The network for 'negative regulation of cellular amino acid metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cellular amino acid metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid.

Homo sapiens
Name Description Probability Func Analog Organism
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 1.000
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.987
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.948
BTK Bruton agammaglobulinemia tyrosine kinase 0.943
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.920
LCK lymphocyte-specific protein tyrosine kinase 0.909
FYN FYN oncogene related to SRC, FGR, YES 0.888
SMAD3 SMAD family member 3 0.881
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.868
SH3KBP1 SH3-domain kinase binding protein 1 0.792
VAV1 vav 1 guanine nucleotide exchange factor 0.783
ESR1 estrogen receptor 1 0.736
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.708
CD44 CD44 molecule (Indian blood group) 0.706
EGFR epidermal growth factor receptor 0.688
NCK1 NCK adaptor protein 1 0.663
NCF1 neutrophil cytosolic factor 1 0.642
GRB2 growth factor receptor-bound protein 2 0.632
SMAD2 SMAD family member 2 0.631
GHR growth hormone receptor 0.616
DTNA dystrobrevin, alpha 0.589
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.579
CAV1 caveolin 1, caveolae protein, 22kDa 0.569
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.527
VIM vimentin 0.521
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.493
SOCS1 suppressor of cytokine signaling 1 0.491
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.490
BLNK B-cell linker 0.486
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.477
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.471
PTPRC protein tyrosine phosphatase, receptor type, C 0.460
TBC1D10A TBC1 domain family, member 10A 0.442
FEM1B fem-1 homolog b (C. elegans) 0.423
BAK1 BCL2-antagonist/killer 1 0.397
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.387
SMAD1 SMAD family member 1 0.383
SPTBN1 spectrin, beta, non-erythrocytic 1 0.357
KLF4 Kruppel-like factor 4 (gut) 0.356
MAPK12 mitogen-activated protein kinase 12 0.350
PRKCB protein kinase C, beta 0.348
VAC14 Vac14 homolog (S. cerevisiae) 0.342
CTBP1 C-terminal binding protein 1 0.341
PRKCA protein kinase C, alpha 0.341
SCHIP1 schwannomin interacting protein 1 0.338
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.335
SETD8 SET domain containing (lysine methyltransferase) 8 0.334
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.318
KLF6 Kruppel-like factor 6 0.313
HIPK2 homeodomain interacting protein kinase 2 0.307
SH3BP2 SH3-domain binding protein 2 0.302
SPRR2A small proline-rich protein 2A 0.302
SPRY2 sprouty homolog 2 (Drosophila) 0.298
SMAD7 SMAD family member 7 0.297
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.295
ACTB actin, beta 0.295
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.286
BAD BCL2-associated agonist of cell death 0.284
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.281
SFN stratifin 0.278
TP53BP2 tumor protein p53 binding protein, 2 0.277
NBN nibrin 0.268
PROX1 prospero homeobox 1 0.266
LRP6 low density lipoprotein receptor-related protein 6 0.263
NCF4 neutrophil cytosolic factor 4, 40kDa 0.261
CREBBP CREB binding protein 0.259
TNS4 tensin 4 0.257
SOCS2 suppressor of cytokine signaling 2 0.255
NOXA1 NADPH oxidase activator 1 0.253
HDAC1 histone deacetylase 1 0.252
BCL2L1 BCL2-like 1 0.252
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.250
TESK1 testis-specific kinase 1 0.247
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.240
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.230
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.227
SKI v-ski sarcoma viral oncogene homolog (avian) 0.225
PTEN phosphatase and tensin homolog 0.223
SH2D1A SH2 domain containing 1A 0.217
NRIP1 nuclear receptor interacting protein 1 0.214
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.213
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.212
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.211
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.205
TRAF4 TNF receptor-associated factor 4 0.199
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.198
SLAMF1 signaling lymphocytic activation molecule family member 1 0.195
CD28 CD28 molecule 0.191
TSC22D1 TSC22 domain family, member 1 0.190
FLNB filamin B, beta 0.190
ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 0.189
ACTN1 actinin, alpha 1 0.187
TFF1 trefoil factor 1 0.185
SCN5A sodium channel, voltage-gated, type V, alpha subunit 0.179
SP1 Sp1 transcription factor 0.176
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.175
F11R F11 receptor 0.174
KAT2B K(lysine) acetyltransferase 2B 0.173
MAPT microtubule-associated protein tau 0.170
