IMP

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Homo sapiens

32 genes annotated in human

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histone deacetylation

GO:0016575

The modification of histones by removal of acetyl groups.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "histone deacetylation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "histone deacetylation" (in gray)

Name	Description	Probability	Func Analog Organism
HDAC1	histone deacetylase 1	1.000
HDAC2	histone deacetylase 2	1.000
NCOR2	nuclear receptor corepressor 2	0.999
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.999	Yeast Worm
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.979
HDAC3	histone deacetylase 3	0.977
HDAC7	histone deacetylase 7	0.915	Human Fly
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.831
ATF2	activating transcription factor 2	0.753
KDM1A	lysine (K)-specific demethylase 1A	0.709
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.674
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.660
NRP1	neuropilin 1	0.614
TGIF1	TGFB-induced factor homeobox 1	0.594
PPARA	peroxisome proliferator-activated receptor alpha	0.557
BRMS1	breast cancer metastasis suppressor 1	0.549	Human
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.419
IRF2BP1	interferon regulatory factor 2 binding protein 1	0.367
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.349
RBBP4	retinoblastoma binding protein 4	0.333
MAPK14	mitogen-activated protein kinase 14	0.317	Human
JUN	jun proto-oncogene	0.307
MRFAP1	Morf4 family associated protein 1	0.262
HDAC4	histone deacetylase 4	0.261
SMAD4	SMAD family member 4	0.251
MED15	mediator complex subunit 15	0.233
CHD4	chromodomain helicase DNA binding protein 4	0.223
MAP2K4	mitogen-activated protein kinase kinase 4	0.215
ADRBK1	adrenergic, beta, receptor kinase 1	0.204
EP300	E1A binding protein p300	0.197
HDAC9	histone deacetylase 9	0.192
MTA3	metastasis associated 1 family, member 3	0.163
SAP30	Sin3A-associated protein, 30kDa	0.156
SMAD3	SMAD family member 3	0.150
HIPK2	homeodomain interacting protein kinase 2	0.137
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.127
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.125
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.120
MEF2C	myocyte enhancer factor 2C	0.113
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.109
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.105
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.104
SKIL	SKI-like oncogene	0.104
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.103	Fly
BCL6	B-cell CLL/lymphoma 6	0.102	Mouse
DAXX	death-domain associated protein	0.092
CTBP1	C-terminal binding protein 1	0.085
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.085
HDAC5	histone deacetylase 5	0.084
SUDS3	suppressor of defective silencing 3 homolog (S. cerevisiae)	0.084
RB1	retinoblastoma 1	0.080
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.078
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.078	Human
YY1	YY1 transcription factor	0.078
ENG	endoglin	0.078
JUB	jub, ajuba homolog (Xenopus laevis)	0.077
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.076
PKN1	protein kinase N1	0.074
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.074
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.073
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.071
BBX	bobby sox homolog (Drosophila)	0.068
ARRB1	arrestin, beta 1	0.064
RBBP7	retinoblastoma binding protein 7	0.064
PGF	placental growth factor	0.059	Human
PDGFA	platelet-derived growth factor alpha polypeptide	0.057	Human
CDR2	cerebellar degeneration-related protein 2, 62kDa	0.054
MORF4L2	mortality factor 4 like 2	0.051	Human Yeast
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.050
SETD7	SET domain containing (lysine methyltransferase) 7	0.050
TBL1X	transducin (beta)-like 1X-linked	0.050	Fly
PML	promyelocytic leukemia	0.049
ZNF148	zinc finger protein 148	0.048
CEP70	centrosomal protein 70kDa	0.047
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.046
PDGFC	platelet derived growth factor C	0.046
KIAA0182	KIAA0182	0.046
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.045
RCOR1	REST corepressor 1	0.043
MAGEA2	melanoma antigen family A, 2	0.042
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.042
PRKD2	protein kinase D2	0.041
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.041
C16orf70	chromosome 16 open reading frame 70	0.040
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.039
BAZ2B	bromodomain adjacent to zinc finger domain, 2B	0.039
PARP1	poly (ADP-ribose) polymerase 1	0.039
TOP1	topoisomerase (DNA) I	0.037
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.036
MAPK15	mitogen-activated protein kinase 15	0.036
STAG1	stromal antigen 1	0.035
TP53	tumor protein p53	0.035	Mouse
NCOR1	nuclear receptor corepressor 1	0.035	Mouse
SIRT1	sirtuin 1	0.034
FSTL1	follistatin-like 1	0.034
CTBP2	C-terminal binding protein 2	0.032	Human
RUNX1	runt-related transcription factor 1	0.032
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.032
CUL7	cullin 7	0.031
ADNP	activity-dependent neuroprotector homeobox	0.031
PKN2	protein kinase N2	0.030
CCDC101	coiled-coil domain containing 101	0.030
CUX1	cut-like homeobox 1	0.030
RSF1	remodeling and spacing factor 1	0.030
RRBP1	ribosome binding protein 1 homolog 180kDa (dog)	0.030
ZMYM2	zinc finger, MYM-type 2	0.030
KAT5	K(lysine) acetyltransferase 5	0.029
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.028
FBXO11	F-box protein 11	0.027
BHLHE40	basic helix-loop-helix family, member e40	0.027
ETV6	ets variant 6	0.027
FOXP3	forkhead box P3	0.027
FUBP1	far upstream element (FUSE) binding protein 1	0.027
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.027
TGFB3	transforming growth factor, beta 3	0.027
VEGFA	vascular endothelial growth factor A	0.025
TGFBR1	transforming growth factor, beta receptor 1	0.025
BPTF	bromodomain PHD finger transcription factor	0.025
XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	0.025
PGR	progesterone receptor	0.025
PBRM1	polybromo 1	0.024
SIRT2	sirtuin 2	0.023
GSK3B	glycogen synthase kinase 3 beta	0.023
MEF2A	myocyte enhancer factor 2A	0.022
PIAS2	protein inhibitor of activated STAT, 2	0.022
HCFC1	host cell factor C1 (VP16-accessory protein)	0.022
RFX7	regulatory factor X, 7	0.022
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.022
MLL5	myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)	0.021
SNAI1	snail homolog 1 (Drosophila)	0.021	Fly
PHF12	PHD finger protein 12	0.021
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.021
INTS6	integrator complex subunit 6	0.021
MSL2	male-specific lethal 2 homolog (Drosophila)	0.021
HMG20A	high mobility group 20A	0.021
PIAS1	protein inhibitor of activated STAT, 1	0.020
SGSM2	small G protein signaling modulator 2	0.020
CREBBP	CREB binding protein	0.020
PTMA	prothymosin, alpha	0.020
MYST1	MYST histone acetyltransferase 1	0.020
IKZF4	IKAROS family zinc finger 4 (Eos)	0.020
TAOK1	TAO kinase 1	0.020
SRSF4	serine/arginine-rich splicing factor 4	0.019
GORASP1	golgi reassembly stacking protein 1, 65kDa	0.019
CREB1	cAMP responsive element binding protein 1	0.019
OBSL1	obscurin-like 1	0.019
CBX1	chromobox homolog 1	0.019
HSPA1L	heat shock 70kDa protein 1-like	0.019
STAG2	stromal antigen 2	0.019
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.019
DICER1	dicer 1, ribonuclease type III	0.019
MTA1	metastasis associated 1	0.019
CDK6	cyclin-dependent kinase 6	0.019
ATF3	activating transcription factor 3	0.019
NFYA	nuclear transcription factor Y, alpha	0.019
ZNF219	zinc finger protein 219	0.018
CHD1	chromodomain helicase DNA binding protein 1	0.018
COL6A1	collagen, type VI, alpha 1	0.018
IKZF1	IKAROS family zinc finger 1 (Ikaros)	0.018
SAP30L	SAP30-like	0.018
L3MBTL2	l(3)mbt-like 2 (Drosophila)	0.018
RREB1	ras responsive element binding protein 1	0.018
KDM5B	lysine (K)-specific demethylase 5B	0.018
SOX13	SRY (sex determining region Y)-box 13	0.018
PRKCA	protein kinase C, alpha	0.018
KDM2A	lysine (K)-specific demethylase 2A	0.018
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.018
SIRT5	sirtuin 5	0.018
KAT2B	K(lysine) acetyltransferase 2B	0.018
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.018
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.017
NONO	non-POU domain containing, octamer-binding	0.017
ZNF12	zinc finger protein 12	0.017
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.017
MRFAP1L1	Morf4 family associated protein 1-like 1	0.017
PHF21A	PHD finger protein 21A	0.017
HDAC6	histone deacetylase 6	0.017
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.017
UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)	0.017
PDLIM7	PDZ and LIM domain 7 (enigma)	0.017
LCORL	ligand dependent nuclear receptor corepressor-like	0.017
KAT2A	K(lysine) acetyltransferase 2A	0.016
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	0.016
COL5A1	collagen, type V, alpha 1	0.016
ARRB2	arrestin, beta 2	0.016
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.016
CSNK1E	casein kinase 1, epsilon	0.016
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.016
NRIP1	nuclear receptor interacting protein 1	0.016
MBD1	methyl-CpG binding domain protein 1	0.015
TPR	translocated promoter region (to activated MET oncogene)	0.015
STC1	stanniocalcin 1	0.015
USP17	ubiquitin specific peptidase 17	0.015
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.015
WWOX	WW domain containing oxidoreductase	0.015
SCAF8	SR-related CTD-associated factor 8	0.015
JDP2	Jun dimerization protein 2	0.015	Mouse
ZMYND11	zinc finger, MYND-type containing 11	0.014
EGR1	early growth response 1	0.014
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.014
PCDH9	protocadherin 9	0.014
ESR1	estrogen receptor 1	0.014
FOXO3	forkhead box O3	0.014
ZMYM3	zinc finger, MYM-type 3	0.014
HSPB1	heat shock 27kDa protein 1	0.014
BANP	BTG3 associated nuclear protein	0.014
KDM3B	lysine (K)-specific demethylase 3B	0.014
EPC2	enhancer of polycomb homolog 2 (Drosophila)	0.014
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.014
ING2	inhibitor of growth family, member 2	0.014
HUWE1	HECT, UBA and WWE domain containing 1	0.013
XPO7	exportin 7	0.013
PLCG1	phospholipase C, gamma 1	0.013
RUNX2	runt-related transcription factor 2	0.013
CYLD	cylindromatosis (turban tumor syndrome)	0.013
BOD1L	biorientation of chromosomes in cell division 1-like	0.013
SAMD3	sterile alpha motif domain containing 3	0.013
UBXN7	UBX domain protein 7	0.013
ZNF227	zinc finger protein 227	0.013
CNOT6	CCR4-NOT transcription complex, subunit 6	0.013
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.013
THRAP3	thyroid hormone receptor associated protein 3	0.013
MATR3	matrin 3	0.013
THBS1	thrombospondin 1	0.013
IPO13	importin 13	0.013
C11orf30	chromosome 11 open reading frame 30	0.012
ZNF644	zinc finger protein 644	0.012
RYK	RYK receptor-like tyrosine kinase	0.012
CEP350	centrosomal protein 350kDa	0.012
IRS2	insulin receptor substrate 2	0.012
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.012	Mouse
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.012
USF2	upstream transcription factor 2, c-fos interacting	0.012
SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.012
MORF4L1	mortality factor 4 like 1	0.012
USP42	ubiquitin specific peptidase 42	0.012
MED1	mediator complex subunit 1	0.012
PUM2	pumilio homolog 2 (Drosophila)	0.012
SP1	Sp1 transcription factor	0.012
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.012
FTSJ3	FtsJ homolog 3 (E. coli)	0.012
LOXL4	lysyl oxidase-like 4	0.012
COL2A1	collagen, type II, alpha 1	0.012
GPS2	G protein pathway suppressor 2	0.012
MAPK8	mitogen-activated protein kinase 8	0.012
SIRT4	sirtuin 4	0.012
CTNNBL1	catenin, beta like 1	0.012
HIC1	hypermethylated in cancer 1	0.011
TGFBR3	transforming growth factor, beta receptor III	0.011
GATAD2B	GATA zinc finger domain containing 2B	0.011
YBX2	Y box binding protein 2	0.011
SPIN1	spindlin 1	0.011
MAPK3	mitogen-activated protein kinase 3	0.011
ATF7	activating transcription factor 7	0.011
TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	0.011
LGALS8	lectin, galactoside-binding, soluble, 8	0.011
RFC1	replication factor C (activator 1) 1, 145kDa	0.011
USF1	upstream transcription factor 1	0.011
TRIM28	tripartite motif containing 28	0.011
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.011
ZC3H18	zinc finger CCCH-type containing 18	0.011
INTS2	integrator complex subunit 2	0.011
REST	RE1-silencing transcription factor	0.011
ELF5	E74-like factor 5 (ets domain transcription factor)	0.011
SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	0.011
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.011
ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	0.011
TP53BP2	tumor protein p53 binding protein, 2	0.011
MAP2K7	mitogen-activated protein kinase kinase 7	0.010
PRIC285	peroxisomal proliferator-activated receptor A interacting complex 285	0.010
BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	0.010
AXIN1	axin 1	0.010
ZEB1	zinc finger E-box binding homeobox 1	0.010
GFI1	growth factor independent 1 transcription repressor	0.010
EPC1	enhancer of polycomb homolog 1 (Drosophila)	0.010
ZBTB25	zinc finger and BTB domain containing 25	0.010
THAP11	THAP domain containing 11	0.010
VEZF1	vascular endothelial zinc finger 1	0.010
SFN	stratifin	0.010