The network for 'regulation of stress activated protein kinase signaling cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of stress activated protein kinase signaling cascade

Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade.

Homo sapiens
Name Description Probability Func Analog Organism
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.998
EGFR epidermal growth factor receptor 0.998
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.997
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.995
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.987
CSNK1E casein kinase 1, epsilon 0.985
FN1 fibronectin 1 0.975
SMAD2 SMAD family member 2 0.965
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.961
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.960
BBS10 Bardet-Biedl syndrome 10 0.954
ZNF43 zinc finger protein 43 0.920
TRAF2 TNF receptor-associated factor 2 0.893
GSK3B glycogen synthase kinase 3 beta 0.876
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.873
TRAF1 TNF receptor-associated factor 1 0.872
RIPK2 receptor-interacting serine-threonine kinase 2 0.867
BCAR1 breast cancer anti-estrogen resistance 1 0.837
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.837
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.836
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.831
FYN FYN oncogene related to SRC, FGR, YES 0.824
LAT linker for activation of T cells 0.784
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.783
TRAF6 TNF receptor-associated factor 6 0.783
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.778
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.749
GRB2 growth factor receptor-bound protein 2 0.744
MYD88 myeloid differentiation primary response gene (88) 0.739
MAPK8 mitogen-activated protein kinase 8 0.731
ILK integrin-linked kinase 0.721
CAV1 caveolin 1, caveolae protein, 22kDa 0.709
TRAF5 TNF receptor-associated factor 5 0.701
PTK2 PTK2 protein tyrosine kinase 2 0.691
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.677
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.660
LCK lymphocyte-specific protein tyrosine kinase 0.657
IL1R1 interleukin 1 receptor, type I 0.647
MAP2K4 mitogen-activated protein kinase kinase 4 0.647
SH3KBP1 SH3-domain kinase binding protein 1 0.637
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.635
CCR5 chemokine (C-C motif) receptor 5 0.608
MAP2K7 mitogen-activated protein kinase kinase 7 0.595
ZNF253 zinc finger protein 253 0.595
ZNF273 zinc finger protein 273 0.592
BLNK B-cell linker 0.569
ZNF746 zinc finger protein 746 0.566
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.544
BMPR1A bone morphogenetic protein receptor, type IA 0.533
TNF tumor necrosis factor 0.528
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.512
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.508
CCNE1 cyclin E1 0.500
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.498
AXIN1 axin 1 0.484
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0.480
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.474
SH3BP2 SH3-domain binding protein 2 0.467
TRADD TNFRSF1A-associated via death domain 0.461
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.461
NRP1 neuropilin 1 0.438
ZNF675 zinc finger protein 675 0.438
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.436
VEGFA vascular endothelial growth factor A 0.424
CD40 CD40 molecule, TNF receptor superfamily member 5 0.422
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.419
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.416
BIRC3 baculoviral IAP repeat containing 3 0.408
SQSTM1 sequestosome 1 0.403
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.398
ARRB1 arrestin, beta 1 0.398
ZMYND11 zinc finger, MYND-type containing 11 0.397
CCL4 chemokine (C-C motif) ligand 4 0.392
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.386
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.384
JUN jun proto-oncogene 0.379
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.376
SMAD3 SMAD family member 3 0.375
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.374
STK4 serine/threonine kinase 4 0.373
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.368
IL1B interleukin 1, beta 0.349
ZNF708 zinc finger protein 708 0.346
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.337
IRAK2 interleukin-1 receptor-associated kinase 2 0.325
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.322
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.314
MOBKL3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 0.314
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.308
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.306
CREBBP CREB binding protein 0.303
TGFB3 transforming growth factor, beta 3 0.300
IRAK1 interleukin-1 receptor-associated kinase 1 0.299
VAV1 vav 1 guanine nucleotide exchange factor 0.293
SKIL SKI-like oncogene 0.293
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.292
