IMP

Process View

Mus musculus

4 genes annotated in mouse

response to nitric oxide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to nitric oxide"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to nitric oxide" (in gray)

Name	Description	Probability	Func Analog Organism
Mapk14	mitogen-activated protein kinase 14	0.998	Mouse
Mapk11	mitogen-activated protein kinase 11	0.945	Mouse
Pten	phosphatase and tensin homolog	0.901
Cav1	caveolin 1, caveolae protein	0.673
Atf2	activating transcription factor 2	0.585
Vhl	von Hippel-Lindau tumor suppressor	0.404
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.403
Mapkapk2	MAP kinase-activated protein kinase 2	0.317
Mapk8ip3	mitogen-activated protein kinase 8 interacting protein 3	0.298
Mknk2	MAP kinase-interacting serine/threonine kinase 2	0.264
Duox2	dual oxidase 2	0.222
Mdm2	transformed mouse 3T3 cell double minute 2	0.206
Mapk8	mitogen-activated protein kinase 8	0.178
Lepr	leptin receptor	0.176
Cd44	CD44 antigen	0.175
Mapk9	mitogen-activated protein kinase 9	0.158	Mouse
Mavs	mitochondrial antiviral signaling protein	0.147
Igh	immunoglobulin heavy chain complex	0.129
Cd40	CD40 antigen	0.127
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.110
Klc1	kinesin light chain 1	0.109
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.109
Vegfa	vascular endothelial growth factor A	0.102
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.102
Tlr4	toll-like receptor 4	0.095
Traf2	TNF receptor-associated factor 2	0.077
Crebbp	CREB binding protein	0.074
Irak3	interleukin-1 receptor-associated kinase 3	0.071
Myd88	myeloid differentiation primary response gene 88	0.071
Plat	plasminogen activator, tissue	0.070
Birc3	baculoviral IAP repeat-containing 3	0.069
Thra	thyroid hormone receptor alpha	0.068
Traf6	TNF receptor-associated factor 6	0.056	Mouse
Rarg	retinoic acid receptor, gamma	0.055
Hif1a	hypoxia inducible factor 1, alpha subunit	0.053
Irak1	interleukin-1 receptor-associated kinase 1	0.053
Trp53	transformation related protein 53	0.049
Dlg1	discs, large homolog 1 (Drosophila)	0.048
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.046
Fst	follistatin	0.045
Trafd1	TRAF type zinc finger domain containing 1	0.044
Spp1	secreted phosphoprotein 1	0.042
Mapk1	mitogen-activated protein kinase 1	0.042
Timp4	tissue inhibitor of metalloproteinase 4	0.040
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.038
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.038
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.038
Ccl2	chemokine (C-C motif) ligand 2	0.038
Jun	Jun oncogene	0.038
Mapk12	mitogen-activated protein kinase 12	0.038	Mouse
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.037
Npc1	Niemann Pick type C1	0.037
Prkce	protein kinase C, epsilon	0.037
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.036
Chst8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	0.036
Ptgs2	prostaglandin-endoperoxide synthase 2	0.035
Smad3	MAD homolog 3 (Drosophila)	0.034
Tgfb2	transforming growth factor, beta 2	0.034
Lep	leptin	0.034
Il6	interleukin 6	0.034
Kiss1	KiSS-1 metastasis-suppressor	0.034
Srpx	sushi-repeat-containing protein	0.033
Gdnf	glial cell line derived neurotrophic factor	0.033
Tnc	tenascin C	0.033
Npy1r	neuropeptide Y receptor Y1	0.033
Mknk1	MAP kinase-interacting serine/threonine kinase 1	0.031
Dusp2	dual specificity phosphatase 2	0.031
Otud7b	OTU domain containing 7B	0.029
Lama4	laminin, alpha 4	0.029
Agtr1a	angiotensin II receptor, type 1a	0.029
Ep300	E1A binding protein p300	0.028
Zeb1	zinc finger E-box binding homeobox 1	0.027
Traf3ip2	TRAF3 interacting protein 2	0.026
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.026
Mdm4	transformed mouse 3T3 cell double minute 4	0.026
Met	met proto-oncogene	0.026
P4htm	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	0.025
Wdfy2	WD repeat and FYVE domain containing 2	0.025
Foxo3	forkhead box O3	0.024	Mouse
Gfpt2	glutamine fructose-6-phosphate transaminase 2	0.024
Stat3	signal transducer and activator of transcription 3	0.024
Dpt	dermatopontin	0.023
Ikbkg	inhibitor of kappaB kinase gamma	0.023
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.023
