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Homo sapiens

18 genes annotated in human

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activation of mapkk activity

GO:0000186

The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "activation of mapkk activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "activation of mapkk activity" (in gray)

Name	Description	Probability	Func Analog Organism
EGFR	epidermal growth factor receptor	0.990
BMPR1A	bone morphogenetic protein receptor, type IA	0.958	Human
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.941	Human
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.797
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.719
SH3KBP1	SH3-domain kinase binding protein 1	0.699
CAV1	caveolin 1, caveolae protein, 22kDa	0.642
MAPK8	mitogen-activated protein kinase 8	0.599
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.576
GADD45GIP1	growth arrest and DNA-damage-inducible, gamma interacting protein 1	0.552
BMP2	bone morphogenetic protein 2	0.543	Human
GBP3	guanylate binding protein 3	0.535
FKBP1A	FK506 binding protein 1A, 12kDa	0.532
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.491
ABI2	abl-interactor 2	0.483
MAP2K1	mitogen-activated protein kinase kinase 1	0.459
FGFR1	fibroblast growth factor receptor 1	0.433
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.369
VEGFA	vascular endothelial growth factor A	0.355
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.345
DCAF7	DDB1 and CUL4 associated factor 7	0.296
IQGAP1	IQ motif containing GTPase activating protein 1	0.281
GRB2	growth factor receptor-bound protein 2	0.240
TRAF6	TNF receptor-associated factor 6	0.239
IGF1R	insulin-like growth factor 1 receptor	0.214
NRP1	neuropilin 1	0.193
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.160
ENG	endoglin	0.156
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.154
DLG1	discs, large homolog 1 (Drosophila)	0.153
IFNGR1	interferon gamma receptor 1	0.148
TGFB1	transforming growth factor, beta 1	0.145
SMAD7	SMAD family member 7	0.137
MAP2K4	mitogen-activated protein kinase kinase 4	0.135
FLNB	filamin B, beta	0.134
ACVR1	activin A receptor, type I	0.132	Human
JAK2	Janus kinase 2	0.129	Rat
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.125
ARRB1	arrestin, beta 1	0.118
LRRK2	leucine-rich repeat kinase 2	0.116
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.111	Yeast
CSNK1E	casein kinase 1, epsilon	0.100
MAP2K7	mitogen-activated protein kinase kinase 7	0.094
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.091
GHR	growth hormone receptor	0.088
PGF	placental growth factor	0.085
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.083
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.079	Rat
INSR	insulin receptor	0.078
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.077
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.075	Rat
BBS10	Bardet-Biedl syndrome 10	0.070
SH3D19	SH3 domain containing 19	0.070
MAP2K6	mitogen-activated protein kinase kinase 6	0.070
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.065
IRS1	insulin receptor substrate 1	0.065
PTPRB	protein tyrosine phosphatase, receptor type, B	0.064
PLCG1	phospholipase C, gamma 1	0.062
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.057
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.057	Rat
PRKCE	protein kinase C, epsilon	0.056
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.055
HDAC4	histone deacetylase 4	0.055
PAK4	p21 protein (Cdc42/Rac)-activated kinase 4	0.054
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.054
TSC22D1	TSC22 domain family, member 1	0.054
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.053	Rat
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.053
FSTL1	follistatin-like 1	0.052
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.051
CLTC	clathrin, heavy chain (Hc)	0.047
LAT	linker for activation of T cells	0.046
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.046
CTNND1	catenin (cadherin-associated protein), delta 1	0.046
PKP4	plakophilin 4	0.045
PSEN2	presenilin 2 (Alzheimer disease 4)	0.042
SOCS1	suppressor of cytokine signaling 1	0.041
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.039
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.037
APP	amyloid beta (A4) precursor protein	0.037
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.037
DAB2IP	DAB2 interacting protein	0.035
PEBP4	phosphatidylethanolamine-binding protein 4	0.035
FKBP5	FK506 binding protein 5	0.035
FRA10AC1	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	0.035
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.034
PRKG1	protein kinase, cGMP-dependent, type I	0.034
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.032
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.031
RXRA	retinoid X receptor, alpha	0.030
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.030
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.030
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.030
MAP2K3	mitogen-activated protein kinase kinase 3	0.029
TNK2	tyrosine kinase, non-receptor, 2	0.029
