IMP

Process View

Mus musculus

4 genes annotated in mouse

apoptotic process involved in mammary gland involution

Any apoptotic process that triggers the activity of proteolytic caspases whose actions dismantle the mammary epithelial cells resulting in their programmed cell death.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "apoptotic process involved in mammary gland involution"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "apoptotic process involved in mammary gland involution" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	1.000
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	1.000
Rxra	retinoid X receptor alpha	0.998
Bcl2	B-cell leukemia/lymphoma 2	0.998	Mouse
Lep	leptin	0.993
Pten	phosphatase and tensin homolog	0.989
Lepr	leptin receptor	0.974
Bax	BCL2-associated X protein	0.955
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.903
Esr1	estrogen receptor 1 (alpha)	0.835
Bak1	BCL2-antagonist/killer 1	0.810	Mouse
Nos3	nitric oxide synthase 3, endothelial cell	0.802
Tgfb1	transforming growth factor, beta 1	0.772
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.752
Kit	kit oncogene	0.729
Vhl	von Hippel-Lindau tumor suppressor	0.709
Nf1	neurofibromatosis 1	0.564
Ncoa3	nuclear receptor coactivator 3	0.533
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.519
Insr	insulin receptor	0.474
Smad3	MAD homolog 3 (Drosophila)	0.453
Col1a1	collagen, type I, alpha 1	0.412
Notch2	Notch gene homolog 2 (Drosophila)	0.403
Vegfa	vascular endothelial growth factor A	0.389
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.364
Cd19	CD19 antigen	0.360
Fgfr2	fibroblast growth factor receptor 2	0.343
Apc	adenomatosis polyposis coli	0.305
Ptgs2	prostaglandin-endoperoxide synthase 2	0.274
Mdm2	transformed mouse 3T3 cell double minute 2	0.255
Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.248
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.234
Csf1	colony stimulating factor 1 (macrophage)	0.233
Cav1	caveolin 1, caveolae protein	0.233
Lyz2	lysozyme 2	0.223
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.207
Pax2	paired box gene 2	0.207
Braf	Braf transforming gene	0.204
Apoe	apolipoprotein E	0.195
Rara	retinoic acid receptor, alpha	0.189
Tcrb	T-cell receptor beta chain	0.182
Wt1	Wilms tumor 1 homolog	0.174
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.169
Stat3	signal transducer and activator of transcription 3	0.157
Rb1	retinoblastoma 1	0.154
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.144
Ar	androgen receptor	0.139
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.121
Ldlr	low density lipoprotein receptor	0.116
Egfr	epidermal growth factor receptor	0.099
Gdnf	glial cell line derived neurotrophic factor	0.095
Ret	ret proto-oncogene	0.092
Daxx	Fas death domain-associated protein	0.091
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.090
Pnpla2	patatin-like phospholipase domain containing 2	0.089
Pparg	peroxisome proliferator activated receptor gamma	0.086	Mouse
Prkci	protein kinase C, iota	0.084
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.084
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.079
Pax8	paired box gene 8	0.078
Hr	hairless	0.076
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.070
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.070
Gata4	GATA binding protein 4	0.069
Skil	SKI-like	0.069
Vav2	vav 2 oncogene	0.069
Psen1	presenilin 1	0.067
Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	0.066
Thrb	thyroid hormone receptor beta	0.064
Ikzf1	IKAROS family zinc finger 1	0.063
Lyst	lysosomal trafficking regulator	0.061
Gata6	GATA binding protein 6	0.061
Lif	leukemia inhibitory factor	0.060
Fas	Fas (TNF receptor superfamily member 6)	0.059
Bbc3	BCL2 binding component 3	0.057
Cd44	CD44 antigen	0.053
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.051
Mtor	mechanistic target of rapamycin (serine/threonine kinase)	0.050
Vdr	vitamin D receptor	0.049
Bid	BH3 interacting domain death agonist	0.049
Tgfbr2	transforming growth factor, beta receptor II	0.046
Lmna	lamin A	0.044
Agpat2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.041
Thra	thyroid hormone receptor alpha	0.040
Nos1	nitric oxide synthase 1, neuronal	0.040
Bcl2l1	BCL2-like 1	0.038	Mouse
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.038
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.037
Src	Rous sarcoma oncogene	0.037
Ctnnb1	catenin (cadherin associated protein), beta 1	0.037
Dok1	docking protein 1	0.036
Mdm4	transformed mouse 3T3 cell double minute 4	0.032
Nos2	nitric oxide synthase 2, inducible	0.032
Lama5	laminin, alpha 5	0.032
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.031
Ltbr	lymphotoxin B receptor	0.031
Apoa4	apolipoprotein A-IV	0.031
Runx1	runt related transcription factor 1	0.030
Mfn2	mitofusin 2	0.029
Arpc4	actin related protein 2/3 complex, subunit 4	0.028
Tssc4	tumor-suppressing subchromosomal transferable fragment 4	0.028
Pxn	paxillin	0.028
Pfn1	profilin 1	0.028
Igh	immunoglobulin heavy chain complex	0.027
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.027
Igf1	insulin-like growth factor 1	0.027
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.027
Kl	klotho	0.027
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.027
Irs2	insulin receptor substrate 2	0.026
Ghr	growth hormone receptor	0.026
Ccl2	chemokine (C-C motif) ligand 2	0.026
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.026
Apoa1	apolipoprotein A-I	0.026
Xpa	xeroderma pigmentosum, complementation group A	0.026
Midn	midnolin	0.025
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.025
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.025
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.024
Lrp5	low density lipoprotein receptor-related protein 5	0.024
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.024
Tlr4	toll-like receptor 4	0.024
Nr1h4	nuclear receptor subfamily 1, group H, member 4	0.024	Mouse
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.024
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.023
Tnip1	TNFAIP3 interacting protein 1	0.023
Gja1	gap junction protein, alpha 1	0.023
Adra1b	adrenergic receptor, alpha 1b	0.023
Sox9	SRY-box containing gene 9	0.022
Lipa	lysosomal acid lipase A	0.022
Rint1	RAD50 interactor 1	0.022
Ccnd1	cyclin D1	0.022
E2f1	E2F transcription factor 1	0.022
Sult1b1	sulfotransferase family 1B, member 1	0.021
Prox1	prospero-related homeobox 1	0.021
Tlr2	toll-like receptor 2	0.021
Pcsk4	proprotein convertase subtilisin/kexin type 4	0.021
Hpd	4-hydroxyphenylpyruvic acid dioxygenase	0.021
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.021
Spry4	sprouty homolog 4 (Drosophila)	0.021
Bmp4	bone morphogenetic protein 4	0.021
Arpc3	actin related protein 2/3 complex, subunit 3	0.021
Il6st	interleukin 6 signal transducer	0.021
Mark4	MAP/microtubule affinity-regulating kinase 4	0.021
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.020
Foxn1	forkhead box N1	0.020
Plxna1	plexin A1	0.020
Jag1	jagged 1	0.020
Hif1a	hypoxia inducible factor 1, alpha subunit	0.020
Pkd1	polycystic kidney disease 1 homolog	0.020
Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	0.020
Rdh16	retinol dehydrogenase 16	0.020
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.020
Ern1	endoplasmic reticulum (ER) to nucleus signalling 1	0.019
Cyld	cylindromatosis (turban tumor syndrome)	0.019
Zbtb7b	zinc finger and BTB domain containing 7B	0.019
Zbtb7a	zinc finger and BTB domain containing 7a	0.019
Lipe	lipase, hormone sensitive	0.018
Scd1	stearoyl-Coenzyme A desaturase 1	0.018
Gcgr	glucagon receptor	0.018
Fam83g	family with sequence similarity 83, member G	0.018
Cdhr5	cadherin-related family member 5	0.018
Pvrl1	poliovirus receptor-related 1	0.018
Ep300	E1A binding protein p300	0.018
Mgmt	O-6-methylguanine-DNA methyltransferase	0.018
Sdc3	syndecan 3	0.018
Ehd3	EH-domain containing 3	0.018
Cdk4	cyclin-dependent kinase 4	0.017
Fam83h	family with sequence similarity 83, member H	0.017
Wwox	WW domain-containing oxidoreductase	0.017
Gli3	GLI-Kruppel family member GLI3	0.017
Fosl2	fos-like antigen 2	0.017
Rxrg	retinoid X receptor gamma	0.017
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.017
Ehd4	EH-domain containing 4	0.017
Ptch1	patched homolog 1	0.017
Sdsl	serine dehydratase-like	0.017
Bach1	BTB and CNC homology 1	0.017
Mafk	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	0.017
Ikzf3	IKAROS family zinc finger 3	0.017
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.016
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.016
Igf1r	insulin-like growth factor I receptor	0.016
Thbs1	thrombospondin 1	0.016
Gdf15	growth differentiation factor 15	0.016
Tead3	TEA domain family member 3	0.016
Stk11	serine/threonine kinase 11	0.016
Bcl3	B-cell leukemia/lymphoma 3	0.016
Mocs1	molybdenum cofactor synthesis 1	0.016
Slc26a1	solute carrier family 26 (sulfate transporter), member 1	0.016
Tcrd	T-cell receptor delta chain	0.016
Adipoq	adiponectin, C1Q and collagen domain containing	0.016
Cdk6	cyclin-dependent kinase 6	0.016
Ahr	aryl-hydrocarbon receptor	0.016
Fabp1	fatty acid binding protein 1, liver	0.016
Socs1	suppressor of cytokine signaling 1	0.016
Stk4	serine/threonine kinase 4	0.015
Nr1i2	nuclear receptor subfamily 1, group I, member 2	0.015	Mouse
Rab17	RAB17, member RAS oncogene family	0.015
Rarg	retinoic acid receptor, gamma	0.015
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.015
Vav3	vav 3 oncogene	0.015
Hnf4a	hepatic nuclear factor 4, alpha	0.015
Efna5	ephrin A5	0.015
Nrg1	neuregulin 1	0.014
Prdm16	PR domain containing 16	0.014
Junb	Jun-B oncogene	0.014
Soat2	sterol O-acyltransferase 2	0.014
Krt7	keratin 7	0.014
Stat6	signal transducer and activator of transcription 6	0.014
Thrsp	thyroid hormone responsive SPOT14 homolog (Rattus)	0.014
Adrb1	adrenergic receptor, beta 1	0.014
Slc39a1	solute carrier family 39 (zinc transporter), member 1	0.014
Abcc2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.014
Sfn	stratifin	0.014
Pdzk1	PDZ domain containing 1	0.014
Rhod	ras homolog gene family, member D	0.014
Acsm3	acyl-CoA synthetase medium-chain family member 3	0.013
Hgd	homogentisate 1, 2-dioxygenase	0.013
Sardh	sarcosine dehydrogenase	0.013
Gata3	GATA binding protein 3	0.013
Sh3pxd2a	SH3 and PX domains 2A	0.013
Btg1	B-cell translocation gene 1, anti-proliferative	0.013
Pvrl2	poliovirus receptor-related 2	0.013
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.013
Ano6	anoctamin 6	0.013
Plin4	perilipin 4	0.013
Gm6484	predicted gene 6484	0.013
Msh2	mutS homolog 2 (E. coli)	0.013
Foxo4	forkhead box O4	0.013
Rptor	regulatory associated protein of MTOR, complex 1	0.013
Agrp	agouti related protein	0.013
Arid5b	AT rich interactive domain 5B (MRF1-like)	0.013
Aldob	aldolase B, fructose-bisphosphate	0.013
Sct	secretin	0.012
Ctnnd1	catenin (cadherin associated protein), delta 1	0.012
Cnnm4	cyclin M4	0.012
Agtr1a	angiotensin II receptor, type 1a	0.012
Dmbt1	deleted in malignant brain tumors 1	0.012
Slc4a4	solute carrier family 4 (anion exchanger), member 4	0.012
Trp63	transformation related protein 63	0.012
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.012
Irf8	interferon regulatory factor 8	0.012
Rrm2b	ribonucleotide reductase M2 B (TP53 inducible)	0.012
Atxn1	ataxin 1	0.012
Ckap4	cytoskeleton-associated protein 4	0.012
Tert	telomerase reverse transcriptase	0.012
Pcx	pyruvate carboxylase	0.012
Gab2	growth factor receptor bound protein 2-associated protein 2	0.012
Furin	furin (paired basic amino acid cleaving enzyme)	0.012
Slc3a1	solute carrier family 3, member 1	0.012
Azgp1	alpha-2-glycoprotein 1, zinc	0.012
Trim25	tripartite motif-containing 25	0.012
Hoxd11	homeobox D11	0.012
Clip2	CAP-GLY domain containing linker protein 2	0.012
Nr1i3	nuclear receptor subfamily 1, group I, member 3	0.012	Mouse
Bcl6	B-cell leukemia/lymphoma 6	0.012
Cd151	CD151 antigen	0.012
Esr2	estrogen receptor 2 (beta)	0.012
P2ry2	purinergic receptor P2Y, G-protein coupled 2	0.012
Per2	period homolog 2 (Drosophila)	0.012
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.012
Pim1	proviral integration site 1	0.012
Vasp	vasodilator-stimulated phosphoprotein	0.012
Apoa2	apolipoprotein A-II	0.012
Huwe1	HECT, UBA and WWE domain containing 1	0.012
Treh	trehalase (brush-border membrane glycoprotein)	0.012
Foxa3	forkhead box A3	0.011
Adrb3	adrenergic receptor, beta 3	0.011
Spp1	secreted phosphoprotein 1	0.011
Prkcd	protein kinase C, delta	0.011
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.011
Epha2	Eph receptor A2	0.011
Egr1	early growth response 1	0.011
Gjb1	gap junction protein, beta 1	0.011
Commd4	COMM domain containing 4	0.011
C8g	complement component 8, gamma polypeptide	0.011
Nans	N-acetylneuraminic acid synthase (sialic acid synthase)	0.011
Inca1	inhibitor of CDK, cyclin A1 interacting protein 1	0.011
Cyp3a13	cytochrome P450, family 3, subfamily a, polypeptide 13	0.011
Hgfac	hepatocyte growth factor activator	0.011
Rab20	RAB20, member RAS oncogene family	0.011
Stat5a	signal transducer and activator of transcription 5A	0.011
a	nonagouti	0.011
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.011
Anpep	alanyl (membrane) aminopeptidase	0.011
Cideb	cell death-inducing DNA fragmentation factor, alpha subunit-like effector B	0.011
Ptpn1	protein tyrosine phosphatase, non-receptor type 1	0.011
Rarb	retinoic acid receptor, beta	0.011
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.011
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.011
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.011
Tob2	transducer of ERBB2, 2	0.011
Aprt	adenine phosphoribosyl transferase	0.011
Il3ra	interleukin 3 receptor, alpha chain	0.011
Tsc1	tuberous sclerosis 1	0.011
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.011
Adamtsl5	ADAMTS-like 5	0.011
Slc6a8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	0.011
Pbx1	pre B-cell leukemia transcription factor 1	0.011
Acy3	aspartoacylase (aminoacylase) 3	0.011
2310036O22Rik	RIKEN cDNA 2310036O22 gene	0.011
2310011J03Rik	RIKEN cDNA 2310011J03 gene	0.011
Asgr2	asialoglycoprotein receptor 2	0.011
Zfp36l2	zinc finger protein 36, C3H type-like 2	0.010
Cish	cytokine inducible SH2-containing protein	0.010
Hamp	hepcidin antimicrobial peptide	0.010
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.010
Trp73	transformation related protein 73	0.010
Dyrk1b	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b	0.010
Cbl	Casitas B-lineage lymphoma	0.010
Fscn1	fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)	0.010
Ogg1	8-oxoguanine DNA-glycosylase 1	0.010
Nt5c	5',3'-nucleotidase, cytosolic	0.010
Afmid	arylformamidase	0.010
Adrb2	adrenergic receptor, beta 2	0.010
Kitl	kit ligand	0.010
Mme	membrane metallo endopeptidase	0.010
N4bp1	NEDD4 binding protein 1	0.010
Psmd13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.010
Smad4	MAD homolog 4 (Drosophila)	0.010
Khk	ketohexokinase	0.010
Yap1	yes-associated protein 1	0.010
Erf	Ets2 repressor factor	0.010