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Danio rerio

0 genes annotated in zebrafish

physical disorder

DOID:0080015

A disease that has material basis in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment.

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "physical disorder" (in gray)

Name	Description	Probability	Func Analog Organism
fgf8a	fibroblast growth factor 8 a	0.480
cdh2	cadherin 2, neuronal	0.454
pafah1b1b	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b	0.376	Human
zic2a	zic family member 2 (odd-paired homolog, Drosophila), a	0.296	Human
pafah1b1a	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a	0.249	Human
pax6a	paired box gene 6a	0.242
zic1	zic family member 1 (odd-paired homolog, Drosophila)	0.241
shha	sonic hedgehog a	0.198
elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.173
pax6b	paired box gene 6b	0.163
otx1b	orthodenticle homolog 1b	0.156
dlx2a	distal-less homeobox gene 2a	0.152
wu:fc51f04	wu:fc51f04	0.137
zic3	zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)	0.136	Human
zc4h2	zinc finger, C4H2 domain containing	0.132
id2a	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a	0.122
etv5b	ets variant 5b	0.119
hmgb1b	high-mobility group box 1b	0.111
lamb1a	laminin, beta 1a	0.105
acvr2a	activin receptor IIa	0.104
tubb5	tubulin, beta 5	0.101
rarab	retinoic acid receptor, alpha b	0.087
tmeff1	transmembrane protein with EGF-like and two follistatin-like domains 1	0.074
fgfr1a	fibroblast growth factor receptor 1a	0.073
runx2b	runt-related transcription factor 2b	0.073
dnmt1	DNA (cytosine-5-)-methyltransferase 1	0.070
zic2b	zic family member 2 (odd-paired homolog, Drosophila) b	0.070
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.070
chd	chordin	0.069
dpysl3	dihydropyrimidinase-like 3	0.067
hoxa9a	homeo box A9a	0.063
sst1.1	somatostatin 1, tandem duplicate 1	0.061
hand2	heart and neural crest derivatives expressed transcript 2	0.060
neurod	neurogenic differentiation	0.059
zgc:158626	zgc:158626	0.059
wnt8b	wingless-type MMTV integration site family, member 8b	0.057
ahctf1	AT hook containing transcription factor 1	0.055
msxe	muscle segment homeobox E	0.054	Human
im:7165141	im:7165141	0.053
msxc	muscle segment homeobox C	0.053
brd2a	bromodomain-containing 2a	0.050
sox2	SRY-box containing gene 2	0.050
olig2	oligodendrocyte lineage transcription factor 2	0.049
spry4	sprouty (Drosophila) homolog 4	0.048
sox19a	SRY-box containing gene 19a	0.048
wu:fb17g07	wu:fb17g07	0.047
zic5	zic family member 5 (odd-paired homolog, Drosophila)	0.047
tbx20	T-box 20	0.046
six3a	sine oculis homeobox homolog 3a	0.046	Human
wt1a	wilms tumor 1a	0.046
marcksa	myristoylated alanine rich protein kinase C substrate a	0.046
msxb	muscle segment homeobox B	0.042
ing4	inhibitor of growth family, member 4	0.042
gli1	GLI-Kruppel family member 1	0.042
foxg1a	forkhead box G1a	0.042
lamc1	laminin, gamma 1	0.041
krcp	kelch repeat-containing protein	0.040
fezf2	FEZ family zinc finger 2	0.039
gnao1a	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a	0.039
sox4a	SRY-box containing gene 4a	0.039
sox9a	SRY-box containing gene 9a	0.037
ntla	no tail a	0.037