MIDN	midnolin	0.028
FNDC3B	fibronectin type III domain containing 3B	0.028
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.028
BAIAP2	BAI1-associated protein 2	0.028
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.027
HSPA1B	heat shock 70kDa protein 1B	0.026
CAV2	caveolin 2	0.025
LDLR	low density lipoprotein receptor	0.025
HOOK3	hook homolog 3 (Drosophila)	0.025
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.025
WASL	Wiskott-Aldrich syndrome-like	0.024
STK4	serine/threonine kinase 4	0.024
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.023
MAPK1	mitogen-activated protein kinase 1	0.023
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.023
WT1	Wilms tumor 1	0.023
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.023
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.022
BAG1	BCL2-associated athanogene	0.021
TSC2	tuberous sclerosis 2	0.021
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.020
KRT18	keratin 18	0.020
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.020
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.020
THBS1	thrombospondin 1	0.019
ADAM10	ADAM metallopeptidase domain 10	0.019
LRP6	low density lipoprotein receptor-related protein 6	0.019
FLNA	filamin A, alpha	0.018
TGFBR1	transforming growth factor, beta receptor 1	0.018
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.018
FAS	Fas (TNF receptor superfamily, member 6)	0.018
EZR	ezrin	0.018
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.018
SOCS3	suppressor of cytokine signaling 3	0.018
NCSTN	nicastrin	0.017
USP15	ubiquitin specific peptidase 15	0.017
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.017
JUN	jun proto-oncogene	0.017
FGF1	fibroblast growth factor 1 (acidic)	0.017
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.017
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.017
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.017
KIF5B	kinesin family member 5B	0.017
TUBA1A	tubulin, alpha 1a	0.017
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.017
PRKCA	protein kinase C, alpha	0.017
GAB1	GRB2-associated binding protein 1	0.016
RHEB	Ras homolog enriched in brain	0.016
JAG1	jagged 1	0.016
KSR1	kinase suppressor of ras 1	0.016
CSRNP1	cysteine-serine-rich nuclear protein 1	0.015
ZRANB1	zinc finger, RAN-binding domain containing 1	0.015
MAPK14	mitogen-activated protein kinase 14	0.015
FSTL3	follistatin-like 3 (secreted glycoprotein)	0.015
ZFYVE9	zinc finger, FYVE domain containing 9	0.015
DST	dystonin	0.015
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.015
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.015
MAP4K2	mitogen-activated protein kinase kinase kinase kinase 2	0.015
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.014
STAT5A	signal transducer and activator of transcription 5A	0.014
PLD2	phospholipase D2	0.014
HSPA8	heat shock 70kDa protein 8	0.014
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.014
EPOR	erythropoietin receptor	0.013
DHX58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.013
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.013
MARK2	MAP/microtubule affinity-regulating kinase 2	0.013
PDE4DIP	phosphodiesterase 4D interacting protein	0.013
CMIP	c-Maf-inducing protein	0.013
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.013
LARP1	La ribonucleoprotein domain family, member 1	0.013
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.012
RGS1	regulator of G-protein signaling 1	0.012
TRIP10	thyroid hormone receptor interactor 10	0.012
KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.012
BCAR1	breast cancer anti-estrogen resistance 1	0.012
IGFBP3	insulin-like growth factor binding protein 3	0.012
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.012
DICER1	dicer 1, ribonuclease type III	0.012
RNF19A	ring finger protein 19A	0.012
ADORA2A	adenosine A2a receptor	0.012
CMTM8	CKLF-like MARVEL transmembrane domain containing 8	0.012
ACVR1B	activin A receptor, type IB	0.011	Human
MARK3	MAP/microtubule affinity-regulating kinase 3	0.011
IER2	immediate early response 2	0.011
PPP5C	protein phosphatase 5, catalytic subunit	0.011
CLIC4	chloride intracellular channel 4	0.011
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.011
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.011
SPTBN1	spectrin, beta, non-erythrocytic 1	0.011
NUMBL	numb homolog (Drosophila)-like	0.011
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.011
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.011
BAD	BCL2-associated agonist of cell death	0.011
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.011
AXIN1	axin 1	0.011
ARHGAP21	Rho GTPase activating protein 21	0.011
GRB10	growth factor receptor-bound protein 10	0.010
MAPT	microtubule-associated protein tau	0.010
IQGAP2	IQ motif containing GTPase activating protein 2	0.010
ARRB2	arrestin, beta 2	0.010
SPRED1	sprouty-related, EVH1 domain containing 1	0.010
PDIA3	protein disulfide isomerase family A, member 3	0.010
RAP1A	RAP1A, member of RAS oncogene family	0.010
HLA-DRB3	major histocompatibility complex, class II, DR beta 3	0.010