	HLA complex P5	0.015
TLR6	toll-like receptor 6	0.014	Human
CCL22	chemokine (C-C motif) ligand 22	0.014
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.014
SIRPB1	signal-regulatory protein beta 1	0.014
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.014	Mouse
DNTTIP2	deoxynucleotidyltransferase, terminal, interacting protein 2	0.014
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.014
CSF1R	colony stimulating factor 1 receptor	0.014
CD48	CD48 molecule	0.014
CAMP	cathelicidin antimicrobial peptide	0.014
GPR18	G protein-coupled receptor 18	0.014
TNIP2	TNFAIP3 interacting protein 2	0.014
IL7R	interleukin 7 receptor	0.014
SERTAD1	SERTA domain containing 1	0.013
MSR1	macrophage scavenger receptor 1	0.013
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.013
SH2D2A	SH2 domain containing 2A	0.013
MR1	major histocompatibility complex, class I-related	0.013
SIGLEC7	sialic acid binding Ig-like lectin 7	0.013
IRF2	interferon regulatory factor 2	0.013	Human
IRS1	insulin receptor substrate 1	0.013
NLRP3	NLR family, pyrin domain containing 3	0.013
TRANK1	tetratricopeptide repeat and ankyrin repeat containing 1	0.013
TGFB1	transforming growth factor, beta 1	0.013
TRAT1	T cell receptor associated transmembrane adaptor 1	0.013
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.013
SH2D1A	SH2 domain containing 1A	0.013
TRIM38	tripartite motif containing 38	0.013
IRF7	interferon regulatory factor 7	0.013	Human
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.013
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.013
FCAR	Fc fragment of IgA, receptor for	0.013
FASLG	Fas ligand (TNF superfamily, member 6)	0.013
PILRA	paired immunoglobin-like type 2 receptor alpha	0.013
CYLD	cylindromatosis (turban tumor syndrome)	0.013
ATG7	ATG7 autophagy related 7 homolog (S. cerevisiae)	0.012
TFF1	trefoil factor 1	0.012
CD274	CD274 molecule	0.012	Human
PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	0.012	Human
GSK3B	glycogen synthase kinase 3 beta	0.012
CXCL10	chemokine (C-X-C motif) ligand 10	0.012
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.012
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.012
HSF1	heat shock transcription factor 1	0.012
HDC	histidine decarboxylase	0.012
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.012
IL2RA	interleukin 2 receptor, alpha	0.012
CD28	CD28 molecule	0.012
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.012
CCR9	chemokine (C-C motif) receptor 9	0.012
PI3	peptidase inhibitor 3, skin-derived	0.012
BST1	bone marrow stromal cell antigen 1	0.011
ICOS	inducible T-cell co-stimulator	0.011
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.011
CCL7	chemokine (C-C motif) ligand 7	0.011
VNN2	vanin 2	0.011
BPI	bactericidal/permeability-increasing protein	0.011
IRF2BP2	interferon regulatory factor 2 binding protein 2	0.011
TFEC	transcription factor EC	0.011
HP	haptoglobin	0.011
CD7	CD7 molecule	0.011
IL15	interleukin 15	0.011
DEFA4	defensin, alpha 4, corticostatin	0.011
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.011
CD33	CD33 molecule	0.011
CXCR2	chemokine (C-X-C motif) receptor 2	0.011
TICAM1	toll-like receptor adaptor molecule 1	0.011	Mouse
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.011
DNTT	deoxynucleotidyltransferase, terminal	0.011
IGJ	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	0.011
IFI16	interferon, gamma-inducible protein 16	0.011
ZBTB48	zinc finger and BTB domain containing 48	0.011
CD27	CD27 molecule	0.011
TRAF3IP2	TRAF3 interacting protein 2	0.011
CCR5	chemokine (C-C motif) receptor 5	0.011
MARCH1	membrane-associated ring finger (C3HC4) 1	0.010
EFTUD2	elongation factor Tu GTP binding domain containing 2	0.010
IL18RAP	interleukin 18 receptor accessory protein	0.010
CD38	CD38 molecule	0.010
ARG1	arginase, liver	0.010
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.010
S100A12	S100 calcium binding protein A12	0.010
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.010
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.010
CIITA	class II, major histocompatibility complex, transactivator	0.010
CXCR3	chemokine (C-X-C motif) receptor 3	0.010
LCN2	lipocalin 2	0.010
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.010
CSF1	colony stimulating factor 1 (macrophage)	0.010
INHBA	inhibin, beta A	0.010
IKZF1	IKAROS family zinc finger 1 (Ikaros)	0.010
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.010