wu:fq41a10	wu:fq41a10	0.036
vax1	ventral anterior homeobox 1	0.035
otx2	orthodenticle homolog 2	0.035
tbx18	T-box 18	0.035
rx3	retinal homeobox gene 3	0.034
barhl2	BarH-like 2	0.033
sncgb	synuclein, gamma b (breast cancer-specific protein 1)	0.033
hp1bp3	heterochromatin protein 1, binding protein 3	0.032
chaf1b	chromatin assembly factor 1, subunit B	0.032
lmo4a	LIM domain only 4a	0.031
cdipt	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)	0.031
axin2	axin 2 (conductin, axil)	0.030
si:ch211-133n4.4	si:ch211-133n4.4	0.030
hmgb1a	high-mobility group box 1a	0.029
il17rd	interleukin 17 receptor D	0.029
epb41l5	erythrocyte membrane protein band 4.1 like 5	0.029
lhx2b	LIM homeobox 2b	0.029
LOC792958	nuclear receptor coactivator 7-like	0.029
snai1b	snail homolog 1b (Drosophila)	0.029
smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.028
whsc1	Wolf-Hirschhorn syndrome candidate 1	0.028
dpysl5a	dihydropyrimidinase-like 5a	0.028
rbpms2	RNA binding protein with multiple splicing 2	0.028
heatr5a	HEAT repeat containing 5a	0.028
cep290	centrosomal protein 290	0.028
pink1	PTEN induced putative kinase 1	0.027
tuba1l	tubulin, alpha 1, like	0.027	Human
tfap2a	transcription factor AP-2 alpha	0.027
gria2a	glutamate receptor, ionotropic, AMPA 2a	0.026
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.026
ptp4a1	protein tyrosine phosphatase type IVA, member 1	0.026
im:7163548	im:7163548	0.026
rassf8b	Ras association (RalGDS/AF-6) domain family 8b	0.026
marcksb	myristoylated alanine rich protein kinase C substrate b	0.025
cx43	connexin 43	0.025
appa	amyloid beta (A4) precursor protein a	0.025
mbd3b	methyl-CpG binding domain protein 3b	0.025
pax2a	paired box gene 2a	0.024
bmp15	bone morphogenetic protein 15	0.024
cx43.4	connexin 43.4	0.024
ddx26b	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	0.023
LOC557001	tetratricopeptide repeat protein 34-like	0.023
tuba1l2	tubulin, alpha 1, like 2	0.023	Human
hesx1	homeo box (expressed in ES cells) 1	0.022
bmp2b	bone morphogenetic protein 2b	0.022
g2e3	G2/M-phase specific E3 ubiquitin ligase	0.022
isl1	islet1	0.022
ppp2r1b	protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform	0.021
nkx2.5	NK2 transcription factor related 5	0.021
ankar	ankyrin and armadillo repeat containing	0.021
plk1	polo-like kinase 1 (Drosophila)	0.021
ndr2	nodal-related 2	0.021
igf1rb	insulin-like growth factor 1b receptor	0.021
LOC572312	similar to CG10038 CG10038-PB	0.021
robo3	roundabout homolog 3	0.021
ephb4a	eph receptor B4a	0.021
rp2	retinitis pigmentosa 2 (X-linked recessive)	0.021
tspan13b	tetraspanin 13b	0.021
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.021
rb1	retinoblastoma 1	0.021
dctn1a	dynactin 1a	0.020
ptch1	patched 1	0.020
fcho2	FCH domain only 2	0.020
LOC561388	hypothetical protein LOC561388	0.020
nat8l	N-acetyltransferase 8-like	0.020
snap25a	synaptosome-associated protein 25a	0.020
dpf2l	D4, zinc and double PHD fingers family 2, like	0.020
shfm1	split hand/foot malformation (ectrodactyly) type 1	0.019
nadl1.2	neural adhesion molecule L1.2	0.019
atp1b2a	ATPase, Na+/K+ transporting, beta 2a polypeptide	0.019
ap1s2	adaptor-related protein complex 1, sigma 2 subunit	0.019
