IMP

Process View

Mus musculus

2 genes annotated in mouse

response to hyperoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to hyperoxia"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to hyperoxia" (in gray)

Name	Description	Probability	Func Analog Organism
Lepr	leptin receptor	0.990
Mmp9	matrix metallopeptidase 9	0.989	Rat
Nos3	nitric oxide synthase 3, endothelial cell	0.962	Rat
Trp53	transformation related protein 53	0.951
Apoe	apolipoprotein E	0.920
Csf1	colony stimulating factor 1 (macrophage)	0.882
Ptgs2	prostaglandin-endoperoxide synthase 2	0.824
Col1a1	collagen, type I, alpha 1	0.641	Rat
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.519
Pten	phosphatase and tensin homolog	0.476
Selp	selectin, platelet	0.444
Fbn1	fibrillin 1	0.417
Lep	leptin	0.371
Ccr2	chemokine (C-C motif) receptor 2	0.371	Rat
Lmna	lamin A	0.369
Lyz2	lysozyme 2	0.354
Tlr4	toll-like receptor 4	0.348
Nos2	nitric oxide synthase 2, inducible	0.340
Nos1	nitric oxide synthase 1, neuronal	0.330
Plat	plasminogen activator, tissue	0.305
Ldlr	low density lipoprotein receptor	0.298
Vdr	vitamin D receptor	0.277
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.271
Vegfa	vascular endothelial growth factor A	0.250
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.239
Tgfbr2	transforming growth factor, beta receptor II	0.235
Cav1	caveolin 1, caveolae protein	0.223	Human
Notch2	Notch gene homolog 2 (Drosophila)	0.155
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.130
Hif1a	hypoxia inducible factor 1, alpha subunit	0.127
Ccl2	chemokine (C-C motif) ligand 2	0.124
Agtr2	angiotensin II receptor, type 2	0.119
Pparg	peroxisome proliferator activated receptor gamma	0.115	Rat
Pkd1	polycystic kidney disease 1 homolog	0.113
Foxp3	forkhead box P3	0.093
Tgfb1	transforming growth factor, beta 1	0.085
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.084	Rat
Ptges	prostaglandin E synthase	0.083
Ifng	interferon gamma	0.083
Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	0.081
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.080
Egfr	epidermal growth factor receptor	0.077
Il6	interleukin 6	0.074
Esr1	estrogen receptor 1 (alpha)	0.072
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.071
Alox5ap	arachidonate 5-lipoxygenase activating protein	0.070
Fas	Fas (TNF receptor superfamily member 6)	0.070	Human
Lox	lysyl oxidase	0.063
Crebbp	CREB binding protein	0.062
Vhl	von Hippel-Lindau tumor suppressor	0.061
Il10	interleukin 10	0.058
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.056
Icam1	intercellular adhesion molecule 1	0.053
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.052
Sele	selectin, endothelial cell	0.049
Mmp2	matrix metallopeptidase 2	0.048	Rat
Ppia	peptidylprolyl isomerase A	0.047
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.047
Spp1	secreted phosphoprotein 1	0.046
Prkch	protein kinase C, eta	0.044
Lpin1	lipin 1	0.043
Nab2	Ngfi-A binding protein 2	0.043
Agtr1a	angiotensin II receptor, type 1a	0.043
Fos	FBJ osteosarcoma oncogene	0.042
Lrp1	low density lipoprotein receptor-related protein 1	0.041
Cyr61	cysteine rich protein 61	0.041
Ar	androgen receptor	0.039
Itgb3	integrin beta 3	0.039
Ctnnb1	catenin (cadherin associated protein), beta 1	0.037
Egr2	early growth response 2	0.036
Wdfy2	WD repeat and FYVE domain containing 2	0.036
Ahr	aryl-hydrocarbon receptor	0.035
Col1a2	collagen, type I, alpha 2	0.034
Col4a3	collagen, type IV, alpha 3	0.034
Kit	kit oncogene	0.033
Ctsk	cathepsin K	0.033
Orai1	ORAI calcium release-activated calcium modulator 1	0.032
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.032	Rat
Insr	insulin receptor	0.032
Pnpla2	patatin-like phospholipase domain containing 2	0.032
Adrb3	adrenergic receptor, beta 3	0.031
Ltbp3	latent transforming growth factor beta binding protein 3	0.031
Slfn4	schlafen 4	0.031
Adipoq	adiponectin, C1Q and collagen domain containing	0.031
Cd151	CD151 antigen	0.031
Timp4	tissue inhibitor of metalloproteinase 4	0.030