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.167
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
htl heartless 0.013
mth methuselah 0.013
krz kurtz 0.013
drk downstream of receptor kinase 0.012
trpml transient receptor potential mucolipin 0.010
EDTP Egg-derived tyrosine phosphatase 0.010
Atg1 Autophagy-specific gene 1 0.010
sktl skittles 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.999
Lepr leptin receptor 0.997
Pten phosphatase and tensin homolog 0.997
Trp53 transformation related protein 53 0.994
Fyn Fyn proto-oncogene 0.993
Egfr epidermal growth factor receptor 0.993
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.988
Slamf1 signaling lymphocytic activation molecule family member 1 0.982
Cbl Casitas B-lineage lymphoma 0.982
Grb2 growth factor receptor bound protein 2 0.981
Smad3 MAD homolog 3 (Drosophila) 0.978
Neurod1 neurogenic differentiation 1 0.975
Axin1 axin 1 0.973
Bcl2 B-cell leukemia/lymphoma 2 0.973
Apc adenomatosis polyposis coli 0.971
Nos3 nitric oxide synthase 3, endothelial cell 0.956
Dusp1 dual specificity phosphatase 1 0.948
Sfrp2 secreted frizzled-related protein 2 0.932
Smad1 MAD homolog 1 (Drosophila) 0.928
Gab2 growth factor receptor bound protein 2-associated protein 2 0.922
Gab1 growth factor receptor bound protein 2-associated protein 1 0.910
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.907
Gsk3b glycogen synthase kinase 3 beta 0.893
Epor erythropoietin receptor 0.884
Shc1 src homology 2 domain-containing transforming protein C1 0.879
Arrb2 arrestin, beta 2 0.871
Gata1 GATA binding protein 1 0.848
Spry4 sprouty homolog 4 (Drosophila) 0.847
Ldb3 LIM domain binding 3 0.830
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.826
Neurod4 neurogenic differentiation 4 0.811
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.786
Tcrd T-cell receptor delta chain 0.786
Sos1 son of sevenless homolog 1 (Drosophila) 0.785
Tcrb T-cell receptor beta chain 0.784
Cd28 CD28 antigen 0.781
Vhl von Hippel-Lindau tumor suppressor 0.781
Klf4 Kruppel-like factor 4 (gut) 0.771
Zeb1 zinc finger E-box binding homeobox 1 0.765
Arrb1 arrestin, beta 1 0.757
Stat3 signal transducer and activator of transcription 3 0.746
Vasp vasodilator-stimulated phosphoprotein 0.741
Egr1 early growth response 1 0.738
Jun Jun oncogene 0.736
Jak2 Janus kinase 2 0.734
Ptpn12 protein tyrosine phosphatase, non-receptor type 12 0.729
Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.715
Ptk2 PTK2 protein tyrosine kinase 2 0.711
Inpp5d inositol polyphosphate-5-phosphatase D 0.701
Atm ataxia telangiectasia mutated homolog (human) 0.669
Dmd dystrophin, muscular dystrophy 0.657
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.652
Rhob ras homolog gene family, member B 0.630
Fos FBJ osteosarcoma oncogene 0.626
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.624
Ptf1a pancreas specific transcription factor, 1a 0.618
Socs2 suppressor of cytokine signaling 2 0.610
Hand2 heart and neural crest derivatives expressed transcript 2 0.610
Mdm2 transformed mouse 3T3 cell double minute 2 0.603
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.592
Prkcb protein kinase C, beta 0.591
Mecom MDS1 and EVI1 complex locus 0.589
Vav1 vav 1 oncogene 0.587
Cish cytokine inducible SH2-containing protein 0.572
Mapk8 mitogen-activated protein kinase 8 0.572
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.571
Gpsm3 G-protein signalling modulator 3 (AGS3-like, C. elegans) 0.571
Sfrp1 secreted frizzled-related protein 1 0.553
Insr insulin receptor 0.553
Cd19 CD19 antigen 0.551
Zfp36 zinc finger protein 36 0.550
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.547
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.537
Ank1 ankyrin 1, erythroid 0.531
Evl Ena-vasodilator stimulated phosphoprotein 0.531
Sh3kbp1 SH3-domain kinase binding protein 1 0.529
Plcg2 phospholipase C, gamma 2 0.516
Slc4a1 solute carrier family 4 (anion exchanger), member 1 0.512
Skil SKI-like 0.508
En1 engrailed 1 0.508
Ikzf1 IKAROS family zinc finger 1 0.502
Ren1 renin 1 structural 0.501
Braf Braf transforming gene 0.497
Otx2 orthodenticle homolog 2 (Drosophila) 0.495
Mdm4 transformed mouse 3T3 cell double minute 4 0.493
Ikzf3 IKAROS family zinc finger 3 0.491
Jak1 Janus kinase 1 0.488
Tcf15 transcription factor 15 0.486
Wt1 Wilms tumor 1 homolog 0.483
Drd2 dopamine receptor D2 0.475
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.468
Icos inducible T-cell co-stimulator 0.467
Neurog2 neurogenin 2 0.466
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.463
Cacng2 calcium channel, voltage-dependent, gamma subunit 2 0.463
Smad4 MAD homolog 4 (Drosophila) 0.460
Enah enabled homolog (Drosophila) 0.446
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.446
Btg2 B-cell translocation gene 2, anti-proliferative 0.444
Klf2 Kruppel-like factor 2 (lung) 0.443
