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Mus musculus

4 genes annotated in mouse

Multi-species View

negative regulation of osteoblast proliferation

GO:0033689

Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of osteoblast proliferation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of osteoblast proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
Smad3	MAD homolog 3 (Drosophila)	1.000
Smad4	MAD homolog 4 (Drosophila)	0.999	Mouse
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.999
Bcl2	B-cell leukemia/lymphoma 2	0.983
Axin1	axin 1	0.973
Smad1	MAD homolog 1 (Drosophila)	0.972	Mouse
Trp53	transformation related protein 53	0.971
Arhgef11	Rho guanine nucleotide exchange factor (GEF) 11	0.971
Apc	adenomatosis polyposis coli	0.952
Bax	BCL2-associated X protein	0.836	Mouse
Ctnnb1	catenin (cadherin associated protein), beta 1	0.820
Sfrp1	secreted frizzled-related protein 1	0.487
Erbb2ip	Erbb2 interacting protein	0.472
Arhgef12	Rho guanine nucleotide exchange factor (GEF) 12	0.431
Vhl	von Hippel-Lindau tumor suppressor	0.387
Sfrp2	secreted frizzled-related protein 2	0.387	Mouse
Smad2	MAD homolog 2 (Drosophila)	0.380	Mouse
Pbx1	pre B-cell leukemia transcription factor 1	0.377
Smurf1	SMAD specific E3 ubiquitin protein ligase 1	0.349
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.330
Nrp1	neuropilin 1	0.321
Kit	kit oncogene	0.307
Pten	phosphatase and tensin homolog	0.292
Rnf111	ring finger 111	0.271
Rarg	retinoic acid receptor, gamma	0.253
Smad7	MAD homolog 7 (Drosophila)	0.250	Mouse
Ednra	endothelin receptor type A	0.236
Acvr1	activin A receptor, type 1	0.197
Vegfa	vascular endothelial growth factor A	0.184
Bak1	BCL2-antagonist/killer 1	0.180	Mouse
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.166
Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.160
Rara	retinoic acid receptor, alpha	0.159
Gata4	GATA binding protein 4	0.157
Thbs1	thrombospondin 1	0.143
Ptgs2	prostaglandin-endoperoxide synthase 2	0.139
Gsk3b	glycogen synthase kinase 3 beta	0.137
Efnb1	ephrin B1	0.136
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.129
Sdc3	syndecan 3	0.128
Fgfr1	fibroblast growth factor receptor 1	0.126
Fzd1	frizzled homolog 1 (Drosophila)	0.114
Epha4	Eph receptor A4	0.107
Braf	Braf transforming gene	0.107
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.099
Hdac7	histone deacetylase 7	0.098
Nrp2	neuropilin 2	0.091
Rxra	retinoid X receptor alpha	0.090
Prmt1	protein arginine N-methyltransferase 1	0.087
Pknox1	Pbx/knotted 1 homeobox	0.082
Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.079
Stat3	signal transducer and activator of transcription 3	0.078
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.077
Prkg1	protein kinase, cGMP-dependent, type I	0.077
Fgfr2	fibroblast growth factor receptor 2	0.077
Axin2	axin2	0.077
Lrp5	low density lipoprotein receptor-related protein 5	0.076
Nynrin	NYN domain and retroviral integrase containing	0.071
Lepr	leptin receptor	0.068
Kitl	kit ligand	0.066
Gata6	GATA binding protein 6	0.066
Nfya	nuclear transcription factor-Y alpha	0.065
Bmp4	bone morphogenetic protein 4	0.065
Hip1	huntingtin interacting protein 1	0.058
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.058
Ret	ret proto-oncogene	0.057