Map2k3	mitogen-activated protein kinase kinase 3	0.023
Plau	plasminogen activator, urokinase	0.023
Ldlr	low density lipoprotein receptor	0.023
Yap1	yes-associated protein 1	0.023
Map3k1	mitogen-activated protein kinase kinase kinase 1	0.022
Lama2	laminin, alpha 2	0.022
Gata6	GATA binding protein 6	0.022
Ctnnb1	catenin (cadherin associated protein), beta 1	0.021
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.021
Fgfr2	fibroblast growth factor receptor 2	0.021
Col16a1	collagen, type XVI, alpha 1	0.021
Epas1	endothelial PAS domain protein 1	0.021
Spag9	sperm associated antigen 9	0.020
Fbn1	fibrillin 1	0.020
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.020
Bcl6	B-cell leukemia/lymphoma 6	0.020
Ghr	growth hormone receptor	0.019
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.019
Nf2	neurofibromatosis 2	0.019
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.019
Adipoq	adiponectin, C1Q and collagen domain containing	0.019
Sun1	Sad1 and UNC84 domain containing 1	0.018
Resp18	regulated endocrine-specific protein 18	0.018
Fbln2	fibulin 2	0.018
Cpe	carboxypeptidase E	0.018
Mcm9	minichromosome maintenance complex component 9	0.017
Mapkbp1	mitogen-activated protein kinase binding protein 1	0.017
Il1rap	interleukin 1 receptor accessory protein	0.017
Gas1	growth arrest specific 1	0.017
Klc2	kinesin light chain 2	0.017
Kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.017
Vdr	vitamin D receptor	0.017
Foxa2	forkhead box A2	0.016
Amhr2	anti-Mullerian hormone type 2 receptor	0.016
Actn3	actinin alpha 3	0.016
Stat5a	signal transducer and activator of transcription 5A	0.016
Esr2	estrogen receptor 2 (beta)	0.016
Sun2	Sad1 and UNC84 domain containing 2	0.016
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.016
Ap1m2	adaptor protein complex AP-1, mu 2 subunit	0.016
Rmnd5a	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	0.016
Wwox	WW domain-containing oxidoreductase	0.016
Gsta4	glutathione S-transferase, alpha 4	0.016
St14	suppression of tumorigenicity 14 (colon carcinoma)	0.015
Dclre1a	DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae)	0.015
Pygm	muscle glycogen phosphorylase	0.015
Klf3	Kruppel-like factor 3 (basic)	0.015
Ptch1	patched homolog 1	0.015
Ctsk	cathepsin K	0.015
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.015
Sharpin	SHANK-associated RH domain interacting protein	0.015
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.015
Cbl	Casitas B-lineage lymphoma	0.015
Bmp7	bone morphogenetic protein 7	0.015
Arhgap8	Rho GTPase activating protein 8	0.015
Ltbp4	latent transforming growth factor beta binding protein 4	0.014
Tef	thyrotroph embryonic factor	0.014
Notch1	Notch gene homolog 1 (Drosophila)	0.014
Gm13290	predicted gene 13290	0.014
Mfap5	microfibrillar associated protein 5	0.014
Helq	helicase, POLQ-like	0.014
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.014
Stk39	serine/threonine kinase 39, STE20/SPS1 homolog (yeast)	0.014
Ager	advanced glycosylation end product-specific receptor	0.014
Scnn1g	sodium channel, nonvoltage-gated 1 gamma	0.014
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.014
Col8a1	collagen, type VIII, alpha 1	0.014
C1qtnf1	C1q and tumor necrosis factor related protein 1	0.014
Col5a1	collagen, type V, alpha 1	0.014
Lif	leukemia inhibitory factor	0.014
Mdk	midkine	0.014
Dmd	dystrophin, muscular dystrophy	0.014
Rtn2	reticulon 2 (Z-band associated protein)	0.014
Col1a2	collagen, type I, alpha 2	0.014
Stat5b	signal transducer and activator of transcription 5B	0.014
Krtcap3	keratinocyte associated protein 3	0.014
Lipe	lipase, hormone sensitive	0.014
Polm	polymerase (DNA directed), mu	0.014
Spsb1	splA/ryanodine receptor domain and SOCS box containing 1	0.014
Dag1	dystroglycan 1	0.014
Twist1	twist homolog 1 (Drosophila)	0.014
Snap25	synaptosomal-associated protein 25	0.014
Flnc	filamin C, gamma	0.014
Skil	SKI-like	0.014
Tnfrsf25	tumor necrosis factor receptor superfamily, member 25	0.014
Thbs4	thrombospondin 4	0.014	Mouse
Taf8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factorq	0.013
Crlf1	cytokine receptor-like factor 1	0.013
Tagln	transgelin	0.013
Rrad	Ras-related associated with diabetes	0.013
Rac1	RAS-related C3 botulinum substrate 1	0.013
