IMP

Process View

Homo sapiens

1 genes annotated in human

autonomic nervous system development

The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "autonomic nervous system development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "autonomic nervous system development" (in gray)

Name	Description	Probability	Func Analog Organism
EGFR	epidermal growth factor receptor	1.000
PAX3	paired box 3	0.810	Zebrafish
POU5F1	POU class 5 homeobox 1	0.667
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.666
POU3F2	POU class 3 homeobox 2	0.624
MEOX2	mesenchyme homeobox 2	0.623
SOX10	SRY (sex determining region Y)-box 10	0.337	Mouse
TCF4	transcription factor 4	0.232
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.209
BTRC	beta-transducin repeat containing	0.181
SUFU	suppressor of fused homolog (Drosophila)	0.170
EGR1	early growth response 1	0.150
MED29	mediator complex subunit 29	0.120
VEGFA	vascular endothelial growth factor A	0.110
BBS10	Bardet-Biedl syndrome 10	0.105
PTCH1	patched 1	0.091
AR	androgen receptor	0.090
APC	adenomatous polyposis coli	0.089
NGF	nerve growth factor (beta polypeptide)	0.083
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.073
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.068
GLIS2	GLIS family zinc finger 2	0.066
KRT5	keratin 5	0.065
RET	ret proto-oncogene	0.050	Zebrafish Mouse
GSK3B	glycogen synthase kinase 3 beta	0.049
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.047
SATB2	SATB homeobox 2	0.046
MDFI	MyoD family inhibitor	0.046
MED12	mediator complex subunit 12	0.046
CABLES1	Cdk5 and Abl enzyme substrate 1	0.045
LPXN	leupaxin	0.042
SH3BP4	SH3-domain binding protein 4	0.042
STK36	serine/threonine kinase 36	0.041
KCTD1	potassium channel tetramerisation domain containing 1	0.039
APP	amyloid beta (A4) precursor protein	0.039
YAP1	Yes-associated protein 1	0.035
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.033
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.033
HOXD13	homeobox D13	0.032
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.031
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.029
MARCKSL1	MARCKS-like 1	0.029
EGR3	early growth response 3	0.027
GAB2	GRB2-associated binding protein 2	0.027
PGF	placental growth factor	0.027
NIPSNAP3A	nipsnap homolog 3A (C. elegans)	0.027
AXIN1	axin 1	0.027
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.026
KRT6C	keratin 6C	0.026
HIC1	hypermethylated in cancer 1	0.026
FERMT2	fermitin family member 2	0.026
MED16	mediator complex subunit 16	0.025
TRIP6	thyroid hormone receptor interactor 6	0.025
ACP5	acid phosphatase 5, tartrate resistant	0.025
ZNF764	zinc finger protein 764	0.025
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.024
POU3F1	POU class 3 homeobox 1	0.024
EYA1	eyes absent homolog 1 (Drosophila)	0.024
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.023
PSEN1	presenilin 1	0.023
EYA2	eyes absent homolog 2 (Drosophila)	0.023
QPRT	quinolinate phosphoribosyltransferase	0.022
HIPK2	homeodomain interacting protein kinase 2	0.022
MUC1	mucin 1, cell surface associated	0.021
GFRA1	GDNF family receptor alpha 1	0.021	Zebrafish
SMAD1	SMAD family member 1	0.021
INSR	insulin receptor	0.021
TGFBR1	transforming growth factor, beta receptor 1	0.021
TGFB3	transforming growth factor, beta 3	0.021
SOX1	SRY (sex determining region Y)-box 1	0.021
SYK	spleen tyrosine kinase	0.021
PEX26	peroxisomal biogenesis factor 26	0.020
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.020
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.020
LBX1	ladybird homeobox 1	0.020
FGFR1	fibroblast growth factor receptor 1	0.020
EPHB1	EPH receptor B1	0.019
GRB7	growth factor receptor-bound protein 7	0.019
DDR2	discoidin domain receptor tyrosine kinase 2	0.019
OTP	orthopedia homeobox	0.019
FGD1	FYVE, RhoGEF and PH domain containing 1	0.019
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.019
NPAS1	neuronal PAS domain protein 1	0.019
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.019