Card11	caspase recruitment domain family, member 11	0.030
Tal1	T-cell acute lymphocytic leukemia 1	0.029
Tmprss11e	transmembrane protease, serine 11e	0.028
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.028
Cd44	CD44 antigen	0.027
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.027
Npc1	Niemann Pick type C1	0.027
Prdx1	peroxiredoxin 1	0.026
Tlr2	toll-like receptor 2	0.026
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.026
Sirt3	sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)	0.026
Tenc1	tensin like C1 domain-containing phosphatase	0.026
Rag1	recombination activating gene 1	0.026
Thbs3	thrombospondin 3	0.026
Il2rg	interleukin 2 receptor, gamma chain	0.025
Pdgfb	platelet derived growth factor, B polypeptide	0.025
Cxcr2	chemokine (C-X-C motif) receptor 2	0.025
Lama5	laminin, alpha 5	0.025
Hif1an	hypoxia-inducible factor 1, alpha subunit inhibitor	0.025
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.024
Ghr	growth hormone receptor	0.023
Map3k6	mitogen-activated protein kinase kinase kinase 6	0.023
Ncoa3	nuclear receptor coactivator 3	0.022
Il6st	interleukin 6 signal transducer	0.022
Pcdh12	protocadherin 12	0.022
Prx	periaxin	0.021
Mt1	metallothionein 1	0.020
Nphs2	nephrosis 2 homolog, podocin (human)	0.020
Foxa2	forkhead box A2	0.020
Agpat2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.020
Nr1h3	nuclear receptor subfamily 1, group H, member 3	0.020
Mta2	metastasis-associated gene family, member 2	0.020
Npr2	natriuretic peptide receptor 2	0.019
Chst14	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14	0.019
S100a9	S100 calcium binding protein A9 (calgranulin B)	0.019
Itgb2	integrin beta 2	0.019
Thbs1	thrombospondin 1	0.019
Bmp2	bone morphogenetic protein 2	0.019
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.018
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.018
Cd36	CD36 antigen	0.018
Smtn	smoothelin	0.018
Mt2	metallothionein 2	0.018
Gja1	gap junction protein, alpha 1	0.018
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.017
Fbln1	fibulin 1	0.017
Hlx	H2.0-like homeobox	0.017
Casp8	caspase 8	0.017
Plg	plasminogen	0.017
Rhoh	ras homolog gene family, member H	0.017
Pyhin1	pyrin and HIN domain family, member 1	0.017
Mapk14	mitogen-activated protein kinase 14	0.016
Hic1	hypermethylated in cancer 1	0.016
Timp3	tissue inhibitor of metalloproteinase 3	0.016
Ptgs1	prostaglandin-endoperoxide synthase 1	0.016
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.016
Ier2	immediate early response 2	0.016
Rp1l1	retinitis pigmentosa 1 homolog (human)-like 1	0.016
Rxra	retinoid X receptor alpha	0.016
Dpep1	dipeptidase 1 (renal)	0.016
Stat3	signal transducer and activator of transcription 3	0.016
Sin3a	transcriptional regulator, SIN3A (yeast)	0.015
Junb	Jun-B oncogene	0.015
Ltbp2	latent transforming growth factor beta binding protein 2	0.015
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.015
Fgfr2	fibroblast growth factor receptor 2	0.015
Runx2	runt related transcription factor 2	0.015
Raf1	v-raf-leukemia viral oncogene 1	0.015
Ifngr1	interferon gamma receptor 1	0.015
Apc	adenomatosis polyposis coli	0.014
Trpv1	transient receptor potential cation channel, subfamily V, member 1	0.014
Fpr2	formyl peptide receptor 2	0.014
Psen1	presenilin 1	0.014
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.014
Robo4	roundabout homolog 4 (Drosophila)	0.014
Bst1	bone marrow stromal cell antigen 1	0.014
Ptger3	prostaglandin E receptor 3 (subtype EP3)	0.014
Arid5b	AT rich interactive domain 5B (MRF1-like)	0.014
Retsat	retinol saturase (all trans retinol 13,14 reductase)	0.014
Rps23	ribosomal protein S23	0.014
Traf3ip2	TRAF3 interacting protein 2	0.013
Gsr	glutathione reductase	0.013
Vmn1r40	vomeronasal 1 receptor 40	0.013
Igbp1	immunoglobulin (CD79A) binding protein 1	0.013
Bhlhe40	basic helix-loop-helix family, member e40	0.013
Pim3	proviral integration site 3	0.013
Gadd45b	growth arrest and DNA-damage-inducible 45 beta	0.013
Itga1	integrin alpha 1	0.013
Tgfbr1	transforming growth factor, beta receptor I	0.013
Tbx5	T-box 5	0.013
Gja4	gap junction protein, alpha 4	0.013
Mmp11	matrix metallopeptidase 11	0.013
Csf1r	colony stimulating factor 1 receptor	0.013
Ptrf	polymerase I and transcript release factor	0.013
Ivd	isovaleryl coenzyme A dehydrogenase	0.013
Procr	protein C receptor, endothelial	0.012
Kl	klotho	0.012
Timm17a	translocase of inner mitochondrial membrane 17a	0.012
Lama2	laminin, alpha 2	0.012
Nxnl1	nucleoredoxin-like 1	0.012
Msr1	macrophage scavenger receptor 1	0.012
March5	membrane-associated ring finger (C3HC4) 5	0.012
Klrc1	killer cell lectin-like receptor subfamily C, member 1	0.012
AU021092	expressed sequence AU021092	0.012
Tnc	tenascin C	0.012
Epha2	Eph receptor A2	0.012
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.012
Lyl1	lymphoblastomic leukemia 1	0.012
Plvap	plasmalemma vesicle associated protein	0.012
Adcy4	adenylate cyclase 4	0.012
Mmp8	matrix metallopeptidase 8	0.012
Thbd	thrombomodulin	0.012
Ffar2	free fatty acid receptor 2	0.012
Ripply3	ripply3 homolog (zebrafish)	0.012
Plaur	plasminogen activator, urokinase receptor	0.012
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.012
Olfml3	olfactomedin-like 3	0.012
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.012
Slc2a10	solute carrier family 2 (facilitated glucose transporter), member 10	0.011
Sertad1	SERTA domain containing 1	0.011
Gfm1	G elongation factor, mitochondrial 1	0.011
Plin5	perilipin 5	0.011
Lipe	lipase, hormone sensitive	0.011
Foxo3	forkhead box O3	0.011
Ehd4	EH-domain containing 4	0.011
Ren1	renin 1 structural	0.011
Mpo	myeloperoxidase	0.011
Cdkn1c	cyclin-dependent kinase inhibitor 1C (P57)	0.011
Bcl2	B-cell leukemia/lymphoma 2	0.011
Acsf3	acyl-CoA synthetase family member 3	0.011
Stap1	signal transducing adaptor family member 1	0.011
Amhr2	anti-Mullerian hormone type 2 receptor	0.011
Rrad	Ras-related associated with diabetes	0.011
Sephs2	selenophosphate synthetase 2	0.011
Egln1	EGL nine homolog 1 (C. elegans)	0.011
Plunc	palate, lung, and nasal epithelium associated	0.011
Tekt2	tektin 2	0.011
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.011
S100g	S100 calcium binding protein G	0.011
Napsa	napsin A aspartic peptidase	0.011
Ctsl	cathepsin L	0.011
Hspa12b	heat shock protein 12B	0.011
Suv39h1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.011
Lipa	lysosomal acid lipase A	0.011
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.011
Abcb8	ATP-binding cassette, sub-family B (MDR/TAP), member 8	0.011
Mfap5	microfibrillar associated protein 5	0.010
Gpsm3	G-protein signalling modulator 3 (AGS3-like, C. elegans)	0.010
Prodh	proline dehydrogenase	0.010
Lrpprc	leucine-rich PPR-motif containing	0.010
Sell	selectin, lymphocyte	0.010	Rat
Kcne2	potassium voltage-gated channel, Isk-related subfamily, gene 2	0.010
Sgpl1	sphingosine phosphate lyase 1	0.010
Slc14a2	solute carrier family 14 (urea transporter), member 2	0.010
Prdx6	peroxiredoxin 6	0.010
Cxcl15	chemokine (C-X-C motif) ligand 15	0.010
Gyk	glycerol kinase	0.010
Cxcl1	chemokine (C-X-C motif) ligand 1	0.010
Klf15	Kruppel-like factor 15	0.010
Bmp6	bone morphogenetic protein 6	0.010
Slc12a4	solute carrier family 12, member 4	0.010
Jag1	jagged 1	0.010
Cnn1	calponin 1	0.010
Plin1	perilipin 1	0.010
Htr2b	5-hydroxytryptamine (serotonin) receptor 2B	0.010
Slc25a13	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	0.010
Fmo3	flavin containing monooxygenase 3	0.010
Rnase10	ribonuclease, RNase A family, 10 (non-active)	0.010
9930032O22Rik	RIKEN cDNA 9930032O22 gene	0.010
Bglap	bone gamma carboxyglutamate protein	0.010
Asb14	ankyrin repeat and SOCS box-containing 14	0.010
S100a8	S100 calcium binding protein A8 (calgranulin A)	0.010
Gclm	glutamate-cysteine ligase, modifier subunit	0.010
Ltbp1	latent transforming growth factor beta binding protein 1	0.010
Fzd4	frizzled homolog 4 (Drosophila)	0.010
Pla2g12a	phospholipase A2, group XIIA	0.010
Tph2	tryptophan hydroxylase 2	0.010
Lif	leukemia inhibitory factor	0.010
Bicc1	bicaudal C homolog 1 (Drosophila)	0.010