IMP

Process View

Homo sapiens

31 genes annotated in human

er associated ubiquitin dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "er associated ubiquitin dependent protein catabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "er associated ubiquitin dependent protein catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
VCP	valosin containing protein	1.000
DERL1	Der1-like domain family, member 1	0.999
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.994
UBQLN1	ubiquilin 1	0.989
PSMC2	proteasome (prosome, macropain) 26S subunit, ATPase, 2	0.955
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.949
PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.927
SELS	selenoprotein S	0.926
PSMC4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.919
SSR1	signal sequence receptor, alpha	0.911
CANX	calnexin	0.907
PSMC5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.907
ATXN3	ataxin 3	0.889
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.883
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.880
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.868
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.854
RPN1	ribophorin I	0.844
PSMD13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.835
AMFR	autocrine motility factor receptor	0.805
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.802
DNAJB11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.769
TRAF6	TNF receptor-associated factor 6	0.717
PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3	0.705
UBC	ubiquitin C	0.700
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.640	Yeast
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.633
HSPA13	heat shock protein 70kDa family, member 13	0.600
NSFL1C	NSFL1 (p97) cofactor (p47)	0.577	Yeast
SEL1L	sel-1 suppressor of lin-12-like (C. elegans)	0.574
RAD23B	RAD23 homolog B (S. cerevisiae)	0.536	Yeast
ADRM1	adhesion regulating molecule 1	0.519
PSMD14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.479
PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	0.473
HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.460
BIRC2	baculoviral IAP repeat containing 2	0.426
TRIM63	tripartite motif containing 63	0.422	Human
PSMD10	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	0.402
PDIA6	protein disulfide isomerase family A, member 6	0.398
SEC61A1	Sec61 alpha 1 subunit (S. cerevisiae)	0.363	Yeast
PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3	0.357
PSMA7	proteasome (prosome, macropain) subunit, alpha type, 7	0.353
UCHL5	ubiquitin carboxyl-terminal hydrolase L5	0.329
UBXN2A	UBX domain protein 2A	0.304
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.281
PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1	0.276
PSMB7	proteasome (prosome, macropain) subunit, beta type, 7	0.265
GFM1	G elongation factor, mitochondrial 1	0.233
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.218	Yeast
PSMA2	proteasome (prosome, macropain) subunit, alpha type, 2	0.208
FAF2	Fas associated factor family member 2	0.194
PPIB	peptidylprolyl isomerase B (cyclophilin B)	0.191
PSMD3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.183
XIAP	X-linked inhibitor of apoptosis	0.171
PSMA6	proteasome (prosome, macropain) subunit, alpha type, 6	0.160
HUWE1	HECT, UBA and WWE domain containing 1	0.152
UFD1L	ubiquitin fusion degradation 1 like (yeast)	0.149	Worm
ERN1	endoplasmic reticulum to nucleus signaling 1	0.143
SPCS3	signal peptidase complex subunit 3 homolog (S. cerevisiae)	0.141
PCGF2	polycomb group ring finger 2	0.119
PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5	0.118
SURF4	surfeit 4	0.112
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.109
TRAM1	translocation associated membrane protein 1	0.108
BCAP31	B-cell receptor-associated protein 31	0.100
DERL2	Der1-like domain family, member 2	0.098
PDIA3	protein disulfide isomerase family A, member 3	0.092
UBE2G1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)	0.091	Human
UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)	0.086	Yeast
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.083
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.082
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.082
TMED2	transmembrane emp24 domain trafficking protein 2	0.076
RPN2	ribophorin II	0.075
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.075
UBE2A	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.072	Yeast
UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.072	Yeast
RFK	riboflavin kinase	0.071
AUP1	ancient ubiquitous protein 1	0.070
ASPSCR1	alveolar soft part sarcoma chromosome region, candidate 1	0.070