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Rattus norvegicus
Name Description Probability Func Analog Organism
Mx1 myxovirus (influenza virus) resistance 1 0.025
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.021
Sgk1 serum/glucocorticoid regulated kinase 1 0.019
Isg15 ISG15 ubiquitin-like modifier 0.018
RT1-S3 RT1 class Ib, locus S3 0.017
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.016
Hck hemopoietic cell kinase 0.016
Stat6 signal transducer and activator of transcription 6 0.015
Rsad2 radical S-adenosyl methionine domain containing 2 0.015
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.014
Clcn5 chloride channel 5 0.014
Tgfbr2 transforming growth factor, beta receptor II 0.014
Tsc22d3 TSC22 domain family, member 3 0.013
Bcl2 B-cell CLL/lymphoma 2 0.013
Efnb1 ephrin B1 0.013
Klf9 Kruppel-like factor 9 0.013
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.013
Gbp2 guanylate binding protein 2 0.013
Usf2 upstream transcription factor 2, c-fos interacting 0.013
Nos3 nitric oxide synthase 3, endothelial cell 0.013
Ptch1 patched homolog 1 (Drosophila) 0.013
Rabac1 Rab acceptor 1 (prenylated) 0.013
Cbl Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.012
Cxcr4 chemokine (C-X-C motif) receptor 4 0.012
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.012
Gja5 gap junction protein, alpha 5 0.012
Fn3k fructosamine 3 kinase 0.012
Gna11 guanine nucleotide binding protein, alpha 11 0.012
Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.012
Slfn2 schlafen 2 0.012
Adhfe1 alcohol dehydrogenase, iron containing, 1 0.012
C3ar1 complement component 3a receptor 1 0.012
Pink1 PTEN induced putative kinase 1 0.012
Arrb1 arrestin, beta 1 0.012
Oas1a 2'-5' oligoadenylate synthetase 1A 0.012
Purb purine rich element binding protein B 0.012
RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase 0.012
Qars glutaminyl-tRNA synthetase 0.012
Dctn1 dynactin 1 0.012
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.012
Fgfr4 fibroblast growth factor receptor 4 0.011
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.011
Npr1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) 0.011
Myo10 myosin X 0.011
Aif1 allograft inflammatory factor 1 0.011
Dusp1 dual specificity phosphatase 1 0.011
Fgfr2 fibroblast growth factor receptor 2 0.011
Rest RE1-silencing transcription factor 0.011
Il6r interleukin 6 receptor 0.011
Acacb acetyl-Coenzyme A carboxylase beta 0.011
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.011
Nr1i2 nuclear receptor subfamily 1, group I, member 2 0.011
Foxi2 forkhead box I2 0.011
Tapbp TAP binding protein 0.011
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.011
Irs1 insulin receptor substrate 1 0.011
St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.011
Ugt2b UDP glycosyltransferase 2 family, polypeptide B 0.011
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.011
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.011
Rps8 ribosomal protein S8 0.011
Zfp36 zinc finger protein 36 0.011
Rara retinoic acid receptor, alpha 0.011
Zfc3h1 zinc finger, C3H1-type containing 0.011
Fabp1 fatty acid binding protein 1, liver 0.011
Gpam glycerol-3-phosphate acyltransferase, mitochondrial 0.011
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.011
Apob apolipoprotein B 0.011
Cldn2 claudin 2 0.011
Foxa3 forkhead box A3 0.011
Rin1 Ras and Rab interactor 1 0.011
Csnk1g2 casein kinase 1, gamma 2 0.011
Fos FBJ osteosarcoma oncogene 0.011
Tmprss2 transmembrane protease, serine 2 0.011
Foxp1 forkhead box P1 0.011
Mug1 murinoglobulin 1 0.011
Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit 0.011
Smad7 SMAD family member 7 0.011
Rab15 RAB15, member RAS oncogene family 0.011
Fnbp1 formin binding protein 1 0.011
Vav1 vav 1 guanine nucleotide exchange factor 0.011
Tbxa2r thromboxane A2 receptor 0.011
Ass1 argininosuccinate synthetase 1 0.011
Ahr aryl hydrocarbon receptor 0.011
Creb1 cAMP responsive element binding protein 1 0.011
Hnf4a hepatocyte nuclear factor 4, alpha 0.011
Ss18l1 synovial sarcoma translocation gene on chromosome 18-like 1 0.011
Bin2 bridging integrator 2 0.011
Nrp2 neuropilin 2 0.011
Slc27a5 solute carrier family 27 (fatty acid transporter), member 5 0.011
Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.011
Litaf lipopolysaccharide-induced TNF factor 0.011
Ikzf1 IKAROS family zinc finger 1 0.011
Pdk2 pyruvate dehydrogenase kinase, isozyme 2 0.011
Map2k5 mitogen activated protein kinase kinase 5 0.011
Vipr1 vasoactive intestinal peptide receptor 1 0.011
Tcf21 transcription factor 21 0.011
Galnt10 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) 0.011
Dbndd2 dysbindin (dystrobrevin binding protein 1) domain containing 2 0.011
Ehf ets homologous factor 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
UBI4 Ubi4p 0.035