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.286
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.273
CCL2 chemokine (C-C motif) ligand 2 0.273
RAB21 RAB21, member RAS oncogene family 0.271
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
cst-1 Protein CST-1 0.085
eor-2 Protein EOR-2 0.046
F21A10.2 Protein F21A10.2 0.022
cst-2 Protein CST-2 0.019
smp-1 Protein SMP-1 0.017
unc-16 Protein UNC-16 0.014
tir-1 Protein TIR-1 0.014
pdl-1 Protein PDL-1 0.014
cap-2 Protein CAP-2 0.013
skn-1 Protein SKN-1 0.012
lat-1 Protein LAT-1 0.011
sta-1 Protein STA-1 0.011
daf-11 Protein DAF-11 0.011
F10G8.8 Protein F10G8.8 0.010
pas-6 Protein PAS-6 0.010
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Danio rerio
Name Description Probability Func Analog Organism
osr1 odd-skipped related 1 (Drosophila) 0.037
dkk1b dickkopf 1b 0.028
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.026
chd chordin 0.023
igf1rb insulin-like growth factor 1b receptor 0.021
fzd5 frizzled homolog 5 0.019
rhoab ras homolog gene family, member Ab 0.019
ephb4b eph receptor B4b 0.018
dvl2 dishevelled, dsh homolog 2 (Drosophila) 0.017
pias4a protein inhibitor of activated STAT, 4a 0.014
jag2 jagged 2 0.013
gro1 groucho 1 0.013
tlr3 toll-like receptor 3 0.012
foxa3 forkhead box A3 0.012
irak4 interleukin-1 receptor-associated kinase 4 0.012
gro2 groucho 2 0.011
LOC563527 brain-specific angiogenesis inhibitor 1-like 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.548
Pkn Protein kinase related to protein kinase N 0.410
skpA CG16983 gene product from transcript CG16983-RD 0.398
Pvr PDGF- and VEGF-receptor related 0.351
chico CG5686 gene product from transcript CG5686-RB 0.312
Akt1 CG4006 gene product from transcript CG4006-RA 0.260
l(2)gl lethal (2) giant larvae 0.254
Rel Relish 0.239
p38b CG7393 gene product from transcript CG7393-RA 0.213
LIMK1 LIM-kinase1 0.209
Rala Ras-related protein 0.170
kibra kibra ortholog 0.150
AttA Attacin-A 0.149
Smox Smad on X 0.148
X11L CG5675 gene product from transcript CG5675-RB 0.144
DptB Diptericin B 0.142
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.135
lgs legless 0.128
Shc SHC-adaptor protein 0.125
Pak PAK-kinase 0.125
babo baboon 0.122
tkv thickveins 0.121
egr eiger 0.115
hep hemipterous 0.108
foxo forkhead box, sub-group O 0.107
CG1021 CG1021 gene product from transcript CG1021-RE 0.106
yki yorkie 0.105
par-1 CG8201 gene product from transcript CG8201-RA 0.098
drk downstream of receptor kinase 0.097
bsk basket 0.092
dock dreadlocks 0.090
spen split ends 0.085
Dad Daughters against dpp 0.084
Ric Ras which interacts with Calmodulin 0.083
Ras64B Ras oncogene at 64B 0.080
p53 CG33336 gene product from transcript CG33336-RB 0.080
Myo31DF Myosin 31DF 0.076
Sara Smad anchor for receptor activation 0.075
Sir2 CG5216 gene product from transcript CG5216-RA 0.075
Jra Jun-related antigen 0.074
baz bazooka 0.072
Abl Abl tyrosine kinase 0.069
Mpk2 CG5475 gene product from transcript CG5475-RB 0.066
Pcaf CG4107 gene product from transcript CG4107-RA 0.065
Rab5 Rab-protein 5 0.064
wdb widerborst 0.062
cact cactus 0.062
Thor CG8846 gene product from transcript CG8846-RA 0.062
ex expanded 0.060
otk off-track 0.059
Pp2B-14D Protein phosphatase 2B at 14D 0.058
p120ctn Adherens junction protein p120 0.054
mib1 mind bomb 1 0.054
dco discs overgrown 0.052
Pink1 PTEN-induced putative kinase 1 0.051
bif bifocal 0.051
CG16718 CG16718 gene product from transcript CG16718-RA 0.051
mbc myoblast city 0.050
CG42863 CG42863 gene product from transcript CG42863-RB 0.049
PGRP-LC Peptidoglycan recognition protein LC 0.048
mxc multi sex combs 0.047
tamo CG4057 gene product from transcript CG4057-RA 0.047
ci cubitus interruptus 0.047
hth homothorax 0.046
Osbp Oxysterol binding protein 0.046
Stim Stromal interaction molecule 0.045
PGRP-SA Peptidoglycan recognition protein SA 0.045
sd scalloped 0.045
myoglianin CG1838 gene product from transcript CG1838-RD 0.044
rok Rho-kinase 0.044
alph alphabet 0.044
Sema-1a CG18405 gene product from transcript CG18405-RD 0.044
tai taiman 0.044
ds dachsous 0.043
Rab7 Rab-protein 7 0.043
PGRP-SD CG7496 gene product from transcript CG7496-RA 0.043
CG10743 CG10743 gene product from transcript CG10743-RB 0.042
Toll-7 CG8595 gene product from transcript CG8595-RA 0.042
CG14614 CG14614 gene product from transcript CG14614-RA 0.042
Tak1 TGF-beta activated kinase 1 0.042
dsh dishevelled 0.040
rst roughest 0.039
PGRP-LB Peptidoglycan recognition protein LB 0.039
RYBP Ring and YY1 Binding Protein 0.038
Gug Grunge 0.038
krz kurtz 0.038
CG9902 CG9902 gene product from transcript CG9902-RA 0.037
coro CG9446 gene product from transcript CG9446-RC 0.037
Pli Pellino 0.037
Apc APC-like 0.037
fwd four wheel drive 0.037
key kenny 0.036
PRL-1 CG4993 gene product from transcript CG4993-RB 0.036
Pk61C Protein kinase 61C 0.035
Gyc76C Guanylyl cyclase at 76C 0.035
ft fat 0.035
CG1347 CG1347 gene product from transcript CG1347-RB 0.035
Wnk CG7177 gene product from transcript CG7177-RA 0.034