Ankrd40	ankyrin repeat domain 40	0.013
1500015O10Rik	RIKEN cDNA 1500015O10 gene	0.013
Men1	multiple endocrine neoplasia 1	0.013
Prrx2	paired related homeobox 2	0.013
Hspa1b	heat shock protein 1B	0.012
Fbln1	fibulin 1	0.012
Tle1	transducin-like enhancer of split 1, homolog of Drosophila E(spl)	0.012
Itch	itchy, E3 ubiquitin protein ligase	0.012
Fgfr1	fibroblast growth factor receptor 1	0.012
Npy2r	neuropeptide Y receptor Y2	0.012
Zbtb37	zinc finger and BTB domain containing 37	0.012
Gpc3	glypican 3	0.012
Tollip	toll interacting protein	0.012
Apod	apolipoprotein D	0.012
Huwe1	HECT, UBA and WWE domain containing 1	0.012
Nod2	nucleotide-binding oligomerization domain containing 2	0.012
Cdkn1c	cyclin-dependent kinase inhibitor 1C (P57)	0.012
Osmr	oncostatin M receptor	0.012
Tnxb	tenascin XB	0.012
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.012
Stx1a	syntaxin 1A (brain)	0.012
Fam134b	family with sequence similarity 134, member B	0.012
Eya2	eyes absent 2 homolog (Drosophila)	0.012
Phkg1	phosphorylase kinase gamma 1	0.012
Mfap4	microfibrillar-associated protein 4	0.012
Hnf1b	HNF1 homeobox B	0.012
Traf3	TNF receptor-associated factor 3	0.012	Mouse
Lox	lysyl oxidase	0.012
Atf3	activating transcription factor 3	0.012
Foxo1	forkhead box O1	0.012
Itga7	integrin alpha 7	0.012
Baiap2l1	BAI1-associated protein 2-like 1	0.012
Nrtn	neurturin	0.012
Ednra	endothelin receptor type A	0.012
Per3	period homolog 3 (Drosophila)	0.011
Fgf7	fibroblast growth factor 7	0.011
Nfkbie	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.011
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.011
Sftpd	surfactant associated protein D	0.011
Trak1	trafficking protein, kinesin binding 1	0.011
Gab1	growth factor receptor bound protein 2-associated protein 1	0.011
Phka1	phosphorylase kinase alpha 1	0.011
Pparg	peroxisome proliferator activated receptor gamma	0.011
Rnf41	ring finger protein 41	0.011
Snta1	syntrophin, acidic 1	0.011
Sema3b	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B	0.011
Map2k7	mitogen-activated protein kinase kinase 7	0.011
Mtap6	microtubule-associated protein 6	0.011
Lsm14b	LSM14 homolog B (SCD6, S. cerevisiae)	0.011
Gdf1	growth differentiation factor 1	0.011
Tcrb	T-cell receptor beta chain	0.011
Lum	lumican	0.011
Fxyd1	FXYD domain-containing ion transport regulator 1	0.011
Snrk	SNF related kinase	0.011
Foxc1	forkhead box C1	0.011
Rasal1	RAS protein activator like 1 (GAP1 like)	0.011
Homer1	homer homolog 1 (Drosophila)	0.011
Cnn1	calponin 1	0.011
Prlr	prolactin receptor	0.011
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.011
Csf1	colony stimulating factor 1 (macrophage)	0.011
Sav1	salvador homolog 1 (Drosophila)	0.011
Sfn	stratifin	0.011
Spop	speckle-type POZ protein	0.011
Tifa	TRAF-interacting protein with forkhead-associated domain	0.011
Gys1	glycogen synthase 1, muscle	0.011
Creb1	cAMP responsive element binding protein 1	0.011
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.011
Ina	internexin neuronal intermediate filament protein, alpha	0.011
Mecom	MDS1 and EVI1 complex locus	0.011
Egfr	epidermal growth factor receptor	0.011
Card11	caspase recruitment domain family, member 11	0.010
Cyr61	cysteine rich protein 61	0.010
Cdkn2d	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.010
Mapk8ip2	mitogen-activated protein kinase 8 interacting protein 2	0.010
Cyp1b1	cytochrome P450, family 1, subfamily b, polypeptide 1	0.010
Errfi1	ERBB receptor feedback inhibitor 1	0.010
Lama1	laminin, alpha 1	0.010
Med14	mediator complex subunit 14	0.010
Hspa1a	heat shock protein 1A	0.010
Bmper	BMP-binding endothelial regulator	0.010
Col2a1	collagen, type II, alpha 1	0.010
Map2k4	mitogen-activated protein kinase kinase 4	0.010
Cd27	CD27 antigen	0.010
Ddit4	DNA-damage-inducible transcript 4	0.010
Pomc	pro-opiomelanocortin-alpha	0.010
Rxra	retinoid X receptor alpha	0.010
Shank2	SH3/ankyrin domain gene 2	0.010
Serpini1	serine (or cysteine) peptidase inhibitor, clade I, member 1	0.010
Chrnb2	cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)	0.010
Mafk	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	0.010
Plp1	proteolipid protein (myelin) 1	0.010
Grm1	glutamate receptor, metabotropic 1	0.010