GATA4	GATA binding protein 4	0.019
HNRNPCL1	heterogeneous nuclear ribonucleoprotein C-like 1	0.019
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.018
CSNK1E	casein kinase 1, epsilon	0.018
ZNF676	zinc finger protein 676	0.018
BCL2	B-cell CLL/lymphoma 2	0.018
JAK1	Janus kinase 1	0.018
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.018
HAND2	heart and neural crest derivatives expressed 2	0.018	Mouse
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.018
PML	promyelocytic leukemia	0.018
NRP2	neuropilin 2	0.018	Mouse
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.018
HOXD12	homeobox D12	0.018
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.018
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.018
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.017
ZNF331	zinc finger protein 331	0.017
JUP	junction plakoglobin	0.017
TP73	tumor protein p73	0.017
HOXD9	homeobox D9	0.017
RND1	Rho family GTPase 1	0.017
PHOX2A	paired-like homeobox 2a	0.017	Human Mouse
SIX6	SIX homeobox 6	0.017
GLI3	GLI family zinc finger 3	0.017
TNS3	tensin 3	0.017
PTK7	PTK7 protein tyrosine kinase 7	0.016
MID1IP1	MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))	0.016
LY6G6F	lymphocyte antigen 6 complex, locus G6F	0.016
SOX2	SRY (sex determining region Y)-box 2	0.016
SIX2	SIX homeobox 2	0.016
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.016
ADCY1	adenylate cyclase 1 (brain)	0.016
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.016
TP53	tumor protein p53	0.016
CTNNBIP1	catenin, beta interacting protein 1	0.016
BNC1	basonuclin 1	0.016
HOXA5	homeobox A5	0.016
SIX3	SIX homeobox 3	0.016
BICD1	bicaudal D homolog 1 (Drosophila)	0.015
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.015
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.015
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.015
PITX2	paired-like homeodomain 2	0.015
BARX1	BARX homeobox 1	0.015
HOXA9	homeobox A9	0.015
COL2A1	collagen, type II, alpha 1	0.015
PAX7	paired box 7	0.015
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.015	Mouse
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.015
HEMGN	hemogen	0.015
LRDD	leucine-rich repeats and death domain containing	0.015
FOXL1	forkhead box L1	0.015
OLIG2	oligodendrocyte lineage transcription factor 2	0.015
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.015
CADM4	cell adhesion molecule 4	0.015
HOXD3	homeobox D3	0.015
HES2	hairy and enhancer of split 2 (Drosophila)	0.014
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.014
HMGA2	high mobility group AT-hook 2	0.014
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.014
KAT2A	K(lysine) acetyltransferase 2A	0.014
JAM2	junctional adhesion molecule 2	0.014
HOXD11	homeobox D11	0.014
BNC2	basonuclin 2	0.014
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.014
BMP7	bone morphogenetic protein 7	0.014
PKP4	plakophilin 4	0.014
HDAC1	histone deacetylase 1	0.014
ACAN	aggrecan	0.014
EMD	emerin	0.014
AQP1	aquaporin 1 (Colton blood group)	0.014
CATSPER1	cation channel, sperm associated 1	0.014
ASCL1	achaete-scute complex homolog 1 (Drosophila)	0.014	Zebrafish Mouse
EN1	engrailed homeobox 1	0.014
MNX1	motor neuron and pancreas homeobox 1	0.014
FOXA1	forkhead box A1	0.014
HOXC8	homeobox C8	0.014
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.014	Mouse
RARG	retinoic acid receptor, gamma	0.014
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.014
RUNX2	runt-related transcription factor 2	0.014
VAV3	vav 3 guanine nucleotide exchange factor	0.014
SCRIB	scribbled homolog (Drosophila)	0.013
NGFR	nerve growth factor receptor	0.013
SEC16A	SEC16 homolog A (S. cerevisiae)	0.013
LYPD3	LY6/PLAUR domain containing 3	0.013
EFNB2	ephrin-B2	0.013
PRNP	prion protein	0.013
FOXC1	forkhead box C1	0.013
EBF3	early B-cell factor 3	0.013
RECK	reversion-inducing-cysteine-rich protein with kazal motifs	0.013
CBX2	chromobox homolog 2	0.013
HMX1	H6 family homeobox 1	0.013
FOXB1	forkhead box B1	0.013
TBX1	T-box 1	0.013
CAPN1	calpain 1, (mu/I) large subunit	0.013
S1PR5	sphingosine-1-phosphate receptor 5	0.013
RARB	retinoic acid receptor, beta	0.013
HOXA4	homeobox A4	0.013
GPR153	G protein-coupled receptor 153	0.013
LEF1	lymphoid enhancer-binding factor 1	0.013
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.013
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.013
MATK	megakaryocyte-associated tyrosine kinase	0.013
NIN	ninein (GSK3B interacting protein)	0.013
TAL1	T-cell acute lymphocytic leukemia 1	0.013
FGF8	fibroblast growth factor 8 (androgen-induced)	0.013
CELSR2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.013
ABI2	abl-interactor 2	0.013
MED25	mediator complex subunit 25	0.013
LAT	linker for activation of T cells	0.013
NKX6-1	NK6 homeobox 1	0.012
HOXB3	homeobox B3	0.012
MYOD1	myogenic differentiation 1	0.012
HOXC11	homeobox C11	0.012
FZD8	frizzled homolog 8 (Drosophila)	0.012
MAP1A	microtubule-associated protein 1A	0.012
DUSP23	dual specificity phosphatase 23	0.012
GTF3C1	general transcription factor IIIC, polypeptide 1, alpha 220kDa	0.012
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.012
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.012
HAND1	heart and neural crest derivatives expressed 1	0.012
SENP3	SUMO1/sentrin/SMT3 specific peptidase 3	0.012
NKX3-2	NK3 homeobox 2	0.012
RAX	retina and anterior neural fold homeobox	0.012
MCC	mutated in colorectal cancers	0.012
FOXG1	forkhead box G1	0.012
GPR161	G protein-coupled receptor 161	0.012
ZFPM1	zinc finger protein, multitype 1	0.012
KDM5B	lysine (K)-specific demethylase 5B	0.012
LINGO1	leucine rich repeat and Ig domain containing 1	0.012
HOXA11	homeobox A11	0.012
LRP6	low density lipoprotein receptor-related protein 6	0.012
HOXB6	homeobox B6	0.012
SCARF2	scavenger receptor class F, member 2	0.012
NKX2-1	NK2 homeobox 1	0.012
ZNF263	zinc finger protein 263	0.012
NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)	0.012
PDX1	pancreatic and duodenal homeobox 1	0.012
HOXD1	homeobox D1	0.012
ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	0.012
PRRX1	paired related homeobox 1	0.012	Human
GHR	growth hormone receptor	0.012
LRRC15	leucine rich repeat containing 15	0.012
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.012
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.012
SFRP1	secreted frizzled-related protein 1	0.012
C19orf26	chromosome 19 open reading frame 26	0.012
FGB	fibrinogen beta chain	0.012
EFNB3	ephrin-B3	0.012
SIM2	single-minded homolog 2 (Drosophila)	0.011
GCN1L1	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	0.011
DIO3	deiodinase, iodothyronine, type III	0.011
HOXC5	homeobox C5	0.011
ZNF579	zinc finger protein 579	0.011
LMO4	LIM domain only 4	0.011
GDNF	glial cell derived neurotrophic factor	0.011	Zebrafish Mouse
KIAA1191	KIAA1191	0.011
MED14	mediator complex subunit 14	0.011
EDN3	endothelin 3	0.011
HOXA2	homeobox A2	0.011
LMO1	LIM domain only 1 (rhombotin 1)	0.011
KRTAP4-12	keratin associated protein 4-12	0.011
ADAM12	ADAM metallopeptidase domain 12	0.011
ALX3	ALX homeobox 3	0.011
IRX5	iroquois homeobox 5	0.011
DLX4	distal-less homeobox 4	0.011
ADCY8	adenylate cyclase 8 (brain)	0.011
VIP	vasoactive intestinal peptide	0.011
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.011
HOXD4	homeobox D4	0.011
GATA2	GATA binding protein 2	0.011
HOXC13	homeobox C13	0.011
SLC18A3	solute carrier family 18 (vesicular acetylcholine), member 3	0.011
SFRP5	secreted frizzled-related protein 5	0.011
FOXF1	forkhead box F1	0.011
DST	dystonin	0.011
PAX9	paired box 9	0.011
LAMA4	laminin, alpha 4	0.011
ACACA	acetyl-CoA carboxylase alpha	0.011
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.011
EFS	embryonal Fyn-associated substrate	0.011
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.011
PDPN	podoplanin	0.011
CTBP1	C-terminal binding protein 1	0.011
DBN1	drebrin 1	0.011
CALCR	calcitonin receptor	0.011
DEFA1	defensin, alpha 1	0.011
HOXA10	homeobox A10	0.011
UTF1	undifferentiated embryonic cell transcription factor 1	0.011