SLC35B1	solute carrier family 35, member B1	0.068
RNF111	ring finger protein 111	0.062
UBXN6	UBX domain protein 6	0.060
ATP6AP1	ATPase, H+ transporting, lysosomal accessory protein 1	0.058
SLC33A1	solute carrier family 33 (acetyl-CoA transporter), member 1	0.056
MKRN1	makorin ring finger protein 1	0.056
PSMB2	proteasome (prosome, macropain) subunit, beta type, 2	0.055
PSMC6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.054	Yeast
TM9SF2	transmembrane 9 superfamily member 2	0.053
PSMB1	proteasome (prosome, macropain) subunit, beta type, 1	0.052
HYOU1	hypoxia up-regulated 1	0.049
EDEM1	ER degradation enhancer, mannosidase alpha-like 1	0.049	Mouse
SEC61B	Sec61 beta subunit	0.048
ATP13A2	ATPase type 13A2	0.048
ZNRF1	zinc and ring finger 1	0.044
PSMD8	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8	0.044
TMED10	transmembrane emp24-like trafficking protein 10 (yeast)	0.040
RING1	ring finger protein 1	0.040
TMEM173	transmembrane protein 173	0.040
HDAC11	histone deacetylase 11	0.038
TXNDC5	thioredoxin domain containing 5 (endoplasmic reticulum)	0.038
DDOST	dolichyl-diphosphooligosaccharide--protein glycosyltransferase	0.038
ARIH2	ariadne homolog 2 (Drosophila)	0.036
TRIM43	tripartite motif containing 43	0.036
TXNL1	thioredoxin-like 1	0.036
UBXN1	UBX domain protein 1	0.035
VCPIP1	valosin containing protein (p97)/p47 complex interacting protein 1	0.035
BRAP	BRCA1 associated protein	0.033
RNF5	ring finger protein 5	0.033
RNF2	ring finger protein 2	0.033
UBE3A	ubiquitin protein ligase E3A	0.031
DNAJA2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.031	Yeast
PSMD9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	0.030
PSMA4	proteasome (prosome, macropain) subunit, alpha type, 4	0.030
RAB21	RAB21, member RAS oncogene family	0.030
CREB3	cAMP responsive element binding protein 3	0.030
NGLY1	N-glycanase 1	0.029
RANBP9	RAN binding protein 9	0.029
UBE2N	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	0.029
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.029
SSR3	signal sequence receptor, gamma (translocon-associated protein gamma)	0.029
RNF114	ring finger protein 114	0.028
MANF	mesencephalic astrocyte-derived neurotrophic factor	0.028
NEURL4	neuralized homolog 4 (Drosophila)	0.028
UBE2J1	ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)	0.028
PDIA4	protein disulfide isomerase family A, member 4	0.027
COPG	coatomer protein complex, subunit gamma	0.027
SEC31A	SEC31 homolog A (S. cerevisiae)	0.027
UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.025
SIAH1	seven in absentia homolog 1 (Drosophila)	0.024
CBX6	chromobox homolog 6	0.024
MARCH5	membrane-associated ring finger (C3HC4) 5	0.024
MTDH	metadherin	0.024
UBE2E2	ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)	0.024
EIF2AK3	eukaryotic translation initiation factor 2-alpha kinase 3	0.024
PPHLN1	periphilin 1	0.024
SIL1	SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)	0.024
MGAT2	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	0.023
CALU	calumenin	0.023
BAG2	BCL2-associated athanogene 2	0.023
BIRC3	baculoviral IAP repeat containing 3	0.022
EIF5	eukaryotic translation initiation factor 5	0.022
RNF4	ring finger protein 4	0.021
HSP90B1	heat shock protein 90kDa beta (Grp94), member 1	0.021
PLAA	phospholipase A2-activating protein	0.021
ZFAND5	zinc finger, AN1-type domain 5	0.021
GFPT1	glutamine--fructose-6-phosphate transaminase 1	0.021
ARF4	ADP-ribosylation factor 4	0.021
TRIM39	tripartite motif containing 39	0.021
LAMTOR3	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	0.021
UBE2E1	ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)	0.020
RIPK2	receptor-interacting serine-threonine kinase 2	0.020
CNNM3	cyclin M3	0.020
XBP1	X-box binding protein 1	0.020
ERLEC1	endoplasmic reticulum lectin 1	0.020
DYNC1LI1	dynein, cytoplasmic 1, light intermediate chain 1	0.020
USP15	ubiquitin specific peptidase 15	0.020	Human
C19orf10	chromosome 19 open reading frame 10	0.020
PPP6C	protein phosphatase 6, catalytic subunit	0.019
BAG3	BCL2-associated athanogene 3	0.019
PSMB5	proteasome (prosome, macropain) subunit, beta type, 5	0.019
ERLIN2	ER lipid raft associated 2	0.019
RNF20	ring finger protein 20	0.019
DNM2	dynamin 2	0.019
ZMPSTE24	zinc metallopeptidase (STE24 homolog, S. cerevisiae)	0.019
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.019
C14orf129	chromosome 14 open reading frame 129	0.018
NIPA2	non imprinted in Prader-Willi/Angelman syndrome 2	0.018
RNF10	ring finger protein 10	0.018
KDELR2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	0.018
TRIP12	thyroid hormone receptor interactor 12	0.017
EGLN1	egl nine homolog 1 (C. elegans)	0.017