Eif4enif1	eukaryotic translation initiation factor 4E nuclear import factor 1	0.057
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.056
Gli3	GLI-Kruppel family member GLI3	0.055
Il6st	interleukin 6 signal transducer	0.055
Zfp36l1	zinc finger protein 36, C3H type-like 1	0.053
Stk11	serine/threonine kinase 11	0.053
Smad6	MAD homolog 6 (Drosophila)	0.052	Mouse
Zfp362	zinc finger protein 362	0.052
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.051
Adam17	a disintegrin and metallopeptidase domain 17	0.051
Arf2	ADP-ribosylation factor 2	0.050
Ece1	endothelin converting enzyme 1	0.050
Vkorc1	vitamin K epoxide reductase complex, subunit 1	0.048
Fscn1	fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)	0.047
Nphs2	nephrosis 2 homolog, podocin (human)	0.047
Bbc3	BCL2 binding component 3	0.047
Klf3	Kruppel-like factor 3 (basic)	0.046
Bach1	BTB and CNC homology 1	0.045
Smad5	MAD homolog 5 (Drosophila)	0.042	Mouse
Mfn2	mitofusin 2	0.042
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.040
Fzd7	frizzled homolog 7 (Drosophila)	0.040
Nf1	neurofibromatosis 1	0.040
Amhr2	anti-Mullerian hormone type 2 receptor	0.039
Foxp1	forkhead box P1	0.038
Tgfb1	transforming growth factor, beta 1	0.038
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.037
Capn5	calpain 5	0.036
Bcl10	B-cell leukemia/lymphoma 10	0.036
Gpc3	glypican 3	0.035
Acaa2	acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)	0.035
Plxna1	plexin A1	0.035	Mouse
Lyst	lysosomal trafficking regulator	0.035
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.035
Fuca1	fucosidase, alpha-L- 1, tissue	0.034
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.034
Efna2	ephrin A2	0.033
Mfap2	microfibrillar-associated protein 2	0.033
Kif3b	kinesin family member 3B	0.033
Skil	SKI-like	0.032
Acvr1b	activin A receptor, type 1B	0.032
Zmym2	zinc finger, MYM-type 2	0.031
Cst3	cystatin C	0.031
Coro1b	coronin, actin binding protein 1B	0.031
Arpc4	actin related protein 2/3 complex, subunit 4	0.030
Rarb	retinoic acid receptor, beta	0.030
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.030
Efs	embryonal Fyn-associated substrate	0.030
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.030
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.030
Surf1	surfeit gene 1	0.030
Efna4	ephrin A4	0.030
Sh2b3	SH2B adaptor protein 3	0.029
Lama5	laminin, alpha 5	0.029
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.029
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.029
Bcap31	B-cell receptor-associated protein 31	0.029
Wnt5a	wingless-related MMTV integration site 5A	0.029
Zbtb7a	zinc finger and BTB domain containing 7a	0.028
Tgfbr1	transforming growth factor, beta receptor I	0.028
Ednrb	endothelin receptor type B	0.028
Ptk2	PTK2 protein tyrosine kinase 2	0.028
Gstz1	glutathione transferase zeta 1 (maleylacetoacetate isomerase)	0.028
Mdm2	transformed mouse 3T3 cell double minute 2	0.027
Ski	ski sarcoma viral oncogene homolog (avian)	0.027
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.026
Ptch1	patched homolog 1	0.026
Nos3	nitric oxide synthase 3, endothelial cell	0.026
Tgfbr3	transforming growth factor, beta receptor III	0.025
Ddx5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.025
Atr	ataxia telangiectasia and Rad3 related	0.025
Aff1	AF4/FMR2 family, member 1	0.025
Cul7	cullin 7	0.025
Dnmt3b	DNA methyltransferase 3B	0.025
Gdnf	glial cell line derived neurotrophic factor	0.024
Notch3	Notch gene homolog 3 (Drosophila)	0.024
Hoxa11	homeobox A11	0.024
Tbx2	T-box 2	0.024
Wrn	Werner syndrome homolog (human)	0.024
Ltbp1	latent transforming growth factor beta binding protein 1	0.024
Ccnd1	cyclin D1	0.023
Ddah2	dimethylarginine dimethylaminohydrolase 2	0.022
Tbx3	T-box 3	0.022
Upk3b	uroplakin 3B	0.022
Vps25	vacuolar protein sorting 25 (yeast)	0.022
Sh3rf1	SH3 domain containing ring finger 1	0.022
Spin1	spindlin 1	0.022
Tbx1	T-box 1	0.022
Tspan9	tetraspanin 9	0.021
Hif1a	hypoxia inducible factor 1, alpha subunit	0.021
Matn4	matrilin 4	0.021
Hs2st1	heparan sulfate 2-O-sulfotransferase 1	0.021
Rab5b	RAB5B, member RAS oncogene family	0.021
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.021
Bid	BH3 interacting domain death agonist	0.021
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.021
Sox10	SRY-box containing gene 10	0.020
Hhex	hematopoietically expressed homeobox	0.020
Htt	huntingtin	0.020
Prkci	protein kinase C, iota	0.020
Dpysl2	dihydropyrimidinase-like 2	0.020
Pml	promyelocytic leukemia	0.020
Tapbp	TAP binding protein	0.019
Yap1	yes-associated protein 1	0.019
Midn	midnolin	0.019
Pxn	paxillin	0.019
Wwtr1	WW domain containing transcription regulator 1	0.019
Trp73	transformation related protein 73	0.019
Sall1	sal-like 1 (Drosophila)	0.019
Pgc	progastricsin (pepsinogen C)	0.019
Wiz	widely-interspaced zinc finger motifs	0.019
Stat2	signal transducer and activator of transcription 2	0.019
Ptk7	PTK7 protein tyrosine kinase 7	0.019
Zfp618	zinc fingerprotein 618	0.019
Nkd1	naked cuticle 1 homolog (Drosophila)	0.019
Ikbkb	inhibitor of kappaB kinase beta	0.019
Cd44	CD44 antigen	0.019
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.018
Fcgrt	Fc receptor, IgG, alpha chain transporter	0.018
Nsd1	nuclear receptor-binding SET-domain protein 1	0.018
Wnt9b	wingless-type MMTV integration site 9B	0.018
Vdr	vitamin D receptor	0.018
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.018
Wnt11	wingless-related MMTV integration site 11	0.018
Zfp358	zinc finger protein 358	0.017
Pdgfb	platelet derived growth factor, B polypeptide	0.017
Id1	inhibitor of DNA binding 1	0.017
Snai1	snail homolog 1 (Drosophila)	0.017
Cdk14	cyclin-dependent kinase 14	0.017
Prdm16	PR domain containing 16	0.017
Trpm6	transient receptor potential cation channel, subfamily M, member 6	0.017
Zfp36l2	zinc finger protein 36, C3H type-like 2	0.017
Smo	smoothened homolog (Drosophila)	0.017
2400003C14Rik	RIKEN cDNA 2400003C14 gene	0.017
Stab1	stabilin 1	0.017
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.017
Ehd3	EH-domain containing 3	0.016
Btg1	B-cell translocation gene 1, anti-proliferative	0.016
Klf10	Kruppel-like factor 10	0.016
Ephb2	Eph receptor B2	0.016
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.016
Nppa	natriuretic peptide type A	0.016
Llgl1	lethal giant larvae homolog 1 (Drosophila)	0.016
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.016
Pld2	phospholipase D2	0.016
Bptf	bromodomain PHD finger transcription factor	0.016
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.016
Rnf44	ring finger protein 44	0.016
Aga	aspartylglucosaminidase	0.015
Zeb2	zinc finger E-box binding homeobox 2	0.015
Acvr2a	activin receptor IIA	0.015
Mrc2	mannose receptor, C type 2	0.015
Mcl1	myeloid cell leukemia sequence 1	0.015	Mouse
4930579J09Rik	RIKEN cDNA 4930579J09 gene	0.015
Trim8	tripartite motif-containing 8	0.015
Scn5a	sodium channel, voltage-gated, type V, alpha	0.015
Map3k11	mitogen-activated protein kinase kinase kinase 11	0.015
Pfn1	profilin 1	0.015
Col20a1	collagen, type XX, alpha 1	0.015
Plxna3	plexin A3	0.015	Mouse
Cic	capicua homolog (Drosophila)	0.015
Fos	FBJ osteosarcoma oncogene	0.015
Fzd8	frizzled homolog 8 (Drosophila)	0.015
Npcd	neuronal pentraxin chromo domain	0.015
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.014
Pga5	pepsinogen 5, group I	0.014
Hoxb3	homeobox B3	0.014
Ncoa2	nuclear receptor coactivator 2	0.014
Ids	iduronate 2-sulfatase	0.014
Klf6	Kruppel-like factor 6	0.014
Usp22	ubiquitin specific peptidase 22	0.014
9930013L23Rik	RIKEN cDNA 9930013L23 gene	0.014
Jun	Jun oncogene	0.014
Cxadr	coxsackie virus and adenovirus receptor	0.014
Fli1	Friend leukemia integration 1	0.014
Ncoa3	nuclear receptor coactivator 3	0.014
Rhod	ras homolog gene family, member D	0.014
Wnt4	wingless-related MMTV integration site 4	0.014
Runx1	runt related transcription factor 1	0.014
Vasp	vasodilator-stimulated phosphoprotein	0.014
Prrc2b	proline-rich coiled-coil 2B	0.014
Sntb2	syntrophin, basic 2	0.013
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.013
Dapk1	death associated protein kinase 1	0.013
Sox4	SRY-box containing gene 4	0.013
Akt3	thymoma viral proto-oncogene 3	0.013
0610031J06Rik	RIKEN cDNA 0610031J06 gene	0.013
Cachd1	cache domain containing 1	0.013
Grb10	growth factor receptor bound protein 10	0.013
Lef1	lymphoid enhancer binding factor 1	0.013
1600012H06Rik	RIKEN cDNA 1600012H06 gene	0.013
Tgfbr2	transforming growth factor, beta receptor II	0.013
Ctsa	cathepsin A	0.013
Mkl2	MKL/myocardin-like 2	0.013
Itga3	integrin alpha 3	0.013
Ptprf	protein tyrosine phosphatase, receptor type, F	0.013
Usp25	ubiquitin specific peptidase 25	0.013
Meis3	Meis homeobox 3	0.013
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.013
Plxnb1	plexin B1	0.013
Mitf	microphthalmia-associated transcription factor	0.013
Ctsz	cathepsin Z	0.013
Rgnef	Rho-guanine nucleotide exchange factor	0.013
Vav2	vav 2 oncogene	0.013
Met	met proto-oncogene	0.013
Homer3	homer homolog 3 (Drosophila)	0.013
Id3	inhibitor of DNA binding 3	0.013
Atoh8	atonal homolog 8 (Drosophila)	0.013
Lama1	laminin, alpha 1	0.013
Creb1	cAMP responsive element binding protein 1	0.013
Emp2	epithelial membrane protein 2	0.013
4931408A02Rik	RIKEN cDNA 4931408A02 gene	0.012
Tcf21	transcription factor 21	0.012
Gnptab	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	0.012
Sntb1	syntrophin, basic 1	0.012
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.012
Dab2	disabled homolog 2 (Drosophila)	0.012
Dscaml1	Down syndrome cell adhesion molecule-like 1	0.012
Lrp6	low density lipoprotein receptor-related protein 6	0.012
Inhbb	inhibin beta-B	0.012
Clip2	CAP-GLY domain containing linker protein 2	0.012
Ilk	integrin linked kinase	0.012
Sept9	septin 9	0.012
Cacng7	calcium channel, voltage-dependent, gamma subunit 7	0.012
P2rx6	purinergic receptor P2X, ligand-gated ion channel, 6	0.012
Tgfa	transforming growth factor alpha	0.012
Plekha4	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	0.012
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.012
Ykt6	YKT6 homolog (S. Cerevisiae)	0.012
Atp6v0a1	ATPase, H+ transporting, lysosomal V0 subunit A1	0.012
Spg21	spastic paraplegia 21 homolog (human)	0.012
Hoxb4	homeobox B4	0.012
Phc2	polyhomeotic-like 2 (Drosophila)	0.012
Gpr27	G protein-coupled receptor 27	0.012
Ptprj	protein tyrosine phosphatase, receptor type, J	0.012
Cux1	cut-like homeobox 1	0.012
Dnahc1	dynein, axonemal, heavy chain 1	0.012
Galk2	galactokinase 2	0.012
Nfia	nuclear factor I/A	0.012
Zfp146	zinc finger protein 146	0.012
Cpd	carboxypeptidase D	0.012
Zfhx3	zinc finger homeobox 3	0.012
Hoxa2	homeobox A2	0.012
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.012
Gas1	growth arrest specific 1	0.011
Slc27a3	solute carrier family 27 (fatty acid transporter), member 3	0.011
Aicda	activation-induced cytidine deaminase	0.011
Irf2bp1	interferon regulatory factor 2 binding protein 1	0.011
Epb4.1l2	erythrocyte protein band 4.1-like 2	0.011
Egr3	early growth response 3	0.011
Sh3bp1	SH3-domain binding protein 1	0.011
Gata2	GATA binding protein 2	0.011
Nedd9	neural precursor cell expressed, developmentally down-regulated gene 9	0.011
Timp2	tissue inhibitor of metalloproteinase 2	0.011
Rai1	retinoic acid induced 1	0.011
S1pr3	sphingosine-1-phosphate receptor 3	0.011
Aatk	apoptosis-associated tyrosine kinase	0.011
Wls	wntless homolog (Drosophila)	0.011
Socs5	suppressor of cytokine signaling 5	0.011
Fgfr4	fibroblast growth factor receptor 4	0.011
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.011
Sirpa	signal-regulatory protein alpha	0.011
Fbxo41	F-box protein 41	0.011
Adamts10	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10	0.011
Plxnb2	plexin B2	0.011	Mouse
Hoxa3	homeobox A3	0.011
Map4k4	mitogen-activated protein kinase kinase kinase kinase 4	0.011
B3gnt8	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	0.011
Ephb3	Eph receptor B3	0.011
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.011
Wnt6	wingless-related MMTV integration site 6	0.011
Sox13	SRY-box containing gene 13	0.011
Nav1	neuron navigator 1	0.011
Cyp1b1	cytochrome P450, family 1, subfamily b, polypeptide 1	0.011
Tbx5	T-box 5	0.011
Tcf7	transcription factor 7, T-cell specific	0.011
Zfp518b	zinc finger protein 518B	0.011
Tmem50a	transmembrane protein 50A	0.010
H2-T24	histocompatibility 2, T region locus 24	0.010
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.010
Ep300	E1A binding protein p300	0.010
Sftpd	surfactant associated protein D	0.010
Tead2	TEA domain family member 2	0.010
Atn1	atrophin 1	0.010
Ptprs	protein tyrosine phosphatase, receptor type, S	0.010
Lamc3	laminin gamma 3	0.010
Foxf1a	forkhead box F1a	0.010
Hes1	hairy and enhancer of split 1 (Drosophila)	0.010
Zfp532	zinc finger protein 532	0.010
Sgpl1	sphingosine phosphate lyase 1	0.010
Btbd3	BTB (POZ) domain containing 3	0.010
Marcks	myristoylated alanine rich protein kinase C substrate	0.010
Ahr	aryl-hydrocarbon receptor	0.010
Nes	nestin	0.010
Nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.010
Ddr2	discoidin domain receptor family, member 2	0.010
Qsox1	quiescin Q6 sulfhydryl oxidase 1	0.010
Crlf1	cytokine receptor-like factor 1	0.010