EDNRA	endothelin receptor type A	0.011
ZNF608	zinc finger protein 608	0.011
WNT4	wingless-type MMTV integration site family, member 4	0.011
SOX11	SRY (sex determining region Y)-box 11	0.011	Mouse
HOXB5	homeobox B5	0.011
LHX1	LIM homeobox 1	0.011
HOXD10	homeobox D10	0.011
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.011
TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	0.011
EPHB4	EPH receptor B4	0.011
VAV2	vav 2 guanine nucleotide exchange factor	0.011
GJA3	gap junction protein, alpha 3, 46kDa	0.011
BHLHE23	basic helix-loop-helix family, member e23	0.011
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.011
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.011
POU4F1	POU class 4 homeobox 1	0.011
MPP1	membrane protein, palmitoylated 1, 55kDa	0.011
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.011
WT1	Wilms tumor 1	0.011
ELAVL4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.011
SIX1	SIX homeobox 1	0.011	Mouse
DDIT4	DNA-damage-inducible transcript 4	0.011
FER	fer (fps/fes related) tyrosine kinase	0.011
DMRT3	doublesex and mab-3 related transcription factor 3	0.011
SLC9A3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.011
EPHB3	EPH receptor B3	0.011
NOTCH1	notch 1	0.011
FOXL2	forkhead box L2	0.011
INHBB	inhibin, beta B	0.011
POU4F3	POU class 4 homeobox 3	0.011
GLI2	GLI family zinc finger 2	0.011
OPRD1	opioid receptor, delta 1	0.011
DYNC1I1	dynein, cytoplasmic 1, intermediate chain 1	0.011
MAPT	microtubule-associated protein tau	0.011
WNT6	wingless-type MMTV integration site family, member 6	0.011
MEX3B	mex-3 homolog B (C. elegans)	0.011
DGKI	diacylglycerol kinase, iota	0.011
BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	0.011
MAB21L1	mab-21-like 1 (C. elegans)	0.011
CDX2	caudal type homeobox 2	0.011
FGF3	fibroblast growth factor 3	0.011
STC1	stanniocalcin 1	0.010
KCNMA1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.010
PENK	proenkephalin	0.010
OAF	OAF homolog (Drosophila)	0.010
MSC	musculin	0.010
AGTR1	angiotensin II receptor, type 1	0.010
ZFHX4	zinc finger homeobox 4	0.010
ARRB1	arrestin, beta 1	0.010
CD28	CD28 molecule	0.010
PLCG1	phospholipase C, gamma 1	0.010
ABCC9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	0.010
SHOX2	short stature homeobox 2	0.010
STRN	striatin, calmodulin binding protein	0.010
PCDH17	protocadherin 17	0.010
DUSP2	dual specificity phosphatase 2	0.010
CRABP1	cellular retinoic acid binding protein 1	0.010
HOXB4	homeobox B4	0.010
LARS2	leucyl-tRNA synthetase 2, mitochondrial	0.010
PPP1R16A	protein phosphatase 1, regulatory (inhibitor) subunit 16A	0.010
IRX4	iroquois homeobox 4	0.010
DOK1	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	0.010
MSX1	msh homeobox 1	0.010
FBXL18	F-box and leucine-rich repeat protein 18	0.010
ZIC2	Zic family member 2 (odd-paired homolog, Drosophila)	0.010
HOXC4	homeobox C4	0.010
RBMS3	RNA binding motif, single stranded interacting protein 3	0.010
PYY	peptide YY	0.010
CELSR1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	0.010
FZD10	frizzled homolog 10 (Drosophila)	0.010
BARHL2	BarH-like homeobox 2	0.010
DUSP15	dual specificity phosphatase 15	0.010
PIAS3	protein inhibitor of activated STAT, 3	0.010
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.010
CTNND1	catenin (cadherin-associated protein), delta 1	0.010
DHH	desert hedgehog	0.010
BMP8A	bone morphogenetic protein 8a	0.010
MDK	midkine (neurite growth-promoting factor 2)	0.010
NOD1	nucleotide-binding oligomerization domain containing 1	0.010
PLVAP	plasmalemma vesicle associated protein	0.010
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.010
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.010
TLX1	T-cell leukemia homeobox 1	0.010
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.010
GJB5	gap junction protein, beta 5, 31.1kDa	0.010
A1BG	alpha-1-B glycoprotein	0.010
C1QL1	complement component 1, q subcomponent-like 1	0.010
BMP8B	bone morphogenetic protein 8b	0.010
STC2	stanniocalcin 2	0.010
FHL1	four and a half LIM domains 1	0.010