PGRP-LF Peptidoglycan recognition protein LF 0.034
Atf-2 Activating transcription factor-2 0.033
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Adora2a adenosine A2a receptor 0.508
Usf2 upstream transcription factor 2, c-fos interacting 0.460
Mapk1 mitogen activated protein kinase 1 0.334
Jak1 Janus kinase 1 0.315
Grm7 glutamate receptor, metabotropic 7 0.309
Gria2 glutamate receptor, ionotropic, AMPA 2 0.262
Nckap1 NCK-associated protein 1 0.240
Jtb jumping translocation breakpoint 0.218
Serinc1 serine incorporator 1 0.159
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.138
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.137
Sqstm1 sequestosome 1 0.133
Myd88 myeloid differentiation primary response gene 88 0.132
Mapk9 mitogen-activated protein kinase 9 0.131
Vegfa vascular endothelial growth factor A 0.126
Nras neuroblastoma ras oncogene 0.124
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.111
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.109
Mapk6 mitogen-activated protein kinase 6 0.099
Map2 microtubule-associated protein 2 0.080
Pdp1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.075
Tgfb2 transforming growth factor, beta 2 0.075
Map2k1 mitogen activated protein kinase kinase 1 0.073
Il1a interleukin 1 alpha 0.072
Arl5a ADP-ribosylation factor-like 5A 0.071
Mapk8 mitogen-activated protein kinase 8 0.065
Ccl4 chemokine (C-C motif) ligand 4 0.064
Ube2a ubiquitin-conjugating enzyme E2A (RAD6 homolog) 0.064
Ptp4a2 protein tyrosine phosphatase 4a2 0.064
Fkbp1a FK506 binding protein 1a 0.063
Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.062
Gja6 gap junction protein, alpha 6 0.062
Pkia protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.059
Grip1 glutamate receptor interacting protein 1 0.059
Cebpg CCAAT/enhancer binding protein (C/EBP), gamma 0.058
Sh3bp1 SH3-domain binding protein 1 0.058
Rab10 RAB10, member RAS oncogene family 0.057
Cttnbp2 cortactin binding protein 2 0.056
Prkg2 protein kinase, cGMP-dependent, type II 0.055
Cyfip2 cytoplasmic FMR1 interacting protein 2 0.054
Syt2 synaptotagmin II 0.054
Nudt3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.054
Il9r interleukin 9 receptor 0.053
Pick1 protein interacting with PRKCA 1 0.052
Masp1 mannan-binding lectin serine peptidase 1 0.052
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.052
Ctdsp1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 0.051
Paqr5 progestin and adipoQ receptor family member V 0.050
Ap3s1 adaptor-related protein complex 3, sigma 1 subunit 0.049
Bcl2l2 Bcl2-like 2 0.047
Rhd Rh blood group, D antigen 0.046
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.046
Homer1 homer homolog 1 (Drosophila) 0.046
Accn2 amiloride-sensitive cation channel 2, neuronal 0.045
Mca32 mast cell antigen 32 0.045
Sema6b sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 0.045
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.045
Dbp D site of albumin promoter (albumin D-box) binding protein 0.044
RGD1305793 similar to hypothetical protein FLJ20154 0.044
Cugbp2 CUG triplet repeat, RNA binding protein 2 0.043
Gria3 glutamate receptor, ionotrophic, AMPA 3 0.043
Slc6a15 solute carrier family 6 (neutral amino acid transporter), member 15 0.041
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.040
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.039
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.039
Utrn utrophin 0.039
Vat1 vesicle amine transport protein 1 homolog (T californica) 0.038
Acr acrosin 0.037
Plscr3 phospholipid scramblase 3 0.037
Il2 interleukin 2 0.036
Nus1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 0.036
Cry2 cryptochrome 2 (photolyase-like) 0.036
Slc24a6 solute carrier family 24 (sodium/potassium/calcium exchanger), member 6 0.035
Fam180a family with sequence similarity 180, member A 0.035
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.035
Ncan neurocan 0.035
Fgfr1 Fibroblast growth factor receptor 1 0.034
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.034
Nrcam neuronal cell adhesion molecule 0.034
Notch3 Notch homolog 3 (Drosophila) 0.033
March5 membrane-associated ring finger (C3HC4) 5 0.033
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.033
Hsph1 heat shock 105/110 protein 1 0.033
Gzmk granzyme K 0.033
Psp parotid secretory protein 0.032
Dtx3l deltex 3-like (Drosophila) 0.032
LOC286960 preprotrypsinogen IV 0.032
Syt4 synaptotagmin IV 0.032
Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.032
Prkcb protein kinase C, beta 0.032
Arrdc1 arrestin domain containing 1 0.031
Gpr4 G protein-coupled receptor 4 0.031
Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) 0.031
Pctk2 PCTAIRE protein kinase 2 0.030
Ucn urocortin 0.030
Itgam integrin, alpha M 0.029
Gpc3 glypican 3 0.029
Vdac1 voltage-dependent anion channel 1 0.029
Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 0.029
Cd247 Cd247 molecule 0.029
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism