IMP

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of leukocyte mediated immunity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of leukocyte mediated immunity" (in gray)

Name	Description	Probability	Func Analog Organism
B2M	beta-2-microglobulin	0.998	Mouse
HLA-A	major histocompatibility complex, class I, A	0.975
HLA-C	major histocompatibility complex, class I, C	0.966	Human
SYK	spleen tyrosine kinase	0.960	Mouse Rat
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.942
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.920
TRAF3	TNF receptor-associated factor 3	0.847	Human
HLA-F	major histocompatibility complex, class I, F	0.756	Human
TAPBP	TAP binding protein (tapasin)	0.746
IL8	interleukin 8	0.714
HLA-G	major histocompatibility complex, class I, G	0.686	Human
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.636
HLA-E	major histocompatibility complex, class I, E	0.580
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.572
HLA-B	major histocompatibility complex, class I, B	0.532
CD84	CD84 molecule	0.483
IL2RB	interleukin 2 receptor, beta	0.415
CCL4	chemokine (C-C motif) ligand 4	0.388	Human
SLAMF1	signaling lymphocytic activation molecule family member 1	0.371
RIPK2	receptor-interacting serine-threonine kinase 2	0.352
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.348	Human
CCR5	chemokine (C-C motif) receptor 5	0.323
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.245	Mouse
CD40	CD40 molecule, TNF receptor superfamily member 5	0.241	Mouse Rat
CXCL3	chemokine (C-X-C motif) ligand 3	0.237	Mouse
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.178
GBA	glucosidase, beta, acid	0.165
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.163
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.150	Human
INSR	insulin receptor	0.143
AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	0.125
IL23A	interleukin 23, alpha subunit p19	0.118	Mouse
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.118
IFNG	interferon, gamma	0.113
TNF	tumor necrosis factor	0.112
ESR1	estrogen receptor 1	0.105
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.098
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.096
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.095
CD2	CD2 molecule	0.095
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.095
CCL8	chemokine (C-C motif) ligand 8	0.092	Human
VAMP4	vesicle-associated membrane protein 4	0.090
CCL2	chemokine (C-C motif) ligand 2	0.085	Human
IL2RG	interleukin 2 receptor, gamma	0.085
PVRL4	poliovirus receptor-related 4	0.084
GRAP2	GRB2-related adaptor protein 2	0.082
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.082
CAV1	caveolin 1, caveolae protein, 22kDa	0.081
TRAF1	TNF receptor-associated factor 1	0.081	Human
PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	0.078
DPP4	dipeptidyl-peptidase 4	0.077
CXCL9	chemokine (C-X-C motif) ligand 9	0.075
RAB14	RAB14, member RAS oncogene family	0.073
ITM2B	integral membrane protein 2B	0.073
UBASH3B	ubiquitin associated and SH3 domain containing B	0.070
GZMK	granzyme K (granzyme 3; tryptase II)	0.069
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.068
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.068
IL4R	interleukin 4 receptor	0.067	Mouse
CXCL2	chemokine (C-X-C motif) ligand 2	0.067	Mouse
TP53BP1	tumor protein p53 binding protein 1	0.066
GAB1	GRB2-associated binding protein 1	0.066
PRF1	perforin 1 (pore forming protein)	0.062
CCL13	chemokine (C-C motif) ligand 13	0.061	Human
PVRL3	poliovirus receptor-related 3	0.061	Human
BIRC3	baculoviral IAP repeat containing 3	0.059
GNLY	granulysin	0.058
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.058
CD80	CD80 molecule	0.057
TRAF2	TNF receptor-associated factor 2	0.057
TNFRSF17	tumor necrosis factor receptor superfamily, member 17	0.054
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.052
NKG7	natural killer cell group 7 sequence	0.052
PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	0.050
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.050	Mouse
ICAM1	intercellular adhesion molecule 1	0.050
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.049
IDE	insulin-degrading enzyme	0.046
CFH	complement factor H	0.045
ASAH1	N-acylsphingosine amidohydrolase (acid ceramidase) 1	0.045
CCL5	chemokine (C-C motif) ligand 5	0.044	Human
CCR7	chemokine (C-C motif) receptor 7	0.042
TYROBP	TYRO protein tyrosine kinase binding protein	0.041
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.040
CRH	corticotropin releasing hormone	0.038
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.036
NCSTN	nicastrin	0.036
FASLG	Fas ligand (TNF superfamily, member 6)	0.036
BLNK	B-cell linker	0.036
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.035
CCR4	chemokine (C-C motif) receptor 4	0.034
KLRC2	killer cell lectin-like receptor subfamily C, member 2	0.034	Human
IL18RAP	interleukin 18 receptor accessory protein	0.033
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.032	Human
KLRC3	killer cell lectin-like receptor subfamily C, member 3	0.032	Human
CCR1	chemokine (C-C motif) receptor 1	0.032
BCL10	B-cell CLL/lymphoma 10	0.031
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.030
CCL7	chemokine (C-C motif) ligand 7	0.029	Human
BCR	breakpoint cluster region	0.029
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.028
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.028
CD8A	CD8a molecule	0.027
BTK	Bruton agammaglobulinemia tyrosine kinase	0.027
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.026
TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.026	Mouse Rat
TGFBR1	transforming growth factor, beta receptor 1	0.026
IL6	interleukin 6 (interferon, beta 2)	0.026
CARD11	caspase recruitment domain family, member 11	0.026
CD22	CD22 molecule	0.026
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.025
ENG	endoglin	0.025
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.025
FAS	Fas (TNF receptor superfamily, member 6)	0.024
TPP1	tripeptidyl peptidase I	0.024
CCL20	chemokine (C-C motif) ligand 20	0.024	Human
FSTL1	follistatin-like 1	0.024
CD48	CD48 molecule	0.024
PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.024
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.023
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.023	Mouse
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.023
IL4	interleukin 4	0.023	Mouse
CXCL5	chemokine (C-X-C motif) ligand 5	0.023
CTSW	cathepsin W	0.022
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.022
CD244	CD244 molecule, natural killer cell receptor 2B4	0.022
KLRF1	killer cell lectin-like receptor subfamily F, member 1	0.021
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.021
GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)	0.021
ITK	IL2-inducible T-cell kinase	0.021
CD83	CD83 molecule	0.021
CXCL10	chemokine (C-X-C motif) ligand 10	0.021
TLR2	toll-like receptor 2	0.021
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.021
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.020
IRF4	interferon regulatory factor 4	0.020
PRKCQ	protein kinase C, theta	0.020
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.020	Mouse
IL1B	interleukin 1, beta	0.020
HCST	hematopoietic cell signal transducer	0.020
TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	0.019
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.019
HSPH1	heat shock 105kDa/110kDa protein 1	0.019
NUMBL	numb homolog (Drosophila)-like	0.019
STAP2	signal transducing adaptor family member 2	0.019
LEPROT	leptin receptor overlapping transcript	0.018
CCL19	chemokine (C-C motif) ligand 19	0.018	Human
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.018
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.018
VCAM1	vascular cell adhesion molecule 1	0.017
GPR65	G protein-coupled receptor 65	0.017
IL10	interleukin 10	0.017
IGSF6	immunoglobulin superfamily, member 6	0.017
PLEK	pleckstrin	0.017
ICOS	inducible T-cell co-stimulator	0.017
XCL2	chemokine (C motif) ligand 2	0.017	Human
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.016
ATP6V1D	ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D	0.016
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.016
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.016
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.015
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.015
SLA	Src-like-adaptor	0.015
SNX3	sorting nexin 3	0.015
CXCR6	chemokine (C-X-C motif) receptor 6	0.015
CD160	CD160 molecule	0.015
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.014
TJP1	tight junction protein 1 (zona occludens 1)	0.014
XCL1	chemokine (C motif) ligand 1	0.014
F11R	F11 receptor	0.014
SH2D1A	SH2 domain containing 1A	0.014	Mouse
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.014
NSF	N-ethylmaleimide-sensitive factor	0.014
ARL6IP5	ADP-ribosylation-like factor 6 interacting protein 5	0.014
CXCL11	chemokine (C-X-C motif) ligand 11	0.013
OASL	2'-5'-oligoadenylate synthetase-like	0.013
IL7R	interleukin 7 receptor	0.013
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.013
CD1C	CD1c molecule	0.013
CCL3	chemokine (C-C motif) ligand 3	0.013	Human
UBD	ubiquitin D	0.013
SELE	selectin E	0.013
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.013
IL21R	interleukin 21 receptor	0.012
DARC	Duffy blood group, chemokine receptor	0.012
CSF1	colony stimulating factor 1 (macrophage)	0.012
GNS	glucosamine (N-acetyl)-6-sulfatase	0.012
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.012
TMEM173	transmembrane protein 173	0.012
CCR3	chemokine (C-C motif) receptor 3	0.012
HFE	hemochromatosis	0.012	Human
TRAF3IP3	TRAF3 interacting protein 3	0.012
SQSTM1	sequestosome 1	0.012
CLEC10A	C-type lectin domain family 10, member A	0.012
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.012
TXK	TXK tyrosine kinase	0.012
STAT4	signal transducer and activator of transcription 4	0.012
TRADD	TNFRSF1A-associated via death domain	0.011
C16orf53	chromosome 16 open reading frame 53	0.011
GPR171	G protein-coupled receptor 171	0.011
CD27	CD27 molecule	0.011
CCL22	chemokine (C-C motif) ligand 22	0.011	Human
IL10RA	interleukin 10 receptor, alpha	0.011
KIR3DL2	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	0.011
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	0.011
BTN3A1	butyrophilin, subfamily 3, member A1	0.011
TAPBPL	TAP binding protein-like	0.011
CREG1	cellular repressor of E1A-stimulated genes 1	0.011
LCK	lymphocyte-specific protein tyrosine kinase	0.011
TARDBP	TAR DNA binding protein	0.010
CFB	complement factor B	0.010
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.010
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.010
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.010
INHBA	inhibin, beta A	0.010
ZNF512B	zinc finger protein 512B	0.010
EPOR	erythropoietin receptor	0.010
SKAP1	src kinase associated phosphoprotein 1	0.010