LOC100535549	cytoplasmic polyadenylation element-binding protein 4-like	0.019
LOC100329473	girdin-like	0.019
dtl	denticleless homolog (Drosophila)	0.018
atoh7	atonal homolog 7	0.018
si:ch211-215h6.2	si:ch211-215h6.2	0.018
tmed4	transmembrane emp24 protein transport domain containing 4	0.018
gamt	guanidinoacetate N-methyltransferase	0.018
st3gal2l	ST3 beta-galactoside alpha-2,3-sialyltransferase 2, like	0.018
mef2d	myocyte enhancer factor 2d	0.018
opa3	optic atrophy 3	0.018
zgc:123017	zgc:123017	0.018
hmgn2	high-mobility group nucleosomal binding domain 2	0.018
aif1l	allograft inflammatory factor 1-like	0.018
mycl1a	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) a	0.017
zgc:162270	zgc:162270	0.017
hoxc11a	homeo box C11a	0.017
LOC557250	microtubule-associated tumor suppressor 1 homolog A-like	0.017
mapk3	mitogen-activated protein kinase 3	0.017
wu:fi26e04	wu:fi26e04	0.017
si:dkeyp-87e7.4	si:dkeyp-87e7.4	0.017
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.017
robo2	roundabout homolog 2	0.017
LOC100537720	hypothetical protein LOC100537720	0.017
pou3f1	POU class 3 homeobox 1	0.017
cdk13	cyclin-dependent kinase 13	0.017
nr2f6a	nuclear receptor subfamily 2, group F, member 6a	0.017
zic4	zic family member 4	0.016
th	tyrosine hydroxylase	0.016
ptmaa	prothymosin, alpha a	0.016
LOC100537862	hypothetical protein LOC100537862	0.016
stmn1b	stathmin 1b	0.016
fabp7a	fatty acid binding protein 7, brain, a	0.016
dlx6a	distal-less homeobox gene 6a	0.016
zgc:64114	zgc:64114	0.016
ap1g1	adaptor-related protein complex 1, gamma 1 subunit	0.016
hoxd12a	homeo box D12a	0.016
LOC565632	BTB/POZ domain-containing protein 16-like	0.016
col2a1a	collagen type II, alpha-1a	0.016
cdc25	cell division cycle 25 homolog	0.016
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.016
suv39h1b	suppressor of variegation 3-9 homolog 1b	0.015
mllt11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11	0.015
pbx2	pre-B-cell leukemia transcription factor 2	0.015
unc5c	unc-5 homolog C (C. elegans)	0.015
ext2	exostoses (multiple) 2	0.015
foxm1	forkhead box M1	0.015
enc1	ectodermal-neural cortex (with BTB-like domain)	0.015
syt13	synaptotagmin XIII	0.015
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.015
hgd	homogentisate 1,2-dioxygenase	0.015
sp8a	sp8 transcription factor a	0.015
synj1	synaptojanin 1	0.015
ntn1a	netrin 1a	0.015
arl4ca	ADP-ribosylation factor-like 4Ca	0.015
gbx2	gastrulation brain homeo box 2	0.015
lgi1a	leucine-rich, glioma inactivated 1a	0.015
ghrl	ghrelin/obestatin preprohormone	0.015
gsc	goosecoid	0.015
sox11b	SRY-box containing gene 11b	0.015
rnf32	ring finger protein 32	0.015
zgc:55876	zgc:55876	0.015
arhgap11a	Rho GTPase activating protein 11A	0.015
foxp2	forkhead box P2	0.015
eng1a	engrailed 1a	0.015
nlgn3a	neuroligin 3a	0.014
stx1b	syntaxin 1B	0.014
oaz2a	ornithine decarboxylase antizyme 2a	0.014
wtap	Wilms tumor 1 associated protein	0.014
unc119.1	unc-119 homolog 1	0.014
LOC100536191	dynein beta chain, ciliary-like	0.014
ptpra	protein tyrosine phosphatase, receptor type, A	0.014
gdf6a	growth differentiation factor 6a	0.014	Human
otpb	orthopedia homolog b	0.014
tll1	tolloid-like 1	0.014
sept7b	septin 7b	0.014
ywhaqb	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b	0.014
htr5al	5-hydroxytryptamine (serotonin) receptor 5A like	0.013
si:ch211-209p5.2	si:ch211-209p5.2	0.013
gpm6ab	glycoprotein M6Ab	0.013
eaf1	ELL associated factor 1	0.013
zgc:73210	zgc:73210	0.013
h3f3b.1	H3 histone, family 3B.1	0.013
prickle2	prickle-like 2 (Drosophila)	0.013
mtnr1al	melatonin receptor type 1A like	0.013
otx1a	orthodenticle homolog 1a	0.013
meis2.1	myeloid ecotropic viral integration site 2.1	0.013
tmem2	transmembrane protein 2	0.013
srsf6b	serine/arginine-rich splicing factor 6b	0.013
gja3	gap junction protein, alpha 3	0.013
nr4a2b	nuclear receptor subfamily 4, group A, member 2b	0.013
prdm1a	PR domain containing 1a, with ZNF domain	0.013
pnx	posterior neuron-specific homeobox	0.013
hdac1	histone deacetylase 1	0.013
olfm1b	olfactomedin 1b	0.013
ahi1	Abelson helper integration site 1	0.013
rgma	RGM domain family, member A	0.013
crh	corticotropin releasing hormone	0.013
foxh1	forkhead box H1	0.013
negr1	neuronal growth regulator 1	0.013
meis2.2	myeloid ecotropic viral integration site 2.2	0.013
oep	one-eyed pinhead	0.013
ankrd6	ankyrin repeat domain 6	0.013
LOC100331568	breast cancer anti-estrogen resistance protein 3 homolog	0.012
ldb2a	LIM-domain binding factor 2a	0.012
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.012
pcdh19	protocadherin 19	0.012
LOC795535	hypothetical protein LOC795535	0.012
psen1	presenilin 1	0.012
metrn	meteorin, glial cell differentiation regulator	0.012
hoxc10a	homeo box C10a and homeobox protein Hox-C10a-like	0.012
uts1	urotensin 1	0.012
im:7162646	im:7162646	0.012
ntrk2a	neurotrophic tyrosine kinase, receptor, type 2a	0.012
pprc1	peroxisome proliferator-activated receptor gamma, coactivator-related 1	0.012
zc3h18	zinc finger CCCH-type containing 18	0.012
her4.2	hairy-related 4.2	0.012
sox11a	SRY-box containing gene 11a	0.012
lhx1b	LIM homeobox 1b	0.012
emx1	empty spiracles homeobox 1	0.012
nadl1.1	neural adhesion molecule L1.1	0.012
pcdh10b	protocadherin 10b	0.012
gria4a	glutamate receptor, ionotropic, AMPA 4a	0.012
btbd6a	BTB (POZ) domain containing 6a	0.012
ntrk1	neurotrophic tyrosine kinase, receptor, type 1	0.012
smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.012
atp2b4	ATPase, Ca++ transporting, plasma membrane 4	0.012
pde6c	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	0.012
si:dkeyp-87a12.1	si:dkeyp-87a12.1	0.012
cadm1a	cell adhesion molecule 1a	0.012
gata4	GATA-binding protein 4	0.012
sp7	Sp7 transcription factor	0.012
wnt5b	wingless-type MMTV integration site family, member 5b	0.012
dusp6	dual specificity phosphatase 6	0.012
ppp1cab	protein phosphatase 1, catalytic subunit, alpha isoform b	0.012
angptl6	angiopoietin-like 6	0.012
tpbgl	trophoblast glycoprotein-like	0.012
hoxa11a	homeo box A11a	0.012
cd82a	CD82 antigen, a	0.012
LOC100535964	hypothetical protein LOC100535964	0.012
LOC567638	hypothetical LOC567638	0.012
si:ch211-81a5.5	si:ch211-81a5.5	0.012
ntn1b	netrin 1b	0.012
slc6a8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	0.012
zgc:154063	zgc:154063	0.012
tmsb	thymosin, beta	0.011
her15.1	hairy and enhancer of split-related 15.1	0.011
zgc:101761	zgc:101761	0.011
si:dkey-181i3.1	si:dkey-181i3.1	0.011
ecm2	extracellular matrix protein 2, female organ and adipocyte specific	0.011
ptch2	patched 2	0.011
ywhae1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	0.011
si:dkey-208b23.5	si:dkey-208b23.5	0.011
rx1	retinal homeobox gene 1	0.011
unc5b	unc-5 homolog B (C. elegans)	0.011
LOC555504	novel protocadherin protein	0.011
wnt1	wingless-type MMTV integration site family, member 1	0.011
alx4a	aristaless-like homeobox 4a	0.011
sfpq	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.011
LOC563527	brain-specific angiogenesis inhibitor 1-like	0.011
si:ch1073-268b21.1	si:ch1073-268b21.1	0.011
mdkb	midkine-related growth factor b	0.011
vax2	ventral anterior homeobox 2	0.011
ggnbp2	gametogenetin binding protein 2	0.011
ved	ventrally expressed dharma/bozozok antagonist	0.011
lztfl1	leucine zipper transcription factor-like 1	0.011
rtdr1	rhabdoid tumor deletion region gene 1	0.011
zgc:153674	zgc:153674	0.011
smad6a	SMAD family member 6a	0.011
si:dkeyp-81f3.1	si:dkeyp-81f3.1	0.011
sulf1	sulfatase 1	0.011
chsy1	chondroitin sulfate synthase 1	0.011
zgc:153910	zgc:153910	0.011
LOC798275	neogenin-like	0.011
sall4	sal-like 4 (Drosophila)	0.011
ift88	intraflagellar transport 88 homolog	0.011
pax7a	paired box gene 7a	0.011
satb2	SATB homeobox 2	0.011
waca	WW domain containing adaptor with coiled-coil a	0.011
ext1a	exostoses (multiple) 1a	0.011
rhoaa	ras homolog gene family, member Aa	0.011
hoxa10b	homeo box A10b	0.011
LOC556026	afadin- and alpha-actinin-binding protein-like	0.011
cbx2	chromobox homolog 2 (Drosophila Pc class)	0.011
elof1	elongation factor 1 homolog (S. cerevisiae)	0.011
setdb1b	SET domain, bifurcated 1b	0.011
dlx1a	distal-less homeobox gene 1a	0.011
hnrnpk	heterogeneous nuclear ribonucleoprotein K	0.011
pdzrn3	PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3	0.011
dmbx1a	diencephalon/mesencephalon homeobox 1a	0.011
tmem170a	transmembrane protein 170A	0.011
mpped2	metallophosphoesterase domain containing 2	0.011
rac3a	ras-related C3 botulinum toxin substrate 3a (rho family, small GTP binding protein Rac3)	0.011
fgfr4	fibroblast growth factor receptor 4	0.011
gng3	guanine nucleotide binding protein (G protein), gamma 3	0.011
erf	Ets2 repressor factor	0.011
lbr	lamin B receptor	0.011
myh10	myosin, heavy polypeptide 10, non-muscle and myosin, heavy chain 10, non-muscle	0.010
lft2	lefty2	0.010
si:ch211-198a12.6	si:ch211-198a12.6	0.010
gria3a	glutamate receptor, ionotropic, AMPA 3a	0.010
pax3a	paired box gene 3a	0.010
LOC793222	cAMP-dependent protein kinase inhibitor alpha-like	0.010
LOC100535597	hypothetical protein LOC100535597	0.010
sass6	spindle assembly 6 homolog (C. elegans)	0.010
wls	wntless homolog (Drosophila)	0.010
dixdc1a	DIX domain containing 1a	0.010
ssbp4	single stranded DNA binding protein 4	0.010
adra2db	adrenergic, alpha-2D-, receptor b	0.010
ppp2r5ea	protein phosphatase 2, regulatory subunit B', epsilon isoform a	0.010
ube4b	ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)	0.010
sec13	SEC13 homolog (S. cerevisiae)	0.010
rgl1	ral guanine nucleotide dissociation stimulator-like 1	0.010