CUL1	cullin 1	0.017
WBSCR22	Williams Beuren syndrome chromosome region 22	0.017
DNAJB9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.016
PRRC1	proline-rich coiled-coil 1	0.016
CLSTN1	calsyntenin 1	0.016
TRIM32	tripartite motif containing 32	0.016
C1orf124	chromosome 1 open reading frame 124	0.015
UBE2H	ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)	0.015
SERP1	stress-associated endoplasmic reticulum protein 1	0.015
POLH	polymerase (DNA directed), eta	0.015
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.015
GORASP2	golgi reassembly stacking protein 2, 55kDa	0.015
G3BP2	GTPase activating protein (SH3 domain) binding protein 2	0.015
GTF2B	general transcription factor IIB	0.015
FBXW2	F-box and WD repeat domain containing 2	0.015
TBK1	TANK-binding kinase 1	0.015
DNAJC3	DnaJ (Hsp40) homolog, subfamily C, member 3	0.015
UBXN7	UBX domain protein 7	0.015
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.014
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.014
DCP1A	DCP1 decapping enzyme homolog A (S. cerevisiae)	0.014
USP9X	ubiquitin specific peptidase 9, X-linked	0.014
UBE2U	ubiquitin-conjugating enzyme E2U (putative)	0.014
OSTC	oligosaccharyltransferase complex subunit	0.014
WDR26	WD repeat domain 26	0.014
RMND5A	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	0.014
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.014
SIK2	salt-inducible kinase 2	0.013
FLNC	filamin C, gamma	0.013
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.013	Human
CHFR	checkpoint with forkhead and ring finger domains	0.013
MRPL41	mitochondrial ribosomal protein L41	0.013
SQSTM1	sequestosome 1	0.013
PNPLA8	patatin-like phospholipase domain containing 8	0.013
SRPR	signal recognition particle receptor (docking protein)	0.013
UBXN4	UBX domain protein 4	0.013
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.013
UGGT1	UDP-glucose glycoprotein glucosyltransferase 1	0.012
BFAR	bifunctional apoptosis regulator	0.012
RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	0.012
UBE2L3	ubiquitin-conjugating enzyme E2L 3	0.012
TMED9	transmembrane emp24 protein transport domain containing 9	0.012
LMAN1	lectin, mannose-binding, 1	0.012
ACTR1A	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	0.012
PSEN2	presenilin 2 (Alzheimer disease 4)	0.012
PSME3	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)	0.012
PPAPDC1B	phosphatidic acid phosphatase type 2 domain containing 1B	0.012
RNF11	ring finger protein 11	0.012
CGRRF1	cell growth regulator with ring finger domain 1	0.012
PSMD5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5	0.012
TTN	titin	0.012
OSBP	oxysterol binding protein	0.012
TOM1L1	target of myb1 (chicken)-like 1	0.012
MARCH7	membrane-associated ring finger (C3HC4) 7	0.012
UBE2Z	ubiquitin-conjugating enzyme E2Z	0.012
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.012
PCM1	pericentriolar material 1	0.012
UBL7	ubiquitin-like 7 (bone marrow stromal cell-derived)	0.011
AP1G1	adaptor-related protein complex 1, gamma 1 subunit	0.011
RIPK3	receptor-interacting serine-threonine kinase 3	0.011
POMP	proteasome maturation protein	0.011
CPEB4	cytoplasmic polyadenylation element binding protein 4	0.011
DCAF6	DDB1 and CUL4 associated factor 6	0.011
STIP1	stress-induced-phosphoprotein 1	0.011
TMEM33	transmembrane protein 33	0.011
GCLM	glutamate-cysteine ligase, modifier subunit	0.011
DR1	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	0.011
XPC	xeroderma pigmentosum, complementation group C	0.011
PAPOLA	poly(A) polymerase alpha	0.011
PRRC2B	proline-rich coiled-coil 2B	0.011
EIF1	eukaryotic translation initiation factor 1	0.011
ERLIN1	ER lipid raft associated 1	0.011
DCP1B	DCP1 decapping enzyme homolog B (S. cerevisiae)	0.011
PTP4A1	protein tyrosine phosphatase type IVA, member 1	0.011
TXNDC15	thioredoxin domain containing 15	0.011
YKT6	YKT6 v-SNARE homolog (S. cerevisiae)	0.011
KIAA0232	KIAA0232	0.011
KCMF1	potassium channel modulatory factor 1	0.011
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.011
CUL7	cullin 7	0.011
GPKOW	G patch domain and KOW motifs	0.011
DES	desmin	0.011
TCAP	titin-cap (telethonin)	0.011
TRIM27	tripartite motif containing 27	0.011
ARF1	ADP-ribosylation factor 1	0.011
MAGT1	magnesium transporter 1	0.010
ACTA1	actin, alpha 1, skeletal muscle	0.010
SAR1B	SAR1 homolog B (S. cerevisiae)	0.010
GET4	golgi to ER traffic protein 4 homolog (S. cerevisiae)	0.010
NUCB2	nucleobindin 2	0.010
TLK1	tousled-like kinase 1	0.010
UBA1	ubiquitin-like modifier activating enzyme 1	0.010
RNF139	ring finger protein 139	0.010	Human
MLEC	malectin	0.010
OTUD5	OTU domain containing 5	0.010